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Immunohistochemical expression of macrophages in chronic periapical lesions

2021; Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências; Volume: 10; Issue: 7 Linguagem: Inglês

10.33448/rsd-v10i7.16622

2525-3409

Zilda Betânia Barbosa Medeiros de Farias, Jade de Souza Cavalcante, Anne Caroline de Lima, Emanuel Sávio de Souza Andrade, Márcia Maria Fonseca da Silveira, Ana Paula Veras Sobral,

Foreign Body Medical Cases

Objective: To analyze the expression of macrophages in periapical granulomas (PGs) and radicular cysts (RCs). Methodology: We selected 264 cases of chronic periapical lesions stored at the Laboratory of Pathology, Dental School of Pernambuco (FOP)/UPE, including 89 PGs and 175 RCs. Seventy-nine cases, 23 PGs and 56 RCs, were submitted to immunohistochemical analysis by the streptavidin-biotin method using anti-CD68 antibody. The chi-square and Fisher’s exact tests were used to determine the existence of associations with categorical and clinical variables, adopting a 95% confidence level (p≤0.05). Results: We observed immunoexpression of CD68 in 83% of cases. The number of CD68+ cells (score 3 or 4) was higher in PGs, with predominantly intense staining. Significant differences in the number of CD68+ cells and staining intensity were observed between the chronic periapical lesions analyzed. Conclusion: The presence of CD68+ cells in periapical tissues may indicate the development, maintenance and/or severity of the inflammation-mediated immune response, which is more intense in PG.