Aitor Odriozola, Álvaro Santos‐Laso, María Del Barrio, Joaquín Cabezas, Paula Iruzubieta, M. Arias, Coral Rivas, Juan Carlos Rodríguez Duque, Ángela Antón, Emilio Fábrega, Javier Crespo,
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, and its incidence has been increasing in recent years because of the high prevalence of obesity and metabolic syndrome in the Western population. Alcohol-related liver disease (ArLD) is the most common cause of cirrhosis and constitutes the leading cause of cirrhosis-related deaths worldwide. Both NAFLD and ArLD constitute well-known causes of liver damage, with some similarities in their pathophysiology. ...
Tópico(s): Diet, Metabolism, and Disease
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Paula Odriozola-González, Álvaro Planchuelo‐Gómez, María Jesús Irurtia Muñiz, Rodrigo de Luis-Garcı́a,
We studied the short-term psychological effects of the COVID-19 crisis and the quarantine on 3550 adults from the Spanish population in a cross-sectional survey. Symptoms of anxiety, depression, and stress were analyzed using the 21-item version of the Depression Anxiety Stress Scale. Symptoms of posttraumatic stress disorder were analyzed using the Impact of Event Scale. Symptomatic scores of anxiety, depression, and stress were observed in 20% to 30% of respondents. Symptomatic scores indicating ...
Tópico(s): Healthcare professionals’ stress and burnout
2020 - SAGE Publishing | Journal of Health Psychology
Paula Odriozola-González, Álvaro Planchuelo‐Gómez, María Jesús Irurtia Muñiz, Rodrigo de Luis-Garcı́a,
The aim of this study was to analyze the psychological impact of COVID-19 in the university community during the first weeks of confinement. A cross-sectional study was conducted. The Depression Anxiety Stress Scale (DASS-21) was employed to assess symptoms of depression, anxiety and stress. The emotional impact of the situation was analyzed using the Impact of Event Scale. An online survey was fulfilled by 2530 members of the University of Valladolid, in Spain. Moderate to extremely severe scores ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2020 - Elsevier BV | Psychiatry Research
Eider Iribar Solaberrieta, C. Escudero, Moisés Odriozola-Maritorena, Álvaro Campos‐Celador, C. García-Gáfaro,
The goal of this study is to characterize the thermal performance of the opaque ventilated facade from sample-scale to building scale. To begin with, a representative sample has been built in order to test it in outdoor conditions using a traceable and precise methodology. The testing equipment used is a PASLINK test cell developed by DYNASTEE network at the Basque Government Laboratory of Quality Control in Buildings. The experimental results provide information to define a mathematical model of ...
Tópico(s): Wind and Air Flow Studies
2015 - Elsevier BV | Energy Procedia
Antonio Morgado Rodríguez, José Antonio Lozano Rodríguez, Leonardo García Sanjuán, Miriam Luciañez Triviño, Carlos P. Odriozola, Daniel Lamarca Irisarri, Álvaro Fernández Flores,
Rock crystal appears relatively frequently in Late Prehistoric Iberian sites, especially in the form of micro-blades and knapping debris. With some exceptions, however, these finds have seldom been looked into in any detail, and therefore little is known about the technology involved in the use of this material, its social and economic relevance or its symbolic significance. In this paper we examine a collection of rock crystal artefacts recently found at Valencina de la Concepción (Seville, Spain), ...
