Isolation and characterization of cardiac steroids from seeds of Elaeopendron glaucum Pers. Structures of elaeodendrosides A,D,E,H,I,J and elaeodendrogenin.

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Isolation and characterization of cardiac steroids from seeds of Elaeopendron glaucum Pers. Structures of elaeodendrosides A,D,E,H,I,J and elaeodendrogenin.

1982; Pharmaceutical Society of Japan; Volume: 30; Issue: 11 Linguagem: Inglês

10.1248/cpb.30.4075

ISSN

1347-5223

Autores

Kazutake Shimada, Tomoko Kyuno, TOSHIO NAMBARA, Itsuo Uchida,

Tópico(s)

Phytochemical Studies and Bioactivities

Resumo

Six cardiac glycosides having a methylenedioxy group in the sugar moiety, elaeodendroside A, D, E, H, I and J, were isolated from seeds of Elaeodendron glaucum PERS. Their structures were elucidated on the basis of chemical correlation with elaeodendroside A, which was characterized by X-ray analysis. A new cradiac steroid named elaeodendrogenin was also isolated from the same plant materials and its structure was established by direct comparison with a synthetic sample obtained from digitoxigenin. The cardiac activities of these compounds were tested with Straub's preparation.

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Isolation and characterization of cardiac steroids from seeds of Elaeopendron glaucum Pers. Structures of elaeodendrosides A,D,E,H,I,J and elaeodendrogenin.