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Synchronous primary neoplasms detected on 18F-FDG PET in staging of patients with esophageal cancer.

2005; National Institutes of Health; Volume: 46; Issue: 8 Linguagem: Inglês

Henderik L. van Westreenen, Marinke Westerterp, Pieter L. Jager, Hendrik M. van Dullemen, Gerrit W. Sloof, Emile F.I. Comans, J. Jan B. van Lanschot, Theo Wiggers, John Th. M. Plukker,

Lung Cancer Treatments and Mutations

Because of improvements in diagnostic technology, the incidental detection of synchronous primary tumors during the preoperative work-up of patients with esophageal cancer has increased. The aim of this study was to determine the rate and clinical relevance of synchronous neoplasms seen on (18)F-FDG PET in staging of esophageal cancer.From January 1996 to July 2004, 366 patients with biopsy-proven malignancy of the esophagus underwent (18)F-FDG PET for initial staging. This series of patients was retrospectively reviewed for the detection of synchronous primary neoplasms.Twenty synchronous primary neoplasms (5.5%) were identified in 366 patients. Eleven neoplasms were in the colorectum, 5 in the kidney, 2 in the thyroid gland, 1 in the lung, and 1 in the gingiva. One of the thyroid lesions and the lung lesion were erroneously interpreted as metastases, leading to incorrect upstaging of the esophageal tumor.(18)F-FDG PET detected unexpected synchronous primary neoplasms in 5.5% of patients with esophageal cancer. Sites of pathologic (18)F-FDG uptake should be confirmed by dedicated additional investigations before treatment, because synchronous neoplasms may mimic metastases.