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This Hairstyle, Called "Tenjinmage," Was Popular from the End of the Edo Period to the Meiji Period. The Hair Is Arranged in an Ordinary Fashion, and the ...
0000 - Gale Group | NCCO Photography
Sanjay Mohan, Cristiana Costa Chase, Jesús G. Berdeja, Lionel Karlin, Karim Belhadj, Aurore Perrot, Philippe Moreau, Cyrille Touzeau, Thomas Chalopin, Alexander M. Lesokhin, Carol Ann Huff, David H. Vesole, Joshua Richter, Jeffrey Matous, Igor Proscurshim, Eileen Wolff, Girish Gudi, Andrew Garton, Vinu Menon, Sunitha Gn, Yacine Salhi, Eric J. Feldman, Mohamad Mohty,
Introduction: ISB 1342 is a heterodimer based on the Ichnos proprietary Bispecific Engagement by Antibodies based on the TCR (BEAT®) platform ... T cells and CD38 on tumor cells, ISB 1342 redirects T cells to kill CD38-expressing tumor ... single-agent phase 1 study (NCT03309111) of ISB 1342 in patients with RRMM. Methods: Adult patients (≥18 ... antibody; received escalating, intravenous (IV) doses of ISB 1342 every two weeks (Q2W) or weekly (QW) with ... or recommended phase 2 dose (RP2D) of ISB 1342. Secondary objectives included evaluation of anti-myeloma activity, ...
Tópico(s): Synthesis and Biological Evaluation
2022 - Elsevier BV | Blood
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Marie‐Agnès Doucey, Blandine Pouleau, Carole Estoppey, Cian Stutz, Amélie Croset, Amélie Laurendon, Thierry Monney, Mégane Pluess, Christelle Ries-Fecourt, Julie Macoin, Riccardo Turrini, Perrine Suere, Moustapha Mbow, Emilie Nallet, Adam Drake, Mario Perro, Stanislas Blein,
8044 Background: ISB 1342 is a bispecific antibody heterodimer based on the Ichnos proprietary Bispecific Engagement by Antibodies based on T cell receptor (BEAT) platform. ISB 1342 is a first-in-class CD38 T cell ... inhibitors (PIs), immunomodulators (IMiDs) and daratumumab (study ISB 1342-101). Methods: ISB 1342 was engineered with a single chain variable fragment ( ... T cells and CD38 on tumor cells, ISB 1342 redirects T cells to kill CD38-expressing tumor ... daratumumab in multiple myeloma. Results: In vitro, ISB 1342 killed a large range of CD38-expressing tumor ...
Tópico(s): Multiple Myeloma Research and Treatments
2021 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Man‐Wook Hur, Howard J. Edenberg,
... Yang (Indiana University School of Medicine). pCAT-X-1342 contains the 1.4-kb FokI fragment of ... gene; it contains ADH5 sequences extending from bp −1342 to +61 relative to the transcription initiation site. ... series of plasmids was derived from pCAT-X-1342 by 5′ nested deletions using exonuclease III or ... Basic at the PstI site (blunted). pCAT-H-1342 contains the same 1.4-kb FokI fragment of ADH5 as in pCAT-X-1342 (bp −1342 to +61), except that it is subcloned into ... pCAT-H-253 was made from pCAT-H-1342 by 3′ deletion as described above; it contains ...
Tópico(s): Pancreatic function and diabetes
1995 - Elsevier BV | Journal of Biological Chemistry
... sheets); 40-57 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jérémy Berret, Maria Pihlgren, Marie‐Agnès Doucey, Girish Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M. Edwards, James Edwards, Emmanuelle Ménoret, Charlotte Kervoëlen, Catherine Pellat‐Deceunynck, Philippe Moreau, Eugene Zhukovsky, Mario Perro, Myriam Chimen,
... patient lifespan, resistance to therapy is inevitable. ISB 1342 was designed to target MM cells from patients ... r/rMM) displaying lower sensitivity to daratumumab. ISB 1342 is a bispecific antibody with a high affinity ... on the TCR (BEAT®) platform. In vitro, ISB 1342 efficiently killed cell lines with different levels of ... wherein multiple modes of action were enabled, ISB 1342 showed higher cytotoxicity towards MM cells compared to ... concomitant combinations with daratumumab. The efficacy of ISB 1342 was maintained in daratumumab-treated bone marrow patient ...
Tópico(s): CAR-T cell therapy research
2023 - Elsevier BV | Blood
PubMed Central (PMC)
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Joshua Richter, Martin Wermke, John Kauh, Jonathan Back, Yacine Salhi, Venkateshwar A. Reddy, Eliel Bayever, Ola Landgren,
... an anti-CD38 human IgG1κ monoclonal antibody. GBR 1342 is a CD3xCD38 bispecific antibody engineered (using Glenmark’ ... CD38-expressing myeloma cells. In preclinical studies, GBR 1342 redirected the cytotoxic potential of T-cells to ... profile and maximum tolerable dose (MTD) of GBR 1342 monotherapy in subjects with relapsed/refractory multiple myeloma ( > ... safety, tolerability, and preliminary clinical activity of GBR 1342 at the MTD. The study is also evaluating the mechanisms by which GBR 1342 redirects T-cells to tumor and enhances cytolytic ...
