Radosław Piszczek, Łukasz Nowak, Wojciech Krajewski, Joanna Chorbińska, Sławomir Poletajew, Marco Moschini, Krzysztof Kaliszewski, Romuald Zdrojowy,
Abstract Background During the past two decades, laparoscopic radical nephroureterectomy (LRNU) has been proposed as an alternative technique to open radical nephroureterectomy (ORNU) and has become increasingly accepted for the treatment of patients with upper tract urothelial carcinoma (UTUC). Nevertheless, the oncologic efficacy of LRNU remains controversial, especially for the treatment of locally advanced (T3/T4 and/or N+) UTUC. In this meta-analysis, we aimed to cumulatively compare the oncological ...
Tópico(s): Esophageal Cancer Research and Treatment
2021 - BioMed Central | World Journal of Surgical Oncology
Dominic Kargl, Joanna Kaczanowska, Sophia Ulonska, Florian Groessl, Łukasz Piszczek, Jelena Lazović, Katja Buehler, Wulf Haubensak,
Affective responses depend on assigning value to environmental predictors of threat or reward. Neuroanatomically, this affective value is encoded at both cortical and subcortical levels. However, the purpose of this distributed representation across functional hierarchies remains unclear. Using fMRI in mice, we mapped a discrete cortico-limbic loop between insular cortex (IC), central amygdala (CE), and nucleus basalis of Meynert (NBM), which decomposes the affective value of a conditioned stimulus ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - eLife Sciences Publications Ltd | eLife
Boris Mlinar, Alberto Montalbano, Łukasz Piszczek, Cornelius T. Gross, Renato Corradetti,
Tonic spiking of serotonergic neurons establishes serotonin levels in the brain. Since the first observations, slow regular spiking has been considered as a defining feature of serotonergic neurons. Recent studies, however, have revealed the heterogeneity of serotonergic neurons at multiple levels, comprising their electrophysiological properties, suggesting the existence of functionally distinct cellular subpopulations. In order to examine in an unbiased manner whether serotonergic neurons of the ...
Tópico(s): Neuroscience and Neuropharmacology Research
2016 - Frontiers Media | Frontiers in Cellular Neuroscience
Łukasz Piszczek, Agnieszka Piszczek, Joanna Kuczmanska, Enrica Audero, Cornelius T. Gross,
Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals. Mice lacking Htr1a show increased anxiety behavior suggesting that its activation by serotonin has an anxiolytic effect. This outcome can be mediated by either Htr1a population present on serotonin (auto-receptor) or non-serotonin neurons (hetero-receptor), ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2015 - Frontiers Media | Frontiers in Behavioral Neuroscience
Olga Ermakova, Łukasz Piszczek, Luisa Luciani, Florence M.G. Cavalli, Tiago Ferreira, Dominika Farley, Stefania Rizzo, Rosa Chiara Paolicelli, Mumna Al‐Banchaabouchi, Claus Nerlov, Richard Moriggl, Nicholas M. Luscombe, Cornelius T. Gross,
Abstract The identification of susceptibility genes for human disease is a major goal of current biomedical research. Both sequence and structural variation have emerged as major genetic sources of phenotypic variability and growing evidence points to copy number variation as a particularly important source of susceptibility for disease. Here we propose and validate a strategy to identify genes in which changes in dosage alter susceptibility to disease‐relevant phenotypes in the mouse. Our approach ...
Tópico(s): Congenital heart defects research
2010 - Springer Nature | EMBO Molecular Medicine
Łukasz Piszczek, Kevin Schlax, Anna Wyrzykowska, Agnieszka Piszczek, Enrica Audero, Cornelius T. Gross,
Abstract The neurotransmitter serotonin plays an important role in modulating diverse behavioral traits. Mice lacking the serotonin 1 A receptor ( H tr1a) show elevated avoidance of novel open spaces, suggesting that it has a role in modulating anxiety behavior. Htr1a is a G αi ‐coupled G ‐protein‐coupled receptor expressed on serotonin neurons (auto‐receptor), where it mediates negative feedback of serotonin neuron firing. Htr1a is also expressed on non‐serotonin neurons (hetero‐receptor) in diverse ...