Tópico(s): Mineralogy and Gemology Studies
2015 - Elsevier BV | Quaternary International
Camilla Stephens, Mercedes Robles‐Díaz, Inmaculada Medina‐Cáliz, Miren García‐Cortés, Aida Ortega‐Alonso, Judith Sanabria‐Cabrera, A. González-Jiménez, Ismael Álvarez‐Álvarez, Mahmoud Slim, Miguel Jiménez‐Pérez, Rocío González‐Grande, M. Carmen Fernández, Marta Casado, Germán Soriano, Eva Román, Hacibe Hallal, Manuel Romero‐Gómez, Agustín Castiella, Isabel Conde, M. Prieto, J.M. Moreno Planas, Álvaro Giráldez Gallego, J. Miguel Moreno-Sanfiel, Neil Kaplowitz, M. Isabel Lucena, Raúl J. Andrade, Raúl J. Andrade, M. Isabel Lucena, Camilla Stephens, M. García Cortés, Mercedes Robles‐Díaz, Aida Ortega‐Alonso, José Pinazo, B. García Muñoz, R. Alcántara, Arielle G. Hernandez, María Dolores García Escaño, E. del Campo, Inmaculada Medina‐Cáliz, Judith Sanabria‐Cabrera, A. González-Jiménez, Rocío Sanjuán‐Jiménez, Abril Rosario Leal Cueto, Ismael Álvarez‐Álvarez, Elvira Bonilla‐Toyos, D. Di Zeo, Hao Niu, Mercè Villanueva, Alyssa M. Papineau, Miguel Jiménez Pérez, Rocío González Grande, S. López Ortega, Ignacio Obando, Alberto Ocaña, Pierina Zevallos Palomino, M. Carmen Fernández, Gloria Isabel Carvajal Peláez, A. Porcel, Marta Casado, Marta Sánchez‐Soto, Manuel Romero‐Gómez, Raquel Millan‐Domínguez, Blanca Fombuena, R. Gallego, Javier Ampuero, J.A. Del Campo, R. Calle-Sanz, Liliana Rojas, Ángela Rojas, Antonio Gil‐Gómez, Eduardo Vilar, Germán Soriano, Carlos Guarner, Eva Román, M.A. Quijada Manuitt, Rosa M. Antonijoan Arbos, Josué Delgado, Montserrat Gómez, Hacibe Hallal, E. García Oltra, J.C. Titos Arcos, A. Pérez Martínez, C. Sánchez Cobarro, J. Caparrós, Agustín Castiella, Eva Zapata, Juan Arenas, Alvaro Garcia, F.J. Esandi, Sonia Blanco, Pedro Martínez Odriozola, Javier Crespo, Paula Iruzubieta, Joaquín Cabezas, Álvaro Giráldez Gallego, E. del P. Rodríguez Seguel, M. Cuaresma, Javier González‐Gallego, Francisco Jorquera, S. Sánchez Campos, Pedro Otazua, ANTÓN GÓMEZ, Javier Salmerón, A. Gómez Gila, R. Quiles, J. M. González, Sandra Lorenzo, M. Prieto, Imri Amiel, Marina Berenguer, María García‐Eliz, J Primo, J.R. Molés, Ana Garayoa, Miguel F. Carrascosa, Eva Dominguez, Lourdes Cuevas, M. Llobet Farré, Eva Montané, Ana María Barriocanal, Ana Lucía Arellano, Yolanda Sanz, R Morillas, Margarita Sala, Helena Masnou Ridaura, Miguel Bruguera, Pere Ginés, Sabela Lens, J C García, Zoe Mariñó, Marta Guerra, Juan M. Moreno Sanfiel, Columbus Campo, María Teresa Tejedor, Ruth González Ferrer, Carmen Muñoz Fernández, Montserrat Gil, JL Montero, Manuel de la Mata, Javier Fuentes Olmo, Elvira Bonilla‐Toyos, J.M. Moreno Planas, P. Martínez-Rodenas, Marı́a J. Garrido, Clara Oliva, Paloma Rendón, Javier García‐Samaniego, Antonio Madejón, José Luís Calleja, José Luis Martínez Porras, JL Cabriada, J.M. Pérez-Moreno, Carmen Lara,
Prospective drug-induced liver injury (DILI) registries are important sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis of 843 patients with DILI enrolled into the Spanish DILI Registry over a 20-year time period.Cases were identified, diagnosed and followed prospectively. Clinical features, drug information and outcome data were collected.A total of 843 patients, with a mean age of 54 years (48% females), were enrolled up to 2018. Hepatocellular injury was ...
Tópico(s): Drug Transport and Resistance Mechanisms
2021 - Elsevier BV | Journal of Hepatology
Álvaro Campos‐Celador, M. Odriozola, J.M. Sala,
This paper considers the effect that different hot water storage tank modelling approaches have on the global simulation of residential CHP plants as well as their impact on their economic feasibility. While a simplified assessment of the heat storage is usually considered in the feasibility studies of CHP plants in buildings, this paper deals with three different levels of modelling of the hot water tank: actual stratified model, ideal stratified model and fully mixed model. These three approaches ...
Tópico(s): Thermodynamic and Exergetic Analyses of Power and Cooling Systems
2011 - Elsevier BV | Energy Conversion and Management
Álvaro Planchuelo‐Gómez, Paula Odriozola-González, María Jesús Irurtia Muñiz, Rodrigo de Luis-Garcı́a,
Strict confinement and social distancing measures have been imposed due to the COVID-19 pandemic in many countries. The aim was to assess the temporal evolution of the psychological impact of the COVID-19 crisis and lockdown from two surveys, separated by one month, performed in Spain. Symptoms of depression, anxiety and stress, and the psychological impact of the situation were longitudinally analyzed using the Depression Anxiety and Stress Scale (DASS-21) and the Impact of Event Scale (IES) respectively. ...
