Highly reactive “RIKEN click” probe for glycoconjugation on lysines
2017; Elsevier BV; Volume: 58; Issue: 20 Linguagem: Inglês
10.1016/j.tetlet.2017.03.081
ISSN1873-3581
AutoresRegina Sibgatullina, Katsumasa Fujiki, Takefumi Murase, Takahiro Yamamoto, Taiji Shimoda, Almira R. Kurbangalieva, Katsunori Tanaka,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoOne pot double click strategy containing strain-promoted click-reaction followed by 6π-azaelectrocyclization (RIKEN click reaction) has worked well in the synthesis of multivalent homogeneous and heterogeneous N-glycoalbumins. We have slightly changed the structure of linker unsaturated aldehyde used in this method. As a result it can be easily synthesized from commercially available material and furthermore, the enhancement of its reactivity towards both click-reactions was observed. The data described in this Communications facilitate the usage of the double click strategy as a general method for the synthesis of a variety of neo-N-glycoproteins.
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