Andrew Robson, Melanie Tringham and Antonia Senior, Peter North, Chief Executive, Phil Yates, Christina Hardyment, Jon Ashworth, Cath Urquhart, Jenne Mannion, Raymond Snoddy Media Editor, Richard Whitehead, Helen Studd, Robert Cole, Guy Ritchie, Catherine Riley, Andrew Pierce, Flona Beckett, Tom Fort, Frank Black, James Moore, Maggie Alderson, Jane MacQuitty, Timothy Elliott, stephen tompkinson, Salome Munuo, Paul Hoggart, Roger Wiltshire, Secretary General, Mark Souster, Carmen Lundy, David Bailey, Stephen Brennan, MacQuitty, Michael Evans Defence Editor, Birna Helgadottir, Philip Howard, J. P. Duguid, Adam Sherwin and John Goodbody, Alan Parry, James Bone, Simon Munnery, Gillian Harris Scotland Correspondent, Anne Robinson, E. Jane Dickson, Radix, Sharon Linnard, Nicholas Parmee, john diamond, Clare Stewart, David Lindsay, Giles Coren, Eckart Jack, Antonia Senior, Ben Webster Transport Correspondent, Pat Gibson, Valerie Elliott Countryside Editor, Noam Friedlander, Shiraz Randeria, Jane Arraf of CNN, Henry Harris, Chandos Elletson, John Clarke, Anita McNaught, Stewart Tendler Crime Correspondent, Stephen Robinson, Dominic Walsh, Ruth Gledhill, Steve Bird, Gary Jacob, Suzanne Clarkson, Rob Penn, Andrew Oswald, Alix Ramsay Tennis Correspondent, Jill Dupleix, Tim Reid, Christopher Darke, General Secretary, Martin Barrow, Dalya Alberge Arts Correspondent, Peter Waymark, MM, Jo Morris, Helen Monks, Robin Young, Oliver Wright, Rodney Milnes, Greg Hurst and Roland Watson, Robin Whiting, Fraser Nelson Scottish Political Correspondent, Doug Sager, Roland Watson, John Law, David Hands, Moragh Gee, Charles Bremner, Helen Rumbelow, Lisa Armstrong Fashion Editor, Greg Hurst, Peter Barnard, Tim Teeman, Nicholas Wapshott, Mark Court, James Daley, Robin Gauldie, Michael Sherbourne, JJ, Will Greenwood, Michael Deeny, Russell Kempson, Paula Hawkins, A. N. Cormack, Vanora Bennett, Mary Gold, Keith Mitchell, Jeremy Bremridge, Liz Jensen, Stephen Anderton, Amber Cowan, Mark Atherton, Michael Theodoulou, Frank Leboeuf, Mark Henderson Science Correspondent, Andy Stephens Football Focus, Simon de Bruxelles, Rob Wright, Claire Wilson, David Powell Athletics Correspondent, Raymond Keene, Vaughan Freeman, Adam Jones and Liesbeth Evers, Viktoria Mullova, Noble Frankland, Matthew Pryor, Matt Dickinson, Lucy Pinney, Alison Kervin Rugby Editor, Paul Wilkinson, Paul Levy, Lawrence Freedman, Sam Bussey, Min Cooper, Alison Kervin and Matthew Pryor, MacHiavelli, Paul Noon, General Secretary, Deborah Brett, caroline Merrell Banking Correspondent, Richard Owen, Peter Matthews, Christopher Martin-Jenkins Chief Cricket Correspondent, Roger Boyes, Oliver August, Nick Hasell, Edward Frewin, Sarah Dunant, Graham Searjeant Personal Investor, John Phillips and Dragan Petrovic and Michael Evans, David Hands Rugby Correspondent, James Collard, Suzanne Marriott, Nick Szczepanik, Roland Watson and Greg Hurst, John Goodbody, Anne Ashworth, James Doran, Giles Whittell, Colin Morey, Brian MacArthur, Linus Gregoriadis, William Oddie, Mike Brewer, Alex Dingwall-Main, Matthew Parris, PB, Jennai Cox, Angus Clarke, Bata, Mark Hodkinson, Michael Hartnack, Chris McGrath, Tim Wapshott, Marjorie Yue, Alan Lee, Jane Owen, DC, Ben MacIntyre, Hunter Davies, Helen Pridham, Kira Nickerson, Richard Beeston Diplomatic Editor, Alison Gibson, Philip Webster and Adam Sherwin, Helen Pickles, Richard Miles, Jane Haxton, Hilary Morison, Kieran Falconer, Lewis Stuart, Catherine Philp, Martin Waller, Michael Horsnell, Chris Ayres, Danny Baker, Pierre J. Jeanniot, Director General, Fran Littlewood, Laura Peek, Benedict Nightingale, Andy Armstrong, Simon Courtenage (Senior Lecturer), Stephen Dalton, Jill Crawshaw, D. R. Pope, Richard Morrison, Sam Kiley, Tom Chesshyre, Arthur Leathley, Doug Sager Ski Correspondent, Tom Baldwin Deputy Political Editor, SJ, Conor McPherson, David Hubbard, Allan Hall, Robert Whymant, Alan Lee Racing Correspondent, Paul Mansfield, Andrew Michael, Sally Patten, Stanley Kubrick, Maurice Fitzpatrick, Tom Baldwin and Dalya Alberge, Sally Patten Retail Correspondent, Catherine Riley Motoring Editor, Patience Wheatcroft, Grainne Gilmore, David Mamet, Susan Emmett,
... five best London exhibitions Richard Cork's choice: Murillo Now booking Japes Nationwide choice: The Trestle at ...
