Andrew Robson, Steve Lumley, Alyn Shipton, John Cleese, Raymond Snoddy Media Editor, David Adams, Steve Bird and Rosemary Bennett, Helen Studd, Andrew Pierce, DJM, David Brown, Christopher Camp, Sam Lambourn, President, Frances Gibb Legal Editor, Judith Henderson, Nigel Hawkes Health Editor and Michael Burke, Michael Evans and James Bone, Claire McDonald, Mark Souster, Paul Hoggart, Austin Mitchell, Chairman, Richard Hobson, Penny Freeston, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Jonny Wilkinson, Jennal Cox Fitness Editor, David Chater, Suna Erdem, Bill Edgar's, Alison Kervin, Christine ter Meulen, James Eve, Gerald Davies, George Parry, Pat Gibson, David McVay, John Clarke, Paul Spare, Donald Hutera, Simon Kuper, Stewart Tendler Crime Correspondent, Anthony Allman, Dominic Walsh, Michael Barley, Tom Bawden, Shirley English, Dennis Connolly, Mark Jones, Stephen O'brien, Rosemary Bennett, Norton, Chairman, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Oliver Del Mar, Robin Young, Stephen Farrell, Ivo Tennant and Geoffrey Dean, Eve-Ann Prentice, Poul Farrow, Phil Gordon, Keith Pike, David Hands, Adam LeBor, Mark Pougatch, Caroline Merrell Banking Correspondent, Michael Cole, MB, Russell Kempson, Daniel McGrory, Suzy Jagger, Oliver Kay, George Rae, Frank Skinner, Neil Harman, Lisa Armstrong, Rick Broadbent, Stephen Burgen, David Lawrenson, Edwin Fleming, John Hopkins, Christopher Martin-Jenkins, Angela Berger, Simon de Bruxelles, Rob Wright, Geoffrey Dean, Marcus Binney, Miranda Eeles, Raymond Keene, Adam Sage, Matthew Pryor, Richard Lambert, Sean MacAulay, Dave Watkin, Rosemary Bennett Deputy Political Editor, Ian Gray, Chris Campling, J. Shepherd, Cathy Harris, Ben Weinkove, Helen Nugent, Shane Warne, Val MacQueen, Christopher Martin-Jenkins Chief Cricket Correspondent, Ned Sherrin, Mick Hume, William Tanzer, Martin Woods, Emily Davies, Oliver August, Sue Collins, Director, Robert Keys, David Hands Rugby Correspondent, Tom Dart, Ken Bates, Andrew Clennell, William Rees-Mogg, Nick Szczepanik, Alyce Faye Cleese, Jane Shilling, Tim Hames, Nan Miller, Mel Webb, Ian Johns, Tim Gray, Ashling O'connor, Robert Thickenesse, Alistair Cooke, George Caulkin, Marjorie Wallace, Chief Executive, Carol Gosmark, Alan Lee, Walter Gammie, Alex Smith, Lea Paterson Economics Editor, Lea Peterson Economics Editor, Michael Dynes, Ian Whittell, Lea Paterson, Gary Duncan Economics Correspondent, Martin Waller, Christopher Irvine, James Jackson, Andrew Lee, Director, Benedict Nightingale, Dr Thomas Stuttaford, James Hendry, Stephen Dalton, Stephen Gardiner, Frank Furedi, Martin Wood, Bill Edgar, Paul Connolly, James Christopher, Mark Venables, Allan Hall, Alan Lee Racing Correspondent, Owen Slot, Maureen Freely, Jenny Davey, Edward Gorman Sailing Correspondent, John Edwards, Chairman, Robin Shepherd, Derek Downer, Janine di Giovanni, Philip Pank, David Lister Ireland Correspondent,
... policy bonuses Man Group 'ponders £150m bid for 1G' New boy beats the perils of G7 Attacks ...
