Juan Sandoval, Ángel Díaz‐Lagares, Rocío Salgado, Octavio Servitje, Fina Climent, Pablo L. Ortiz‐Romero, A. Pérez‐Ferriols, M. Pilar García-Muret, Teresa Estrach, M. García García, Lara Nonell, Manel Esteller, Ramón M. Pujol, Blanca Espinet, Fernando Gallardo,
Tópico(s): Lymphoma Diagnosis and Treatment
2014 - Elsevier BV | Journal of Investigative Dermatology
Fernando Gallardo, Juan Sandoval, Ángel Díaz‐Lagares, Ricard Garcia, Teresa D’Altri, Jéssica González, V. Alegre, Octavio Servitje, Ana B. Crujeiras, Ólafur-Andri Stefánsson, Blanca Espinet, Maria-Inmaculada Hernández, Beatríz Bellosillo, Manel Esteller, Ramón M. Pujol, Anna Bigas, Lluı́s Espinosa,
Notch is a family of transmembrane receptors that participate in the regulation of cell differentiation, proliferation, and stemness. Notch pathway activation has also been found associated with different human cancers including primary cutaneous T-cell lymphomas (CTCL). The elucidation of the mechanisms driving Notch activation in these particular diseases has remained elusive. Here we studied the possibility that DNA methylation at Notch pathway gene promoters and/or deregulation of Notch-associated ...
Tópico(s): Histone Deacetylase Inhibitors Research
2015 - Elsevier BV | Journal of Investigative Dermatology
Felipe de Jesús Escalona‐Alcázar, Luigi Solari, Juan Carlos García y Barragán, Carlos Carrillo-Castillo, Jorge Bluhm-Gutiérrez, Perla García-Sandoval, Ángel F. Nieto-Samaniego, Ernesto Patricio Núñez-Peña,
Felipe de Jesús Escalona-Alcázara*, Luigi Solarib, Juan Carlos García y Barragánc, Carlos Carrillo-Castilloa, Jorge Bluhm-Gutiérreza, Perla García-Sandovala, Ángel Francisco Nieto-Samaniegob & Ernesto Patricio Núñez-Peñaaa Unidad Académica de Ciencias de la Tierra, Universidad Autónoma de Zacatecas, Zacatecas, Méxicob Centro de Geociencias, Universidad Nacional Autónoma de México (UNAM), Juriquilla, Méxicoc Instituto de Geología, Universidad Nacional Autónoma de México (UNAM), Hermosillo, México
Tópico(s): Geological and Tectonic Studies in Latin America
2016 - Taylor & Francis | International Geology Review
Mithun Pai, Carlos Sandoval, Angel Guevara E., Manuel Calvopiña, Philip J. Cooper, S G Reed, Ronald H. Guderian,
Two well-defined synthetic peptides TcD and PEP2 were used in a sero-epidemiological study for the detection of Trypanosoma cruzi infections in an indigenous group in the Amazon region of Ecuador. Of the 18 communities studied along the Río Napo, province of Napo, 15 (83.3%) were found to be positive for T. cruzi infection. Of the 1,011 individuals examined 61 (6.03%) resulted positive. A prevalence of infection of 4.8% was found in children aged 1-5 years. The prevalence of infection increased with ...
Tópico(s): Trypanosoma species research and implications
1997 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Eva Harris, T. Guy Roberts, Leila Smith, John Selle, Laura D. Kramer, Sonia Valle, Erick Sandoval, Ángel Balmaseda,
ABSTRACT In recent years, dengue viruses (serotypes 1 to 4) have spread throughout tropical regions worldwide. In many places, multiple dengue virus serotypes are circulating concurrently, which may increase the risk for the more severe form of the disease, dengue hemorrhagic fever. For the control and prevention of dengue fever, it is important to rapidly detect and type the virus in clinical samples and mosquitoes. Assays based on reverse transcriptase (RT) PCR (RT-PCR) amplification of dengue viral ...
Tópico(s): Malaria Research and Control
1998 - American Society for Microbiology | Journal of Clinical Microbiology
Dejan Kepić, Stefania Sandoval, Ángel Pérez del Pino, E. M. Gyorgy, Laura Cabana, Belén Ballesteros, Gerard Tobías,
Abstract N‐doped reduced graphene oxide (RGO) has been prepared in bulk form by laser irradiation of graphene oxide (GO) dispersed in an aqueous solution of ammonia. A pulsed Nd:YAG laser with emission wavelengths in the infrared (IR) 1064 nm, visible (Vis) 532 nm, and ultraviolet (UV) 266 nm spectral regions was employed for the preparation of the N‐doped RGO samples. Regardless of the laser energy employed, the resulting material presents a higher fraction of pyrrolic nitrogen compared to nitrogen ...
