... to the Delhi Sultanate under Alauddin Khalji in 1305. Kalika, a name for the goddess Durga, was ...
0000 - Gale Group | NCCO Photography
Laurent O. Martinez, Birgit Agerholm-Larsen, Nan Wang, Wengen Chen, Alan R. Tall,
... PEST sequence and identified Thr-1286 and Thr-1305 as constitutively phosphorylated residues. The ABCA1-T1286A/T1305A ... PEST sequence and identified Thr-1286 and Thr-1305 as constitutively phosphorylated residues. The ABCA1-T1286A/T1305A ... calpain proteolysis. We identified Thr-1286 and Thr-1305 as constitutively phosphorylated sites in the ABCA1-PEST ... critical role of the Thr-1286 and Thr-1305 phosphorylation sites in the process of ABCA1 degradation ... Thr-1286, Ser-1296, Ser-1302, and The-1305 to Ala were generated by PCR using Pfu ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2003 - Elsevier BV | Journal of Biological Chemistry
Springer Link
... to the Delhi Sultanate under Alauddin Khalji in 1305. Kalika, a name for the goddess Durga, was ...
0000 - Gale Group | NCCO Photography
Józefa Wȩsierska‐Ga̧dek, Daniela Schloffer, Marieta Gueorguieva, Maria Uhl, Andrzej Składanowski,
Triazoloacridone C-1305 is a novel inhibitor of DNA topoisomerase II, which exhibits potent antitumor activity toward solid tumors. In this study, antiproliferative action of C-1305 and its close analog C-1533 was investigated ... PARP-1 gene was specifically disrupted. Unexpectedly, C-1305 very strongly affected proliferation of cells lacking poly( ... was comparable. The IC(50) concentration of C-1305 determined for PARP-1 knockout cells was approximately ... drugs. Analysis of DNA damage induced by C-1305 by the Comet assay showed that this drug ...
Tópico(s): DNA Repair Mechanisms
2004 - American Association for Cancer Research | Cancer Research
... It was conquered by the Delhi Sultanate in 1305 and then became part of the independent province ...
0000 - Gale Group | NCCO Photography
Krzysztof Lemke, Virginie Poindessous, Andrzej Składanowski, Annette K. Larsen,
C-1305 [S-[[3-(dimethylamino)propyl]amino]-8-hydroxy-6H-v-triazolo[4,5,1- de ]acridin-6-one] ... in colon cancer models. The mechanism of C-1305 is unknown, although similarities in the chemical structure between C-1305 and amsacrine suggest common cellular targets. Here, we report that C-1305 is a topoisomerase II poison that is able ... in living cells. Even at optimal concentrations, C-1305 is a much weaker inducer of cleavable complexes ... low levels of cleavable complexes induced by C-1305 may be unusually toxic. In contrast to amsacrine, ...
Tópico(s): Synthesis and pharmacology of benzodiazepine derivatives
2004 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
... The Paramaras were defeated by Alauddin Khalji in 1305 and Dhar became part of the Delhi Sultanate. ...
0000 - Gale Group | NCCO Photography
Yoshihide Kuboki, Michihiko Ito, Nobuhiko Takamatsu, Ken-ichi Yamamoto, Tadayoshi Shiba, Katsuji Yoshioka,
... mapped to the COOH-terminal region (residues 1054–1305) of JSAP1. We next examined the effect of ... mapped to the COOH-terminal region (residues 1054–1305) of JSAP1. We next examined the effect of ... Raf-C. The COOH-terminal region (residues 1054–1305) of JSAP1 was amplified by PCR with pcDNA3- ... thioredoxin (Trx)-histidine (His)-S-JSAP1 (residues 1054–1305). The resulting plasmid was termed pET32-JSAP1-C. ... JSAP1 proteins, His-S-JSAP1-FL (residues 1–1305), His-S-JSAP1-ΔC (residues 1–1053), or His-S-JSAP1-C (residues 1054–1305), were recovered from the cell extracts by affinity ...
Tópico(s): Signaling Pathways in Disease
2000 - Elsevier BV | Journal of Biological Chemistry
... It was conquered by the Delhi Sultanate in 1305 and then became part of the independent province ...
0000 - Gale Group | NCCO Photography
Kathleen A. Williamson, Joe Rainger, James Floyd, Morad Ansari, Alison Meynert, Kishan V. Aldridge, Jacqueline K. Rainger, Carl A. Anderson, Anthony T. Moore, Matthew E. Hurles, Angus Clarke, Veronica van Heyningen, Alain Verloès, Martin S. Taylor, Andrew O.M. Wilkie, David Fitzpatrick,
... transcripts, the c.370C>T mutation in family 1305 is within the 5′ UTR and cannot result ... transcripts, the c.370C>T mutation in family 1305 is within the 5′ UTR and cannot result ... niece pair with bilateral OFCDs (Figure 1, family 1305 individuals II:2 and III:1; clinical examination ... inherited from the unaffected grandfather (Figure 1, family 1305 individual I:1). There was no evidence of ... for the segregation of nonsense mutations in families 1305 and 132 was 4.2. Another family has ... was available from any affected member of family 1305. However, YAP1 expression could not be detected. One ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2014 - Elsevier BV | The American Journal of Human Genetics
... were famed for their patronage of literature. In 1305 Dhar was absorbed into the Delhi Sultanate by ...