2003 - Gale Group | TDA
J. Ferguson, Hans U. Güdel, Elmars Krausz,
... doubly excited states 4 Eg a , 4 A 1g (Mn)3 T 1g a (Ni) and 4 Eg b (Mn)3 T 1g a (Ni) were observed. The participation of the spin-allowed 3 A 2g →3 T 1g a excitation on Ni2+ in the pair transition ... explained by spin-orbit mixing between 3 T 1g a and 1 Eg . The prominent electronic origins ... to the double spin-flip transitions 6 A 1g (Mn)3 A 2g (Ni) →4 Egu(Mn)3 T 1g a (Γ3)v(Ni) and 4 A 1g (Mn)3 T 1g a (Γ3)v(Ni). The former lie at ... are more intense than the corresponding 6 A 1g (Mn)3 A 2g (Ni) →4 Egv(Mn) ...
Tópico(s): Inorganic Chemistry and Materials
1975 - Taylor & Francis | Molecular Physics
A MEMBER OF THE CORPORATION., FREDERICK BARRY, Sworn Broker, 7, Birchin-lane, Cornhill., JOSEPH COHEN, Sworn Broker, 2, Bartholomew-lane., T. BISH, Stock Broker, Old State Lottery Offices, 4, Cornhill, and 9, Charing-cross.,
... SOLD, at Messrs. Thorn and Co.'s, coachmakers, 1G, John-street, Oxford-street, a. Politics and Parliament: ...
1825 - Gale Group | TDA
J. Ferguson, H.U. Güdel, Elmars Krausz, H. J. Guggenheim,
... following pair states have been observed: 6 A 1g 4 T 1g a ; 6 A 1g 4 E g a ; 6 A 1g 4 A 1g ; 6 A 1g 4 E g b ; 4 T 1g a 4 T 1g a ; 4 E g a 4 T 1g a and 4 A 1g 4 T 1g a . Quantitative estimates of intensities ...
Tópico(s): Crystal Structures and Properties
1974 - Taylor & Francis | Molecular Physics
Barry J. Holmes, James Landale, Jon Ashworth, Sally Staples, Andrew Eames, David Adams, Stella Shamoon, Helen Johnstone, Portia Colwell, Andrew Chilvers, Andrew Pierce, Sally Brock, Patricia Davies, P. B, Grace Bradberry, Sarah Anticoni, Frances Gibb Legal Editor, George Sebastian Rousseau, Jennifer Lane, Gary Neville, Monica Guevara, Bruce Millar, Magnus Linklater, John Morgan, Clive Weatherley, Barbara Green, Osman Streater, Paul Hoggart, Mark Souster, Sue Lampitt, Richard Hobson, Martin Richards, Philip Webster John O'Leary and James Landale, Ivo Tennant, John Miles, T. P, Alex Todorovic, Douglas Friedli, David Lyon, James Bone, D. R. Pitcher, Edwin Entecott, Leonard Gibson, Joyce Blake, Elizabeth Judge, Sharon Linnard, Tony Patrick, Clare Stewart, John O'Leary Education Editor, Antonia Senior, Martin Fletcher, Pat Gibson, Paul Fitzpatrick, D. R., C. Helen Thornton, Jason Allardyce, Melanie Tringham, Norman Shepherd, Dominic Walsh, Steve Bird, Ruth Gledhill, Kerry Conn, Sylvia E. Montgomery, Mike Pattenden, Alix Ramsay Tennis Correspondent, Grainne Gilmore, Michael Harvey, Jeanette Winterson, Martin Barrow, Dalya Alberge Arts Correspondent, Simon Morris, Richard Ford Home Correspondent, Jo Morris, Robin Young, Stephen Farrell, T. D. Thompson, Peter Millar, Rodney Milnes, Jenny MacArthur, T. P., Nick Wyke, James Landale Political Correspondent, Helen Rumbelow Medical Reporter, Frances Bissell, Jason Allardyce Scottish Political Reporter, David Hands, Clive Hookney, Charles Bremner, P. B., Michael Cable, Helen Rumbelow, David Jones, Ian Johnston, Brian Kilcline, Peter Barnard, Anthea Lawson, Derwent May, Patricia MacIntyre, Matthew SIMS(Principal), Paula Hawkins, Mary Gold, Ed Potton, Paul Armstrong, Nigel Williamson, Stephen