... the left of print 3204. India Museum no. 1447. Received from Captain Lyon, 7 February 1871. Duplicate ...
0000 - Gale Group | NCCO Photography
... study aimed to investigate the effects of RKI-1447, a selective inhibitor of Rho-associated ROCK kinases, ... high-fat diet (HFD) group; the HFD+RKI-1447 (2 mg/kg) group; and the HFD+RKI-1447 (8 mg/kg) group. Mice were fed a ... for 12 weeks. Mice in the HFD+RKI-1447 groups were fed a high-fat diet for 12 weeks and treated with RKI-1447 twice weekly for three weeks. The HepG2 human ... carcinoma cells were treated with or without RKI-1447 for 2 h and treated with oleic acid ... RESULTS:In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2020 - International Scientific Information Inc. | Medical Science Monitor
Ernest Newman, Norah Odgers, Henry Longhurst, E. Colston Shepherd The Sunday Times Air Correspondent, Mary Dunbar, S. C. H. Davis, the Rt. Hon. Malcolm McCorquodale M. P., Eric Forbes-Boyd, Elizabeth Nicholas, Wilma Cawdor, F. G. Hails, Harold Hobson, John Rivers, J. S. Gardner, John Knox (Capt., R. N., retd.), Ann Bowes-Lyon, Roger Mortimer, Iain Lang, Norman Crump The Sunday Times City Editor, Felix Aprahamian, P. N. Carter, E. S. Squirrell, Charles Harris, C. H. O'd. Alexander, J. W. Lambert, George Schwartz, Philip Day, Sir Barry Jackson, Atticus, F. A., J. A. Mactaggart, Maurice Wiggin, D. R. Gent, Cyril Connolly, Lieut.-Gen. Sir Brian Horrocks, R. L. Hollands, Alan McGregor Representative of The Sunday Times, Cyril Beaumont, Gordon Ross, Dilys Powell, W. W. Lawrence, Ludovic Kennedy, Richard L. Strout, G. Kitson Clark, (Miss) W. Walshe Hon. Sec. Rural Reconstruction Association, E. R. B. Drummond, John Lardner, Charles E. Gayton The Sunday Times Political Correspondent, Raymond Mortimer, Roland Allen, Norman F. Webb, John Hyslop Special Representative of The Sunday Times, Kenneth Konstam, John Russell, Sir James Marchant, O. H. Brandon The Sunday Times Representative, Colin Cleghorn, Theo A. Stephens,
... Classified Advertising Items The Sunday Times Crossword No. 1447 Bourne & Hollingsworth Ltd Debenham & Freebody Multiple Display Advertising ...
1952 - Gale Group | Sunday Times HA GDA
Liyi Li, Qin Chen, Yaojun Yu, Hui Chen, Mingdong Lu, Yingpeng Huang, Pihong Li, Hong Chang,
... basis of a novel Rho/ROCK inhibitor RKI-1447. Here, we found RKI-1447 could drastically suppress HCT-8 and HCT-116 ... data indicated suppressed cytoskeletal dynamics induced by RKI-1447 inhibition on mitochondrial respiration, which was evidenced by ... capacity were also reduced in response to RKI-1447. Moreover, RKI-1447 caused excessive reactive oxygen species generation and membrane ... We also demonstrated CHOP is essential for RKI-1447 induced cell apoptosis. Finally, we proved inhibition of ROCK by RKI-1447 could effectively inhibit CRC growth in vivo. Taken ...
Tópico(s): Enzyme function and inhibition
2019 - Wiley | Journal of Cellular Physiology
Douglas Owen, Henry W. Wolff, Indian Merchant, Ebenezer Howard, Chas. John Wilson, Philip Bright, Edmund Backhouse, F. O'Halloran,
... Foreign And Colonial Produce Markets (Continued from page 1447.) The Economist
1910 - Gale Group | The Economist
YoHan Nam, Jong‐Hwa Kim, Maytiya Konkit, Wonyong Kim,
... we evaluated the effects of Lactococcus chungangensis CAU 1447 dry cells (CAU 1447) and cream cheese derived from CAU 1447 on ALD progression following long-term alcohol consumption in rats. Oral administration of CAU 1447 and CAU 1447 cream cheese significantly reduced alkaline phosphatase, aspartate aminotransferase, ... aminotransferase, and triglyceride levels. We found that CAU 1447 and CAU 1447 cream cheese downregulated mRNA encoding various cytokines and antioxidative factors in the liver. Oral CAU 1447 cream cheese administration increased short-chain fatty acid, ...