Tópico(s): CAR-T cell therapy research
2018 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Yulia I. Deryabina, Elena N. Bazhenova, Nils‐Erik L. Saris, R. A. Zvyagilskaya,
... Physiol. Rev. 1999; 79: 1127-1155Crossref PubMed Scopus (1342) Google Scholar). Yeast mitochondria generally lack a Ca2+ ... Physiol. Rev. 1999; 79: 1127-1155Crossref PubMed Scopus (1342) Google Scholar, 28Gunter T.E. Gunter K.K. ... Physiol. Rev. 1999; 79: 1127-1155Crossref PubMed Scopus (1342) Google Scholar). Massive accumulation was observed in animal ... Physiol. Rev. 1999; 79: 1127-1155Crossref PubMed Scopus (1342) Google Scholar). In the absence of adenine nucleotides, ... Physiol. Rev. 1999; 79: 1127-1155Crossref PubMed Scopus (1342) Google Scholar, 19Rottenberg H. Marbach M. FEBS Lett. ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2001 - Elsevier BV | Journal of Biological Chemistry
J-STAGE
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
John R. Daum, Gary J. Gorbsky,
... to the region of HsTIIα containing phosphorylated threonine 1342. This threonine lies within a consensus sequence for ... 2 phosphoepitope on fragments of HsTIIα containing threonine 1342. These results indicate that the mitotic 3F3/2 ... phosphoepitope reflects a CKII-catalyzed phosphorylation of threonine 1342 that may regulate mitotic functions of HsTIIα. The ... to the region of HsTIIα containing phosphorylated threonine 1342. This threonine lies within a consensus sequence for ... 2 phosphoepitope on fragments of HsTIIα containing threonine 1342. These results indicate that the mitotic 3F3/2 ...
Tópico(s): Plant nutrient uptake and metabolism
1998 - Elsevier BV | Journal of Biological Chemistry
... 355, 310 sheets); 35 cm English Fleet, in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Julie Lekstrom-Himes, Kleanthis G. Xanthopoulos,
... Genes Dev. 1991; 5: 1538-1552Crossref PubMed Scopus (1342) Google Scholar); however, Table I lists alternative nomenclature. ... Genes Dev. 1991; 5: 1538-1552Crossref PubMed Scopus (1342) Google Scholar, 19Thomassin H. Hamel D. Bernier D. ... Genes Dev. 1991; 5: 1538-1552Crossref PubMed Scopus (1342) Google Scholar). Stimulation with lipopolysaccharide (LPS), IL-6, ... Genes Dev. 1991; 5: 1538-1552Crossref PubMed Scopus (1342) Google Scholar, 34Jenkins N.A. Gilbert D.J. ... Genes Dev. 1991; 5: 1538-1552Crossref PubMed Scopus (1342) Google Scholar, 25Alam T. An M.R. Papaconstantinou ...
Tópico(s): interferon and immune responses
1998 - Elsevier BV | Journal of Biological Chemistry
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
Ryoji Ishida, Miwako Iwai, Katherine L. Marsh, Caroline A. Austin, Takeo Yano, Masao Shibata, Naohito Nozaki, Akira Hara,
... with the human topoisomerase IIα mutated at codon 1342 from threonine to alanine, showing that PT1342 was directed against the phosphorylated threonine 1342. To examine the level of phosphorylation of threonine 1342 of topoisomerase IIα through the cell cycle, HeLa ... seen with anti-topoisomerase IIα antibody. Thus, threonine 1342 in topoisomerase IIα is phosphorylated throughout the cell ... with the human topoisomerase IIα mutated at codon 1342 from threonine to alanine, showing that PT1342 was directed against the phosphorylated threonine 1342. To examine the level of phosphorylation of threonine ...
Tópico(s): Lung Cancer Research Studies
1996 - Elsevier BV | Journal of Biological Chemistry
... 442 sheets; 37 cm The English Fleet in 1342. Performance Program.
0000 - Gale Group | NCCO British Theatre
... historischer Seite wenig erforschte Ereignis der Magdalenenflut von 1342 unter Einbeziehung administrativer Überlieferung, vor allem aus Urkunden ... zweijährigen Hochwasserkatastrophe mit peaks im Februar und Juli 1342, aber auch im Juli 1343 zu gewinnen, sondern auch mehrmonatige Trockenphasen im März bis Juni 1342 erstmals zu fassen, die den (auch in Schriftquellen nachgewiesenen) Erosionseffekt der Starkregenfälle im Juli 1342 besser erklären als bislang. Dabei wird klar, dass 1342/43 ein multifaktorieller compound event vorliegt, der erst ...
Tópico(s): Geology and Paleoclimatology Research
2019 - Birkhäuser | NTM Zeitschrift für Geschichte der Wissenschaften Technik und Medizin