Anderton, Sharon O'Connell, David Lister, John Stott, Michael Theodoulou, Matt Dickinson Football Correspondent, Michael Durham, Ian M-Blake, Janet Ellard-Smith, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Adam Jones, D. R, Raymond Keene, David Willoughby, Adam Sage, Gareth Huw Davies, David Robinson, Clive Mathieson, Matthew Pryor, John Russell Taylor, Matt Dickinson, Paul Wilkinson, Karina Mantavia, Gina McKee, Katie Owen, Min Cooper, Timothy Hughes, Carolyn Panson, Christopher Walker Chief Ireland Correspondent, Chris Ayres Media Business Correspondent, Cathy Harris, John Stone, Oliver Holt, Shane Warne, Damian Whitworth, David Kettle, graham wood, Karen Armstrong, Nick Hasell, Stephanie Billen, David Hands Rugby Correspondent, Ed Sutton, Glen Owen, Steve Jelbert, Nick Szczepanik, John Goodbody, Dominic Kennedy, Anne Ashworth, James Doran, Philip Webster Political Editor, Giles Whittell, Christopher Walker, Jane Shilling, Jack Pridham, Mel Webb, Alex O'Connell, Paul McCann Media Correspondent, Kevin McCarra, Jennai Cox, George Caulkin, Chris McGrath, Tim Wapshott, John Shaw, Caitlin Moran, Michael Austin, Jane Owen, Ben MacIntyre, Helen Pridham, Roy Hattersley, Ian Woodrow, Graham Searjeant, Richard Miles, Nick Roe, Lauris Morgan-Griffiths, Geoffrey Rowell, Martin Waller, Martin Symington and Andrew Eames, Chris Ayres, Peter Ingham, Danny Baker, Fran Littlewood, Richard Miles and Susan Emmett, Benedict Nightingale, Chris Ayres and Clive Mathieson, Stephen Dalton, Jill Crawshaw, Richard Morrison, Alyson Rudd, Sam Kiley, Jack Bailey, David Powell, Margaret Wright, Valerie Grove, Adam Sherwin, Tom Chesshyre, Michael Evans, Fiona Beckett, Ross Dunn and Richard Beeston, Allan Hall, Stephen Forster, Susie Steiner, Sally Patten, Cath Urquhart Travel Editor, Penny Perrick, Will Hide, Kirsty MacLeod, Fraser Nelson Retail Correspondent, Patience Wheatcroft, Jonathan Richmond, Susan Emmett, Arthur Leathley Transport Correspondent,
... Palatial Multiple Classified Advertising Items Wandsworth Bdg Lux 1g 2 bed bath port o/1 river fr… ...
2000 - Gale Group | TDA
... increasing energy of the Mn 3+ 5 B 1g → 5 A 1g transition as determined from the optical spectra. The ... are identified near 15000 cm- 1 [ 5 B 1g → 5 A 1g ( D )], 18000 cm -1 { 5 B 1g →[ 3 T 1g ( H )]}, 19700cm -1 { 5 B 1g →[ 3 T 1g ( H )]}, 21800cm -1 [ 5 B 1g → 5 B 2g ( D )], 23300cm -1 [ 5 B 1g → 5 E g ( D )] and spin forbidden Fe ...
Tópico(s): Advanced Condensed Matter Physics
1981 - De Gruyter | Zeitschrift für Kristallographie - Crystalline Materials
Hiroaki Egawa, Morio Nakayama, Takamasa Nonaka, Eiichi Sugihara,
... synthesized by using various amounts of ethyleneglycol dimethacrylate (1G), dimethyleneglycol dimethacrylate (2G), triethyleneglycol dimethacrylate (3G), tetraethyleneglycol dimethacrylate ( ... for uranium of RNH was investigated. RNH (RNH–1G) prepared by using 1G were showed to have macroreticular structures by the measure of specific surface area. RNH–1G had the high adsorption ability and physical stability. ... stability, the simultaneous use of divinylbenzene (DVB) and 1G or 4G as crosslinking reagent was examined (abbreviated ...
