Artigo Acesso aberto Revisado por pares

Predictors of major ventricular arrhythmias (NSVT) in HCM

2023; Elsevier BV; Volume: 117; Issue: 1 Linguagem: Inglês

10.1016/j.acvd.2023.10.184

ISSN

1875-2136

Autores

Lila Bourahla, Salim Benkhedda, Aissa Amrouche, F. Makhlouf,

Tópico(s)

Cardiovascular Function and Risk Factors

Resumo

Hypertrophic Cardiomyopathy (HCM) is a hereditary disease associated with rhythm disorder leadingto sudden death. The occurrence of lethal ventricular arrhythmias is triggered by complex rhythmdisorders with multifactorial origin. Identifying new markers associated with non sustained ventricular tachycardia (NSVT)could improve the identification of patients who run this risk. A longitudinal cohort study conducted in 106 HCM aged 47 ± 16.6 years (sex ratio: 7 M/3W). A 48 hours Holter ECG was performed in 102 patients. We examined clinical, echocardiographic and MRI parameters associated or predicted NSVT. The mean age of NSVT onset was 51 ± 13.8 years. NSVT was recorded in 26.5% patients, of whom 11.8% had at least 2 runs. NSVT was associated with NYHA dyspnea (P = .024) and baseline ECG (P = .037). Runs of NSVT were associated with baseline ECG rythm and Holterrhythm (P = .009), with intermittent SVT (P = .011), and permanent AF recorded on the holter (P = .019). Multivariate predictors of TVNS are Left atrial diameter (OR: 4.63; CI95%; 1.025–20.869; P = .046) and NYHA dyspnea (OR: .264; CI95%; .073–.952; P = .042). Age of onset of disease tends to predict NSVT (OR: 4.81; CI95%; .95–24.2; P = .059). Left arial diameter and NYHA dyspnea are multivariate predictors of NSVT and could be used to improve identification of patients at risk of severe arrhythmias.

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