Tópico(s): Mental Health Research Topics
2020 - Elsevier BV | Journal of Affective Disorders
Rodrigo Martino, MD Caballero, Javier de la Serna, José L. Díez‐Martín, Álvaro Urbano‐Ispizua, JF Tomás, J Odriozola, Agathe León, Carmen Canals, Jesús F. San Miguel, Jorge Sierra,
Tópico(s): Acute Myeloid Leukemia Research
2002 - Springer Nature | Bone Marrow Transplantation
María Del Barrio, Lucía Lavín-Alconero, Álvaro Santos‐Laso, M. Arias, Aitor Odriozola, Juan Carlos Rodriguez‐Duque, Coral Rivas, Paula Iruzubieta, Javier Crespo,
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease (CLD). Currently, the only therapeutic recommendation available is a lifestyle change. However, adherence to this approach is often difficult to guarantee. Alteration of the microbiota and an increase in intestinal permeability seem to be key in the development and progression of NAFLD. Therefore, the manipulation of microbiota seems to provide a promising therapeutic strategy. One way to do so ...
Tópico(s): Liver Disease and Transplantation
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Álvaro Urbano‐Ispizua, Carlos Solano, Salut Brunet, Javier de la Rubia, J Odriozola, J Zuazu, Á Figuera, D. Caballero, Carmen Martı́nez, Joan Garcı́a, Guillermo Sanz, Marta Torrabadella, Adrián Alegre, J Pérez-Oteiza, M. Jurado, Salvador Oyonarte, Jorge Sierra, J Garcı́a-Conde, C Rozmán,
The objective of this study was to analyze CD34+ cell recovery and T cell depletion (TCD) achieved in CD34+ cell grafts using either immunoadsorption or immunomagnetic methods applied to leukapheresis products from healthy donors. We also wanted to determine the kinetics of engraftment and incidence and severity of graft-versus-host disease (GVHD) after allogeneic transplantation of selected CD34+ cells. HLA-identical sibling donors received G-CSF. After leukapheresis, peripheral blood progenitor ...
Tópico(s): Polyomavirus and related diseases
1998 - Springer Nature | Bone Marrow Transplantation
Rodrigo Martino, Marı́a Dolores Caballero, Carmen Canals, José Antonio Pérez‐Simón, Carlos Solano, Álvaro Urbano‐Ispizua, Joan Bargay, Consolación Rayón, Antonio Léon, Josep Sarrà, J Odriozola, Javier García Conde, Jorge Sierra, Jesús F. San Miguel,
Reduced‐intensity conditioning (RIC) regimens for allogeneic haematopoietic stem cell transplantation (SCT) have been shown to lead to engraftment of donor stem cells without the severe extra‐haematological toxicities of traditional myeloablative transplants. Between December 1998 and December 2000, 76 patients underwent a RIC peripheral blood SCT in a prospective multicentre study. The median age was 53 years, and 57 patients were beyond the early phase of their disease. The conditioning regimens ...
Tópico(s): Polyomavirus and related diseases
2001 - Wiley | British Journal of Haematology
Javier Bustamante Odriozola, Álvaro Pérez Martín, Romina Verónica Quintana, María José Agüeros Fernández, Daniel Martínez Revuelta, Inés Rivera Panizo,
Tópico(s): Corneal surgery and disorders
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, María José Agüeros Fernández, Daniel Martínez Revuelta, Pedro Bermúdez Martí,
Tópico(s): Neurogenetic and Muscular Disorders Research
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Romina Verónica Quintana, María José Agüeros Fernández, Daniel Martínez Revuelta, Inés Rivera Panizo,
espanolLa endoftalmitis es una infeccion ocular grave generalmente producida por bacterias y hongos en el contexto de una cirugia ocular previa, aunque existen otras causas. Se trata de una enfermedad inflamatoria infecciosa grave que puede originar la perdida de vision e incluso la perdida ocular. El tratamiento consiste en antibioticos intravitreos y sistemicos, ajustados segun el antibiograma. El diagnostico de la enfermedad es clinico, si bien cuando se trata una urgencia puede ser vista desde ...
