Catalytic Asymmetric Michael Reaction under Phase-Transfer Catalysis: Construction of Chiral Tetrasubstituted Carbon and Its Application to the Synthesis of a Chiral Pyrrolidone
2006; Elsevier BV; Volume: 67; Issue: 2 Linguagem: Inglês
10.3987/com-05-s(t)41
ISSN1881-0942
AutoresShigeru Arai, Fumie Takahashi, Riichiro Tsuji, Atsushi Nishida,
Tópico(s)Microwave-Assisted Synthesis and Applications
ResumoA catalytic asymmetric Michael reaction using Schiff bases promoted by D 2 -symmetrical ammonium salts as phase-transfer catalysts is described.The reaction of glycine Schiff base (1a) gave the Michael adduct with up to 91% ee and tetrasubstituted carbons was also constructed using alanine Schiff base (3a) with up to 63% ee.
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