Yihu Feng, Tayyab Naseer, G. Mustafa, S. K. Maurya,
... mathcal {T}^{\zeta \gamma })$$ f ( R , T , R ζ γ T ζ γ ) gravity theory. The study adopts a static ... mathcal {T}^{\zeta \gamma }$$ f ( R , T , R ζ γ T ζ γ ) = R + η R ζ γ T ζ γ , and (ii) $$f(\mathcal {R},\mathcal {T},\ ... mathcal {T}^{\zeta \gamma })$$ f ( R , T , R ζ γ T ζ γ ) = R ( 1 + η R ζ γ T ζ γ ) , where $$\eta $$ η is a constant parameter. ...
Tópico(s): Advanced Differential Geometry Research
2025 - Springer Science+Business Media | The European Physical Journal C
Montgomery Gray, Paige E. Bowling, John M. Herbert,
... heights, using a variety of double- and triple-ζ basis sets. A main conclusion of that study ... advice, (2) as is the suggestion that triple-ζ basis sets are needed for DFT thermochemistry. (3) ... should employ basis sets of at least triple-ζ quality, (51−54) although a composite model wherein triple-ζ single-point energies are evaluated at double-ζ geometries is often an acceptable compromise. (5,39,55) Triple-ζ basis sets are also required to obtain converged ... is employed. (20,58) In all cases, quadruple-ζ basis sets should be used to establish the ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2024 - American Chemical Society | The Journal of Physical Chemistry A
Chiara Animali, Vincent Vennin,
... of large fluctuations is of the form P (ζ R 1 , ζ R 2 ) = F ( R 1 , R 2 , r ) P (ζ R 1 ) P ( ζ R 2 ), where ζ R 1 and ζ R 2 denote the curvature perturbation coarse-grained ... tail, the reduced correlation function, defined as P (ζ R 1 > ζ c , ζ R 2 > ζ c )/[ P (ζ R 1 > ζ c ) P ( ...
Tópico(s): Dark Matter and Cosmic Phenomena
2024 - Institute of Physics | Journal of Cosmology and Astroparticle Physics
V. Nagarajan, R. Chandiramouli,
... the adsorption properties of two drug molecules on ζ – phosphorene nanotube (ζ-PNT) present in the aqueous environment. Firstly, the structural stableness of ζ-PNT is ensured with the support of formation ... 005 eV/atom). Additionally, the electronic properties of ζ-PNT are studied by band structure and projected ... states (PDOS) spectrum. The energy band gap of ζ-PNT is found to be 1.298 eV, ... the semiconductor nature of the base substrate. The ζ-PNT is used as the base substrate to ... in the contaminated water. The adsorption energy of ζ-PNT owing to molecular adsorption of drug molecules ...
Tópico(s): 2D Materials and Applications
2022 - Taylor & Francis | Molecular Simulation
Feiyan Chen, Lin Chen, Weifeng Liang, Zhengguang Zhang, Jiao Li, Wan Zheng, Zhu Zhu, Jiapeng Zhu, Yunan Zhao,
... affinity chromatography and identified the 14-3-3 ζ protein as a potential target of ginsenosides in ... highest direct interaction to the 14-3-3 ζ protein. Subsequently, BLI kinetics analysis and isothermal titration ... PPD specifically bound to the 14-3-3 ζ protein. The cocrystal structure of the 14-3-3 ζ protein-PPD complex showed that the main interactions ... R127, and Y128 of the 14-3-3 ζ protein and a portion of PPD. Moreover, mutating ... affinity between PPD and the 14-3-3 ζ protein.Our results indicate the 14-3-3 ...
Tópico(s): Pharmacological Effects of Natural Compounds
2020 - Elsevier BV | Journal of Ginseng Research
María Moreno‐del Álamo, Chiara Marchisone, Juan C. Alonso,
... adaptation remains a matter of debate. The inactive ζ-ε2-ζ TA complex is composed of one labile ε2 antitoxin dimer flanked by two stable ζ toxin monomers. Free toxin ζ reduces the ATP and GTP levels, increases the ( ... action. Here, employing a genetic orthogonal control of ζ and ε levels, the fate of bacteriophage SPP1 infection was analyzed. Toxin ζ induces an active slow-growth state that halts ... antitoxin expression rather than promoting abortive infection. Toxin ζ-induced and toxin-facilitated ampicillin (Amp) dormants have ...
Tópico(s): Vibrio bacteria research studies
2020 - Multidisciplinary Digital Publishing Institute | Toxins
Tracess Smalley, Rainer Metcalf, Rekha Patel, Sayemul Islam, Raja Reddy Bommareddy, Mildred Acevedo‐Duncan,
... atypical PKC (aPKC) isoforms, PKC-ι and PKC-ζ, have been suggested to participate in the increased ... indicated that novel aPKC inhibitors ICA-1S and ζ-Stat decreased the migratory behaviors of colorectal cancer ... were selective for PKC-ι/λ and PKC-ζ, respectively. The aims of this investigation were to further determine the binding mechanisms of ζ-Stat, expand on the tissue range of these compounds, investigate the therapeutic potential of ζ-Stat in CCOC, and to illustrate the disruption of invasion via the PKC-ζ signaling cascade. The methods utilized were molecular docking ...
Tópico(s): Melanoma and MAPK Pathways
2020 - Frontiers Media | Frontiers in Oncology
María I. Cano-Linares, Aurora Yáñez‐Vilches, Néstor García‐Rodríguez, Marta Barrientos‐Moreno, Román González‐Prieto, Pedro A. San-Segundo, Helle D. Ulrich, Félix Prado,
... Rad18-mediated PCNA ubiquitylation and polymerases Rev1/Pol ζ) to repair MMS and UV light-induced ssDNA ... cerevisiae, there are three TLS polymerases: Rev1, Pol ζ (formed by the catalytic subunit Rev3 and the ... and their activity (at least for Rev1/ Pol ζ) is most dominant in G2/M (Prakash, 1981; ... of the highly mutagenic polymerases, Rev1 or Pol ζ, in rev1∆ or rev3∆ cells reduced the efficiency ... the lack of a regulatory subunit of Pol ζ in pol32∆ cells caused a more severe defect (~ ... consistent with a cooperation between Rev1 and Pol ζ (Haracska et al, 2001). In fact, the double ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2020 - Springer Nature | EMBO Reports
Rachel Bezalel‐Buch, Young Cheun, Upasana Roy, Orlando D. Schärer, Peter Burgers,
DNA polymerase ζ (Pol ζ) and Rev1 are essential for the repair of DNA interstrand crosslink (ICL) damage. We have used yeast DNA polymerases η, ζ and Rev1 to study translesion synthesis (TLS) past ... linker between the crosslinked bases. The Rev1-Pol ζ complex was most efficient in complete bypass synthesis, by 2-3 fold, compared to Pol ζ alone or Pol η. Rev1 protein, but not ... across the ICL-G by Pol η, Pol ζ, and Rev1-Pol ζ. Rev1-Pol ζ, and particularly Pol ζ alone showed a tendency to stall before the ...
Tópico(s): DNA and Nucleic Acid Chemistry
2020 - Oxford University Press | Nucleic Acids Research
Renáta Zákányiné Mészáros, A. Jobbik, Gyula Varga, Sándor Bárány,
... dodecyl sulphate and cetyltrimethylammonium bromide on the zeta-(ζ) potential and electrical conductivity of suspensions containing Na- ... external electric field can be summarized as follows: ζ-potential of particles show low sensitivity to pH and they display relatively high ζ values (from −35 mV to −52 mV) both in water and in supporting electrolytes solution; the ζ(C) dependencies for RbCl and CsCl are characterized by a constant ζ-potential at C 10−5–10−3 mol/ ... 2 mol/L; the relative position of the ζ(C) curves corresponds to the regular Hofmeister series; ...
