Inhibition of Mitochondrial Bioenergetics and Hypoxia to Radiosensitize Diffuse Intrinsic Pontine Glioma
2024; Oxford University Press; Linguagem: Inglês
10.1093/neuonc/noae255
ISSN1523-5866
AutoresHan Shen, Faiqa Mudassar, Shiyong Ma, Xingyu Wang, Sandy L. Nguyen, Neha Bal, Q K Huynh, Dongwei Wang, Cecilia Chang, Prunella Ing, Winny Varikatt, Joey Lai, Brian Gloss, Jeff Holst, Geraldine M. O’Neill, Harriet E. Gee, Kristina M. Cook, Eric Hau,
Tópico(s)Cancer, Hypoxia, and Metabolism
ResumoDiffuse Intrinsic Pontine Gliomas (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are brain tumors that primarily affect children. Radiotherapy is the standard of care but only provides temporary symptomatic relief due to radioresistance. While hypoxia is a major driver of radioresistance in other tumors, there is no definitive evidence that DIPGs are hypoxic. DIPGs often contain histone mutations, which alter tumor metabolism and are also associated with radioresistance. Our objective was to identify the metabolic profiles of DIPG cells, detect hypoxia signatures, and uncover metabolism-linked mechanisms of radioresistance to improve tumor radiosensitivity.
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