Tópico(s): Diet, Metabolism, and Disease
2019 - Elsevier BV | Journal of Dairy Science
... Shriever, Maj. 1941 to 1944. 32. 060-EA-1447. German. P.III.i. No.345. (Belgium). 60. ...
1941 - Gale Group | ArchivesUnbound Holocaust Rare
Yalong Dang, Chao Wang, Priyal Shah, Susannah Waxman, Ralitsa T. Loewen, Nils A. Loewen,
This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor, in a porcine ex ... ml for 48 h before treatment with RKI-1447 (n = 16) or vehicle control (n = 12). Intraocular ... Primary trabecular meshwork cells were exposed to RKI-1447 or vehicle control; effects on the cytoskeleton, motility, ... a significant increase in IOP in the RKI-1447 group (P = 0.003) at 48 h. Subsequent treatment with RKI-1447 significantly reduced IOP from 20.14 ± 2.59 ... 0.001). This was partially reversed with RKI-1447. RKI-1447 caused no apparent histological changes in ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2018 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Charles Owen, Victoria McKee, R Lappin, Kenneth McLeish, Barbara Hall, David Levy, Renee Bravo, Adrian Room, Joan Bakewell, Jon Swain, Helen Davidson, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Pam Barrett, Mark Reason, Eric Dymock, Tony Francis, Robert Breckman, Danby Bloch, John Bratby, Hong Kong, John Caglione, Roy Porter, Sheridan Morley, John Diamond, Norman Howell, Richard Bickers, Peter King, Michael Meadmore, Sally Payne, Robert Burchfield, David Smith, Lynne Birch, David Hart, Steve Clarke, William Ward, Bob Holmes, Toby Eady, Jason Tomas, Mark Hosenball, R West, Edward Welsh, Carol Sarler, Rex Harrison, Aneta Kreglicka, Susannah Constantine, Kathryn Flett, Geordie Greig, Tony Allen-Mills, Patrick Stoddart, Susan Marling, M Roddy, Robert Sandall, Boris Yeltsin, Eamon Dunphy, Irwin Stelzer, Keith Austin, Robert Hewison, Ivan Fallon, F W de Klerk, David Dougill, Geordie Greig Arts Correspondent, Joe Irving, Hugh Aidersey-Williams, Cliff Temple, John Rae, Robert Turnbull, Harvey Porlock, Hugh Canning, Margarette Driscoll, Alan Bruce, Jane Bird Technology Editor, Mark Wesley, Susan Crosland, Peter Kemp, Bobby Robson, John Melmoth, Nicky Maitlis, Andrew Morton, John Dodd, Richard Hadlee, Susan Grossman, Robert Harris, Caroline Lees, Richard Palmer Environment Correspondent, George Perry, John Cassidy, Sue Mott, Robin Marlar, Mark Skipworth, Pauline Scudamore, Harry Ritchie, Paul Bailey, Tracy Edwards, Adrian Turner, Bernard Cafferty, A Ingham, Peter Hounam, Janette Marshall, William Shawcross, Nigella Lawson, Brian Blessed, Jeff Randall, Paul Wheeler, Susan Blackmore, Paul Driver, Fran Abrams, Ritchie Cogan, Frederick Starr, Clare Colvin, Sue Fox, Boris Schapiro, Dori Schmetterling, Austin MacCurtain, Tim Rayment, Peter Plant, Kevin Taylor, Dominic Prince, John Stalker, Simon Inglis, Rufus Olins, Anne Williams, Michael Durham, John Sansome, John Hopkins, Joseph Sheehy, Sue