Portal de Periódicos da CAPES

Methylxanthine Drug Monitoring with Wearable Sweat Sensors

2018; Volume: 30; Issue: 23 Linguagem: Inglês

10.1002/adma.201707442

1521-4095

Li‐Chia Tai, Wei Gao, Minghan Chao, Mallika Bariya, Quynh Phuong Ngo, Ziba Shahpar, Hnin Yin Yin Nyein, Hyejin Park, Junfeng Sun, Younsu Jung, Eric Wu, Hossain M. Fahad, Der‐Hsien Lien, Hiroki Ota, Gyoujin Cho, Ali Javey,

Analytical Chemistry and Sensors

Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. Here, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.