Volume 123
0000 - Gale Group | NCCO BritishPolitics
... 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a close structural analogue of the hepatotoxic anaesthetic ... in vitro and in vivo. P450 activates HCFC-123, both oxidatively and reductively, to reactive species which ... investigate the mechanism of P450 inactivation by HCFC-123. We found that MHA can reductively activate HCFC-123 to reactive species resulting in the loss of ... anaerobic incubation of MHA with 10 mM HCFC-123, a typical reduced difference spectrum was observed with ... increased with time, indicating an interaction between HCFC-123 or HCFC-123 metabolites and haem. In similar ...
Tópico(s): Hemoglobin structure and function
1964 - Elsevier BV | Biochemical Pharmacology
Volume 123
0000 - Gale Group | NCCO BritishPolitics
John W. McCauley, Jackie Bye, Kay Elder, M J Gething, J.J. Skehel, Alan E. Smith, Michael D. Waterfield,
... J. Bye Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, EnglandSearch ... K. Elder Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, EnglandSearch ... J. Gething Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, EnglandSearch ... A. Smith Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, EnglandSearch ... D. Waterfield Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London, WC2A 3PX, EnglandSearch ...
Tópico(s): Virus-based gene therapy research
1979 - Wiley | FEBS Letters
IEEE Xplore
1870, Foreign: Volume 123:1
0000 - Gale Group | NCCO AsiaWest
James S. Rellas, James R. Corbett, Padmakar V. Kulkarni, C. Morgan, Michael D. Devous, L. Maximilian Buja, Larry R. Bush, Robert W. Parkey, James T. Willerson, Samuel E. Lewis,
The ability of an iodinated fatty acid, iodine-123 Phenylpentadecanoic acid (1–123 PPA), and single-photon emission computed tomography (SPECT) ... of reflow, 2 to 6 mCi of 1–123 PPA were injected and the dogs were imaged ... showed relatively uniform uptake and clearance of 1–123 PPA in similar left ventricular (LV) regions. Dogs ... computer algorithm as having regions of decreased 1–123 PPA uptake in the infarct-related area and a reduced rate of 1–123 PPA clearance (−9.4% in infarct sectors [washin], + ... occlusion and reperfusion had decreased clearance of 1–123 PPA from the regions with infarction; 1–123 ...
Tópico(s): Cardiovascular Function and Risk Factors
1983 - Elsevier BV | The American Journal of Cardiology
Springer Link
Volume 123 1. January 1915. Government Document. From W. S. C.
0000 - Gale Group | NCCO BritishPolitics
Björn Ringdahl, Bahram Resul, F. J. Ehlert, Donald J. Jenden, Richard Dahlbom,
... 4-(2-chloroethylmethylamino)-2-butynyl]-2-pyrrolidone (BM 123) and N-[4-(2-chloromethylpyrrolidino)-2-butynyl]-2-pyrrolidone (BM 130), were synthesized. BM 123 and BM 130 cyclize in neutral aqueous solution ... methylatropine and by pretreatment of solutions of BM 123 and BM 130 with thiosulfate. The parent 2- ... guinea pig ileum for 30 min with BM 123 at 20 microM and 2 microM caused 94% ... time period. These calculated receptor occupancies by BM 123 and BM 130 agreed with those estimated from ... homogenates of the ileum following exposure to BM 123 and BM 130. Methylatropine (20 nM) protected against ...
Tópico(s): Chemical Synthesis and Analysis
1984 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
OECD iLibrary
Volume 123
0000 - Gale Group | NCCO BritishPolitics
Dan J. Castro, Paul H. Ward, Harold R. Fetterman, Christopher S. Foote, Romaine E. Saxton, J. Daniel Markley, Donna J. Castro,
... that the cationic, mito‐chondrial‐specific dye Rhodamine‐123 (Rh‐123), is an efficient tumor photosensitizer for Argon laser ... were tested for in vitro sensitivity to Rh‐123 and the Argon laser (514.5 nm) in ... cells in suspension were first sensitized to Rh‐123 (1 or 20 μg/ml for 1 hour), ... thymidine uptake 24 hours after sensitization with Rh‐123 and laser treatment was significantly decreased in tumor ... decrease in DNA synthesis was seen in Rh‐123 and laser treated cells kept in an N 2 environment. Control tumor cells treated with Rh‐123 or the Argon laser separately did not show ...