0000 - Gale Group | NCCO Photography
... diseases, but the underlying mechanism remains unclear. miR-1305 upregulation and its potential target RUNX2 downregulation exist ... proliferation, migration, and osteogenic differentiation by increasing miR-1305 level and decreasing RUNX2 level.Quantitative real-time ... performed to detect the expression levels of miR-1305 and RUNX2 in the PDLSCs exposed to nicotine, respectively. PDLSCs with miR-1305 overexpression, low expression, or RUNX2 overexpression were constructed ... were applied to assess the effect of miR-1305 on PDLSC proliferation, migration, and osteogenic differentiation, respectively. ...
Tópico(s): RNA Interference and Gene Delivery
2016 - Wiley | Journal of Oral Pathology and Medicine
... were famed for their patronage of literature. In 1305 Dhar was absorbed into the Delhi Sultanate by ...
0000 - Gale Group | NCCO Photography
Yuxing Cai, Yi Hao, Haifeng Ren, ZhiGuo Dang, Hui Xu, Xiangfei Xue, Yan Gao,
... have shown the tumor-suppressive function of miR-1305 in cancer; however, the role of miR-1305 in NSCLC has not been fully understood.The expression of miR-1305 in NSCLC was detected by RT-qPCR. The influence of miR-1305 on the growth of NSCLC cells was determined ... formation and FACS analysis. The targets of miR-1305 were predicted with the miRDB database. Luciferase reporter ... was performed to investigate the binding between miR-1305 and 3'-UTR of MDM2. Western blot was ... to check the expression of MDM2 with miR-1305.Here, we found that miR-1305 was down- ...
Tópico(s): Cancer-related molecular mechanisms research
2019 - Dove Medical Press | Cancer Management and Research
... were famed for their patronage of literature. In 1305 Dhar was absorbed into the Delhi Sultanate by ...
0000 - Gale Group | NCCO Photography
Ji Young Lee, Daeun Ryu, Sung Won Lim, Kyung Ju Ryu, Myung Eun Choi, Sang Eun Yoon, Kihyun Kım, Chaehwa Park, Seok Jin Kim,
... miRNA analysis identified a higher expression of miR-1305 in exosomes isolated from hypoxic MM cells than ... overall survival of patients with high exosomal miR-1305 was poorer than it was in patients with low exosomal miR-1305.In hypoxic MM cells, an increase of exosomal miR-1305 led to a decrease of cellular miR-1305 and increased expression of the miR-1305 target genes, MDM2, IGF1 and FGF2 resulted in ... promotion of oncogenic activity of MM.Exosomal miR-1305 was also transferred from MM cells to macrophages, ...
Tópico(s): MicroRNA in disease regulation
2021 - Ivyspring International Publisher | Journal of Cancer
... were famed for their patronage of literature. In 1305 Dhar was absorbed into the Delhi Sultanate by ...
0000 - Gale Group | NCCO Photography
Quanneng Zhao, Bing Zhang, Zhilian Li, Wei Tang, Lijun Du, Hongyang Sang,
... cells together with its targeted regulation on miR-1305. To adopt qRT-PCR to test PROX1-AS1 and miR-1305 expression levels in lung cancer tissues and adjacent ... si-NC, si-PROX1-AS1, miR-NC, miR-1305, si-PROX1-AS1 plus anti-miR-NC, and si-PROX1-AS1 plus anti-miR-1305. To adopt the CCK-8 method to test ... the targeting relationship between PROX1-AS1 and miR-1305. Then we adopted the western blot method to ... was remarkably higher, while the expression of miR-1305 was remarkably lower ( P < 0.05 ). After PROX1-AS1 knockdown expression or miR-1305 overexpression, cell activity, migration, and invasion ability were ...
Tópico(s): MicroRNA in disease regulation
2022 - Hindawi Publishing Corporation | Journal of Healthcare Engineering
... 10th century, and remained under Hindu rule until 1305 when it was conquered by the Sultans of ...
0000 - Gale Group | NCCO Photography
... recently reported that the antitumor triazoloacridone, compound C-1305, is a topoisomerase II poison with unusual properties. ... study we characterize the DNA interactions of C-1305 in vitro , in comparison with other topoisomerase II inhibitors. Our results show that C-1305 binds to DNA by intercalation and possesses higher ... studies. Chemical probing with DEPC indicated that C-1305 induces structural perturbations in DNA regions with three ... Importantly, this effect was highly specific for C-1305 since none of the other 22 DNA interacting ...
Tópico(s): Polyomavirus and related diseases
2005 - Oxford University Press | Nucleic Acids Research