Wellcome Library, London. Series: Archives & Manuscripts.
0000 - Gale Group | NCCO Photography
Yan Zhu, Liu Liu, Liepeng Chu, Jingjing Lan, Jingsi Wei, Wei Li, Chao Xue,
... miRNA, and determine the effect of exosomal miR-1287-5p and its target gene CBL on vascular ... measured the expression levels of miR-1303, miR-1287-5p, and miR-129-1-3p using quantitative ... to confirm the downstream target gene of miR-1287-5p. In addition, we treated human umbilical vein ... with MPA-exo, or transfected them with miR-1287-5p mimic/inhibitor or with CBL-siRNA/CBL-siRNA+ miR-1287-5p inhibitor. After cell culture, we evaluated the ... sequencing and observed a high abundance of miR-1287-5p in the exosomes obtained from MPA plasma. ...
Tópico(s): Extracellular vesicles in disease
2023 - PeerJ, Inc. | PeerJ
Ernest Newman, R. F. Mortimer, A. H. Master (Capt.), Julian Huxley, L. J. Corbett, G. T. Garwood, Henry Longhurst, Christopher Hollis, Michael Hordern, Maurice Gorham, E. Colston Shepherd The Sunday Times Air Correspondent, Stanley Unwin, J. D. Ramsay, Rt. Hon. Thomas Johnston, Eric Forbes-Boyd, Yarborough, W. Kay Robinson, Ralph Straus, Marcus Cheke, A. F. Ensor, Peter Fleming, Leslie Smith, Hugh Wynne, Eric Newton, Norman Crump The Sunday Times City Editor, Richard Hughes The Sunday Times Special Correspondent in Tokio, Norman Ablett, Dora Shackell, O. H. Brandon, J. W. Lambert, George Schwartz, Desmond MacCarthy, C. H. O'd. Alexander, Rennie Barker, Dorothy Margaret, Elizabeth MacKENZIE Kidderminster, Atticus, Maurice Wiggin, E. S., D. R. Gent, (Dr.) Nevil Leyton, A. V. Coton, (Mrs.) Helen H. Cosley, A. H. G., Joanna Richardson, Dilys Powell, D. G. Woozley, Neville Cardus, G. M. Young, Rev. R. F. V. Scott D. D., Elton Ede, J. L. Hays, Charles E. Gayton The Sunday Times Political Correspondent, D. McK, Raymond Mortimer, Roland Allen, C. M. Edmondston, Gerald Pawle, Frank MacDermot, Harold Raymond, Sir Robert Bruce Lockhart, Brig. J. G. Smyth V. C.,
... Make Fine Recovery The Sunday Times Crossword No. 1287 The Sunday Times
1949 - Gale Group | Sunday Times HA GDA
Teng Zhang, Xiaohong Chen, Yueqing Qu, Yanbing Ding,
... antioxidant effects. Previous studies have indicated that miR-1287-5p was downregulated in patients with ischemic stroke. ... in oxidative stress regulation, is targeted by miR-1287-5p. The aim of the current study is ... reperfusion (OGD/R). OGD/R treatment downregulated miR-1287-5p and upregulated LONP2 in SH-SY5Y cells, ... of OGD/R on the expression of miR-1287-5p and LONP2. Furthermore, we confirmed the interactive relationship between miR-1287-5p and LONP2 (negative regulation). We revealed that miR-1287-5p overexpression alleviated OGD/R-induced oxidative damage ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2021 - Springer Science+Business Media | Analytical Cellular Pathology
... Letter. From John M. Hartman. Nos. 1235 and 1287 North Front Street Philadelphia.
0000 - Gale Group | NCCO-STM 1of2
Zhengquan Xu, Lanhua Chen, Changsheng Wang, Liqun Zhang, Weihong Xu,
... ferroptosis is implicated in its pathogenesis. MicroRNA (miR)-1287-5p plays critical roles in multiple human cancers, ... investigate the role and underlying mechanisms of miR-1287-5p in regulating ferroptosis and osteosarcoma progression. Human ... the mimic, inhibitor or matched controls of miR-1287-5p. Cell viability, colony formation, cell death ratio and ferroptosis were determined. miR-1287-5p expression was downregulated in human osteosarcoma, but upregulated upon ferroptotic stimulation. Overexpression of miR-1287-5p significantly induced, while inhibition of miR-1287- ...