Tópico(s): Nuclear materials and radiation effects
1987 - Wiley | Journal of Applied Polymer Science
Morio Nakayama, Keiji Uemura, Takamasa Nonaka, Hiroaki Egawa,
Abstract Macroporous chelating resins (RNH‐DVB‐1G) containing amidoxime groups with various degrees of crosslinking were synthesized by varying the amount of divinylbenzene (DVB) and ethyleneglycol dimethacrylate (1G). It was confirmed that the content of amidoxime ... was found that the macropore of RNH‐DVB‐1G with the same degree of crosslinking was remarkably ... by the composition of crosslinking reagent (DVB and 1G). The RNH‐DVB‐1G prepared in the present work were applied to ... that the uranium adsorption ability of RNH‐DVB‐1G with the same degree of crosslinking was remarkably ...
Tópico(s): Covalent Organic Framework Applications
1988 - Wiley | Journal of Applied Polymer Science
Hiroaki Egawa, Takamasa Nonaka, Morio Nakayama,
... of natural seawater or U-spiked seawater. RNH-1G samples prepared by using 1G were shown to have macroreticular structures by measuring the specific surface area. RNH-1G had high adsorption ability and good physical stability. ... physical stability, the simultaneous use of DVB and 1G or 4G as crosslinking reagent was examined (abbreviated as RNH-DVB-1G and RNH-DVB-4G). The RNH-DVB-1G showed high adsorption ability for uranium. Repeated use did not cause deterioration of either RNH-DVB-1G or RNH-DVB-4G. RNH-DVB-1G samples ...
Tópico(s): Nuclear Materials and Properties
1988 - Marcel Dekker | Journal of Macromolecular Science Part A - Chemistry
Produção Nacional
Revisado por pares
Jacqueline Miranda de Lima, Lessileia Gomes de Souza, Ismael Dale Cotrim Guerreiro da Silva, Nora Manoukian Forones,
... reaction-restriction fragment length polymorphism.Patients with the 1G allele and a family history of CRC showed ... metastatic disease was observed for MMP-1 genotypes 1G/1G and 1G/2G (OR: 2.97, 95% CI: 0.93- ... the risk of CRC development. Patients with the 1G/1G or 1G/2G genotype and a family history of CRC ... higher risk of CRC. The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with ...
Tópico(s): Cancer-related gene regulation
2009 - SAGE Publishing | The International Journal of Biological Markers
Amanda B. Spurdle, Sunil R. Lakhani, Leonard Da Silva, Rosemary L. Balleine, kConFab Investigators, David E. Goldgar,
... be difficult to interpret. The BRCA1 c.135-1G>T (IVS3-1G>T) variant has been shown to give rise ... to encode 26 amino acids. BRCA2 c.7977-1G>C (IVS17-1G>C) was shown to increase the expression of ... from a single family with BRCA1 c.135-1G>T was 9528:1, and incorporation of pathology ... from five informative families with BRCA2 c.7977-1G>C was 47401:1, and the combined Bayes- ... likelihood analysis indicates that the BRCA1 c.135-1G>T and BRCA2 c.7977-1G>C variants are disease-associated mutations which should ...
Tópico(s): CRISPR and Genetic Engineering
2009 - Wiley | Human Mutation
Bo Peng, Lihuan Cao, Wenzhang Wang, Lingling Xian, Deke Jiang, Jing Hua Zhao, Zhen Zhang, Xiaoli Wang, Long Yu,
... on the association between polymorphisms of MMP1 −1607 1G>2G and MMP3 −1171 5A>6A and cancer ... risk of colorectal cancer [2G/2G versus 2G/1G + 1G/1G, odds ratio (OR) = 1.48, 95% confidence interval ( ... head and neck cancer [2G/2G versus 2G/1G + 1G/1G, OR = 1.61, 95% CI (1.26–2. ... 7%] and renal cancer [2G/2G versus 2G/1G + 1G/1G, OR = 1.82, 95% CI (1.38–2. ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2009 - Oxford University Press | Mutagenesis
Vincenzo Maffei, Emiliano Macaluso, Iole Indovina, Guy A. Orban, Francesco Lacquaniti,
... target could move along the vertical under gravity (1g), under reversed gravity (-1g), or at constant speed (0g). In the first ... responses. Average BOLD signals were significantly greater for 1g targets than either 0g or -1g targets in a distributed network including bilateral insulae, ... these regions, the mean activity decreased monotonically from 1g to 0g and to -1g. In the second experiment, subjects intercepted 1g, 0g, and -1g targets either in smooth motion (RM) or in ... left lingual gyrus, which were selectively engaged by 1g targets in the first experiment, were also significantly ...