Tópico(s): Graphene and Nanomaterials Applications
2017 - Wiley | ChemPhysChem
Maria M. Romero-Chávez, Kayim Pineda‐Urbina, David Pérez, Fernando Obledo-Benicio, Angelina Flores‐Parra, Zeferino Gómez‐Sandoval, Ángel Ramos-Organillo,
New tributyl-, dibutyl- and diphenyl-tin(IV) complexes derived from ibuprofen and cinnamic acids were synthesized. All compounds were structurally characterized by FT-IR, multinuclear 1H, 13C, 19F and 119Sn NMR and corroborated by 2D spectra. The NMR data in CDCl3 revealed several hexacoordinated compounds with octahedral geometry. Moreover, in DMSO-d6 some of these complexes switched to heptacoordination with a pentagonal-bipyramidal geometry due to the inclusion of a solvent's molecule; their ...
Tópico(s): Crystal structures of chemical compounds
2018 - Elsevier BV | Journal of Organometallic Chemistry
María J. Chaparro, Jaume Vidal, Íñigo Angulo‐Barturen, José M. Bueno, Jeremy N. Burrows, N. Cammack, Pablo Castañeda, Gonzalo Colmenarejo, José M. Coterón, Laura de las Heras, Esther Fernández, Santiago Ferrer, Raquel Gabarró, Francisco‐Javier Gamo, Mercedes García, Marı́a Belén Jiménez-Dı́az, María José Lafuente, María Luisa León, María Santos Martínez, Douglas J. Minick, Sara Prats, Margarita Puente, Lourdes Rueda, Elena Sandoval, Ángel Santos-Villarejo, Michael J. Witty, Félix Calderón,
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4–0.5 μM are able to show in vivo activity.
Tópico(s): Computational Drug Discovery Methods
2014 - American Chemical Society | ACS Medicinal Chemistry Letters
Paul N. Black, Angel Sandoval, Elsa Arias‐Barrau, Concetta Dirusso,
One principal process driving fatty acid transport is vectorial acylation, where fatty acids traverse the membrane concomitant with activation to CoA thioesters. Current evidence is consistent with the proposal that specific fatty acid transport (FATP) isoforms alone or in concert with specific long chain acyl CoA synthetase (Acsl) isoforms function to drive this energy-dependent process. Understanding the details of vectorial acylation is of particular importance as disturbances in lipid metabolism ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2009 - Bentham Science Publishers | Immunology Endocrine & Metabolic Agents - Medicinal Chemistry
Angel Sandoval, Aalap Chokshi, Elliot D. Jesch, Paul N. Black, Concetta Dirusso,
Fatty acid transport proteins (FATPs) are bifunctional proteins, which transport long chain fatty acids into cells and activate very long chain fatty acids by esterification with coenzyme A. In an effort to understand the linkage between cellular fatty acid transport and the pathology associated with excessive accumulation of exogenous fatty acids, we targeted FATP-mediated fatty acid transport in a high throughput screen of more than 100,000 small diverse chemical compounds in yeast expressing human ...
Tópico(s): Lipid metabolism and biosynthesis
2009 - Elsevier BV | Biochemical Pharmacology
Angel Sandoval, Peter Fraisl, Elsa Arias‐Barrau, Concetta Dirusso, Diane V. Singer, Whitney Sealls, Paul N. Black,
These studies defined the expression patterns of genes involved in fatty acid transport, activation and trafficking using quantitative PCR (qPCR) and established the kinetic constants of fatty acid transport in an effort to define whether vectorial acylation represents a common mechanism in different cell types (3T3-L1 fibroblasts and adipocytes, Caco-2 and HepG2 cells and three endothelial cell lines (b-END3, HAEC, and HMEC)). As expected, fatty acid transport protein (FATP)1 and long-chain acyl CoA ...
Tópico(s): Adipose Tissue and Metabolism
2008 - Elsevier BV | Archives of Biochemistry and Biophysics
Hong Li, Paul N. Black, Aalap Chokshi, Angel Sandoval‐Alvarez, Ravi Vatsyayan, Whitney Sealls, Concetta Dirusso,
Fatty acids are implicated in the development of dyslipidemias, leading to type 2 diabetes and cardiovascular disease. We used a standardized small compound library to screen humanized yeast to identify compounds that inhibit fatty acid transport protein (FATP)-mediated fatty acid uptake into cells. This screening procedure used live yeast cells expressing human FATP2 to identify small compounds that reduced the import of a fluorescent fatty acid analog, 4,4-difluoro-5-methyl-4-bora-3a,4a-diaza-s- ...
