Palladium-catalyzed cross-coupling of 2-iodoadenosine with terminal alkynes: Synthesis and biological activities of 2-alkynyladenosines.
1985; Pharmaceutical Society of Japan; Volume: 33; Issue: 4 Linguagem: Inglês
10.1248/cpb.33.1766
ISSN1347-5223
AutoresAkira Matsuda, Misao Shinozaki, Tadashi Miyasaka, Haruhiko Machida, Tohichi Abiru,
Tópico(s)Click Chemistry and Applications
ResumoReaction of 2-iodoadenosine (2) with terminal alkynes in the presence of bis (triphenylphosphine) palladium dichloride and cuprous iodide in triethylamine and N, N, -dimethylformamide gave 2-alkynyl-adenosines (3a-h) in excellent yields. Several compounds showed high activity as inhibitors in rat passive cutaneous anaphylaxis (PCA) reaction. Among them, 2-(3-hydroxypropynyl)- and 2-(3-hydroxybutynyl)-adenosines (3d, f) are much more potent than disodium cromoglycate (DSCG).
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