Tópico(s): Neuroendocrine regulation and behavior
2013 - Wiley | European Journal of Neuroscience
Dominika Farley, Łukasz Piszczek, Przemysław Bąbel,
Pain can be overestimated, underestimated or reported accurately at recall. The way pain is remembered seems to depend on certain factors, including the type of pain or, in other words, its cause, the context, and the meaning it has for the person suffering from it. For instance, episodes of chronic pain, as well as pain related to surgery, are often overestimated at recall. Interestingly, research shows that pain induced by parturition or marathon running is often underestimated at recall despite ...
Tópico(s): Human-Animal Interaction Studies
2019 - Elsevier BV | Medical Hypotheses
Łukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazović, Anton Pekcec, Janet R. Nicholson, Wulf Haubensak,
Behavioral strategies require gating of premature responses to optimize outcomes. Several brain areas control impulsive actions, but the neuronal basis of natural variation in impulsivity between individuals remains largely unknown. Here, by combining a Go/No-Go behavioral assay with resting-state (rs) functional MRI in mice, we identified the subthalamic nucleus (STN), a known gate for motor control in the basal ganglia, as a major hotspot for trait impulsivity. In vivo recorded STN neural activity ...
Tópico(s): Neurological disorders and treatments
2022 - eLife Sciences Publications Ltd | eLife
Krzysztof Chmielowiec, Łukasz Topolski, Aleks Piszczek, Zbigniew Hanzelka,
The presently observed rapid increase in photovoltaic (PV) micro-installation connections to low-voltage networks, resulting from numerous financial support programmes, European Union (EU) energy policy and growing social awareness of environmental and economic issues, raise the question if PV inverters widely available in EU market fulfil the numerous technical requirements specified in European and Polish regulations. The paper presents the results of an experimental study carried out on three PV ...
Tópico(s): Power System Reliability and Maintenance
2021 - Multidisciplinary Digital Publishing Institute | Energies
Olga Ermakova, Ekaterina Salimova, Łukasz Piszczek, Cornelius T. Gross,
Tópico(s): Gene expression and cancer classification
2012 - Springer Science+Business Media | Mammalian Genome
P. Skonieczek, M. Nowakowski, J. Píszczek, Łukasz Matyka, Marcin Żurek, B. Rychcik, Milena Kaźmierczak,
1. Abdollahian-Noghabi M., Froud-Williams R.J., 1998. Effect of moisture stress and re-watering on growth and dry matter partitioning in three cultivars of sugar beet. Aspects Appl. Biol., 52, 71-78. Google Scholar
Tópico(s): Irrigation Practices and Water Management
2018 - | Acta Agrophysica
Krzysztof Chmielowiec, Łukasz Topolski, Aleks Piszczek, Tomasz Rodziewicz, Zbigniew Hanzelka,
The paper presents the results of an experimental study of 26 brand new photovoltaic (PV) inverters widely available for sale on the EU market; the study was conducted in 2021 by researchers at the AGH University of Science and Technology and Tauron Dystrybucja (Polish DSO). The purpose of the study was to compare and assess PV inverter performances in terms of their DC/AC conversion efficiencies, MPPT efficiencies, and harmonic current emissions. To examine the PV inverters, a laboratory test stand ...
Tópico(s): Energy and Environment Impacts
2022 - Multidisciplinary Digital Publishing Institute | Energies
Skonieczek Paweł, M. Nowakowski, J. Píszczek, Żurek Marcin, Matyka Łukasz,
Abstract From 2008 to 2010 the levels of sugar beet seedlings infection caused by Rhizoctonia solani were compared in laboratory tests. Seven sugar beet lines were tested: H56, H66, S2, S3, S4, S5 and S6 as well as three control cultivars: Carlos, Esperanza and Janosik. Sugar beet lines with tolerance to rhizoctoniosis and cultivars without tolerance were infected artificially by R. solani isolates: R1, R28a and R28b. These isolates belong to the second anastomosis group (AG), which is usually highly ...
