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Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection

2022; Oxford University Press; Volume: 226; Issue: Supplement_1 Linguagem: Inglês

10.1093/infdis/jiac163

1537-6613

Joseph McGinley, Gu Lung Lin, Deniz Öner, Tanya Golubchik, Daniel O’Connor, Matthew D. Snape, Olivier Gruselle, Annefleur C Langedijk, Joanne Wildenbeest, Peter Openshaw, Harish Nair, Jeroen Aerssens, Louis Bont, Federico Martinón‐Torres, Simon B. Drysdale, Andrew J. Pollard, Harish Nair, Harry Campbell, Steve Cunningham, Debby Bogaert, Philippe Beutels, Louis Bont, Joanne Wildenbeest, Annefleur C Langedijk, Andrew J. Pollard, Christopher Butler, Matthew D. Snape, Simon B. Drysdale, Gu-Lung Lin, Daniel O’Connor, Elizabeth Clutterbuck, Joseph McGinley, Peter Openshaw, Ryan S. Thwaites, Dexter Wiseman, Federico Martinón‐Torres, Alberto Gómez‐Carballa, Carmen Rodrı́guez-Tenreiro, Irene Rivero‐Calle, Ana Dacosta-Urbieta, Terho Heikkinen, Adam Meijer, Thea Kølsen Fischer, Maarten van den Berge, Carlo Giaquinto, Michael E. Abram, Myint Tin Tin Htar, Olivier Gruselle, Bishoy Rizkalla, Charlotte Vernhes, Scott Gallichan, Jeroen Aerssens, Deniz Öner, Veena Kumar, Eva Molero,

Congenital Diaphragmatic Hernia Studies

Abstract Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017–2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants (<3 months vs 3 to <6 months and 3 to <6 months vs ≥6 months). Older age (≥6 months vs <3 months), higher viral load, and RSV-A were associated with a greater probability of fever. RSV-A and RSV-B caused similar disease severity and had similar viral dynamics. Infants with a more severe RSV infection, demonstrated by having a higher ReSViNET score, fever, and requiring hospitalization and intensive care, were more likely to have developed subsequent wheezing at 1 year of age. Clinical Trials Registration NCT03756766.