Project Gutenberg
"Published at the request of the hearers." Book.
0000 - Gale Group | Sabin June 2012
Jennifer L. Houmani, Christopher I. Davis, Ingrid K. Ruf,
ABSTRACT The Epstein-Barr virus (EBV)-encoded RNAs, EBER-1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency. The EBERs have been shown to impart significant tumorigenic potential ... derived cell lines. However, the mechanisms underlying this EBER-dependent enhancement of cell growth potential remain to ... Here we focused on the known interaction between EBER-1 and the cellular ribosomal protein L22 and ... respect to the growth-promoting properties of the EBERs. L22, a component of 60S ribosomal subunits, binds ...
Tópico(s): Cancer-related molecular mechanisms research
2009 - American Society for Microbiology | Journal of Virology
Project Gutenberg
Dai Iwakiri, Li Zhou, Mrinal Samanta, Misako Matsumoto, Takashi Ebihara, Tsukasa Seya, Shosuke Imai, Mikiya Fujieda, Keisei Kawa, Kenzo Takada,
Epstein-Barr virus–encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop structure by intermolecular base-pairing, giving rise to double-stranded RNA (dsRNA)–like molecules, ... in EBV-infected cells. Here, we report that EBER induces signaling from the Toll-like receptor 3 ( ... IFN and proinflammatory cytokines. A substantial amount of EBER, which was sufficient to induce signaling from TLR3, ... infected cells, and the majority of the released EBER existed as a complex with a cellular EBER- ...
Tópico(s): Parvovirus B19 Infection Studies
2009 - Rockefeller University Press | The Journal of Experimental Medicine
Putnam, John Milton, Mann, Cyrus, Phillips, Alonzo, Clark, Eber L. (Eber Liscom),
... 29]-31. "Address to the people / by Rev. Eber L. Clark, of Winchendon."--P. [33]-36. Book.
0000 - Gale Group | Sabin backfiles 2011
Epstein-Barr virus (EBV)-encoded small RNAs (EBERs) are polyA-, non-coding RNAs that are expressed abundantly in all forms of cells latently infected with EBV. EBERs (EBER1 and EBER2) contribute to the clonal proliferation ... and maintenance of malignant phenotypes in BL cells. EBERs induce the expression of interleukin (IL)-10 in ... as an autocrine growth factor. In BL cells, EBERs bind the double-stranded RNA-activated protein kinase ... prevent IFN-alpha-mediated apoptosis. In epithelial cells, EBERs confer resistance to Fas-mediated apoptosis by blocking ...
Tópico(s): Cytomegalovirus and herpesvirus research
2009 - Wiley | Cancer Science
Letters: Eber Carpente; November 13, 1865 to W. E. Whiting; Colchester, Connecticut.
1865 - Gale Group | SAS Part 1
Paul A. Clarke, Nigel A. Sharp, M J Clemens,
... abundant Epstein—Barr virus (EBV)-encoded small RNAs, EBER-1 and EBER-2, were examined in Daudi Burkitt's lymphoma ... approximately equal rates, the steady-state level of EBER-1 is at least 10-fold greater than that of EBER-2. This is shown to be due to a much faster rate of turnover of EBER-2. In the presence of actinomycin D, the half-lives of EBER-1 and EBER-2 are 8 to 9 h and 0. ... RNAs is strongly inhibited. However, the level of EBER-1 increases up to twofold, indicating a further ...
Tópico(s): T-cell and Retrovirus Studies
1992 - Microbiology Society | Journal of General Virology
Letters: Eber S. Hotchkiss; February 21, 1875 to W. E. Whiting; West Meriden, Connecticut.
1875 - Gale Group | SAS Part 1
... cells revealed that EBV-encoded poly(A)− RNAs (EBERs) were responsible for IFN resistance. EBERs bound double-stranded (ds) RNA-activated protein kinase ( ... cells resistant to IFN-α-induced apoptosis. Furthermore, EBERs did not bind mutant PKR, which was catalytically ... they inhibit its phosphorylation. These results indicate that EBERs confer resistance to IFN-α-induced apoptosis via ... antigen 1 (EBNA1), EBV-encoded poly(A)− RNAs (EBERs) and transcripts from the BamHI A region (BARF0), ... relative resistance to apoptosis. Furthermore, we show that EBERs are responsible for resistance to IFN-α-induced ...
Tópico(s): Viral-associated cancers and disorders
2002 - Springer Nature | The EMBO Journal
Hotchkiss, Eber S.Letter: Guilford, Connecticut, November 2, 1870, to W. E. Whiting.
1870 - Gale Group | SAS Part 1
Shinya Yuge, Koji Inoue, Susumu Hyodo, Yoshio Takei,
... and uroguanylin (5Hamra F.K. Forte L.R. Eber S.L. Pidhorodeckyj N.V. Krause W.J. ... Google Scholar, 5Hamra F.K. Forte L.R. Eber S.L. Pidhorodeckyj N.V. Krause W.J. ... been identified in the opossum (7Forte L.R. Eber S.L. Fan X. London R.M. Wang ... of fish (8Forte L.R. London R.M. Eber S.L. Freeman R.H. Krause W.J. ... Scholar), reptiles (9Krause W.J. Freeman R.H. Eber S.L. Hamra F.K. Currie M.G. ... and birds (10Krause W.J. Freeman R.H. Eber S.L. Hamra F.K. Fok K.F. ... Google Scholar, 5Hamra F.K. Forte L.R. Eber S.L. Pidhorodeckyj N.V. Krause W.J. ...
Tópico(s): Plant and animal studies
2003 - Elsevier BV | Journal of Biological Chemistry
Hotchkiss, Eber S.Letter: West Meriden, Connecticut, June 11, 1874, to W. E. Whiting.
1874 - Gale Group | SAS Part 1
Thomas J. Owen, John D. O’Neil, William O. Dawson, Chunfang Hu, Xiaoyi Chen, Yunhong Yao, Victoria Wood, Louise Mitchell, Robert J. White, Lawrence S. Young, John R. Arrand,
Abstract Background Epstein-Barr Virus (EBV)-encoded RNAs (EBERs) are non-polyadenylated RNA molecules transcribed from the EBV genome by RNA polymerase III (pol III). EBERs are the most abundant viral latent gene products, ... is able to achieve such high levels of EBER expression are not fully understood. Previously EBV has been demonstrated to induce transcription factors associated with EBER expression, including pol III transcription factors and ATF- ... investigated the role of EBNA1 in induction of EBER-associated transcription factors. Results Our data confirm that ...
Tópico(s): Lymphoma Diagnosis and Treatment
2010 - BioMed Central | Molecular Cancer
Directory of Open Access Journals (DOAJ)
Hotchkiss, Eber S.Letter: Meriden, Connecticut, October 5, 1875, to W. E. Whiting.
1875 - Gale Group | SAS Part 1
Epstein–Barr virus (EBV)-encoded small RNAs (EBERs) are noncoding RNAs that are expressed abundantly in latently EBV-infected cells. Previous studies demonstrated that EBERs (EBER1 and EBER2) play significant roles in various EBV-infected cancer cells. EBERs are responsible for malignant phenotypes of Burkitt's ... BL) cells including resistance to apoptosis. In addition, EBERs induce the expression of interleukin (IL)-10 in ... autocrine growth factor. It was also reported that EBERs play critical roles in the B cell growth ...
Tópico(s): Immune Cell Function and Interaction
2010 - Elsevier BV | Advances in cancer research
Hotchkiss, Eber S.Letter: West Meriden, Connecticut, January 29, 1876, to W. E. Whiting.
1876 - Gale Group | SAS Part 1
Sarah Park, Jeeyun Lee, Young Hyeh Ko, Arum Han, Hyun Jung Jun, Sang Chul Lee, In Gyu Hwang, Winnie Yeo, Jin Seok Ahn, Chul Won Jung, Kihyun Kım, Yong Chan Ahn, Won Ki Kang, Keunchil Park, Won Seog Kim,
... available for analysis by EBV-encoded RNA-1 (EBER) in situ hybridization, and 34 cases (9.0%) were identified as EBER-positive. EBER positivity was significantly associated with age greater than ... poorer outcome to initial treatment (P = .006). The EBER+ patients with DLBCL demonstrated substantially poorer overall survival (EBER+ vs EBER− 35.8 months [95% confidence interval (CI), 0- ... not reached, P = .026) and progression-free survival (EBER+ vs EBER− 12.8 months [95% CI, 0-31.8 ... 018). In nongerminal center B-cell–like subtype, EBER in situ hybridization positivity retained its statistical significance ...
Tópico(s): Eosinophilic Disorders and Syndromes
2007 - Elsevier BV | Blood
Letters: Eber S. Hotchkiss; August 05, 1872 to Mr. W. E. Whiting; Guilford, Connecticut.
1872 - Gale Group | SAS Part 1
Tomokazu Yoshizaki, Kazuhira Endo, Qingchun Ren, Naohiro Wakisaka, Shigeyuki Murono, Satoru Kondo, Hiroshi Sato, Mitsuru Furukawa,
... in NPC, EBV-encoded non-polyadenylated RNAs, termed EBERs, are the most abundant transcripts of EBV in NPC. However, the role of EBERs still remains unclear. This study was designed to investigate the relevance of EBERs to the oncogenesis of NPC.Two types of EBERs expression vectors (EBERs-high-expression vector and EBERs-low-expression vector) were constructed and transfected into ... by anchor independent growth, was evaluated between the EBERs-transfected cells and EBERs-negative cells using a soft agar colony formation ...
Tópico(s): T-cell and Retrovirus Studies
2006 - Elsevier BV | Auris Nasus Larynx
Mrs. Eber Whittmore, Mrs. B. Nichols,
Letters: Mrs. Eber Whittmore and Mrs. B. Nichols; November 1869; Rochdale, Massachusetts.
1869 - Gale Group | SAS Part 1
Zoë A. Felton-Edkins, Alexander Kondrashov, Dimitra Karali, Jennifer A. Fairley, William O. Dawson, John R. Arrand, Lawrence S. Young, Robert J. White,
The EBER genes of Epstein-Barr virus (EBV) are transcribed by RNA polymerase (pol) III to produce untranslated RNAs that are implicated in oncogenesis. These EBER transcripts are the most highly expressed viral gene ... that may contribute to the high levels of EBER RNA. These include phosphorylation of ATF2, which interacts with EBER promoters. A second is induction of TFIIIC, a pol III-specific factor that activates EBER genes; all five subunits of TFIIIC are overexpressed ... by EBV, its induction is sufficient to stimulate EBER expression in vivo, implying a limiting function. The ...
Tópico(s): Eosinophilic Disorders and Syndromes
2006 - Elsevier BV | Journal of Biological Chemistry