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Blackberry Jam Fruit (Randia Formosa (Jacq.) K. Schum): An Amazon Superfruit with in Vitro Neuroprotective Properties

2022; RELX Group (Netherlands); Linguagem: Inglês

10.2139/ssrn.4181138

1556-5068

Giovanna Nascimento de Mello e Silva, Edson Silvio Batista Rodrigues, Isaac Yves Lopes de Macêdo, Henric Pietro Vicente Gil, Hericles Mesquita Campos, Paulo César Ghedini, Lidya Cardozo da Silva, Érica Aparecida Batista, Giovanna Lopes de Araújo, Boniek G. Vaz, Tânia Aparecida Pinto de Castro Ferreira, Renê Oliveira do Couto, Eric de Souza Gil,

Plant biochemistry and biosynthesis

We report on for the first time the bromatological profile, the preliminary phytochemical composition, the antioxidant capacity, and the in vitro neuroprotective effects of Blackberry Jam fruit (JF). The carbohydrates were the major macronutrients (20 g/100g) in the pulp of JF, which also showcased a low lipid content (0.14 g/100g) and an appreciable energy value (89 Kcal/100 g). One furanocoumarin, two sphingosines, and three flavonoids have been identified in the hydroalcoholic extract of the pulp (JFE) by mass spectrometry. The electrochemical index of JFE was around 6.8 μA/V and two reversible cathode peaks were observed up to 0.5 V, thus shedding light to its antioxidant capacity, which was reinforced by the results of DPPH• and ABTS+ radical scavenging assays. The JFE significantly decreased both the in vitro lipid peroxidation and contents of carbonyl proteins in H2O2 treated murine brain cells. Conversely, the JFE increased the superoxide dismutase and catalase activities. The JFE also markedly decreased both the in vitro acetylcholinesterase and butyrylcholinesterase activities, with up to 26-fold more sensitivity for the last one. Therefore, allied to a nutritional value, this Amazon superfruit may contribute for mitigating the neurodegeneration related to the oxidative stress, bringing nutraceutical prospects for the management of several neurodegenerative and neuropsychological disorders such as Alzheimer’s disease, Parkinson’s disease, autism spectrum disorder and attention deficit hyperactive syndrome.