Tópico(s): Nanoplatforms for cancer theranostics
1990 - Wiley | The Laryngoscope
National Library of Medicine (NCBI)
Volume 123
0000 - Gale Group | NCCO BritishPolitics
Koichi Sugita, Armando E. Giuliano, Nobuyo Sugita, Dan J. Castro, Harold R. Fetterman, Paul H. Ward, Romaine E. Saxton,
Rhodamine 123 has been shown to be an efficient photosensitizer for the argon laser treatment of a human squamous ... and a melanoma cell line in vitro. Rhodamine 123 laser phototherapy also eradicates these human squamous cell ... histologic origins for in vitro sensitivity to rhodamine 123 and the argon laser. Rhodamine 123 with an absorption maxima of 502 nm in ... by the mitochondria of human tumor cells. Rhodamine 123-sensitized brain tumor cells were inhibited by over ... thymidine incorporation into cellular DNA. Laser or rhodamine 123 alone did not significantly inhibit (>20%) tumor cell [ ...
Tópico(s): bioluminescence and chemiluminescence research
1990 - Elsevier BV | American Journal of Otolaryngology
OECD iLibrary
Volume 123
0000 - Gale Group | NCCO BritishPolitics
Patrice Morlière, R. Santus, M. Bazin, Elli Kohen, Véronique Carillet, François Bon, J. Rainasse, Louis Dubertret,
... of conflicting reports on the phototoxicity of rhodamine 123 (Rh 123), we have undertaken a study of Rh 123 photosensitization in several in vitro systems. First, Rh 123 is not a photodynamic agent and does not ... when bound to cytochrome c (Cyt c), Rh 123 photosensitizes ferro Cyt c but not ferri Cyt ... skin fibroblasts where it specifically stains mitochondria, Rh 123 photosensitizes membrane damage. These results are consistent with the hypothesis that Rh 123 is a phototoxic stain. The lack of photosensitivity ...
Tópico(s): Nanoplatforms for cancer theranostics
1990 - Wiley | Photochemistry and Photobiology
National Library of Medicine (NCBI)
Volume 123
0000 - Gale Group | NCCO BritishPolitics
Stephen K. Powers, William C. Beckman, J. Tony Brown, Linda C. Kolpack,
... photochemotherapy with the mitochondrial-specific intravital dye rhodamine-123 (Rh-123) was studied using a malignant rat glioma model ... into the cerebrum of adult rats. The Rh-123 photosensitization was produced by direct intratumoral injection of Rh-123 into the mouse RT2 flank tumors and by intravenous Rh-123 administration to adult rats with implanted RT2 intracerebral ... groups of animals received either no treatment, Rh-123 injections, or administration of 150 mW of argon ... progressive diminution in size after treatment with Rh-123 photochemotherapy. There was no evidence of tumor recurrence ...
Tópico(s): Neurobiology and Insect Physiology Research
1987 - American Association of Neurological Surgeons | Journal of neurosurgery
Volume 123
0000 - Gale Group | NCCO BritishPolitics
Perry B. Cregan, H. H. Keyser,
The displacement of indigenous Brudyrhizobium juponicum serogroup USDA 123 in soybean [ Glycine mar (L.) Merr.] nodules in ... in the greenhouse with B. juponicum strain USDA 123. Thirteen genotypes demonstrated restricted nodulation with USDA 123 when compared to five standard cultivars. Two of ... free of B. juponicum and inoculated with USDA 123 and either USDA 110,122, or 138. In ... the nodules of Williams were occupied by USDA 123 whereas, in all cases, less than 10% of the nodules of the PI genotypes contained USDA 123. The PI genotypes excluded strain USDA 123 in ...
Tópico(s): Nematode management and characterization studies
1986 - Wiley | Crop Science
Project Gutenberg
Volume 123 2. 6 January 1915. Government Document.
0000 - Gale Group | NCCO BritishPolitics
Beverly A. Teicher, Sylvia A. Holden, John L. Jacobs, Michael J. Abrams, Alun G. Jones,
... platinum(II) tetrachlorodianion and two molecules of rhodamine-123 associate to form a neutral tight ion pair. ... SCC-25 cells. The uptake of Pt(Rh-123) 2 was measured by two independent methods: fluorescence ... methods as to the amount of Pt(Rh-123)2 which was taken up by the cells, indicating that the Pt(Rh-123)2 is probably entering cell intact. Association with Rh-123 increased the amount of platinum which entered the ... to K2PtCl4. The subcellular distributions of Pt(Rh-123)2, Rh-123, CDDP and K2PtCl4 were also ...
Tópico(s): Molecular Sensors and Ion Detection
1986 - Elsevier BV | Biochemical Pharmacology