Tópico(s): Receptor Mechanisms and Signaling
2007 - Elsevier BV | Journal of Lipid Research
Nela Durisic, Lara Laparra-Cuervo, Ángel Sandoval-Álvarez, J. S. Borbely, Melike Lakadamyali,
A system using the human glycine receptor expressed in Xenopus oocytes allows characterization of the photoactivation efficiency of photoactivatable and photoconvertible fluorescent proteins at the single-molecule level, providing crucial data for using these probes for quantitative super-resolution microscopy. Photoswitchable fluorescent probes are central to localization-based super-resolution microscopy. Among these probes, fluorescent proteins are appealing because they are genetically encoded. ...
Tópico(s): Cell Image Analysis Techniques
2014 - Nature Portfolio | Nature Methods
Johnny Tam, Guillaume Alan Cordier, Štefan Bálint, Ángel Sandoval Álvarez, J. S. Borbely, Melike Lakadamyali,
Recently, super-resolution microscopy methods such as stochastic optical reconstruction microscopy (STORM) have enabled visualization of subcellular structures below the optical resolution limit. Due to the poor temporal resolution, however, these methods have mostly been used to image fixed cells or dynamic processes that evolve on slow time-scales. In particular, fast dynamic processes and their relationship to the underlying ultrastructure or nanoscale protein organization cannot be discerned. ...
Tópico(s): Advanced Electron Microscopy Techniques and Applications
2014 - Public Library of Science | PLoS ONE
Johnny Tam, Guillaume Alan Cordier, J. S. Borbely, Ángel Sandoval Álvarez, Melike Lakadamyali,
Multi-color stochastic optical reconstruction microscopy (STORM) is routinely performed; however, the various approaches for achieving multiple colors have important caveats. Color cross-talk, limited availability of spectrally distinct fluorophores with optimal brightness and duty cycle, incompatibility of imaging buffers for different fluorophores, and chromatic aberrations impact the spatial resolution and ultimately the number of colors that can be achieved. We overcome these complexities and ...
Tópico(s): Single-cell and spatial transcriptomics
2014 - Public Library of Science | PLoS ONE
Štefan Bálint, Ione Verdeny Vilanova, Ángel Sandoval Álvarez, Melike Lakadamyali,
Intracellular transport plays an essential role in maintaining the organization of polarized cells. Motor proteins tether and move cargos along microtubules during long-range transport to deliver them to their proper location of function. To reach their destination, cargo-bound motors must overcome barriers to their forward motion such as intersection points between microtubules. The ability to visualize how motors navigate these barriers can give important information about the mechanisms that ...
Tópico(s): Cellular Mechanics and Interactions
2013 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Dafné Moreno-Lorenzana, Sócrates Avilés‐Vázquez, Miguel Angel Sandoval Esquivel, Antonio Alvarado-Moreno, Vianney Ortiz‐Navarrete, Héctor H. Torres-Martínez, Manuel Ayala‐Sánchez, Héctor Mayani, Antonieta Chávez‐González,
Chronic Myeloid Leukemia (CML) is sustained by a small population of cells with stem cell characteristics known as Leukemic Stem Cells that are positive to BCR-ABL fusion protein, involved with several abnormalities in cell proliferation, expansion, apoptosis and cell cycle regulation. Current treatment options for CML involve the use of Tirosine Kinase Inhibitor (Imatinib, Nilotinib and Dasatinib), that efficiently reduce proliferation proliferative cells but do not kill non proliferating CML primitive ...
Tópico(s): Acute Myeloid Leukemia Research
2016 - Taylor & Francis | Cell Cycle
Éric Arnaud, Giovanna Paternoster, Syril James, M.-P. Morisseau-Durand, V. Couloigner, P.A. Diner, C. Tomat, V. Viot-Blanc, Brigitte Fauroux, Valérie Cormier‐Daire, Geneviève Baujat, M Robert, A. Picard, Sergio Ángel Sandoval Antúnez, Roman Hossein Khonsari, L. Pamphile-Tabuteau, Christophe Legros, Michel Zérah, P Meyer,
Tópico(s): Head and Neck Surgical Oncology
2016 - Elsevier BV | Annales de Chirurgie Plastique Esthétique
Produção Nacional
Revisado por pares
Roberto Aguilar Machado Santos Silva, Angel Egüez, Gustavo Morales, Erick Eulert, Aurelio Montenegro, Ramón Ybañez, Andrew Seidl, Alberto M. R. Dávila, Lucia N. Ramirez,
... provinces of Nuflo de Chavez, Guayaros, Velasco, Chiquitos, Angel Sandoval and Cordillera (M Hall et al.