Cock, Brian Walden, Phil Baker, Roger Williams, Gareth David, Margarety Park, Melissa Watson Peking, John Karter, Nigel Crompton, Nicholas Read, Philip Willan, Kate Saunders, Lisa O'kelly, Richard Cook, Marie Colvin, Craig Brown, K Harris, Andrew Lorenz Industrial Editor, Nick Smurthwaite, Peter Bryan, Christopher Hirst, Stephen Jones, San Kitley, Andrew Neil, Mel Gooding, Andrew Grice, Digby Anderson, Susan Kelly, Roy Dean, Ivan Hill, Keith Wheatley, Chris Dawes, Ian McEwan, Andrew Hogg Durban, Dilys Powell, Bryan Appleyard, Dame Margot Fonteyn, Roddy Martine, Bryan Robson, G D Broatch, Ian Glover-James, Alison Beckett, David Selbourne, Norman Stone, Richard Woods, Tony Osman, Frances Rafferty, George Ace, Marion Hume, Maurice Chittenden, Ian Dunning, Iola Smith, John Walsh, Neil Lyndon, Brian MacArthur, Alan Tillier, Michael Jones Political Editor, Sarah Maitland, Andrew Yates, James Blitz, Lyndal Melrose, Geoffrey Hobbs, Mihir Bose, Bernard Davies, Wall St Journal, Michael Austin, Dudley Reed, Roy Hattersley, Alan Jabez, Paul Barker, Clive Appearance, Brian Glanville, Robert De Niro, John Carey, Norman Macrae, Chris Dighton, Munro Ferguson, Godfrey Golzen, Deirdre Fernand, Alan Sillitoe, Nick Hayes Editor, Gareth David Deputy City Editor, Andrew Lorenz, Jerry Hall, Luca Di Montezemolo, Barbara Cartland, Hrh Prince Charles, Sam Kiley, Chris Lightbown, Jeff Randall City Editor, Hugh Pearman, David Calrns, Richard Caseby, Margaret Park, Angela Long, Anthony Powell, Germaine Greer, Sara Richardson, Rosemary Sowden, David Smith Economics Editor, Penny Perrick, Peter Robinson, William Haseltine, Tony Hetherington, Peter Roebuck, Joanna Simon, Terry Lunn, Iain Jenkins, Tom Tirckell, Neil Jordan, Hilary Bristow, A Trevenen James, Nitu Ceaucescu,
... Bank Obas Orthopaedic and Medibeds Andrex Bridge Brainteaser 1447 Many meetings Mephisto 1555 Chess Bookwise Chess Backfriend ...
1990 - Gale Group | Sunday Times HA GDA
Ronil A. Patel, Kara D. Forinash, Roberta Pireddu, Ying Sun, Nan Sun, Mathew P. Martin, E. Schönbrunn, Nicholas J. Lawrence, Saı̈d M. Sebti,
... we describe the discovery and development of RKI-1447, a potent small molecule inhibitor of ROCK1 and ROCK2. Crystal structures of the RKI-1447/ROCK1 complex revealed that RKI-1447 is a Type I kinase inhibitor that binds ... the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 ... concentrations as high as 10 μmol/L. RKI-1447 was also highly selective at inhibiting ROCK-mediated ... formation following PDGF and Bradykinin stimulation, respectively. RKI-1447 inhibited migration, invasion and anchorage-independent tumor growth ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2012 - American Association for Cancer Research | Cancer Research
Wiley Online Library
J. M. R. Cowley, John Hird, W. Banks,
... Masons, M. Gambetta to Be Imprisoned, The "Rodney," 1447 Tons, Captain A. Louttit Chartered by Sir Arthur ...
