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Artigo

Hideo Mogami, Hiroshi Shibata, Romi Nobusawa, Hideki Ohnota, Fumiyasu Satou, Jun‐ichi Miyazaki, Itaru Kojima,

We studied the mechanism of action of KAD-1229, a non-sulfonylurea compound shown to stimulate insulin ... In microsomal fraction of MIN 6 cells, KAD-1229 displaced binding of [3H]glibenclamide in a concentration- ... inside out configuration of patch-clamp technique, KAD-1229 attenuated the opening of ATP-sensitive K+ channels. The effect of KAD-1229 was detected at 10(-8) M, and 10(-5) M KAD-1229 almost completely blocked the activity of ATP-sensitive ... by a perforated mode of patch clamp, KAD-1229 induced depolarization of plasma membrane, which was followed ...

Tópico(s): Cardiac electrophysiology and arrhythmias

1994 - Elsevier BV | European Journal of Pharmacology Molecular Pharmacology

Livro

Springer Link

Primary Document -- Manuscript Acesso aberto

Herbert Schultz,

... Eyewitness Accounts. Schultz, Herbert. 1941. 2. 057-EA-1229. German. P.III.h. No.1030g. (Riga). 57. ...

1941 - Gale Group | ArchivesUnbound Holocaust Rare

Artigo Revisado por pares

Jae Min Cho, Hye Won Jang, Hwanju Cheon, Yeon Taek Jeong, Do‐Hoon Kim, Yu-Mi Lim, Song‐hyen Choi, E. F. Yang, Chang-Yell Shin, Moon Ho Son, Soon Hoe Kim, Heung-Jae Kim, Myung‐Shik Lee,

... novel dipeptidyl peptidase IV (DPP IV) inhibitor, DA-1229, on blood glucose profile and pancreatic β-cell ... of STZ 100mg/kg were treated with DA-1229 for 13 weeks. DA-1229 significantly reduced plasma DPP IV activity, and enhanced ... 1) levels. In STZ-treated mice fed DA-1229 (STZ-DA), blood glucose levels were significantly lower ... glucose tolerance test were significantly improved by DA-1229 administration. Volume density of β-cell was significantly ... compared to STZ-NC mice, suggesting that DA-1229-mediated amelioration of established diabetes was due to ...

Tópico(s): Peptidase Inhibition and Analysis

2010 - Elsevier BV | Diabetes Research and Clinical Practice

Livro

Springer Link

Jornais Acesso aberto

Srikumar Sen, Boxing Correspondent, Charles Bremner, and Leyla Linton, James Landale, Phil Yates, Jon Ashworth, Andrew Pierce, Political Correspondent, Roger Davis, Adrian Lee, Jeremy Laurance, Richard Ford, Home Correspondent, Magnus Linklater, Bill Frost, Marc Jordon, Alexandra Frean, Media Correspondent, Inigo Gilmore, Janet Bush, Economics Correspondent, Harvey Elliott, Roy Porter, Ted Hailstone, Alexandra Frean and Eric Reguly, Philip Howard, Michael Binyon, Alexandra Frean Media Correspondent, Jeremy Kingston, Lynne Truss, Carl Mortished, Morag Preston, Simon Wilde, Geoff Brown, Clare Stewart, Philip Bassett Industrial Editor, Robert Sheehan, Bridge Correspondent, Keith Rodgers, Jill Sherman, Chief Political Correspondent, John Gribbin, John Bryant, Tony Lloyd, Gillian Bardinet, Steve Keenan, Stewart Tendler Crime Correspondent, Pugh & Way, Peter Capella, Norman Hammond, Archaeology Correspondent, Peter Ball, Shirley English, Raymond Keene Chess Correspondent, Peter Ball and Russell Kempson, Ruth Gledhill Religion Correspondent, Peter Waymark, Michael Evans, Defence Correspondent, Alan Hamilton, Amanda Loose, Rodney Milnes, Hywel James, Robert Bruce, P.h.s, David Hands, Charles Bremner, Trefor Vaughan, Ian McIntyre, Peter Barnard, David Grant, Brian Crozier, Daniel McGrory, Dick Hinder, Rosamond Dundas, Anne Karpf, Paul Durman, Robert Ford, Michael Theodoulou, Barry Millington, Hilary Lloyd, Arthur Leathley, Political Correspondent, Raymond Keene, Peter Davalle, Alan Lee, Cricket Correspondent, Jack Aspinall, Emma Wilkins, Frances Gibb, Legal Correspondent, Paul Wilkinson, P. H. S, Tom Benyon, Gavin Drake, Oliver Holt, Richard Owen, Roger Boyes, Nigel Hawkes, Science Editor, D. P. Hannon, Farrol Kahn, Harvey White, Christopher Thomas, William Rees-Mogg, John Goodbody, David Churchill, Giles Whittell, Philip Webster Political Editor, Christopher Walker, Chris Parker, Jason Nissé, Derek Sawyer, Des Dearlove, Matthew Parris, Bruce Anderson, John Shaw, Tony Dawe, Richard Beeston, Brian Glanville, Alan Challoner, Graham Searjeant, Fraser Nelson, Andras Bereznay, Tim Jones, Godfrey Golzen, Michael Horsnell, Mike Murphy Internet Editor, Dominic Kennedy, Social Affairs Correspondent, Tom Rhodes, Dr Thomas Stuttaford, Marianne Curphey, Stephen Dalton, Richard Morrison, Valerie Grove, Alasdair Murray, Edward Gorman Sailing Correspondent, David Hands, Rugby Correspondent, Carol Twinch, Jonathan Mirsky,