Tópico(s): Plant Disease Management Techniques
2016 - De Gruyter Open | Journal of Plant Protection Research
Łukasz Piszczek, Wulf Haubensak,
Behavioral neuroscience has successfully and in great detail deconstructed circuit mechanisms underlying fear behaviors using reductionist approaches. Recent research in more naturalistic settings now reveals additional higher-level organization, where hypothalamic circuits multiplex threat detection and fear memory updating to safely navigate complex environments.
Tópico(s): Neural dynamics and brain function
2024 - Elsevier BV | Current Biology
Jerzy Strużyna, Agnieszka Surowiecka, Tomasz Korzeniowski, Joanna Piszczek, Patrycja Korulczyk, Lukasz A. Drozd, Aldona Stachura, Kamil Torres, Andrzej Krajewski,
Lyell's syndrome, or toxic epidermal necrolysis (TEN) is a rare but life-threatening condition. It manifests with blistering of skin and mucous due to subepidermal bullae and keratinocyte necrosis. In most cases, it is an immune response to drugs or their metabolites. The mortality in TEN is high despite optimal infection and wound control. There are no unequivocal treatment guidelines in TEN. Immunosuppressive treatment may increase the wound infection risk and mortality. The aim of the study was ...
Tópico(s): Contact Dermatitis and Allergies
2022 - Oxford University Press | Journal of Burn Care & Research
Bartosz Puła, Monika Długosz‐Danecka, Aleksander Salomon‐Perzyński, Agnieszka Szymczyk, Edyta Subocz, Bożena Katarzyna Budziszewska, Justyna Rybka, Lidia Gil, Anna Waszczuk‐Gajda, Elżbieta Iskierka‐Jażdżewska, Jan Maciej Zaucha, Michał Osowiecki, Weronika Piszczek, Paweł Steckiewicz, Łukasz Szukalski, Marek Hus, Ewa Lech‐Marańda, Wojciech Jurczak, Krzysztof Jamroziak,
High-dose methylprednisolone (HDMP) with or without anti-CD20 antibody treatment in the pre B-cell receptor inhibitor (BCRi) era was used as potential salvage therapy for relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (r/r CLL/SLL) patients bearing the 17p deletion. Outcomes were compared in retrospect between r/r patients treated with HDMP (n = 20), ibrutinib (n = 39) and idelalisib with rituximab (n = 14). Higher overall response rates were found in those patients undergoing BCRi ...
Tópico(s): Advanced Breast Cancer Therapies
2020 - Elsevier BV | Advances in Medical Sciences
Marek Piszczek, Lukasz Szerszen, M. Szustakowski,
Ultrasounds have been used widely in medicine and devices which using acoustic waves have been giving more and more information in medicine. We propose the solution that based on phase analysis of acoustic wave packet in medicine diagnosis of soft tissue tumor. The aim of these investigations has been a construction of such a device and algorithm that would enable to find new diagnostic applications. Experimental results of 2D visualization of phase relations between acoustics fields are presented. ...
Tópico(s): Ultrasound Imaging and Elastography
2005 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Bartosz Puła, Katarzyna Pruszczyk, Ewa Pietrusza, Marta Morawska, Weronika Piszczek, Elżbieta Kalicińska, Agnieszka Szeremet, Jagoda Tryc-Szponder, Ewa Wąsik‐Szczepanek, Joanna Drozd‐Sokołowska, Helena Krzemień, Aleksandra Rejus, Małgorzata Gajewska, Kamil Wiśniewski, Maciej Wysocki, Alan Majeranowski, Ewa Paszkiewicz‐Kozik, Paweł Steckiewicz, Łukasz Szukalski, Łukasz Bołkuń, Monika Długosz‐Danecka, Krzysztof Giannopoulos, Krzysztof Jamroziak, Ewa Lech‐Marańda, Iwona Hus,
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has become the cause of a worldwide pandemic, and its clinical infection course in patients with hematological malignancies may be severe.We performed a retrospective study on 188 chronic lymphocytic leukemia patients (CLL) with COVID-19 infection.At the time of infection 51 patients (27.1%) were treated with Bruton tyrosine kinase inhibitor (BTKi), 46 (24.5%) with anti-CD20 antibodies while 37 patients (19.7%) received venetoclax. In total, ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Łukasz Piszczek, Joanna Kaczanowska, Wulf Haubensak,
Retracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies ...
Tópico(s): Morphological variations and asymmetry
2023 - De Gruyter | Biological Chemistry
Łukasz Piszczek, Simone Memoli, Angelo Raggioli, José Viosca, Jeanette Rientjes, Philip Hublitz, Weronika Czaban, Anna Wyrzykowska, Cornelius T. Gross,
Abstract Genetic factors play a significant role in risk for mood and anxiety disorders. Polymorphisms in genes that regulate the brain monoamine systems, such as catabolic enzymes and transporters, are attractive candidates for being risk factors for emotional disorders given the weight of evidence implicating monoamines involvement in these conditions. Several common genetic variants have been identified in the human serotonin transporter (5-HTT) gene, including a repetitive sequence located in ...
Tópico(s): Neuroendocrine regulation and behavior
2019 - Springer Science+Business Media | Mammalian Genome
Radosław Piszczek, Wojciech Krajewski, Marco Moschini, Anna Kołodziej, Łukasz Nowak, Adrian Poterek, Romuald Zdrojowy,
The majority of patients with bladder cancer are diagnosed in non-muscle invasive stage. Most of them will experience recurrence or progression to more aggressive disease during follow-up. That raises the need for improvements with regard to risk assessment. Current risk stratification, based only on clinicopathologic features, does not fully reflect biological heterogeneity of the cancer and its role in prognosis. Many studies addressed the topic of variant histology and its influence on treatment ...
Tópico(s): Urinary and Genital Oncology Studies
2020 - AME Publishing Company | Translational Cancer Research
Krzysztof Chmielowiec, Łukasz Topolski, Mateusz Dutka, Aleks Piszczek, Zbigniew Hanzelka, Tomasz Rodziewicz,
The paper presents the results of an experimental study, which was conducted in 2021 and briefly presented at the conference CIGRE Paris Session 2022, as a part of a joint initiative for comparative studies of PV inverters, of AGH University of Science and Technology and Tauron Dystrybucja (Polish DSO). The study was performed on a representative sample of 29 brand new PV inverters, widely available for sale in the EU, from over 20 various manufacturers from and outside the EU. For the purposes of ...
Tópico(s): Islanding Detection in Power Systems
2024 - Multidisciplinary Digital Publishing Institute | Inventions
Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen‐Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Francesco Cianflone, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Álvarez‐Maestro, A. Rodríguez-Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Ekaterina Laukhtina, Karl H. Tully, Anna Kołodziej, Joanna Krajewska, Radosław Piszczek, Évanguelos Xylinas, Romuald Zdrojowy,
Abstract Purpose This study was carried out to assess whether a prolonged time between primary transurethral resection of non-muscle-invasive bladder cancer (TURB) and implementation of bacillus Calmette–Guerin (BCG) immunotherapy (time to BCG; TTBCG) is associated with adverse oncological survival in patients with T1 high-grade (HG) non-muscle-invasive bladder cancer (NMIBC). Materials and methods Data on 429 patients from 13 tertiary care centers with primary T1HG NMIBC treated with reTURB and maintenance ...