1877 - Gale Group | NCCO BritishPolitics
Christophe Béclin, Stéphanie Boutet, Peter M. Waterhouse, Hervé Vaucheret,
... mutants impaired in cosuppression.Plant Cell. 1998; 10: 1447-1457Crossref Scopus (193) Google Scholar]. We have challenged ... mutants impaired in cosuppression.Plant Cell. 1998; 10: 1447-1457Crossref Scopus (193) Google Scholar, 11Mourrain P. Béclin ... mutants impaired in cosuppression.Plant Cell. 1998; 10: 1447-1457Crossref Scopus (193) Google Scholar]. We have challenged ... mutants impaired in cosuppression.Plant Cell. 1998; 10: 1447-1457Crossref Scopus (193) Google Scholar, 11Mourrain P. Béclin ... mutants impaired in cosuppression.Plant Cell. 1998; 10: 1447-1457Crossref Scopus (193) Google Scholar, 11Mourrain P. Béclin ...
Tópico(s): CRISPR and Genetic Engineering
2002 - Elsevier BV | Current Biology
From Our Military Correspondent, From Our Aeronautical Correspondent, From Our Correspondent, From Our Racing Correspondent, From Our Motor Racing Correspondent, From Our Cricket Correspondent, From Our Special Correspondent, From Our Own Correspondent, From Our Milan Correspondent, From Our Labour Correspondent, From Our Diplomatic Correspondent, From Our Parliamentary Correspondent, Thomas Dunbabin., Alan P. Franklin., Stephen Wilkinson. Peascod Street, Windsor., Yours, &C., R. F. Rattray. 26, Queen Edith's Way, Cambridge, June 10., Yours, &C., Ralph Assheton. House Of Commons, June 13., Frank Bowles. House Of Commons, June 12., J. W. Struthers., By Lord Hailey, N. M. Jensen, Chairman, Tunnel Portland Cement Company, Limited. 1, Great Cumberland Place, W.1, June 12., Alan Anderson., From A Correspondent,
... University News Oxford, 500Th Anniversary Of Wye College 1447 Statutes Returned, From The London Gazette Friday, June ...
1947 - Gale Group | TDA
Carol Butters, Jeremy Tobacman, Larry S. Tobacman,
... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ... M. Tobacman L.S. Biophys. J. 1996; 70: 1447-1455Abstract Full Text PDF PubMed Scopus (23) Google ...
Tópico(s): Cardiovascular Effects of Exercise
1997 - Elsevier BV | Journal of Biological Chemistry
... Erste Abtheilung, Enthalt Die Geschichte Vom Jahre 1347— 1447. Munchen, 1838 in Commission Bey Georg Franz. 320 ...
1839 - Gale Group | NCCO SciTechMed 2 of 2
Naoki Ashizawa, Motoyuki Yoshida, Yoshiko Sugiyama, Nobuhide Akaike, Shigeo Ohbayashi, Tomoji Aotsuka, Naoki Abe, Kanako Fukushima, Akihiro Matsuura,
GP-1447 {3-[(4,5,7-trifluorobenzothiazol-2-yl) methyl]-5-methylphenylacetic acid}, a novel aldose reductase (AR) inhibitor, ... beta-NADPH and inhibition of AR by GP-1447. In contrast to epalrestat, AR activity inhibited by GP-1447 did not recover after dialysis for 24 hr. Administration of GP-1447 to streptozotocin (STZ)-induced diabetic rats for 5 ... after the induction of diabetes. Treatment with GP-1447 for the following 2 weeks dose-dependently restored ... 0.28 mg/kg/day. Administration of GP-1447 (3 and 15 mg/kg/day for 12 ...