... Child I. B. Taurus, £16.96 ISBN 186064 1229 The Times Bookshop BG Still a great distance ...

1996 - Gale Group | TDA

Artigo Revisado por pares

Mi Kyung Kim, Yu Na Chae, Ha Dong Kim, Eun Kyoung Yang, Eun‐Jung Cho, Song‐hyen Choi, Ye-Hwang Cheong, Hae-Sun Kim, Heung Jae Kim, Yeong Woo Jo, Moon-Ho Son, Soon-Hoe Kim, Chang Yell Shin,

To characterize the pharmacodynamic profile of DA-1229, a novel dipeptidyl peptidase (DPP) 4 inhibitor. Enzyme inhibition assays against DPP4, DPP8 and DPP9. Antidiabetic effects of DA-1229 in HF-DIO mice and young db/db mice. DA-1229 was shown to potently inhibit the DPP4 enzyme ... respectively. As a reversible and competitive inhibitor, DA-1229 was more selective to human DPP4 (6000-fold) than to human DPP8 and DPP9. DA-1229 (0.1–3 mg/kg) dose-dependently inhibited ... oral dose of 100 mg/kg of DA-1229 reduced plasma DPP4 activity by over 80% during ...

Tópico(s): Neuropeptides and Animal Physiology

2011 - Elsevier BV | Life Sciences

Livro

Springer Link

Imagens Acesso aberto

... ud-Din-Mahmud, who died in 1228 or 1229. The tomb consists of an octagonal structure in ...

0000 - Gale Group | NCCO Photography

Artigo Acesso aberto Revisado por pares

Inbal Ziv, Yaron Fuchs, Ella Preger, Ariel Shabtay, Haggar Harduf, Tal Zilpa, Naama Dym, Dina Ron,

... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar, 15Yang R. ... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar, 15Yang R. ... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar). hSef-b ... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar). The ability ... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar). For the ... Natl. Acad. Sci. U. S. A. 2004; 101: 1229-1234Crossref PubMed Scopus (55) Google Scholar). Each Sef ...

Tópico(s): Wnt/β-catenin signaling in development and cancer

2006 - Elsevier BV | Journal of Biological Chemistry

Livro

Springer Link

Imagens Acesso aberto

... ud-Din-Mahmud, who died in 1228 or 1229. The tomb consists of an octagonal structure in ...

0000 - Gale Group | NCCO Photography

Artigo Revisado por pares

Tae-Eun Kim, Kyoung Soo Lim, Min Kyu Park, Seo-Hyun Yoon, Joo‐Youn Cho, Sang-Goo Shin, In‐Jin Jang, Kyung‐Sang Yu,

... evaluated the pharmacokinetics, pharmacodynamics, and tolerability of DA-1229, which is a newly developed DPP IV inhibitor. ... male volunteers. A single oral dose of DA-1229 or placebo was given to 10 subjects (8 ... dose group received a single dose of DA-1229 10 mg after a high-fat meal, crossing over from the administration of DA-1229 under a fasting state, after a 7-day ... were mild, and all subjects recovered spontaneously. DA-1229 reached a peak at 3.0 to 5. ... last included 1.0. The pharmacokinetics of DA-1229 were unchanged by food. The degree of DPP ...

