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Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).

1990; Springer Nature; Volume: 9; Issue: 1 Linguagem: Inglês

10.1002/j.1460-2075.1990.tb08094.x

1460-2075

Yoko Suda, Shinichi Aizawa, Yasuhide Furuta, Takeshi Yagi, Yoji Ikawa, K Saitoh, Yuki Yamada, K Toyoshima, Tadashi Yamamoto,

Lymphoma Diagnosis and Treatment

Research Article1 January 1990free access Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659). Y. Suda Y. Suda Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author S. Aizawa S. Aizawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Furuta Y. Furuta Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yagi T. Yagi Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Ikawa Y. Ikawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Saitoh K. Saitoh Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Yamada Y. Yamada Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Toyoshima K. Toyoshima Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yamamoto T. Yamamoto Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Suda Y. Suda Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author S. Aizawa S. Aizawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Furuta Y. Furuta Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yagi T. Yagi Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Ikawa Y. Ikawa Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Saitoh K. Saitoh Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Y. Yamada Y. Yamada Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author K. Toyoshima K. Toyoshima Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author T. Yamamoto T. Yamamoto Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. Search for more papers by this author Author Information Y. Suda1, S. Aizawa1, Y. Furuta1, T. Yagi1, Y. Ikawa1, K. Saitoh1, Y. Yamada1, K. Toyoshima1 and T. Yamamoto1 1Laboratory of Molecular Regulation of Aging, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan. The EMBO Journal (1990)9:181-190https://doi.org/10.1002/j.1460-2075.1990.tb08094.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The c-erbB2 gene is expressed uniquely in fetal epithelium in vivo and has been suggested to contribute to the development and/or progression of adenocarcinomas in man. In order to assess the oncogenicity of the c-erbB2 gene in vivo, normal c-erbB2 and mutant c-erbB2 encoding glutamic acid instead of valine at position 659 within the transmembrane domain were introduced into mice under the transcriptional regulatory unit of mouse mammary tumor virus long terminal repeat (MMTV-LTR) or immunoglobulin enhancer--SV40 early gene promoter (Ig/Tp). In transgenic mice with normal c-erbB2 under MMTV-LTR, not only adenocarcinomas but also a variety of tumors including B lymphomas were induced at relatively late onset. Induction of pre-B cell lymphomas with normal c-erbB2 was also observed using the Ig/Tp regulatory unit within 6-10 months in some members of one transgenic family among seven lines established. In contrast, with the mutant c-erbB2 under the Ig/Tp regulatory unit, the lymphoma was induced neonatally in all members of four transgenic families among ten lines obtained. However, the immunoglobulin heavy chain gene rearrangement pattern indicated that even with the mutant c-erbB2 the induced lymphomas were clonal. Previous ArticleNext Article Volume 9Issue 11 January 1990In this issue RelatedDetailsLoading ...