Tópico(s): Prenatal Substance Exposure Effects
1997 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
PubMed Central (PMC)
John Guillerbaud, John Goodbody and Howard Foster, Clifford Longley, William Stephens, Vijitha Yapa, Pearce Wright and Robert Matthews, Gordon Allan, Paul Jennings, Martin Spence, Cliff Feltham, Alexander Johnson, Robin Oakley, Philip Howard, Janey Buchan, Michael McCarthy and Richard Ford, Ian Murray, Michael Binyon, Reg Hayter, Richard Evans, Media Editor, Charles Holroyd, Gerald Priestland, Stuart Jones Football Correspondent, Caroline Moorehead, Colin Narbrough, Joe Joseph, Tony Hodges, Sarah Thompson, Education Reporter, Mohsin Ali, Ruth Gledhill, Jill Sherman, Social Services Correspondent, John Spicer, Richard Owen Bonn, Richard Cobb, A. C. Street, Peter Ackroyd, Peter Waymark, Martin Cropper, David Smith Economics Correspondent, Ann Kent, Ronald Faux, Employment Affairs Correspondent, Michael Hamlyn, David Hands, David Jones, Ian Murray and Michael Binyon, Rosemary Kirkman (Chairman), Paul Vallely, Neil Kelly, Sydney Friskin, Alan Lee Williams Warden and Chief Executive, David Smith, Economics Correspondent, Christine Watson, Mitchell Platts Golf Correspondent, Philip Webster, Chief Political Correspondent, George C. Comninel, (Michael Phillips), Kerry Gill, Alison Eadie, David Robinson, E. R. Davies, Peter Davalle, Nicholas Beeston, Dennis Shaw, John McEwan, Paul Griffiths, John Cooney, Liz Gill, Conrad Voss Bark, Till Haberfeld, Stewart Tendler, Crime Reporter, David Young, Energy Correspondent, Sheila Biddell (Chairman), Ronald Butt, Geoffrey Foster, Stephen J. Wooler, Keith MacKlin, Tim Heald, James Oestreich, Gerald Seymour, John Goodbody, T. D. Wood, Martyn T. Lucking, J. A. Condon, George Hill, Clive White, Robert Matthews, Technology Correspondent, Michael Seely, Lynda Murdin, Peter Dear and Peter Davalle, Sarah Jane Checkland, Conamore Smith, Boy George, Tony Dawe, Ian Stafford, David Walker, David Sinclair, Robert Alter and Frank Kermode, Tim Jones, M. A. Farrell, John Young Agriculture Correspondent, Dr Thomas Stuttaford, Robert Fisk, Michael Evans Defence Correspondent, Hergé, Dow Jones, Richard Ford, Political Correspondent, Harvey Elliott Air Correspondent, Colin Campbell, Jan Raath, Terry Burwell, David Hands, Rugby Correspondent, David Kemp, Colin McQuillan, Gerald Hartup (Campaign Director),
... art world Calls for release Concise Crossword No 1447 Can you survive your family? Christmas brings out ...
1987 - Gale Group | TDA
Thomas Dudler, Michael H. Gelb,
... 57: 1167-1177Abstract Full Text PDF PubMed Scopus (1447) Google Scholar, 11.Clarke S. Annu. Rev. Biochem. ... 57: 1167-1177Abstract Full Text PDF PubMed Scopus (1447) Google Scholar). Although this modification appears to be ... 57: 1167-1177Abstract Full Text PDF PubMed Scopus (1447) Google Scholar). However, the mislocalized protein retains the ... 57: 1167-1177Abstract Full Text PDF PubMed Scopus (1447) Google Scholar). This view has been challenged recently ... 57: 1167-1177Abstract Full Text PDF PubMed Scopus (1447) Google Scholar, 27.McGeady P. Kuroda S. Shimizu ...
Tópico(s): Metabolism, Diabetes, and Cancer
1996 - Elsevier BV | Journal of Biological Chemistry
BY PROFESSOR FRANK., BY W. HENRY HUNTER, , BY J. EMERSON DOWSON., F.1447., F.R.C.S., WILFRID SCAWEN BLUNT., BY FIELD-MARSHAL SIR EVELYN WOOD, ,
Births. Marriages. Deaths. Classified Advertising: Charities, &c., United States of Brazil Government Five per Cent. Loan of 1903., Shipping., To Brewers, ...
1907 - Gale Group | TDA
EcologyVolume 80, Issue 4 p. 1447-1447 Book Review Environmental Microbiology Kristi M. Westover, Kristi M. Westover Duke University Department of Botany Durham, North Carolina 27708Search for more papers ... doi.org/10.1890/0012-9658(1999)080[1447:EM]2.0.CO;2Read the full textAboutPDF ... URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume80, Issue4June 1999Pages 1447-1447 RelatedInformation
Tópico(s): Invertebrate Taxonomy and Ecology
1999 - Wiley | Ecology