Tópico(s): Ocular Infections and Treatments
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Nuria San Martín, Daniel Martínez Revuelta, Alexandra del Rey Rozas, Alicia Azagra Calero, Marta Nielfa González,
Tópico(s): Medical and Biological Sciences
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, María José Agüeros Fernández, Daniel Martínez Revuelta, Pedro Bermúdez Martí,
espanolLas distrofias musculares congenitas son enfermedades con una escasa prevalencia e incidencia por lo que son consideradas enfermedades raras. Son enfermedades diagnosticadas en su mayoria durante la infancia, con un pronostico variable en funcion del tipo de distrofia. No tienen tratamiento, ya que el origen de la patologia es genetico. Por tanto, este es sintomatico. Como enfermedad rara, es importante el conocimiento de la misma a la hora del manejo a nivel de Atencion primaria. EnglishCongenital ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Nuria San Martín, Daniel Martínez Revuelta, Alexandra del Rey Rozas, Alicia Azagra Calero, Marta Nielfa González,
Tópico(s): Medical and Biological Sciences
2018 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Nuria San Martín, Daniel Martínez Revuelta, Janire Villar Ramos, Meryam Maamar el Asri, Itziar Ostolaza Tazón,
espanolEl antrax es una infeccion cutanea producida por estafilococos (generalmente Staphylococcus aureus) formada por una agrupacion de forunculos con extension de la infeccion al tejido subcutaneo. El diagnostico del antrax o forunculosis por Staphylococcus aureus se basa en el cultivo del microorganismo, bien de la zona afectada o bien de hemocultivos en caso de cuadros sistemicos. El tratamiento sera con antibioticos betalactamicos, salvo en casos de resistencia a meticilina, en que se emplearan ...
Tópico(s): Nail Diseases and Treatments
2019 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Nadia Huarachi Berne, Ana Isabel Rodríguez, Nuria San Martín, Daniel Martínez Revuelta,
espanolEl insulinoma es un tumor formado por celulas especializadas beta de los islotes de Langerhans pancreaticos, que segregan constantemente insulina, lo que causa hipoglucemia. El diagnostico del insulinoma se realiza mediante la clinica (sintomas neuroglucopenicos y adrenergicos), la analitica (glucemia, peptido C e insulina) y la prueba de imagen complementaria (normalmente tomografia axial computerizada) que objetiva el insulinoma. El tratamiento consiste en la intervencion quirurgica mediante ...
Tópico(s): Neuroendocrine Tumor Research Advances
2020 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Daniel Martínez Revuelta, Rosalía López Sánchez, Janire Villar Ramos, Pedro Bermúdez Martí, Meryam Maamar el Asri,
espanolLos sindromes linfoproliferativos engloban una gran variedad de subtipos cuyo diagnostico y abordaje difiere en funcion del subtipo. El diagnostico de los sindromes linfoproliferativos se basa en criterios que abarcan tanto clinica como analitica. Algunas de las pruebas solo pueden realizarse desde el Servicio de Hematologia, por lo que la sospecha a partir de la clinica es fundamental en atencion primaria para completar estudio en el hospital. El tratamiento varia en funcion del subtipo ...
Tópico(s): Lymphoma Diagnosis and Treatment
2020 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Daniel Martínez Revuelta, Patricia Fierro, Matthew Domínguez Suárez, Nadia Huarachi Berne, Ana Isabel Rodríguez,
espanolLa granulomatosis eosinofilica con poliangeitis es un trastorno multisistemico caracterizado por rinosinusitis cronica, asma y eosinofilia prominente de sangre periferica. La clinica es muy variable; tienen principal predileccion por el pulmon y la piel, pero puede afectar tambien a otros organos. Para el diagnostico se emplean tanto criterios clinicos como analiticos. Existen multiples guias; la del American College of Rheumatology es la mas empleada. El tratamiento puede requerir del uso ...
Tópico(s): Urticaria and Related Conditions
2021 - Elsevier BV | Medicina General y de Familia
Javier Bustamante Odriozola, Álvaro Pérez Martín, Silvia Somonte Segares, María José Agüeros Fernández,
espanolEl sindrome de Stevens-Johnson es una reaccion mucocutanea grave cuya etiologia es principalmente secundaria a farmacos o a infecciones; existen otras causas menos frecuentes. Clinicamente los signos y sintomas que deben alertarnos sobre dicho sindrome son fiebre, mucositis y afectacion dermatologica extensa. El diagnostico se basa fundamentalmente en la clinica y puede apoyarse en pruebas complementarias como la biopsia cutanea. El tratamiento suele requerir atencion hospitalaria urgente, ...