2001 - Gale Group | TDA
Clare L. Murray, Eric S. Meadows, Oscar Murillo, George W. Gokel,
... Bilayer Conductance StudiesClare L. Murray, Eric S. Meadows, Oscar Murillo, and George W. GokelView Author Information Bioorganic Chemistry ...
Tópico(s): Photosynthetic Processes and Mechanisms
1997 - American Chemical Society | Journal of the American Chemical Society
Ernesto Abel, Glenn E. M. Maguire, Eric S. Meadows, Óscar Murillo, Takashi Jin, George W. Gokel,
... Abel, Glenn E. M. Maguire, Eric S. Meadows, Oscar Murillo, Takashi Jin, and George W. GokelView Author Information ...
Tópico(s): Photosynthetic Processes and Mechanisms
1997 - American Chemical Society | Journal of the American Chemical Society
Shrabanti Chowdhury, Jacob J. Kennedy, Richard G. Ivey, Oscar Murillo, Noshad Hosseini, Xiaoyu Song, Francesca Petralia, Anna Calinawan, Sara R. Savage, Anna B. Berry, Boris Reva, Umut Özbek, Azra Krek, Weiping Ma, Felipe da Veiga Leprevost, Jiayi Ji, Seungyeul Yoo, Chenwei Lin, Uliana J. Voytovich, Yajue Huang, Sun Hee Lee, Lindsay Bergan, Travis D. Lorentzen, Mehdi Mesri, Henry Rodriguez, Andrew N. Hoofnagle, Zachary T. Herbert, Alexey I. Nesvizhskii, Bing Zhang, Jeffrey R. Whiteaker, David Fenyö, Wilson McKerrow, Joshua Wang, Stephan C. Schürer, Vasileios Stathias, X. Steven Chen, Mary Helen Barcellos‐Hoff, Timothy K. Starr, Boris Winterhoff, Andrew C. Nelson, Samuel C. Mok, Scott H. Kaufmann, Charles W. Drescher, Marcin Cieślik, Pei Wang, Michael J. Birrer, Amanda G. Paulovich,
To improve the understanding of chemo-refractory high-grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two validation cohorts across two biospecimen types (formalin-fixed paraffin-embedded and frozen). We identified a 64-protein signature that predicts with high specificity a subset of HGSOCs refractory to initial platinum-based therapy and is validated in two independent patient cohorts. We ...
Tópico(s): PARP inhibition in cancer therapy
2023 - Cell Press | Cell
Jacob J. Kennedy, Jeffrey R. Whiteaker, Richard G. Ivey, Aura Burian, Shrabanti Chowdhury, Chia‐Feng Tsai, Tao Liu, Chenwei Lin, Oscar Murillo, Rachel A. Lundeen, Lisa Jones, Philip R. Gafken, Gary Longton, Karin Rodland, Steven J. Skates, John D. Landua, Pei Wang, Michael T. Lewis, Amanda G. Paulovich,
Despite advances in proteomic technologies, clinical translation of plasma biomarkers remains low, partly due to a major bottleneck between the discovery of candidate biomarkers and costly clinical validation studies. Due to a dearth of multiplexable assays, generally only a few candidate biomarkers are tested, and the validation success rate is accordingly low. Previously, mass spectrometry-based approaches have been used to fill this gap but feature poor quantitative performance and were generally ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2022 - American Chemical Society | Analytical Chemistry
Reinaldo Espíndola, Venanzio Vella, Natividad Benito, Isabel Mur, Sara Tedeschi, Eleonora Zamparini, Johannes G.E. Hendriks, Luisa Sorlí, Oscar Murillo, Laura Soldevila, Matthew Scarborough, Claire Scarborough, Jan Kluytmans, Mateo Carlo Ferrari, Mathias W. Pletz, Iain McNamara, Rosa Escudero-Sánchez, C. Arvieux, Cécile Batailler, Frédéric‐Antoine Dauchy, Wai-Yan Liu, Jaime Lora-Tamayo, Julia Praena, Andrew Ustianowski, Elisa Cinconze, Michele Pellegrini, Fábio Bagnoli, Jesús Rodríguez‐Baño, María Dolores del Toro, Nienke Cuperus, Giuseppe Manfré, Ana Isabel Suárez-Barrenechea, Alvaro Pascual-Hernandez, Alba Rivera, Xavier Crusi, Marcos Jordán, Nicolò Rossi, Tessa vande Kerkhof, Juan Pablo Horcajada, Joan Gómez‐Junyent, Albert Alier, Miranda van Rijen, Jannie Romme, Juliane Ankert, Celia E. Whitehouse, Adrian Jones, Javier Cobo, Javier Moreno, Anne Méheut, Claire Gledel, Pauline Perreau, Remco J. A. van Wensen, Gabriella Lindergard,
Guidelines have improved the management of prosthetic joint infections (PJI). However, it is necessary to reassess the incidence and risk factors for treatment failure (TF) of Staphylococcus aureus PJI (SA-PJI) including functional loss, which has so far been neglected as an outcome.A retrospective cohort study of SA-PJI was performed in 19 European hospitals between 2014 and 2016. The outcome variable was TF, including related mortality, clinical failure and functional loss both after the initial ...
Tópico(s): Surgical site infection prevention
2022 - Adis, Springer Healthcare | Infectious Diseases and Therapy
Laura Soldevila‐Boixader, Bernat Villanueva, Marta Ulldemolins, Eva Benavent, Ariadna Padullés, Alba Ribera, I. Borras, Javier Ariza, Óscar Murillo,
Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014–December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2021 - Multidisciplinary Digital Publishing Institute | Antibiotics
Eva Benavent, Laura Morata, Francesc Escrihuela-Vidal, Esteban Reynaga, Laura Soldevila, Laia Albiach, María Luisa Pedro-Botet, Ariadna Padullés, Álex Soriano, Óscar Murillo,
Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular infection cases treated with tedizolid. Failure: clinical worsening despite antibiotic treatment or the need of suppressive treatment. Results: Cases (n = 51; 59% women, mean age of 65 years) included osteoarthritis (n = 27, 53%), prosthetic joint infection (n = 17, 33.3%), and diabetic foot infections (n = 9, 18%); where, ...
Tópico(s): Surgical site infection prevention
2021 - Multidisciplinary Digital Publishing Institute | Antibiotics

Harrison H. Jones, Elisa Barreto, Oscar Murillo, Scott K. Robinson,
Andean forests, a hotspot of biodiversity, have suffered extensive fragmentation, yet we have little understanding of how this process has affected biodiversity. We surveyed bird communities across a gradient of fragment sizes (10–170 ha) and a continuous forest reference site in the Colombian Western Andes. Using a multi-species occupancy model to combine survey data from audio-visual transect surveys, mist netting, and playbacks for owls, we estimated alpha and beta taxonomic and functional diversity. ...