Tópico(s): Rural Development and Agriculture
1998 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Salvador Ruíz-Correa, Darshan Santani, Beatriz Ramirez-Salazar, Itzia Ruiz-Correa, Fatima Alba Rendon-Huerta, Carlo Olmos-Carrillo, Brisa Carmina Sandoval-Mexicano, Angel Humberto Arcos-Garcia, Rogelio Hasimoto-Beltrán, Daniel Gática-Pérez,
This work describes SenseCityVity, an approach to engage and support youth in a city in Mexico as they investigate, document, and reflect upon urban problems through mobile crowdsourcing. SenseCityVity focused on the development of a mobile crowdsourcing platform; the deployment of the Urban Data Challenge, codesigned by the authors' research team and actors to collect geolocalized images, audio, and video; and the analysis, appropriation, and creative use of the collected data for community reflection ...
Tópico(s): ICT in Developing Communities
2017 - Institute of Electrical and Electronics Engineers | IEEE Pervasive Computing
Sócrates Avilés‐Vázquez, Antonieta Chávez‐González, Alfredo Hidalgo‐Miranda, Dafné Moreno-Lorenzana, Lourdes Arriaga‐Pizano, Miguel Angel Sandoval-Esquivel, Manuel Ayala‐Sánchez, R Jauregui Aguilar, Luis Alfaro-Ruíz, Héctor Mayani,
Abstract In this study, we determined the gene expression profiles of bone marrow‐derived cell fractions, obtained from normal subjects and Chronic Myeloid Leukemia ( CML ) patients, that were highly enriched for hematopoietic stem ( HSC s) and progenitor ( HPC s) cells. Our results indicate that the profiles of CML HSC s and HPC s were closer to that of normal progenitors, whereas normal HSC s showed the most different expression profile of all. We found that the expression profiles of HSC s and HPC s ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2017 - Wiley | Cancer Medicine
Ione Verdeny-Vilanova, Fabian Wehnekamp, Nitin Mohan, Ángel Sandoval Álvarez, J. S. Borbely, Jason Otterstrom, Don C. Lamb, Melike Lakadamyali,
ABSTRACT Vesicle transport is regulated at multiple levels, including regulation by scaffolding proteins and the cytoskeleton. This tight regulation is essential, since slowing or stoppage of transport can cause accumulation of obstacles and has been linked to diseases. Understanding the mechanisms by which transport is regulated as well as how motor proteins overcome obstacles can give important clues as to how these mechanisms break down in disease states. Here, we describe that the cytoskeleton ...
Tópico(s): Cellular Mechanics and Interactions
2017 - The Company of Biologists | Journal of Cell Science
Francesca Cella Zanacchi, Carlo Manzo, Ángel Sandoval Álvarez, Nathan D. Derr, M.F. Garcia Parajo, Melike Lakadamyali,
Single-molecule-based super-resolution microscopy offers researchers a unique opportunity to quantify protein copy number with nanoscale resolution. However, while fluorescent proteins have been characterized for quantitative imaging using calibration standards, similar calibration tools for immunofluorescence with small organic fluorophores are lacking. Here we show that DNA origami, in combination with GFP antibodies, is a versatile platform for calibrating fluorophore and antibody labeling efficiency ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2017 - Nature Portfolio | Nature Methods
Laurent Ladépêche, Jesús Planagumà, Shreyasi Thakur, Irina Suárez, Makoto Hara, J. S. Borbely, Angel Sandoval, Lara Laparra-Cuervo, Josep Dalmau, Melike Lakadamyali,
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder mediated by autoantibodies against the GluN1 subunit of the NMDAR. Patients' antibodies cause cross-linking and internalization of NMDAR, but the synaptic events leading to depletion of NMDAR are poorly understood. Using super-resolution microscopy, we studied the effects of the autoantibodies on the nanoscale distribution of NMDAR in cultured neurons. Our findings show that, under control conditions, NMDARs ...
Tópico(s): Neuroscience and Neuropharmacology Research
2018 - Cell Press | Cell Reports
Nitin Mohan, Elena M. Sorokina, Ione Vilanova Verdeny, Ángel Sandoval Álvarez, Melike Lakadamyali,
Microtubule post-translational modifications impart functional diversity to microtubules by affecting their dynamics, organization, and interaction with proteins. Using super-resolution microscopy, we show that only a small subpopulation of microtubules are detyrosinated in epithelial cells, while acetylated and tyrosinated microtubules comprise the majority of all microtubules. Surprisingly, lysosomes are enriched by approximately threefold on detyrosinated microtubules. Further, their motility ...
Tópico(s): Cellular transport and secretion
2018 - Rockefeller University Press | The Journal of Cell Biology
Yuan Lu, Angel Sandoval, Sarah M. Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage, Christi A. Walter, Wes Warren, Manfred Schartl, Ronald B. Walter,
Significance The Bateson–Dobzhansky–Muller (BDM) model describes negative epistatic interactions that occur between genes with a different evolutionary history to account for hybrid incompatibility and is a central theory explaining genetic mechanisms underlying speciation. Since the early 1900 s when the BDM model was forwarded examples of BDM incompatibility have been described in only a few nonvertebrate cases. This study reports the only vertebrate system, with clearly defined interacting loci, ...
Tópico(s): Parasite Biology and Host Interactions
2020 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Antonieta Chávez‐González, Sandra Centeno-Llanos, Dafné Moreno-Lorenzana, Miguel Angel Sandoval-Esquivel, Sócrates Avilés‐Vázquez, María Elena Bravo‐Gómez, Lena Ruiz‐Azuara, Manuel Ayala‐Sánchez, Héctor H. Torres-Martínez, Héctor Mayani,
Several novel compounds have been developed for the treatment of different types of leukemia. In the present study, we have assessed the in vitro effects of Casiopeina III-Ea, a copper-containing small molecule, on cells from patients with Chronic Myeloid Leukemia (CML). We included primary CD34+ Lineage-negative (Lin-) cells selected from CML bone marrow, as well as the K562 and MEG01 cell lines. Bone marrow cells obtained from normal individuals - both total mononuclear cells as well as CD34+ Lin- ...
Tópico(s): Acute Lymphoblastic Leukemia research
2016 - Elsevier BV | Leukemia Research
Sadoth Sandoval-Torres, Angel Pérez Santiago, Emilio Hernández-Bautista,
A multiphase one-dimensional mathematical model was developed in order to elucidate the spatial moisture pattern (SMP) in Mexican pine wood (Pinus pseudostrobus) during a convective drying process using warm air. The mathematical model is based on the mechanics of the continuous and considers the balance of mass and energy in the representative elementary volume. The liquid, solid, and gas phases were considered. The transition from the nonhygroscopic to the hygroscopic phase was analyzed, dividing ...
Tópico(s): Material Properties and Processing
2018 - Taylor & Francis | Drying Technology
Edgar Javier Morales Morales, Martín Rubí-Arriaga, José Antonio López-Sandoval, Ángel Roberto Martínez-Campos, Edgar Jesús Morales-Rosales,
Los fertilizantes nitrogenados son necesarios, ya que gracias a ellos se mejora la producción de los cultivos. Después del agua y la temperatura se considera como el tercer factor en importancia en la producción de alimentos de origen vegetal. La urea como fertilizante, presenta la ventaja de proporcionar un alto contenido de nitrógeno (46%), el cual, es esencial en el metabolismo de la planta. La mayor desventaja que tiene es la pérdida de nitrógeno (N) en forma de gas amoniaco (NH3), proveniente ...
Tópico(s): Plant and soil sciences
2019 - National Institute of Forestry, Agriculture and Livestock Research ( INIFAP ) | Revista Mexicana de Ciencias Agrícolas
Omar Alejandro Ramos Rodríguez, Juan Pablo Mojica-Sánchez, José Antonio Valcárcel Gamiño, Fernando Obledo Benicio, Carlos Eduardo Macías-Hernández, M. Martínez, Francisco J. Martínez Martínez, Zeferino Gómez‐Sandoval, Ángel Ramos-Organillo,
The structures of thioethers I-III and the new amidic compounds 1(a-f)-3(a-f) derived from 2-mercaptobenzimidazole (MBZ) and cinnamic acids were confirmed by NMR and elemental analysis. Antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH●) radical scavenging assay and 2,2-azinobis (3-ethyl benzothiazoline-6-sulfonic acid) ABTS●+ radical cation decolorization method. Besides, donor-acceptor maps (DAM) and electrophilicity were calculated using DFT/B3LYP method with a 6-311G(d,p) ...
Tópico(s): Metal complexes synthesis and properties
2020 - Elsevier BV | Journal of Molecular Structure