Tópico(s): Neuropeptides and Animal Physiology

2012 - Elsevier BV | Clinical Therapeutics

Livro

Springer Link

Outros Acesso aberto

Xenos Clark,

... 714a, 754a, 848a, 871a. Letter. From Xenos Clark. 1229 N. Broad St., Philadelphia.

0000 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Jinxia Dai, Jasbir S. Dalal, Sonal Thakar, Mark Henkemeyer, Vance Lemmon, Jill S. Harunaga, Monika C. Schlatter, Mona Buhusi, Patricia F. Maness,

... mutated in the L1 ankyrin-binding motif (FIGQY(1229)H) display abnormal mapping of RGC axons along ... phospho-specific antibody to the tyrosine phosphorylated FIGQY(1229) motif. EphB2, but not an EphB2 kinase dead mutant, induced tyrosine phosphorylation of L1 at FIGQY(1229) and perturbed ankyrin recruitment to the membrane in ... Src family kinases mediated L1 phosphorylation at FIGQY(1229) by EphB2. Other EphB receptors that regulate medial- ... EphB3, also mediated phosphorylation of L1 at FIGQY(1229). Tyrosine(1176) in the cytoplasmic domain of L1, ...

Tópico(s): Retinal Development and Disorders

2012 - Elsevier BV | Molecular and Cellular Neuroscience

Livro

OAPEN Free

Jornais Acesso aberto

John Uri Lloyd, Max B. Walkow, J. F. Wuist, Byron H. Nellans, R. C. Heflebower, Edwin O. Jordan, Jay Frank Schamberg, W. A. Newman Dorland, William H. Howell, George E. De Schweinitz,

... A. Newman Dorland, M. D. Large Octavo of 1229 Pages with 338 Illustrations, 141 in Colors. Containing ...

1922 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto

Theresa Calvelli, Thomas N. Denny, Helene Paxton, Rebecca Gelman, Jonathan Kagan,

... Immunopathol 52: 19–27, 1989. 10.1016/0090-1229(89)90189-X CASPubMedWeb of Science®Google Scholar ... Immunopathol 52: 28–37, 1989. 10.1016/0090-1229(89)90190-6 CASPubMedWeb of Science®Google Scholar ... Immunopathol 52: 3–9, 1989. 10.1016/0090-1229(89)90187-6 CASPubMedWeb of Science®Google Scholar ... Immunopathol 52: 10–18, 1989. 10.1016/0090-1229(89)90188-8 CASPubMedWeb of Science®Google Scholar ... Immunopathol 52: 38–47, 1989. 10.1016/0090-1229(89)90191-8 CASPubMedWeb of Science®Google Scholar ... Immunopathol 52: 48–60, 1989. 10.1016/0090-1229(89)90192-X CASPubMedWeb of Science®Google Scholar ...

Tópico(s): Single-cell and spatial transcriptomics

1993 - Wiley | Cytometry

Livro

Project Gutenberg

Jornais Acesso aberto

Frances Gibb, Legal Affairs Correspondent, Juan Carlos Gumucio, Daniel Ward, Motor Industry Correspondent, William Stephens, Frank Johnson, Simon Barnes, Caroline Phillips, Geraldine Norman, Sale Room Correspondent, Gordon Allan, Cliff Feltham, Ivo Tennant, Clifford Webb, Michael Stevenson, A. Sandman, Robin Oakley, John Bell, City Editor, George Schöpflin, Roger W. Wallbank, Carol Leonard, Harry Eyres, Richard Streeton, Stuart Jones Football Correspondent, Clifford Longley Religious Affairs Correspondent, Geoffrey Smith, Roland Rudd and Ian Smith, Michael O'Donnell, John Newell, Gerald Davies, Joe Joseph, Stephen Taylor, Stuart Jones, John Rae, Guy du Parc Braham (Captain), Michael Tate, Jill Sherman, Social Services Correspondent, David Sapsted Zeebrugge, David Bernstein, Lawrence Lever, Rodney Cowton, Transport Correspondent, David Bonavia, Peter Waymark, Michael Evans, Defence Correspondent, Alan Hamilton, Martin Cropper, Henry Stanhope, Jenny MacArthur, Thomson Prentice, Science Correspondent, J. P. Connerade, Member, Barry Fantoni, Charles Bremner, R. N. G. Stone, John Hennessy, Norman de Mesquita, C. N. Hudson, Chairman, Harvey Elliott, Air Correspondent, Geoffrey Alderman, Gavin Bell, Sydney Friskin, David Smith, Economics Correspondent, David Miller, Mitchell Platts Golf Correspondent, Philip Webster, Chief Political Correspondent, Mel Webb La Moye, Nicolas Soames, (Michael Phillips), T. J. Winnifrith, Nicholas Wood Political Reporter, Robin Oakley, Political Editor, Mark Farrer, Russell Wood, David Robinson, Barbara Amiel, Paul Griffiths, Bailey Morris and Rodney Lord, Andrew McEwen, Diplomatic Correspondent, Alexandra Jackson, Richard Evans, Francis Witts (Captain of the Academics), Robert Matthews, John Blunsden, Richard Owen, Barry Pickthall, Joyce Whitehead, Ian Ross, Sarah Thompson Education Reporter, David Tremayne, Richard Bassett, David Crouch, Derek Harris, Industrial Editor, Brian Beel, Keith MacKlin, Kenneth Fleet, Jonathan Miller Media Correspondent, John Goodbody, John England, Peter Aykroyd, George Hill, Robin P. G. Gates, Clive White, Malcolm McKeag, Paul Newman, Michael Hornsby, Robert Grieves, Peter Dear and Peter Davalle, Peta Levi, Stephen Pettitt, Alan Peacock, Bailey Morris, Bryan Jennett, Michael Evans Defence Correspondent, Pearce Wright, Science Editor, Harvey Elliott Air Correspondent, Mac Margolis, F. E. S. Hatfield, David Young Energy Correspondent, David Hands, Rugby Correspondent, Michael Coleman, Richard Ford, Colin McQuillan, Mary Dejevsky, Richard Wigg, Richard Williams,