Tópico(s): Soil and Unsaturated Flow
2019 - Elsevier BV | Applied Clay Science
Ryuta Muromoto, Keisuke Tawa, Yui Ohgakiuchi, Ami Sato, Yuka Saino, Koki Hirashima, Hiroya Minoguchi, Yuichi Kitai, Jun‐ichi Kashiwakura, Kazuya Shimoda, Kenji Oritani, Tadashi Matsuda,
... such as psoriasis. The IκB family protein IκB-ζ mediates IL-17–induced responses. However, the mechanism controlling IκB-ζ expression in IL-17–stimulated cells remains elusive. ... kinase TYK2 positively regulates IL-17–induced IκB-ζ expression. TYK2-deficient mice showed reduced inflammation and concomitant reduction of IκB-ζ mRNA compared with wild-type mice in imiquimod-induced skin inflammation. The analysis of the IκB-ζ promoter activity using human cell lines (HaCaT and ... but not IL-17, is required for IκB-ζ promoter activity. In contrast, IL-17–induced signaling, ...
Tópico(s): Dermatology and Skin Diseases
2019 - | ImmunoHorizons
Sara K. Martin, Richard D. Wood,
... we survey the diverse functions of DNA polymerase ζ (pol ζ) in eukaryotes. In mammalian cells, REV3L (3130 residues) ... The orthologous subunit in yeast is Rev3p. Pol ζ also includes REV7 subunits (encoded by Rev7 in ... with the replicative DNA polymerase, pol δ. Pol ζ is used in response to circumstances that stall ... recent evidence that uncovers various roles of pol ζ that extend beyond translesion synthesis. For instance, pol ζ is also employed when the replisome operates sub- ... or at difficult-to-replicate DNA sequences. Pol ζ also participates in repair by microhomology mediated break- ...
Tópico(s): Cancer-related Molecular Pathways
2019 - Oxford University Press | Nucleic Acids Research
Jingyan Li, Junying Huang, Jing Lü, Zhen Guo, Zhuoming Li, Hui Gao, Panxia Wang, Wenwei Luo, Sidong Cai, Yuehuai Hu, Kaiteng Guo, Luping Wang, Zhenzhen Li, Minghui Wang, Xiaolei Zhang, Peiqing Liu,
Background and Purpose Activation of PKC‐ζ is closely linked to the pathogenesis of cardiac hypertrophy. PKC‐ζ can be activated by certain lipid metabolites such as phosphatidylinositol (3, ... defined. Here, the role of the sirtuin1‐PKC‐ζ signalling axis and the underlying molecular mechanisms were ... of hypertrophic biomarkers. Interaction between sirtuin1 and PKC‐ζ was investigated by co‐immunoprecipitation and confocal immunofluorescence ... isoprenaline in vivo . Key Results Overexpression of PKC‐ζ led to cardiac hypertrophy and increased activity of ...
Tópico(s): Signaling Pathways in Disease
2018 - Wiley | British Journal of Pharmacology
Yumi Matsumiya, Hiroshi Watanabe, Yuichi Masubuchi, Qian Huang, Ole Hassager,
... effect due to reduction of the segment friction ζ occurring for the highly stretched and oriented chain. Thus, the ζ reduction, speculatively discussed for entangled melts so far, ... nK values, which suggested that the magnitude of ζ reduction depends on the chemical structure of the ... averaged FENE spring strength) was modified for the ζ reduction in an empirical way with an assumption that ζ at a given time is fully determined by ... the steady state ηE data excellently, and the ζ reduction utilized in the modification was weaker for ...
Tópico(s): Polymer Nanocomposites and Properties
2018 - American Chemical Society | Macromolecules
Zhongzhen Yi, Brooke Prinzing, Felicia Cao, Stephen Gottschalk, Giedre Krenciute,
... We demonstrate here that T cells expressing CD28.ζ and 41BB.ζ CARs with short spacers had similar effector function, ... addition, incorporating the 41BB signaling domain into CD28.ζ CARs did not improve CAR T cell function. ... we could not determine functional differences between CD28.ζ, 41BB.ζ, and CD28.41BB.ζ CAR T cells, we selected CD28.ζ CAR T cells for further clinical development based ... We demonstrate here that T cells expressing CD28.ζ and 41BB.ζ CARs with short spacers had similar effector function, ...
Tópico(s): Nanowire Synthesis and Applications
2018 - Cell Press | Molecular Therapy — Methods & Clinical Development
Tracess Smalley, Sayemul Islam, Christopher Apostolatos, Andr� Apostolatos, Mildred Acevedo‐Duncan,
... has demonstrated that the atypical protein kinase C‑ζ (PKC‑ζ) is a component of numerous dysregulated pathways in ... cycle upregulation. The present study investigated the PKC‑ζ protein in breast tissue to evaluate its potential ... invasion, and demonstrated that an overexpression of PKC‑ζ protein can be indicative of carcinogenesis. The present study analyzed the expression of PKC‑ζ in individuals with no tumor complications and malignant ... breast cancer cells following the knockdown of PKC‑ζ with a Transwell invasion assay and an immunofluorescent ...
Tópico(s): HER2/EGFR in Cancer Research
2018 - Spandidos Publishing | Oncology Letters
Subhash Ayirala, S. H. Saleh, Sultan Enezi, Ali Al‐Yousef,
... recovery in smartwater flooding. Unfortunately, these studies determined ζ-potentials using the technique of electrophoretic-mobility (EPM) ... dependent on streaming-potential (SP) measurements to determine ζ-potentials in intact carbonate reservoir core samples saturated ... sulfate ions in carbonate reservoir cores to alter ζ-potentials toward more negative, and the reactivity of ... calcium showed the highest reactivity to shift the ζ-potentials to slightly positive. Both magnesium and sodium ions showed almost similar behavior to change the ζ-potentials toward less negative. In addition, only minor ...
Tópico(s): Hydrocarbon exploration and reservoir analysis
2018 - | SPE Reservoir Evaluation & Engineering
Yufu Tang, Yibing Zhang, Chunhui Wang, Zhongyi Sun, Longfei Li, Jiahong Dong, Wenping Zhou,
Abstract 14‐3‐3 ζ , a phosphopeptide‐binding molecule, is reportedly overexpressed in the cancerous tissues of patients with hepatocellular carcinoma ( HCC ). Hepatitis B virus ( ... to investigate whether and how 14‐3‐3 ζ interacts with HB x. The coimmunoprecipitation (Co‐ IP ) results showed that 14‐3‐3 ζ bond to HB x in HBV ‐infected Hep3B ... motif in HB x for 14‐3‐3 ζ docking. This 14‐3‐3 ζ ‐ HB x interaction was partly impaired when Akt ... blocked by LY 294002. Furthermore, 14‐3‐3 ζ silencing augmented HB x ubiquitination and decreased its ...
Tópico(s): Peptidase Inhibition and Analysis
2018 - Wiley | Cancer Medicine
Sigal Fishman, Mark Lewis, L. Khai Siew, Evy De Leenheer, Dimitri Kakabadse, Joanne Davies, Doron Ziv, Alon Margalit, Nathan Karin, Gideon Gross, F. Susan Wong,
... MHC-I molecules when fused with the CD3-ζ chain. Linking the H-2Kd-binding insulin B ... 23) to the N terminus of β2m/CD3-ζ, redirected polyclonal CD8 T cells against pathogenic CD8 ... describe mRNA electroporation for delivering peptide/β2m/CD3-ζ genes to a reporter T cell line and ... mouse CD8 T cells. The peptide/β2m/CD3-ζ products paired with endogenous MHC-I chains and ... cell line transfected with InsB15–23/β2m/CD3-ζ mRNA was activated by an InsB15–23-H- ... T cells expressing either InsB15–23/β2m/CD3-ζ or islet-specific glucose-6-phosphatase catalytic subunit- ...
Tópico(s): CAR-T cell therapy research
2017 - Elsevier BV | Molecular Therapy
I. Flores, Natalia Chiquete‐Félix, Ícela Palma-Lara, Salvador Uribe‐Carvajal, Marı́a de Lourdes Juárez-Mosqueda,
The migration pattern of sperm-specific phospholipase C-ζ (PLC-ζ) was followed and the role of this migration ... cytoskeleton dynamics was determined. We investigated whether PLC-ζ exits sperm, opening the possibility that PLC-ζ is the 'spermatozoidal activator factor' (SOAF). As capacitation ... proteins to regulate their location and activity. PLC-ζ participation at the start of fertilization was established. In non-capacitated spermatozoa, PLC-ζ is in the perinuclear theca (PT) and in ... determine whether bovine sperm actin interacts with PLC-ζ to direct its relocation as it progresses from ...
Tópico(s): Ovarian function and disorders
2017 - Cambridge University Press | Zygote
Ajamaluddin Malik, Shurog Albogami, Abdulrahman M. Alsenaidy, Abeer Al‐Dbass, Mohammad A. Alsenaidy, Shams Tabrez Khan,
... animal lenses contain novel proteins in bulk quantities. ζ-crystallin occurred in three ecologically divergent species, but ... physiological role not known. The truncated variant of ζ-crystallin causes hereditary cataract. Guinea pig ζ-crystallin is temperature-sensitive and rapidly aggregates at ... have optimized expression and purification of recombinant camel ζ-crystallin. We have studied thermodynamic and spectroscopic properties ... techniques. Dynamic multimode spectroscopy results showed that camel ζ-crystallin unfolds via single transition with Tm value ...
Tópico(s): Advanced Glycation End Products research
2017 - Elsevier BV | International Journal of Biological Macromolecules
Ewa Szwajczak, Iwona J. Fijałkowska, Catherine Suski,
... and subunit composition of DNA polymerase zeta (Pol ζ). Pol ζ is predominantly involved in induced mutagenesis as well ... replicative DNA polymerases. Two active forms of Pol ζ, heterodimeric (Pol ζ2) and heterotetrameric (Pol ζ4) ones, ... and spontaneous mutagenesis and diverse interactions within Pol ζ holoenzyme, combined with Pol ζ binding to the TLS polymerase Rev1p, we discuss the subunit composition of Pol ζ in various cellular physiological conditions. Available data show that it is the heterotetrameric form of Pol ζ that is involved both during spontaneous and induced ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2017 - Springer Science+Business Media | Current Genetics
Elizabeth Thompson, Steven A. Rutledge, Brenda Dolan, Merhala Thurai, V. Chandrasekar,
... K dp ), R ( A h ), R ( K dp , ζ dr ), R ( z , ζ dr ), and R ( A h , ζ dr ), which use linear versions of Z dr and Z h , namely ζ dr and z . Except for R ( K dp ), ... The best-performing estimator was R ( K dp , ζ dr ), followed by R ( A h , ζ dr ) and R ( z , ζ dr ). The R error was further reduced in ... blended algorithm choosing between R ( z ), R ( z , ζ dr ), R ( K dp ), and R ( K dp , ζ dr ) depending on Z dr > 0.25 dB ... rain volume. As wavelength decreased, R ( K dp , ζ dr ) was used more often, R ( z , ζ ...
Tópico(s): Soil Moisture and Remote Sensing
2017 - American Meteorological Society | Journal of Applied Meteorology and Climatology
C. A. Herron, Christoph Federrath, B. M. Gaensler, Geraint F. Lewis, N. M. McClure‐Griffiths, Blakesley Burkhart,
... The turbulent driving is characterised by the parameter $ζ$, with $ζ=0$ for compressive, curl-free driving (e.g. accretion or supernova explosions), and $ζ=1$ for solenoidal, divergence-free driving (e.g. ... Here we develop a new method to measure $ζ$ from observations of synchrotron emission from molecular clouds. ... driving was controlled to produce different values of $ζ$. We find that the mean and standard deviation ... the log-normalised synchrotron intensity are sensitive to $ζ$, for values of $ζ$ between $0$ (curl-free ...
Tópico(s): Atmospheric Ozone and Climate
2016 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Stefan Dultz, Harald Behrens, Gundula Helsch, Joachim Deubener,
... surface chemistry is important. Here the zeta potential (ζ) as a characteristic parameter of the magnitude of ... 0, 2.5, and 5.0 mmol/L. ζ was traced in time sequences up to 12, ... released after 4000 h. A marked decrease of ζ in deionized water within the first 3 h ... addition of anions resulted in stronger negative initial ζ values in comparison with the experiment in deionized ... obvious for F−, C2O42 − and HPO42 −. The initial ζ was increased upon the addition of divalent cations ... time a striking shift from negative to positive ζ was obtained, most markedly for Ca2 + and Zn2 +. ...
