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An Estrogen-like Activity in Pomegranate Juice.

2001; Japanese Society for Food Science and Technology; Volume: 48; Issue: 2 Linguagem: Inglês

10.3136/nskkk.48.146

1881-6681

Isafumi Maru, Jun Ohnishi, Shinya Yamaguchi, Yasuo Oda, Kazuaki Kakehi, Yasuhiro Ohta,

Hops Chemistry and Applications

We examined an estrogen-like activity in the pomegranate (Punica granatum) juice. The juice or its methanol eluate from C18 cartridge competed with 17β-estradiol for estrogen receptor (ER) binding and also stimulated proliferation of human ER-positive cell (MCF-7) in vitro. Furthermore, they effectively increased uterine weight in the ovariectomized rat. On the basis of these data, we concluded that the pomegranate juice contained estrogen-like compounds.