Tópico(s): Wildlife-Road Interactions and Conservation
2021 - Elsevier BV | Global Ecology and Conservation
Jeffrey R. Whiteaker, Rachel A. Lundeen, Lei Zhao, Regine M. Schoenherr, Aura Burian, Dongqing Huang, Ulianna Voytovich, Tao Wang, Jacob J. Kennedy, Richard G. Ivey, Chenwei Lin, Oscar Murillo, Travis D. Lorentzen, Mathangi Thiagarajan, Simona Colantonio, Tessa W. Caceres, Rhonda R. Roberts, Joseph G. Knotts, Joshua J. Reading, Jan Kaczmarczyk, Christopher W. Richardson, Sandra S. Garcia-Buntley, William Bocik, Stephen M. Hewitt, Karen Murray, Nhan Do, Mary T. Brophy, Stephen W. Wilz, Hongbo Yu, Samuel Ajjarapu, Emily S. Boja, Tara Hiltke, Henry Rodriguez, Amanda G. Paulovich,
Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understanding of tumor immunobiology is incomplete. While hundreds of immunomodulatory proteins in the tumor microenvironment shape the anti-tumor response, few of them can be reliably quantified. To address this need, we developed a multiplex panel of targeted proteomic ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2021 - Frontiers Media | Frontiers in Immunology
Shelly A. Buffington, Sean W. Dooling, Martina Sgritta, Cecilia Noecker, Oscar Murillo, Daniela Felice, Peter J. Turnbaugh, Mauro Costa‐Mattioli,
The core symptoms of many neurological disorders have traditionally been thought to be caused by genetic variants affecting brain development and function. However, the gut microbiome, another important source of variation, can also influence specific behaviors. Thus, it is critical to unravel the contributions of host genetic variation, the microbiome, and their interactions to complex behaviors. Unexpectedly, we discovered that different maladaptive behaviors are interdependently regulated by ...
Tópico(s): Tryptophan and brain disorders
2021 - Cell Press | Cell
Rocco Lucero, Valentina Zappulli, Alessandro Sammarco, Oscar Murillo, Pike-See Cheah, Srimeenakshi Srinivasan, Eric C. Tai, David T. Ting, Zhiyun Wei, Matthew E. Roth, Louise C. Laurent, Anna M. Krichevsky, Xandra O. Breakefield, Aleksandar Milosavljevic,
Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests pathways of GBM neovascularization, possibly attributable to glioblastoma stem cells (GSCs) and their interplay with the tumor microenvironment. It has been established that GSC-derived extracellular vesicles (GSC-EVs) and their cargoes are proangiogenic in vitro. To further elucidate EV-mediated mechanisms of neovascularization in vitro, we perform ...
Tópico(s): Circular RNAs in diseases
2020 - Cell Press | Cell Reports

Aramys Silva Reis, Renato Barboza, Oscar Murillo, André Barateiro, Erika Paula Machado Peixoto, Flávia Afonso Lima, Vinícius M. Gomes, Jamille Gregório Dombrowski, Vinícius Nunes Cordeiro Leal, Franciele Rodrigues Araújo, Carla Letícia Bandeira, Rosana Beatriz Duque Araujo, Rita Neres, Rodrigo Medeiros de Souza, Fábio Trindade Maranhão Costa, Alessandra Pontillo, Estela Bevilacqua, Carsten Wrenger, Gerhard Wunderlich, Giuseppe Palmisano, Letícia Labriola, Karina Ramalho Bortoluci, Carlos Penha‐Gonçalves, Lígia Antunes Gonçalves, Sabrina Epiphânio, Cláudio Romero Farias Marinho,
IL-1 axis activation during placental malaria induces poor pregnancy outcomes that are obliterated after treatment with Anakinra.
Tópico(s): COVID-19 Impact on Reproduction
2020 - American Association for the Advancement of Science | Science Advances
Jaime Lora‐Tamayo, Óscar Murillo, Javier Ariza,
Biofilm is an adaptive bacterial strategy whereby microorganisms become encased in a complex glycoproteic matrix. The low concentration of oxygen and nutrients in this environment leads to heterogeneous phenotypic changes in the bacteria, with antimicrobial tolerance being of paramount importance. As with other antibiotics, the activity of colistin is impaired by biofilm-embedded bacteria. Therefore, the recommendation for administering high doses in combination with a second drug, indicated for ...
Tópico(s): Infections and bacterial resistance
2019 - Springer Nature | Advances in experimental medicine and biology
Sara Grillo, Guillermo Cuervo, Jordi Carratalà, Inmaculada Grau, Natàlia Pallarès, Cristian Tebé, Lluïsa Guillem, Óscar Murillo, Carmen Ardanuy, M.A. Domı́nguez, Evelyn Shaw, Carlota Gudiol, Miquel Pujol,
Abstract Background Mortality rates from Staphylococcus aureus bacteremia are high and have only modestly improved in recent decades. We compared the efficacies of a β-lactam in combination with daptomycin (BL/D-C) and β-lactam monotherapy (BL-M) in improving clinical outcomes in methicillin-susceptible S. aureus (MSSA) bacteremia. Methods A retrospective cohort study of MSSA bacteremia was performed in a tertiary hospital from January 2011 to December 2017. Patients receiving BL/D-C and BL-M were ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2019 - Oxford University Press | Clinical Infectious Diseases

Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Flávia Afonso Lima, Carla Letícia Bandeira, Oscar Murillo, Douglas de Sousa Costa, Erika Paula Machado Peixoto, Marielton dos Passos Cunha, Paolo Marinho de Andrade Zanotto, Estela Bevilacqua, Marcos Grisotto, Antonio Carlos Pedroso de Lima, Júlio M. Singer, Susana Campino, Taane G. Clark, Sabrina Epiphânio, Lígia Antunes Gonçalves, Cláudio Romero Farias Marinho,
Importance Malaria during pregnancy is associated with adverse events for the fetus and newborn, but the association of malaria during pregnancy with the head circumference of the newborn is unclear. Objective To investigate the association of malaria during pregnancy with fetal head growth. Design, Setting, and Participants Two cohort studies were conducted at the general maternity hospital of Cruzeiro do Sul (Acre, Brazil) in the Amazonian region. One cohort study prospectively enrolled noninfected and malaria- ...
Tópico(s): Hemoglobinopathies and Related Disorders
2019 - American Medical Association | JAMA Network Open
Saumya Das, K. Mark Ansel, Markus Bitzer, Xandra O. Breakefield, Alain Charest, David J. Galas, Mark Gerstein, Mihir Gupta, Aleksandar Milosavljević, Michael T. McManus, Tushar Patel, Robert L. Raffaı̈, Joel Rozowsky, Matthew E. Roth, Julie A. Saugstad, Kendall Van Keuren‐Jensen, Alissa M. Weaver, Louise C. Laurent, Asim B. Abdel‐Mageed, Catherine Adamidi, P. David Adelson, Kemal M. Akat, Eric Alsop, K. Mark Ansel, Jorge Arango, Neil Aronin, Seda Kilinc Avsaroglu, Azadeh Azizian, Leonora Balaj, Iddo Z. Ben‐Dov, Karl Bertram, Markus Bitzer, Robert Blelloch, Kimberly A. Bogardus, Xandra O. Breakefield, George A. Călin, Bob S. Carter, Al Charest, Clark C. Chen, Tanuja Chitnis, Robert J. Coffey, Amanda Courtright-Lim, Saumya Das, Amrita Datta, Peter DeHoff, Thomas G. Diacovo, David J. Erle, Alton Etheridge, Marc Ferrer, Jeffrey L. Franklin, Jane E. Freedman, David J. Galas, Timur R. Galeev, Roopali Gandhi, Aitor Garcia, Mark Gerstein, Vikas Ghai, Ionita Ghiran, María D. Giraldez, Andrei Goga, Tasos Gogakos, Béatrice Goilav, Stephen J. Gould, Peixuan Guo, Mihir Gupta, Fred H. Hochberg, Bo Huang, Matt Huentelman, Craig P. Hunter, Elizabeth Hutchins, Andrew R. Jackson, M. Yashar S. Kalani, Pınar Kanlikilicer, Reka Agnes Karaszti, Kendall Van Keuren‐Jensen, Anastasia Khvorova, Yong Kim, Hogyoung Kim, Taek‐Kyun Kim, Robert R. Kitchen, Richard P. Kraig, Anna M. Krichevsky, Raymond Y. Kwong, Louise C. Laurent, Min Young Lee, Noëlle D. L’Étoile, Shawn Levy, Feng Li, Jenny Li, Xin Li, Gabriel López-Berestein, Rocco Lucero, Bogdan Mateescu, A. Matin, Klaas E.A. Max, Michael T. McManus, Thorsten R. Mempel, Cindy Meyer, Aleksandar Milosavljević, Debasis Mondal, Kenneth J. Mukamal, Oscar Murillo, Thangamani Muthukumar, Deborah A. Nickerson, Christopher J. O’Donnell, Dinshaw J. Patel, Tushar Patel, James G. Patton, Anu Paul, Elaine R. Peskind, Mitch A. Phelps, Chaim Putterman, Peter J. Quesenberry, Joseph F. Quinn, Robert L. Raffaı̈, Saritha Ranabothu, Shannon Jiang Rao, Cristian Rodriguez‐Aguayo, Anthony Rosenzweig, Matthew E. Roth, Joel Rozowsky, Marc S. Sabatine, Nikita A. Sakhanenko, Julie A. Saugstad, Thomas D. Schmittgen, Neethu Shah, Ravi V. Shah, Kerby Shedden, Jian Shi, Anil K. Sood, Anuoluwapo Sopeyin, Ryan M. Spengler, Robert Spetzler, Srimeenakshi Srinivasan, Sai Lakshmi Subramanian, Manikkam Suthanthiran, Kahraman Tanrıverdi, Yun Teng, Muneesh Tewari, William Thistlethwaite, Thomas Tuschl, Karolina Kaczor Urbanowicz, Kasey C. Vickers, Olivier Voinnet, Kai Wang, Alissa M. Weaver, Zhiyun Wei, Howard L. Weiner, Zachary R. Weiss, Zev Williams, David T. Wong, Prescott G. Woodruff, Xinshu Xiao, Irene K. Yan, Ashish Yeri, Bing Zhang, Huang‐Ge Zhang,
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference ...
Tópico(s): RNA regulation and disease
2019 - Cell Press | Cell
Joan Gómez‐Junyent, Eva Benavent, Yanik Sierra, Cristina El Haj, Laura Soldevila, Benjamín Torrejón, Raúl Rigo‐Bonnin, Fé Tubau, Javier Ariza, Óscar Murillo,
Ceftolozane/tazobactam is a potential tool for infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa), but its efficacy against some difficult-to-treat infections has not been well defined.Using an in vitro pharmacodynamic biofilm model, this study evaluated the comparative efficacy of ceftolozane/tazobactam against MDR/extensively drug-resistant (XDR) P. aeruginosa strains, alone and in combination with colistin. Simulated regimens of ceftolozane/tazobactam (2 g/1 g every ...
Tópico(s): Pneumonia and Respiratory Infections
2019 - Elsevier BV | International Journal of Antimicrobial Agents
Oscar Murillo, William Thistlethwaite, Joel Rozowsky, Sai Lakshmi Subramanian, Rocco Lucero, Neethu Shah, Andrew R. Jackson, Srimeenakshi Srinivasan, Allen Chung, Clara D. Laurent, Robert R. Kitchen, Timur R. Galeev, Jonathan Warrell, James A. Diao, Joshua A Welsh, Kristina Hanspers, Anders Riutta, Sebastian Burgstaller-Muehlbacher, Ravi V. Shah, Ashish Yeri, Lisa M. Jenkins, Mehmet Eren Ahsen, Carlos Cordón-Cardo, Navneet Dogra, Stacey M. Gifford, Joshua T. Smith, Gustavo Stolovitzky, Ashutosh Tewari, Benjamin H. Wunsch, Kamlesh K. Yadav, Kirsty Danielson, Justyna Filant, Courtney Moeller, Parham Nejad, Anu Paul, Bridget Simonson, David Wong, Xuan Zhang, Leonora Balaj, Roopali Gandhi, Anil K. Sood, Roger P. Alexander, Liang Wang, Chunlei Wu, David T. Wong, David J. Galas, Kendall Van Keuren‐Jensen, Tushar Patel, Jennifer Jones, Saumya Das, Kei-Hoi Cheung, Alexander R. Pico, Andrew I. Su, Robert L. Raffaı̈, Louise C. Laurent, Matthew E. Roth, Mark Gerstein, Aleksandar Milosavljevic,
To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://exrna-atlas.org). The Atlas version 4P1 hosts 5,309 exRNA-seq and exRNA qPCR profiles from 19 studies and a suite of analysis and visualization tools. To analyze variation between profiles, we apply computational deconvolution. The analysis leads to a model with six exRNA cargo types (CT1, CT2, CT3A, CT3B, CT3C, CT4), each detectable ...
Tópico(s): RNA modifications and cancer
2019 - Cell Press | Cell

Flávia Afonso Lima, André Barateiro, Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Douglas de Sousa Costa, Oscar Murillo, Sabrina Epiphânio, Lígia Antunes Gonçalves, Cláudio Romero Farias Marinho,
Plasmodium (P.) falciparum malaria during pregnancy has been frequently associated with severe consequences such as maternal anemia, abortion, premature birth, and reduced birth weight. Placental damage promotes disruption of the local homeostasis; though, the mechanisms underlying these events are still to be elucidated. Autophagy is a fundamental homeostatic mechanism in the natural course of pregnancy by which cells self-recycle in order to survive in stressful environments. Placentas from non- ...
