Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Insights on Zika virus envelope gene conservation in American outbreaks

2020; Springer Nature; Volume: 51; Issue: 4 Linguagem: Inglês

10.1007/s42770-020-00349-3

1678-4405

Mateus Vailant Thomazella, Quirino Alves de Lima Neto, Francisco Ferreira Duarte, Fernando Américo Jorge, Déborah de Castro Moreira, Amauri Donadon Leal, Mayra Marinho Presibella, Irina Nastassja Riediger, Rafael A. da Silva, Isabel Maria Vicente Guedes de Carvalho-Mello, Dennis Armando Bertolini,

Viral Infections and Vectors

Phylogenetic studies with Zika virus (ZIKV) have been conducted in Brazil. In this study, we sequenced 8 new sequences of the ZIKV envelope (E) gene from strains of cases from the Paraná and Mato Grosso do Sul states in 2016. A low phylogenetic signal was observed, with more than 40% of unresolved quartets, and the Maximum Likelihood Tree grouped all sequences in the Brazilian branches within the Asian genotype. In addition, a Shannon entropy analysis was conducted, showing a high stability in the E protein through the ZIKV polyprotein. Taken together, these results suggest a high degree of conservation in the ZIKV E gene from the recent American outbreaks.