Tópico(s): Urinary Tract Infections Management
2020 - Springer Science+Business Media | World Journal of Urology
Marcin Piszczek, Katarzyna Izworska, Paweł Kapusta, Przemysław Kurek, Łukasz Piechnik, Barbara Seget, Grażyna Szarek‐Łukaszewska, Tomasz Zielonka, Jan Holeksa,
Tópico(s): Botany and Plant Ecology Studies
2020 - | Fragmenta Floristica et Geobotanica Polonica
Radosław Piszczek, Wojciech Krajewski, José Daniel Subiela, Francesco Del Giudice, Łukasz Nowak, Joanna Chorbińska, Marco Moschini, A. Masson-Lecomte, S. Bebane, Alessia Cimadamore, Élisabeth Grobet-Jeandin, Morgan Rouprêt, David D’Andrea, Riccardo Mastroianni, Beatriz Gutierrez Hidalgo, Juan Gómez Rivas, Keiichiro Mori, Francesco Soria, Ekaterina Laukhtina, Andrea Mari, Simone Albisinni, Andrea Gallioli, Laura S. Mertens, Renate Pichler, Gautier Marcq, Jan Łaszkiewicz, Agnieszka Hałoń, Diego M. Carrión, Murat Akand, Benjamin Pradère, Shahrokh F. Shariat, Juan Palou, Marko Babjuk, Javier Burgos Revilla, Bartosz Małkiewicz, Tomasz Szydełko,
BACKGROUND: The existence and prognosis of T1LG (T1 low-grade) bladder cancer is controversial. Also, because of data paucity, it remains unclear what is the clinical history of bacillus Calmette-Guérin (BCG) treated T1LG tumors and if it differs from other NMIBC (non-muscle-invasive bladder cancer) representatives. The aim of this study was to analyse recurrence-free survival (RFS) and progression-free survival (PFS) in patients with T1LG bladder cancers treated with BCG immunotherapy.METHODS: A multi- ...
Tópico(s): Infectious Disease Case Reports and Treatments
2023 - | Minerva Urology and Nephrology
Łukasz Nowak, Wojciech Krajewski, Marco Moschini, Joanna Chorbińska, Sławomir Poletajew, Andrzej Tukiendorf, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Rossella Orlando, Ettore Di Trapani, Mario Álvarez‐Maestro, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Radosław Piszczek, Évanguelos Xylinas, Romuald Zdrojowy,
: To determine whether there are significant differences in oncological outcomes between three different bacillus Calmette-Guérin (BCG) strains used for adjuvant intravesical immunotherapy in patients with high-grade T1 (T1HG) non-muscle-invasive bladder cancer (NMIBC).: Data of 590 patients with a diagnosis of primary T1HG NMIBC were retrospectively reviewed. The study included 138 (23.4%) patients who were treated with the Moreau, 272 (46.1%) with the TICE, and 180 (30.5%) with the RIVM strains. All patients ...
Tópico(s): Urinary Tract Infections Management
2021 - Elsevier BV | Arab Journal of Urology
Wojciech Krajewski, Marco Moschini, Łukasz Nowak, Sławomir Poletajew, Andrzej Tukiendorf, Luca Afferi, Jeremy Yuen‐Chun Teoh, Tim Muilwijk, Steven Joniau, Alessandro Tafuri, Alessandro Antonelli, Alessandra Gozzo, Andrea Mari, Ettore Di Trapani, Kees Hendricksen, Mario Álvarez‐Maestro, Andrea Rodriguez Serrano, Giuseppe Simone, Stefania Zamboni, Claudio Simeone, Maria Cristina Marconi, Riccardo Mastroianni, Guillaume Ploussard, Paweł Rajwa, Ekaterina Laukhtina, Aleksandra Zdrojowy-Wełna, Anna Kołodziej, Andrzej Paradysz, Karl H. Tully, Joanna Krajewska, Radosław Piszczek, Évanguelos Xylinas, Romuald Zdrojowy,
The European Association of Urology guidelines recommend restaging transurethral resection of bladder tumours (reTURB) 2-6 weeks after primary TURB. However, in clinical practice some patients undergo a second TURB procedure after Bacillus Calmette-Guérin immunotherapy (BCG)induction. To date, there are no studies comparing post-BCG reTURB with the classic pre-BCG approach. The aim of this study was to assess whether the performance of reTURB after BCG induction in T1HG bladder cancer is related to ...
Tópico(s): Urological Disorders and Treatments
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine