Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Chen, Stefan Rentas, Véronique Voisin, Gabriela Krivdova, Eric R. Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope,
Abstract Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell function, little is understood of the preventive machinery present in human HSCs that may serve to resist their activation and promote HSC self-renewal. We demonstrate that the transcription factor PLAG1 is essential for long-term HSC function and, ...
Tópico(s): T-cell and B-cell Immunology
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