Tópico(s): Eosinophilic Disorders and Syndromes
2021 - Elsevier BV | Medicina General y de Familia
Alicia González‐Martínez, Álvaro Planchuelo‐Gómez, Ángel Luis Guerrero Peral, David García‐Azorín, Sonia Santos‐Lasaosa, María Pilar Navarro‐Pérez, Paula Odriozola-González, María Jesús Irurtia Muñiz, Sonia Quintas, Rodrigo de Luis-Garcı́a, Ana Beatriz Gago‐Veiga,
Previous studies have demonstrated that emotional stress, changes in lifestyle habits and infections can worsen the clinical course of migraine. We hypothesize that changes in habits and medical care during coronavirus disease 2019 (COVID-19) lockdown might have worsened the clinical course of migraine.Retrospective survey study collecting online responses from migraine patients followed-up by neurologists at three tertiary hospitals between June and July 2020.We used a web-based survey that included ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2020 - Oxford University Press | Pain Medicine
Javier López‐Jiménez, Jaime Pérez de Oteyza, Alvaro Muñoz, Cindy Parra, Loïc Villalon, Pedro Ramos, M Maldonado, José García‐Laraña, Enrique Otheo, Roldán Ej, Angel Garciá‐Avello, J Odriozola,
Tópico(s): Herpesvirus Infections and Treatments
1997 - Springer Nature | Bone Marrow Transplantation
Alicia González‐Martínez, Álvaro Planchuelo‐Gómez, Ángel Luis Guerrero Peral, David García‐Azorín, Sonia Santos‐Lasaosa, María Pilar Navarro‐Pérez, Paula Odriozola-González, María Jesús Irurtia Muñiz, Sonia Quintas, Rodrigo de Luis-Garcı́a, Ana Beatriz Gago‐Veiga,
Face-to-face procedures have been postponed during COVID-19 pandemic. We aim to evaluate the impact of onabotulinumtoxinA follow-up delay in migraine during COVID-19 pandemic. Subjective worsening, intensity of migraine attacks, and frequency of headache and migraine were retrospectively compared between patients with unmodified and interrupted onabotulinumtoxinA follow-up in Headache Units. We included 67 patients with chronic migraine or high-frequency episodic migraine under onabotulinumtoxinA ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2021 - Springer Science+Business Media | Neurological Sciences
Javier Bustamante Odriozola, Lorena Rodríguez, Álvaro Pérez Martín, Daniel Mrtínez Revuelta, Matthew Serradilla Suárez, Patricia Fierro, Sonia Fernández Jorde,
Tópico(s): Folate and B Vitamins Research
2025 - Elsevier BV | Medicina General y de Familia
Alvaro Ramos Peralta, Gerardo Odriozola,
We have developed an all-atom pairwise additive model for hydrogen peroxide using an optimization procedure based on artificial neural networks (ANNs). The model is based on experimental molecular geometry and includes a dihedral potential that hinders the cis-type configuration and allows for crossing the trans one, defined between the planes that have the two oxygen atoms and each hydrogen. The model's parametrization is achieved by training simple ANNs to minimize a target function that measures ...
Tópico(s): Computational Drug Discovery Methods
2023 - American Chemical Society | Journal of Chemical Theory and Computation
Javier Bustamante Odriozola, Laura Valdés Rodríguez, Álvaro Pérez Martín, Daniel Martínez Revuelta, Bruno Simón Tárrega, C. Durán Vian, J. L. Martín-Varillas,
Tópico(s): Dermatology and Skin Diseases
2024 - Elsevier BV | Medicina General y de Familia
Álvaro Urbano‐Ispizua, C Rozmán, Pedro Pimentel, Carlos Solano, Javier de la Rubia, Salut Brunet, Jaime Pérez de Oteyza, Christelle Ferrà, J Zuazu, Dolores Caballero, Joan Bargay, Alzira Carvalhais, José Luis Díez Gil, Ildefonso Espigado, Adrián Alegre, Montserrat Rovira, Fernando Campilho, J Odriozola, Miguel Á. Sanz, Jordi Sierra, J Garcı́a-Conde, Emili Montserrat,
Abstract A study on 315 patients undergoing transplantation with CD34+ selected blood cells from HLA-identical siblings was performed to determine risk factors for acute GVHD (aGVHD). Recipients of a dose of CD34+ cells (× 106/kg) of 2 or less, more than 2 to 4, and more than 4 had a cumulative incidence of aGVHD grades I-IV of 21%, 35%, and 43%, respectively (log-rankP = .01); similarly, recipients of a dose of CD3+ cells (× 106/kg) of 0.05 or less, more than 0.05 to 0.1, and more than 0.1 had a cumulative ...
Tópico(s): T-cell and B-cell Immunology
2002 - Elsevier BV | Blood