Tópico(s): Functional Brain Connectivity Studies
2009 - American Physiological Society | Journal of Neurophysiology
Victoria M. Pratt, Michele Caggana, Christina Bridges, Arlene Buller, Lisa DiAntonio, W. Edward Highsmith, Leonard M. Holtegaard, Kasinathan Muralidharan, Elizabeth M. Rohlfs, Jack Tarleton, Lorraine H. Toji, Shannon Barker, Lisa V. Kalman,
... 444delA (c.312delA), G178R (c.532G>C), 1812–1G>A (c.1680–1G>A), P574H (c.1721C>A), Y1092X (c.3277C> ... 444delA (c.312delA), G178R (c.532G>C), 1812–1G>A (c.1680–1G>A), P574H (c.1721C>A), Y1092X (c.3277C> ... 3277C>AY1092Xyesnoyesyesnoyesc.1721C>AP574Hnonoyesnonoyesc.532G>CG178Ryesnoyesnonoyesc.312delA444delAyesnoyesnonoyesc.1680-1G>A (AJ574983.1:g.92G>A)1812-1G>Ayesyesyesnonoyesc.1040G>AR347Hyesyesyesyesyesyesc.3744delA3876delAyesyesyesyesyesyesc.1647G>AS549Nyesyesyesyesyesyesc.3773_3774insT3905insTyesnoyesyesyesyesc. ...
Tópico(s): Genomics and Rare Diseases
2009 - Elsevier BV | Journal of Molecular Diagnostics
Produção Nacional
Revisado por pares
Jacqueline Miranda de Lima, Lessileia Gomes de Souza, Ismael Dale Cotrim Guerreiro da Silva, Nora Manoukian Forones,
... restriction fragment length polymorphism. Results Patients with the 1G allele and a family history of CRC showed ... metastatic disease was observed for MMP-1 genotypes 1G/1G and 1G/2G (OR: 2.97, 95%CI: 0.93– ... the risk of CRC development. Patients with the 1G/1G or 1G/2G genotype and a family history of CRC ... higher risk of CRC. The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with ...
Tópico(s): Cancer-related gene regulation
2009 - SAGE Publishing | The International Journal of Biological Markers
André B. P. Kuilenburg, Joke W. Baars, Rutger Meinsma, Albert H. Gennip,
... of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.Clin Cancer Res. ... of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.Clin Cancer Res. ... patient proved to be heterozygous for the IVS14+1G→A mutation. As a result, the mature DPD ... that the two mutations 61C→T and IVS14+1G→A are located on different alleles, thus causing ... of DPD.A high prevalence of the IVS14+1G→A mutation has been observed in the normal ... of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.Clin Cancer Res. ...
Tópico(s): Cancer Treatment and Pharmacology
2003 - Elsevier BV | Annals of Oncology
Marie des Georges, Caroline Guittard, Carine Templin, Jean-Pierre Altiéri, Candice de Carvalho, Michèle Ramsay, Mireille Claustres,
... patient who was heterozygous for the mutation 3120+1G>A. The Caucasian deletion involving the same exon [ ... patient who was heterozygous for the mutation 3120+1G>A. The Caucasian deletion involving the same exon [ ... with two mutations including one homozygote for 3120+1G>A and three compound heterozygotes ([3120+1G>A]+[p.G1249E], [3120+1G>A]+ [3196del54], [3120+1G>A]+[2183delAA]) and two samples were found with only one mutation (3120+1G>A and −94G>T, respectively).2Carles S Desgeorges ... CFTR gene, only one mutation was found, 3120+1G>A. We describe here our successful strategy to ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2008 - Elsevier BV | Journal of Molecular Diagnostics
Nobuo Terada, Nobuhiko Ohno, Sei Saitoh, Yurika Saitoh, Masayuki Komada, Hiroshi Kubota, Shinichi Ohno,
... previously reported that a membrane skeletal protein, 4.1G (also known as EPB41L2), is immunolocalized in mouse seminiferous tubules. In this study, the 4.1G immunolocalizaiton was precisely evaluated at various stages of ... with glycerol treatment before cryosectioning. In addition, 4.1G-deficient mice were produced, and the morphology of their seminiferous tubules was also evaluated. The 4.1G immunolocalization was different among stages, indicating that it ... spermatogonia and early spermatocytes. To confirm the 4.1G immunolocalization in germ cells, in vitro culture of ...
Tópico(s): Renal and related cancers
2010 - Bioscientifica | Reproduction
Seth L. Masters, Lisa A. Mielke, Ann L. Cornish, Caroline E. Sutton, Joanne A. O’Donnell, Louise H. Cengia, Andrew W. Roberts, Ian P. Wicks, Kingston H. G. Mills, Ben A. Croker,
... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052 Australia Search for ... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052 Australia Search for ... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052 Australia Search for ... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052 Australia Search for ... Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3052 Australia Search for ...
Tópico(s): Immune Cell Function and Interaction
2010 - Springer Nature | EMBO Reports
Baoxia He, Lei Shi, Jian Qiu, Tao Liang, Rui Li, Liang Yang, Zhao Shu-jin,
... the CYP3A4 gene, IVS10+12G>A, named CYP3A4*1G (rs2242480), has been identified. The aim of this ... to evaluate the potential relationship between the CYP3A4*1G allele and the susceptibility of coronary heart disease ( ... polymorphism (PCR-RFLP) was used to identify CYP3A4*1G. We also analysed the functional significance of IVS10+ ... results showed that the frequency of the CYP3A4*1G allele was 0.290 and the CYP3A4*1G/*1G genotype was 0.090 in the patients with CHD. The patients with the CYP3A4*1G/*1G genotype had higher CHD risk, with an ...
Tópico(s): Hormonal Regulation and Hypertension
2010 - Wiley | Basic & Clinical Pharmacology & Toxicology
Monique Johnson, Marvin J. Yoshitomi, C. Sue Richards,
... AR553XΔF508/2789 + 5G>AR553X/G551DR347P/ΔF508ΔF508/R1162XΔF508/G85E621 + 1G>T711 + 1G>T/ΔF508ΔF508/711 + 1G>T621 + 1G>T/W1282XΔF508/G551D1898 + 1G>A/R117HΔF508/R117H621 + 1G>T/G542XΔF508/R347P621 + 1G>T/3120 + 1G>A3849 + 10kbC>TΔF508/G542XR117H2789 + 5G>AΔI507R117H/ΔF5082789 + 5G>A/ΔF508R117H/1898 + 1G>AG542X3659delCG542X/G542X1717 − 1G>AG542X/621 + 1G>T1717 − 1G>A/ΔF508I148TG542X/ΔF508G551DA455E/ ...
Tópico(s): Biosensors and Analytical Detection
2007 - Elsevier BV | Journal of Molecular Diagnostics
Saskia W. C. van Mil, Alexandra Milona, Peter H. Dixon, Roman Müllenbach, Victoria Geenes, Jenny Chambers, Vasylyna Shevchuk, Gudrun E. Moore, Frank Lammert, Anna Glantz, Lars‐Åke Mattsson, John C. Whittaker, Malcolm G. Parker, Roger White, Catherine Williamson,
... Results: We identified 4 novel heterozygous FXR variants (−1g>t, M1V, W80R, M173T) in ICP. W80R was ... detected uniquely in 1 British case. M173T and −1g>t occur both in Caucasian cases and controls, ... or activity for 3 of the 4 variants (−1g>t, M1V, M173T). Conclusions: This is the first ... Results: We identified 4 novel heterozygous FXR variants (−1g>t, M1V, W80R, M173T) in ICP. W80R was ... detected uniquely in 1 British case. M173T and −1g>t occur both in Caucasian cases and controls, ... or activity for 3 of the 4 variants (−1g>t, M1V, M173T). Conclusions: This is the first ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2007 - Elsevier BV | Gastroenterology
Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, Masayuki Komada, Sei Saitoh, Elior Peles, Shinichi Ohno,
Protein 4.1G is a membrane skeletal protein found in specific subcellular structures in myelinated Schwann cells and seminiferous tubules. Here, ... that in the mouse sciatic nerve, protein 4.1G colocalized at Schmidt-Lanterman incisures (SLI) and the ... revealed that MPP6 was interacting with protein 4.1G. In contrast to wild-type nerves, in 4.1G knockout mice, MPP6 was found largely in the ... transport. Although the SLI remained in the 4.1G knockout sciatic nerves, as confirmed by E-cadherin immunostaining, their shape was altered in aged 4.1G knockout nerves compared to their shape in wild- ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2011 - Taylor & Francis | Molecular and Cellular Biology
Mortaza Bonyadi, Nikou Fotouhi, Mohsen Esmaeili,
... hearing loss (ARNSHL) all over the world. IVS1+1G>A which is splice site mutation have been ... to assess the significance of this mutation, IVS1+1G>A, to the autosomal recessive non-syndromic genetic ... GJB2. All these patients were screened for IVS1+1G>A by applying PCR-RFLP assay. Among studied ... six patients were detected with only one IVS1+1G>A mutated allele. In these patients, the other ... patient was identified to be homozygous for IVS1+1G>A. Further studies carried out on parents of ... healthy parents (mother) to be homozygous for IVS1+1G>A mutation. By self-report, this person had ...
Tópico(s): Vestibular and auditory disorders
2011 - Elsevier BV | International Journal of Pediatric Otorhinolaryngology
Ruimei Yuan, Xianwei Zhang, Qian Deng, Yuan Wu, Guifang Xiang,
... study aimed to investigate the impact of CYP3A4*1G genetic polymorphism on metabolism of fentanyl in Chinese ... were recruited into this study. Genotyping of CYP3A4*1G was carried out by direct sequencing. The plasma ... 24 h after surgery.The frequency of CYP3A4*1G variant allele was 0.227 (80/352, 95% ... After grouping according to the genotype of CYP3A4*1G, plasma fentanyl concentration in the *1/*1 variant ( ... was significantly lower than that in the *1/*1G group (16.8±9.0 ng/ml, P<0.01) and the *1G/*1G group (28.1±9.5 ng/ml, ...
Tópico(s): Diet and metabolism studies
2011 - Elsevier BV | Clinica Chimica Acta
Zhenlin Zhang, Weibo Xia, Jian He, Zeng Zhang, Yaohua Ke, Hua Yue, Chun Wang, Hao Zhang, Jie‐Mei Gu, Weiwei Hu, Wen‐Zhen Fu, Yun-qiu Hu, Miao Li, Yujuan Liu,
... the acceptor site of intron 1 (c.97−1G>A) in solute carrier organic anion transporter family ... the acceptor site of intron 1 (c.97−1G>A) in solute carrier organic anion transporter family ... the acceptor site of intron 1 (c.97−1G>A) in solute carrier organic anion transporter family ... the acceptor site of intron 1 (c.97−1G>A) in SLCO2A1 (Figure 3A ) of the proband, ... the acceptor site of intron 7 (c.940+1G>A) (Figure 3A). The single-base deletion in ... codon (p.Asn545Thrfs∗15), and the c.940+1G>A mutation is predicted to cause an abnormal ...
Tópico(s): Dermatological and Skeletal Disorders
2011 - Elsevier BV | The American Journal of Human Genetics
Andrew Gibson, Xinrui Li, Jianming Wu, J G Baskin, Chander Raman, Jeffrey C. Edberg, Robert P. Kimberly,
... have shown that FcγRI interacts with protein 4.1G (EPB41L2). Our mutational analyses identified two required 4.1G-interacting regions in the FcγRI CY and one ... site in the C-terminus of protein 4.1G. Herein, we explore mechanism(s) that may regulate the interaction between protein 4.1G and FcγRI CY and influence FcγRI membrane mobility ... show that FcγRI CY interacts with protein 4.1G in vitro and that FcγRI coimmunoprecipitates protein 4.1G in freshly isolated human PBMC. With the use ... we show that FcγRI colocalizes with protein 4.1G in unstimulated U937 cells, in which the FcγRI ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2011 - Oxford University Press | Journal of Leukocyte Biology