Tópico(s): Circular RNAs in diseases
2021 - Taylor & Francis | Free Radical Research
371/6682 F 1287. Minutes. Japan.
0000 - Gale Group | NCCO AsiaWest
Wenwei Hao, Yongping Zhu, Ying Guo, Hao‐Wei Wang,
... symptom that influences daily lives of patients. miR-1287-5p was discovered to play a suppressive role ... This study investigated the potential role of miR-1287-5p in the in-vitro model of chronic ... Cells underwent LPS treatment after SNAI1 downregulation, miR-1287-5p upregulation or pretreatment of the HMGB1 inhibitor, ... used to measure the RNA expression of miR-1287-5p, SNAI1 and HMGB1. ELISA was used for ... predict the targets (SNAI1 and HMGB1) of miR-1287-5p. Dual-luciferase reporter assays were applied to ...
Tópico(s): Immune Response and Inflammation
2021 - Elsevier BV | Transplant Immunology
Tacques Laurent, Malcolm Brown, Fred Jarvis General Secretary, Barbara Hall, Howard Roberts Nut Executive Member, John Jay City Editor, John Davison, Philip Norman, Chris Ryder, Bryn Colton, Rob Hughes, John Peter, R Botwood Director-General, Eric Dymock, Jill Hartley, Christopher Smallwood Economics Editor, A S Byatt, Sarah Miller, John Jay, Graham Rose, B Mitchell, Glenn Wilson, Ian Williams Business Correspondent, Linda Taylor, Frederic Raphael, Jason Tomas, Edward Welsh, Bruce Kemble, Denise Heywood, Caroline Baker, Nigel Lawson, John Westwell, Geordie Greig, Neville Hodgkinson, Patrick Stoddart, Susan Marling, Robert Sandall, Judi Bevan Deputy City Editor, Iain Johnstone, Irwin Stelzer, Robert Hewison, Peter Godwin, Ivan Fallon, Deryk Brown, Mick Brown, Keith Botsford, David Dougill, Margaret Bennett, Mitchell Platts, Stephen Ward, Joe Irving, Brian Redhead, Paul Wilce, Jane Bird, Christine Walker, John Witherow, Maria Laura Avignolo, John Westmorland, John Montgomery, Clare Dyer Mother and medical journalist, Albert Goodwin, Edmund Stevens, Norman Harris, Charles Ouiton, Geoff Whitten, George Perry, Fiona Malcolm, Rose Shepherd, Robin Marlar, Clive Freeman, Christine Toomey, Tessa Sanderson, Bernard Cafferty, Brain Moynahan, Nicola Shulman, Marie Colvin Middle East Correspondent, Amit Roy, David Howell, Simon Tait, Paul Driver, James Adams, Marjorie Wallace, Catherine Wilson Assistant Director (Museums), William Maw, Peter Freedman, David Leppard, Tim Rayment, Andrew Hislop, Mazher Mahmood, Brian Jackman, John Witherow Diplomatic Correspondent, John Hopkins, Judi Bevan, Brian Walden, J. Kearns, Stephen Pile, Steve Ellis, James Wilson, Richard Cook, J. H. Perryman, Diana Wright, Simon Regan, Stephen Jones, Mike Harrison, Brian Deer, Colin Wallace, Alison Coles, Pat Turton Lecturer at Manchester, Denis Haviland Chairman, Gabriel Ronay, Bruce Kemble Education Correspondent, Dilys Powell, Chris Mitchell, Brough Scott, Tony Rocca, Norman Stone, Clive Everton, Louise Branson, Anita Roddick, Maurice Chittenden, Barrie Penrose, Dudley Doust, Felix Aprahamian, Ian Dunning, David Hughes Political Correspondent, Michael Jones Political Editor, Annabel Walker, Russell Harty's, Brian Glanville, John Carey, Nigel Ryan, Simon Jenkins, Deirdre Fernand, Richard Bullock Director-General, Simon Duffy, Roy Isacowitz, Will Elisworth-Jones, Keith Waterhouse, Hugh Thompson, Simon Rose, Ian Williams, Julie T. Wallace, Hugo Sabogal, Will Elisworth Jones, Valerie Grove, Chris Lightbown, Marina Vaizey, Margaret Park, Penny Perrick, Roger Eglin editor of Business, Alan Sugar, Tony Hetherington, David Blum, Ian Bailey, John Henry, T S Eliot, A. Abayomi, Roger Ratcliffe, Jon Connell, Paul, Boris Schapiro, Mark Brennan,
... Midland FAAC UK Ltd. Armitage Shanks Bridge Brainteaser 1287 Mephisto 1395 Chess Bookwise Lloyds Bowmaker Fuji Heavy ...
1987 - Gale Group | Sunday Times HA GDA
Wontak Kim, Hillary Haws, Peter Peterson, Clifford J. Whatcott, Steven Weitman, Steven L. Warner, David J. Bearss, Adam Siddiqui-Jain,
... We synthesized a phosphate prodrug of alvocidib, TP-1287, in three steps from the parent compound. The solubility of TP-1287, was determined at various pH levels. It was ... studies were conducted in mice in which TP-1287 was efficiently converted to the parent alvocidib (Cmax = ... levels), were evaluated in tumor xenograft models. TP-1287 demonstrated significant anti-tumor efficacy in the MV4- ... 75-fold therapeutic dosing window. In addition, TP-1287 strongly inhibited tumor growth, achieving 109.1% tumor ...
Tópico(s): Nanoparticle-Based Drug Delivery
2017 - American Association for Cancer Research | Cancer Research
... Reference to the Case of W. K. Kelly (1287).
0000 - Gale Group | NCCO British Theatre
Ádám Horváth, Awt Menghis, Bálint Botz, Éva Borbély, Ágnes Kemény, Valéria Tékus, Janka Zsófia Csepregi, Attila Mócsai, Tamás Juhász, Róza Zákány, Dóra Bogdán, Péter Mátyus, Julie Keeble, Erika Pintér, Zsuzsanna Helyes,
... the effects of our novel SSAO inhibitor SzV-1287 in chronic mouse models of joint inflammation. Effects of SzV-1287 (20 mg/kg i.p./day) were investigated ... semiquantitative evaluation, and cytokines by Luminex assay. SzV-1287 significantly inhibited hyperalgesia and oedema in both models. ... not myeloperoxidase activity was significantly reduced by SzV-1287 in K/BxN-arthritis. SzV-1287 did not influence vascular and cellular mechanisms in ... anti-hyperalgesic and anti-inflammatory actions of SzV-1287 and LJP-1207, but only SzV-1287 decreased ...
Tópico(s): Pain Mechanisms and Treatments
2017 - Nature Portfolio | Scientific Reports
IEEE Xplore
... Eyewitness Accounts. Friedrichs, Dr. Theodor. 204. 058-EA-1287. German. P.III.h. No.941. (Shanghai). 58. ...
0000 - Gale Group | ArchivesUnbound Holocaust Rare
Nina Bögershausen, Nassim Shahrzad, Jessica X. Chong, Jürgen‐Christoph von Kleist-Retzow, Daniela Stanga, Yun Li, François Bernier, Catrina M. Loucks, Radu Wirth, Erik G. Puffenberger, Robert A. Hegele, Julia Schreml, Gabriel Lapointe, Katharina Keupp, Christopher L. Brett, Rebecca L. Anderson, Andreas Hahn, A. Micheil Innes, Oksana Suchowersky, Marilyn B. Mets, Gudrun Nürnberg, D. Ross McLeod, Hölger Thiele, Darrel Waggoner, Janine Altmüller, Kym M. Boycott, Benedikt Schoser, Peter Nürnberg, Carole Ober, Raoul Heller, Jillian S. Parboosingh, Bernd Wollnik, Michael Sacher, Ryan E. Lamont,
... the Syrian LGMD family and the homozygous c.1287+5G>A splice-site mutation resulting in a ... the Syrian LGMD family and the homozygous c.1287+5G>A splice-site mutation resulting in a ... 2938G>A p.Gly980Argc.2938G>A p.Gly980Argc.1287+5G>Ac.1287+5G>Ac.1287+5G>Ac.1287+5G>Ac.1287+5G>AGenderfemalefemalefemalemalemalemalefemalemaleAge (years)2016262522202018Height (centile)10th25–50th25th<5th3rd< ... of less than 0.02. Only the c.1287+5G>A splice-site variant at the donor ... a gene. With the exception of TRAPPC11 c.1287+5G>A, the same mutation identified in family ...
Tópico(s): Cellular transport and secretion
2013 - Elsevier BV | The American Journal of Human Genetics
W. Tuttle, C. F. Butler, Benj. L. Simmons, Edwin M. Hale, James M. Anders, Benj. L. Simmons, W. S. Hall, Andrew Jackson Howe, Wm. R. Warner, Charles Gatchell, E. W. Rockwood, Stacey Jones, T. L. Bradford, O. H. Crandall, Cornelius G. Coakley, Chas. A. Bailey,
... James M. Anders, M. D. Illustrated. Revised. 8vo. 1287 Pp. Cloth, $5. 50. W. B. Saunders, Publisher, ...
1899 - Gale Group | NCCO-STM 1of2
Patricia LoRusso, Pasi A. Jänne, Moacyr Oliveira, Naiyer A. Rizvi, Lisa Malburg, Vicki L. Keedy, Lorrin Yee, Catherine Copigneaux, Thore Hettmann, Chi‐Yuan Wu, Agnes Ang, Abdel‐Baset Halim, Robert A. Beckman, Darrin M. Beaupre, Jordan Berlin,
... prognosis. This first-in-human study of U3-1287 (NCT00730470), a fully human anti-HER3 monoclonal antibody, ... doses (0.3–20 mg/kg) of U3-1287 every 2 weeks, starting 3 weeks after the ... received 9, 14, or 20 mg/kg U3-1287 every 2 weeks, based on observed tolerability and ... part 1: 26; part 2: 31) received U3-1287. As no dose-limiting toxicities were reported, the ... The most frequent adverse events related to U3-1287 were fatigue (21.1%), diarrhea (12.3%), nausea ( ... dysgeusia (5.3%). No patient developed anti-U3-1287 antibodies. In these heavily pretreated patients, stable disease ...
Tópico(s): Peptidase Inhibition and Analysis
2013 - American Association for Cancer Research | Clinical Cancer Research
W. F. Waugh, Andrew Jackson Howe, J. M. Anders, H. A. Hare,
... the Medico-Chirurgical College, Philadelphia, Etc. Illustrated. 8vo., 1287 Pages. W. B. Saunders, Philadelphia, Publisher. Cloth, $5. ...
1897 - Gale Group | NCCO-STM 1of2
Daniel J. Freeman, Selam Ogbagabriel, James Bready, Ji-Rong Sun, Robert Radinsky, Thore Hettmann,
... in vitro and in vivo activity of U3–1287 (AMG 888) as a single agent and in ... Methods: FaDu (SCCHN) cells were treated with U3–1287 (AMG 888), panitumumab, the combination or control mAbs ... cells were treated with 1 μg/mL U3–1287 (AMG 888), 1 μg/ml panitumumab, the combination ... FaDu xenografts were treated 2×/week with U3–1287 (AMG 888), panitumumab, the combination or control mAbs. Results: Treatment with either U3–1287 (AMG 888) or panitumumab resulted in inhibition of ... pERK1/2. Although treatment with panitumumab or U3–1287 (AMG 888) alone significantly inhibited in vitro cell ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2011 - American Association for Cancer Research | Molecular Cancer Therapeutics
Juan Carlos Gumucio, Chris Petit, Jenny Mezciems, Andrew Longmore, David Miller Chief Sports Correspondent, Geraldine Norman, Sale Room Correspondent, Ivo Tennant, Clifford Webb, Linda Pentz, Michael Binyon, Jeremy Kingston, Carol Leonard, Richard Eaton, Stuart Jones Football Correspondent, Geoffrey Smith, Colin Narbrough, John Spicer, Employment Affairs Correspondent, Gerald Davies, Joe Joseph, Jim Railton, Giles Hunt Guy Yeoman, Mitchell Platts, Golf Correspondent, John