... rapid and alarming decline Meridien Concise Crossword No 1229 Where are They now? Parkinson's Disease Society ...

1987 - Gale Group | TDA

Artigo Acesso aberto Revisado por pares

Alexander Schmitz, Marc L. Short, Ole Ammerpohl, Christian Asbrand, Joachim Nickel, Rainer Renkawitz,

... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ... I. Yisraeli J. Cedar H. Cell. 1990; 63: 1229-1237Abstract Full Text PDF PubMed Scopus (128) Google ...

Tópico(s): RNA modifications and cancer

1997 - Elsevier BV | Journal of Biological Chemistry

Jornais Acesso aberto

Thomas L. Stedman, Dr. E. Von Hofmann, Frederick Peterson, Dr. L. Grunwald, Charles P. Grayson, L. Bolton Bangs, W. A. Hardaway, Dr. Geo. C. Pitzer, Dr. J. V. Stevens, Dr. Geo. W. Boskowitz, Wm. Boericke, Thomas C. Duncan, William Collins Hatch,

... Colored Plates. Philadelphia: W. B. Saunders. Imperial Octavo; 1229 Pages, Cloth, $7. 00. Subscription Only, Treatment of ...

1898 - Gale Group | NCCO-STM 1of2

Artigo Revisado por pares

Huiying Hu, Chen-Huan Yu, Huan‐Huan Zhang, Songzhao Zhang, Wen-Ying Yu, Yang� Yang, Qin Chen,

... In this study, we found that circulating exomiR-1229 levels were significantly increased in the serum exosomes ... ALIX and GW4869 repressed the expression of exomiR-1229 secreted from CRC cells. Both CRC-derived exosomes and exomiR-1229 mimic promoted the tubulogenesis of HUVECs, but transfection with exomiR-1229 inhibitor anta-miR-1229 significantly suppressed tube formation. Subsequently, HIPK2 was identified as a target of exomiR-1229 and responsible for the effect of exomiR-1229 on angiogenesis of HUVECs. ExomiR-1229 inhibited the ...

Tópico(s): Circular RNAs in diseases

2019 - Elsevier BV | International Journal of Biological Macromolecules

Periodico Acesso aberto Revisado por pares

Directory of Open Access Journals (DOAJ)

Artigo Acesso aberto Revisado por pares

Joshua A. Imperatore, McKenna L. Then, Keefe B. McDougal, Mihaela‐Rita Mihailescu,

... single nucleotide polymorphism (SNP) rs2291418 within premature microRNA-1229 (pre-miRNA-1229) is significantly associated with AD. Moreover, the levels of the mature miRNA-1229-3p, which has been shown to regulate the ... translation, are increased in the rs2291418 pre-miRNA-1229 variant. In this study we used various biophysical techniques to show that pre-miRNA-1229 forms a G-quadruplex secondary structure that coexists ... potentially controlling the production of the mature miR-1229-3p, and furthermore, that the AD-associated SNP ...

Tópico(s): RNA Research and Splicing

2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences