... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039 India Public Department
0000 - Gale Group | NCCO EuropeAfrica
Lifei Wang, Yunfeng Hu, Yanjuan Zhang, Songmei Wang, Zhihui Cui, Yi Bao, Wei Jiang, Bin Hong,
Abstract Background C-1027, produced by Streptomyces globisporus C-1027, is one of the most potent antitumoral agents. The biosynthetic gene cluster of C-1027, previously cloned and sequenced, contains at least three ... to investigate the role of sgcR3 in C-1027 biosynthesis. Results Overexpression of sgcR3 in S. globisporus C-1027 resulted in a 30–40% increase in C-1027 production. Consistent with this, disruption of sgcR3 abolished C-1027 production. Complementation of the sgcR3 -disrupted strain R3KO ...
Tópico(s): Marine Sponges and Natural Products
2009 - BioMed Central | BMC Microbiology
... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039
0000 - Gale Group | NCCO EuropeAfrica
Shuangjun Lin, Geoff P. Horsman, Yihua Chen, Wenli Li, Ben Shen,
C-1027 is a chromoprotein antitumor antibiotic consisting of an apoprotein and the C-1027 chromophore. The C-1027 chromophore possesses four distinct structural moieties—an enediyne ... of SgcF, an epoxide hydrolase from the C-1027 biosynthetic gene cluster that catalyzes regio- and stereospecific ... to form a vicinal diol. Abolishment of C-1027 production in the ΔsgcF mutant strain Streptomyces globisporus ... that sgcF plays an indispensable role in C-1027 biosynthesis. SgcF efficiently hydrolyzes (S)-styrene oxide, displaying ...
Tópico(s): Microbial Natural Products and Biosynthesis
2009 - American Chemical Society | Journal of the American Chemical Society
Alexander Street
... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039
0000 - Gale Group | NCCO EuropeAfrica
Catherine Terraz, Gaëlle Brideau, Pierre Ronco, Jérôme Rossert,
... Natl. Acad. Sci. U. S. A. 1996; 93: 1027-1031Crossref PubMed Scopus (90) Google Scholar). Introduction of ... Natl. Acad. Sci. U. S. A. 1996; 93: 1027-1031Crossref PubMed Scopus (90) Google Scholar). In contrast, ... Natl. Acad. Sci. U. S. A. 1996; 93: 1027-1031Crossref PubMed Scopus (90) Google Scholar). Gel shift ... Natl. Acad. Sci. U. S. A. 1996; 93: 1027-1031Crossref PubMed Scopus (90) Google Scholar). Moreover, generation ... Natl. Acad. Sci. U. S. A. 1996; 93: 1027-1031Crossref PubMed Scopus (90) Google Scholar).The existence ...
Tópico(s): Dupuytren's Contracture and Treatments
2002 - Elsevier BV | Journal of Biological Chemistry
... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039 Bengal Madras Bombay Public Department
0000 - Gale Group | NCCO EuropeAfrica
Jaroslaw Dziegielewski, Terry A. Beerman,
... have contrasted cell responses to IR and C-1027, a radiomimetic antibiotic that induces DNA strand breaks. ... classical hypersensitivity to IR but not to C-1027. Moreover, phosphorylation of p53 Ser-15 induced by C-1027 was independent of ATM, ATR, or DNA-PK ... have contrasted cell responses to IR and C-1027, a radiomimetic antibiotic that induces DNA strand breaks. ... classical hypersensitivity to IR but not to C-1027. Moreover, phosphorylation of p53 Ser-15 induced by C-1027 was independent of ATM, ATR, or DNA-PK ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2002 - Elsevier BV | Journal of Biological Chemistry
Alexander Street
... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039
0000 - Gale Group | NCCO EuropeAfrica
... Published Online:February 22, 2010https://doi.org/10.1027/1618-3169/a000001PDFView Full Text ToolsAdd to favoritesDownload ... strengths. Experimental Psychology, 56, 329–343, doi: 10.1027/1618-3169.56.5.329. First citation in ... projection? Experimental Psychology, 56, 198–205, doi: 10.1027/1618-3169.56.3.198. First citation in ... Journal of Psychology, 217, 15–26, doi: 10.1027/0044-3409.217.1.15. First citation in ... information. Experimental Psychology, 56, 84–91, doi: 10.1027/1618-3169.56.2.84. First citation in ...
Tópico(s): Cultural Differences and Values
2010 - Hogrefe Verlag | Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie)
... Forwarded for Transmission. IORE/4/827, pp. 1025-1027, 1037-1039
0000 - Gale Group | NCCO EuropeAfrica
Yusaku Akashi, Iwao Okamoto, Manabu Suzuki, Kenji Tamura, Tsutomu Iwasa, Shoji Hisada, Tomoya Satoh, Kazuhiko Nakagawa, Kisho Ono, M. Fukuoka,
TZT-1027 is a novel anticancer agent that inhibits microtubule polymerisation and manifests potent antitumour activity in preclinical models. We have examined the effect of TZT-1027 on cell cycle progression as well as the ... sensitive mutant of Cdc2, we found that TZT-1027 arrests cell cycle progression in mitosis, the phase ... radiation. A clonogenic assay indeed revealed that TZT-1027 increased the sensitivity of H460 cells to γ- ... dose enhancement factor of 1.2. Furthermore, TZT-1027 increased the radiosensitivity of H460 and A549 cells ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2007 - Springer Nature | British Journal of Cancer
... Solanki period in Gujarat. It was built in 1027 and although in ruinous condition it still reflects ...
0000 - Gale Group | NCCO Photography
Daniel R. Kennedy, Loretta S. Gawron, Jianhua Ju, Wen Liu, Ben Shen, Terry A. Beerman,
Abstract The radiomimetic enediyne C-1027 induces almost exclusively DNA double-strand breaks (DSB) and is extremely cytotoxic. Unique among radiomimetics, ataxia-telangiectasia mutated (ATM) is dispensable for cellular responses to C-1027-induced DNA damage. This study explores the biological activity of three recently bioengineered C-1027 analogues: 7″-desmethyl-C-1027 (desmethyl), 20′-deschloro-C-1027 (deschloro), and 22′-deshydroxy-C-1027 (deshydroxy). Each compound maintains the characteristic ability of ...
Tópico(s): Synthesis and Biological Evaluation
2007 - American Association for Cancer Research | Cancer Research
Project Muse
... Solanki period in Gujarat. It was built in 1027 and although in ruinous condition it still reflects ...
0000 - Gale Group | NCCO Photography
Junichi Watanabe, Tsugitaka Natsume, Motohiro Kobayashi,
We investigated the ability of TZT‐1027 (Soblidotin), a novel antimicrotubule agent, to induce antivascular effects, because most vascular targeting agents that selectively disrupt tumor vasculature also inhibit tubulin polymerization. Treatment with 10 −7 g/mL TZT‐1027 rapidly disrupted the microtubule cytoskeleton in human umbilical ... single intravenous administration of 2 mg/kg TZT‐1027 to mice bearing Colon26 tumors significantly reduced tumor ... administration, respectively. These results strongly suggest that TZT‐1027 possesses antivascular effects. TZT‐1027 induced apoptosis not ...
Tópico(s): Microbial Natural Products and Biosynthesis
2006 - Wiley | Cancer Science
SciELO
... Solanki period in Gujarat. It was built in 1027 and although in ruinous condition it still reflects ...
0000 - Gale Group | NCCO Photography
Steven G. Van Lanen, Shuangjun Lin, Pieter C. Dorrestein, Neil L. Kelleher, Ben Shen,
C-1027 is an enediyne antitumor antibiotic composed of a chromophore with four distinct chemical moieties, including an (S)- ... 4,5-dihydroxy-β-phenylalanine moiety of C-1027, presenting downstream enzymes with an (S)-β-tyrosyl- ... amino acid-specific adenylation enzyme characterized biochemically. C-1027 is an enediyne antitumor antibiotic composed of a ... 4,5-dihydroxy-β-phenylalanine moiety of C-1027, presenting downstream enzymes with an (S)-β-tyrosyl- ... amino acid-specific adenylation enzyme characterized biochemically. C-1027 is an enediyne antitumor antibiotic isolated from the ...
Tópico(s): Sesquiterpenes and Asteraceae Studies
2006 - Elsevier BV | Journal of Biological Chemistry
... Solanki period in Gujarat. It was built in 1027 and although in ruinous condition it still reflects ...
0000 - Gale Group | NCCO Photography
Markus Hausmann, Barbara Schober,
... this authorPublished OnlineFebruary 28, 2015https://doi.org/10.1027/2151-2604/a000096PDF ToolsAdd to favoritesDownload CitationsTrack Citations ... Zeitschrift für Psychologie, 220, 98–108. doi: 10.1027/2151-2604/a000101 First citation in articleLink, Google ... Zeitschrift für Psychologie, 220, 137–143. doi: 10.1027/2151-2604/a000105 First citation in articleLink, Google ... Zeitschrift für Psychologie, 220, 70–77. doi: 10.1027/2151-2604/a000098 First citation in articleLink, Google ... Zeitschrift für Psychologie, 220, 109–120. doi: 10.1027/2151-2604/a000102 First citation in articleLink, Google ...
Tópico(s): Early Childhood Education and Development
2012 - Johann Ambrosius Barth Verlag | Zeitschrift für Psychologie