Rae, Michael Tate, Ruth Gledhill, Jill Sherman, Social Services Correspondent, Marie Myerscough, Andre Previn, Rodney Cowton, Transport Correspondent, Lawrence Lever, Martin Cropper, Robin Young, Henry Stanhope, David Smith Economics Correspondent, Jenny MacArthur, Martin Fletcher, Political Reporter, Marcus Williams, M. V. Bayes, Jiri Toknyama, Jennifer Selway, David Hands, Michael Berry, Charles Bremner, Richard Thomson, Banking Correspondent, Rex Bellamy, Tennis Correspondent, John Hennessy, Robert Fisk Middle East Correspondent, Harvey Elliott, Air Correspondent, Penny Vincenzi, Rex Bellamy Tennis Correspondent, Alan Booth, Paul Vallely, David Cross, David Smith, Economics Correspondent, Chris Thau, David Miller, Geoffrey Wheeler, (Michael Phillips), David Watts, Robin Oakley, Political Editor, Adrienne Bridges, Barbara Amiel, Neville Sandelson, Andrew McEwen, Diplomatic Correspondent, Peter Bryan, Stewart Tendler Crime Reporter, Kuldip Nayar, Sheila Gunn, Political Staff, PHS, John Clare Education Correspondent, Stewart Tendler, Crime Reporter, Sidney Friskin, Barry Pickthall, Irving Wardle, Joyce Whitehead, Ian Ross, John Bell City Editor, David Sapsted, Alex McCall-Smith, Edward Townsend Industrial Correspondent, David Hands Rugby Correspondent, Peter Davalle and Jane Rackham, Kenneth Fleet, Jill Sherman Social Services Correspondent, Winston S. Churchill Graham Thompson, Edward Townsend, Industrial Correspondent, Daniel Ward Motor Industry Correspondent, Graham Searjeant Financial Editor, Liz Smith, Michael Hornsby, Robert Grieves, Michael Seely, Irene Carr, Alan Lee, Richard A. Bailey, Managing Director, Michael Clark and Geoffrey Foster, John Goodbody Sports News Correspondent, Stephen Pettitt, Tim Jones, George Chesterton, John Woodcock, Cricket Correspondent, Frances Gibb Legal Affairs Correspondent, Noël Goodwin, Bailey Morris, Robert Fisk, Rodney Lord, Economics Editor, Peter Strafford, Michael Evans Defence Correspondent, Simon Wallace, Richard Morrison, Pat Butcher Athletics Correspondent, Jack Bailey, Anthony Krais, Executive Director, Edward Townsend, Colin Campbell, William Whitfield, Colin Moynihan, Peter Evans, Home Affairs Correspondent, Ray Heath,
... 2,000th Letter form America Concise Crossword No 1287 Rolex Issued by the Tobacco Advisory Council for ...
1987 - Gale Group | TDA
... B.A. Berditchevski F. Biochim. Biophys. Acta. 1996; 1287: 67-71PubMed Google Scholar, 9Hemler M. Curr. Opin. ... B.A. Berditchevski F. Biochim. Biophys. Acta. 1996; 1287: 67-71PubMed Google Scholar, 9Hemler M. Curr. Opin. ... B.A. Berditchevski F. Biochim. Biophys. Acta. 1996; 1287: 67-71PubMed Google Scholar, 9Hemler M. Curr. Opin. ... B.A. Berditchevski F. Biochim. Biophys. Acta. 1996; 1287: 67-71PubMed Google Scholar, 9Hemler M. Curr. Opin. ... B.A. Berditchevski F. Biochim. Biophys. Acta. 1996; 1287: 67-71PubMed Google Scholar). Some are nearly ubiquitously ...
Tópico(s): Cellular Mechanics and Interactions
2000 - Elsevier BV | Journal of Biological Chemistry