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Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development

2000; Elsevier BV; Volume: 16; Issue: 5 Linguagem: Inglês

10.1016/s0168-9525(00)01982-x

1362-4555

Xing‐Wang Deng, Wolfgang Dubiel, Ning Wei, Kay Hofmann, Kirsten Mundt, John Colicelli, Jun‐ya Kato, Michael Naumann, Daniel Segal, Michael Seeger, Michael H. Glickman, Daniel Chamovitz, Antony M. Carr,

Photosynthetic Processes and Mechanisms

The COP9 signalosome was first identified in Arabidopsis thaliana as an essential regulator of light signal transduction 1 Wei N et al. Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell. 1994; 78: 117-124 Abstract Full Text PDF PubMed Scopus (301) Google Scholar . Subsequently, the COP9 signalosome was identified in animal systems, suggesting that this complex had a general role in developmental regulation 2 Chamovitz D.A Deng X.W The COP9 complex: a link between photomorphogenesis and general developmental regulation?. Plant Cell Environ. 1997; 20: 734-739 Crossref Scopus (7) Google Scholar , 3 Wei N Deng X.W Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Trends Genet. 1999; 15: 98-103 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar . Genetic analysis in Drosophila indicated that this complex is essential for animal development 4 Freilich S et al. The COP9 complex is essential for development of Drosophila melanogaster. Curr. Biol. 1999; 9: 1187-1190 Abstract Full Text Full Text PDF PubMed Scopus (129) Google Scholar . This role might include the control of the cell cycle and regulation of MAP-kinase signaling 3 Wei N Deng X.W Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Trends Genet. 1999; 15: 98-103 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar , 5 Mundt K.E et al. Conservation of the COP9 signalosome in fission yeast S. pombe. Curr. Biol. 1999; 9: 1427-1430 Abstract Full Text Full Text PDF PubMed Google Scholar , 6 Tomoda K et al. Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1. Nature. 1999; 398: 160-165 Crossref PubMed Scopus (554) Google Scholar , 7 Karniol B et al. ArabidopsisFUSCA5 encodes a novel phosphoprotein that is a component of the COP9 complex. Plant Cell. 1999; 11: 839-848 Crossref PubMed Scopus (62) Google Scholar , 8 Naumann M et al. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J. Biol. Chem. 1999; 274: 35297-35300 Crossref PubMed Scopus (130) Google Scholar , 9 Seeger M et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998; 12: 469-478 Crossref PubMed Scopus (315) Google Scholar , 10 Spain B.H et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol. Cell. Biol. 1996; 16: 6698-6706 Crossref PubMed Scopus (102) Google Scholar . The biochemical purification of the COP9 signalosome from cauliflower 11 Chamovitz D.A et al. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell. 1996; 86: 115-121 Abstract Full Text Full Text PDF PubMed Scopus (274) Google Scholar , mammals 9 Seeger M et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998; 12: 469-478 Crossref PubMed Scopus (315) Google Scholar , 16 Wei N et al. Conservation of the COP9 complex between plants and mammals and its relationship to the 26S proteasome regulatory complex. Curr. Biol. 1998; 8: 919-922 Abstract Full Text Full Text PDF PubMed Google Scholar and Arabidopsis12 Serino G et al. Arabidopsiscop8 and fus4 mutations define the same locus that encodes subunit 4 of the COP9 signalosome. Plant Cell. 1999; 11: 1967-1980 Crossref PubMed Scopus (88) Google Scholar indicated that this complex comprises eight core subunits. The complex does not exist in Saccharomyces cerevisiae but appears to be present in Schizosaccharomyces pombe5 Mundt K.E et al. Conservation of the COP9 signalosome in fission yeast S. pombe. Curr. Biol. 1999; 9: 1427-1430 Abstract Full Text Full Text PDF PubMed Google Scholar . The OP9 igalosome is similar, both in size and composition, to two other regulatory complexes: the lid of the 19S proteasome regulatory particle and the eukaryotic translational regulatory complex eIF3 ( 13 Glickman M.H et al. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell. 1998; 94: 615-623 Abstract Full Text Full Text PDF PubMed Scopus (783) Google Scholar , 14 Hofmann K Bucher P The PCI domain A common theme in three multi-protein complexes. Trends Biochem. Sci. 1998; 23: 204-205 Abstract Full Text Full Text PDF PubMed Scopus (242) Google Scholar ). Most subunits from all three complexes contain one of two structural motifs: the PCI/PINT domain and the MPN domain 14 Hofmann K Bucher P The PCI domain A common theme in three multi-protein complexes. Trends Biochem. Sci. 1998; 23: 204-205 Abstract Full Text Full Text PDF PubMed Scopus (242) Google Scholar , 15 Aravind L Ponting C.P Homologues of 26S proteasome subunits are regulators of transcription and translation. Protein Sci. 1998; 7: 1250-1254 Crossref PubMed Scopus (113) Google Scholar . Reports have suggested interactions between these complexes and/or their subunits 3 Wei N Deng X.W Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Trends Genet. 1999; 15: 98-103 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar . Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of developmentDeng et al.Trends in GeneticsJuly 01, 2000In Brief Full-Text PDF