Tópico(s): Poverty, Education, and Child Welfare
2019 - Public Library of Science | PLoS ONE
Rosa Escudero-Sánchez, Éric Senneville, M Digumber, Álex Soriano, María Dolores del Toro, Alberto Bahamonde, José Luís del Pozo, Laura Guío Carrión, Óscar Murillo, Alicia Rico, María José García-País, Dolors Rodríguez-Pardo, José Antonio Iribarren, María Maza, Natividad Benito, Gema Fresco, Alfonso Muriel, Javier Ariza, J. Cobo,
ObjectivesThe aim was to describe the effectiveness of suppressive antibiotic treatment (SAT) in routine clinical practice when used in situations in which removal of a prosthetic implant is considered essential for the eradication of an infection, and it cannot be performed.MethodsThis was a descriptive retrospective and multicentre cohort study of prosthetic joint infection (PJI) cases managed with SAT. SAT was considered to have failed if a fistula appeared or persisted, if debridement was necessary, ...
Tópico(s): Surgical site infection prevention
2019 - Elsevier BV | Clinical Microbiology and Infection

Marjan Wouthuyzen‐Bakker, Marine Sebillotte, José Manuel Lomas, Benjamin Kendrick, Eva Benavent, Óscar Murillo, Javad Parvizi, Noam Shohat, Javier Cobo Reinoso, Rosa Escudero Sánchez, Marta Fernández-Sampedro, Éric Senneville, Kaisa Huotari, José María Barbero Allende, Antonio Blanco García, Jaime Lora-Tamayo, Matteo Carlo Ferrari, Danguolė Važnaisienė, Erlangga Yusuf, Craig Aboltins, Rihard Trebše, Mauro José Costa Salles, Natividad Benito, Andrea Vila, María Dolores del Toro, Tobias Siegfried Kramer, Sabine Petersdorf, Vicens Díaz-Brito, Zeliha Koçak Tufan, Marisa Sánchez, C. Arvieux, Álex Soriano,
Objectives We evaluated the treatment outcome in late acute (LA) periprosthetic joint infections (PJI) treated with debridement and implant retention (DAIR) versus implant removal. Methods In a large multicenter study, LA PJIs of the hip and knee were retrospectively evaluated. Failure was defined as: PJI related death, prosthesis removal or the need for suppressive antibiotic therapy. LA PJI was defined as acute symptoms <3 weeks in patients more than 3 months after the index surgery and with a history ...
Tópico(s): Total Knee Arthroplasty Outcomes
2019 - Elsevier BV | Journal of Infection
Brian de Beaubien, Katherine A. Belden, Kerri Bell, K. Keely Boyle, José Cordero‐Ampuero, Craig J. Della Valle, Henk Eijer, Christopher Ferry, Viktor Janz, Bernard Kessler, Adam Kratky, Anne M. Lachiewicz, Kimberly E. Martin, Óscar Murillo, Marc W. Nijhof, Scott R. Nodzo, Michael J. Petrie, I Stockley, Linda I. Suleiman,
Question 1: (a) What is the optimal length of administration for antibiotic treatment after resection arthroplasty? (b) What is the optimal mode of administration for antibiotic treatment after resection arthroplasty?
Tópico(s): Infectious Diseases and Tuberculosis
2018 - Elsevier BV | The Journal of Arthroplasty
Laura Escolà‐Vergé, Dolors Rodríguez-Pardo, Jaime Lora-Tamayo, Laura Morata, Óscar Murillo, Helem Vílchez, Luisa Sorlí, Laura Guío Carrión, José Ma Barbero, J Palomino-Nicás, Alberto Bahamonde, A Jover, Natividad Benito, Rosa Escudero, Marta Fernández Sampedro, Rafael Pérez Vidal, Lucía Gómez, Pablo S. Corona, Benito Almirante, Javier Ariza, Carles Pigrau,
Candida periprosthetic joint infection (CPJI) is a rare, difficult-to-treat disease. The purpose of this study was to evaluate the clinical characteristics and outcomes of CPJI treated with various surgical and antifungal strategies.We conducted a multicenter retrospective study of all CPJI diagnosed between 2003 and 2015 in 16 Spanish hospitals.Forty-three patients included: median age, 75 years, and median Charlson Comorbidity Index score, 4. Thirty-four (79.1%) patients had ≥1 risk factor for Candida ...
Tópico(s): Orthopaedic implants and arthroplasty
2018 - Elsevier BV | Journal of Infection
Cristina El Haj, Óscar Murillo, Alba Ribera, Núria Lloberas, Joan Gómez‐Junyent, Fé Tubau, Pere Fontova, Carmen Cabellos, Javier Ariza,
Combinations of linezolid (LZD) or trimethoprim/sulfamethoxazole (SXT) plus rifampicin (RIF) are alternative oral treatments for staphylococcal prosthetic joint infections (PJIs) when fluoroquinolones are not possible to use, but there is limited evidence regarding their activity. This study evaluated the efficacy of LZD and SXT, alone and in combination with RIF, against Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic biofilm model. Using the CDC Biofilm Reactor® system, simulated ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2018 - Elsevier BV | International Journal of Antimicrobial Agents
Sayaka Miura, Karen Gomez, Oscar Murillo, Louise A. Huuki-Myers, Tracy Vu, Tiffany Buturla, Sudhir Kumar,
Abstract Motivation Analyses of data generated from bulk sequencing of tumors have revealed extensive genomic heterogeneity within patients. Many computational methods have been developed to enable the inference of genotypes of tumor cell populations (clones) from bulk sequencing data. However, the relative and absolute accuracy of available computational methods in estimating clone counts and clone genotypes is not yet known. Results We have assessed the performance of nine methods, including eight ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Oxford University Press | Bioinformatics
Óscar Murillo, Inmaculada Grau, Joan Gómez‐Junyent, Celina Cabrera, Alba Ribera, Fé Tubau, Carmen Peña, Javier Ariza, Román Pallarés,
Tópico(s): Infectious Diseases and Tuberculosis
2018 - Springer Science+Business Media | Infection

Marjan Wouthuyzen‐Bakker, Marine Sebillotte, José Manuel Lomas, Adrian Taylor, Eva Benavent, Óscar Murillo, Javad Parvizi, Noam Shohat, Javier Cobo Reinoso, Rosa Escudero Sánchez, Marta Fernández-Sampedro, Éric Senneville, Kaisa Huotari, José María Barbero, Joaquín García-Cañete, Jaime Lora-Tamayo, Matteo Ferrari, Danguolė Važnaisienė, Erlangga Yusuf, Craig Aboltins, Rihard Trebše, Mauro José Costa Salles, Natividad Benito, Andrea Vila, María Dolores del Toro, Tobias Siegfried Kramer, Sabine Petersdorf, Vicens Díaz-Brito, Zeliha Koçak Tufan, Marisa Sánchez, C. Arvieux, Álex Soriano,
Debridement, antibiotics and implant retention (DAIR) is the recommended treatment for all acute prosthetic joint infections (PJI), but its efficacy in patients with late acute (LA) PJI is not well described.Patients diagnosed with LA PJI between 2005 and 2015 were retrospectively evaluated. LA PJI was defined as the development of acute symptoms (≤ 3 weeks) occurring ≥ 3 months after arthroplasty. Failure was defined as: (i) the need for implant removal, (ii) infection related death, (iii) the need for suppressive ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2018 - Elsevier BV | Journal of Infection
Javier Ariza, Javier Cobo, Josu Baraia‐Etxaburu, Natividad Benito, Guillermo Bori, Javier Cabo, Pablo S. Corona, Jaime Esteban, Juan Pablo Horcajada, Jaime Lora-Tamayo, Óscar Murillo, Julián Palomino, Jorge Eduardo Duque Parra, Carlos Pigrau, José Luís del Pozo, Melchor Riera, Dolors Rodríguez-Pardo, Mar Sánchez-Somolinos, Álex Soriano, María Dolores del Toro, Basilio de la Torre,
The incidence of prosthetic joint infection (PJI) is expected to increase in the coming years. PJI has serious consequences for patients, and high costs for the health system. The complexity of these infections makes it necessary to organize the vast quantity of information published in the last several years. The indications for the choice of a given surgical strategy and the corresponding antimicrobial therapy are specifically reviewed. The authors selected clinically relevant questions and then ...
Tópico(s): Total Knee Arthroplasty Outcomes
2017 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
Raúl Rigo‐Bonnin, Alba Ribera, Ariadna Arbiol‐Roca, Sara Cobo‐Sacristán, Ariadna Padullés, Óscar Murillo, Evelyn Shaw, R. Granada, Xosé Pérez-Fernández, Fé Tubau, Pedro Alía,
The administration of β-lactam antibiotics in continuous infusion could let optimize the pharmacokinetic/pharmacodynamic parameters, especially in the treatment of serious bacterial infections. In this context, and also due to variability in their plasmatic concentrations, therapeutic drug monitoring (TDM) may be useful to optimize dosing and, therefore, be useful for the clinicians.We developed and validated a measurement procedure based on ultra-high performance liquid chromatography-tandem mass ...
Tópico(s): Pneumonia and Respiratory Infections
2017 - Elsevier BV | Clinica Chimica Acta