Tópico(s): Mineralogy and Gemology Studies
2016 - Elsevier BV | Chemical Geology
José J. García‐Trejo, Mariel Zarco‐Zavala, Francisco Mendoza-Hoffmann, Eduardo Hernández-Luna, Raquel Ortega, Guillermo Mendoza‐Hernández,
The ζ subunit is a novel inhibitor of the F1FO-ATPase of Paracoccus denitrificans and related α-proteobacteria. It ... and mitochondrial (IF1) inhibitors. The N terminus of ζ blocks rotation of the γ subunit of the ... and protein docking. The F1-ATPase and F1-ζ models of P. denitrificans were supported by cross- ... and functional data. The final models show that ζ enters into F1-ATPase at the open catalytic ... partial γ rotations lock the N terminus of ζ in an “inhibition-general core region,” blocking further ...
Tópico(s): RNA and protein synthesis mechanisms
2015 - Elsevier BV | Journal of Biological Chemistry
Asif A. Dar, Trupti Pradhan, Dakshayni P. Kulkarni, Sagar Shah, Kanury V. S. Rao, Devendra Chaukar, Anil D’Cruz, Shubhada V. Chiplunkar,
Summary Decreased expression of CD 3‐ ζ chain, an adaptor protein associated with T‐cell signalling, is well documented in patients with oral cancer, but the mechanistic justifications are ... have shown that decreased expression of CD 3‐ ζ chain was associated with decreased responsiveness of T ... promote immune suppression by down‐regulating CD 3‐ ζ chain expression. 2′5′‐Oligoadenylate synthetase 2 ( OAS ... results established a causative link between CD 3‐ ζ chain down‐regulation and OAS 2 stimulation. The ...
Tópico(s): Immune Cell Function and Interaction
2015 - Wiley | Immunology
Jeongsoo Han, Minjee Kwon, Myeounghoon Cha, Motomasa Tanioka, Seong‐Karp Hong, Sun Joon Bai, Bae Hwan Lee,
... chronic pain. Continuous active kinase, protein kinase M ζ (PKM ζ ), has been known to maintain the long-term ... was conducted to determine the role of PKM ζ in the IC, which may be involved in ... neuronal plasticity, were performed after nerve injury. After ζ -pseudosubstrate inhibitory peptide (ZIP, a selective inhibitor of PKM ζ ) injection, mechanical allodynia test and immunoblotting of PKM ζ , phospho-PKM ζ (p-PKM ζ ), and GluR1 and GluR2 were observed. IHC demonstrated ... the levels of GluR1, GluR2, and p-PKM ζ were decreased after ZIP microinjection. These results suggest ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2015 - Hindawi Publishing Corporation | Neural Plasticity
Zhen Li, Yunhui Liu, Xiao‐bai Liu, Yixue Xue, Ping Wang, Libo Liu,
... PKC)-α/β signaling pathway and that PKC-ζ is involved in this process via other mechanisms. ... detected the exact signaling mechanisms by which PKC-ζ activation affects EMAP-II-induced BTB hyperpermeability. Our ... cells (RBMECs). There was an interaction between PKC-ζ and PP2A in RBMECs. In addition, EMAP-II ... activity of PP2A in RBMECs. Inhibition of PKC-ζ with PKC-ζ pseudosubstrate inhibitor (PKC-ζ-PI) completely blocked EMAP-II-induced PP2A activation. ... had no effect on EMAP-II-induced PKC-ζ activation. Like PKC-ζ-PI, OA partially prevented ...
Tópico(s): Cell Adhesion Molecules Research
2015 - Elsevier BV | Experimental Cell Research
Takashi Maruyama, Shuhei Kobayashi, Kouetsu Ogasawara, Akihiko Yoshimura, WanJun Chen, Tatsushi Muta,
Abstract The transcriptional regulator IκB-ζ is important for the control of apoptosis in keratinocytes. Thus, IκB-ζ-deficient mice develop autoimmune diseases, such as Sjögren’s ... s syndrome. To study the role of IκB-ζ in T cells, we generated T cell-specific, IκB-ζ-deficient mice. We observed increased numbers of peripheral ... 3-week-old mice. We found that IκB-ζ can be up-regulated by TGF-β1 in ... expression. In addition, we generated Treg-specific, IκB-ζ deficient mice and found that IκB-ζ is dispensable for the plasticity and stability of ...
Tópico(s): Immune Cell Function and Interaction
2015 - Oxford University Press | Journal of Leukocyte Biology