Feb. 23, 1877-Feb. 23, 1880
0000 - Gale Group | NCCO AsiaWest
James G. Krueger, Kilian Eyerich, Vijay K. Kuchroo, Christopher T. Ritchlin, María T. Abreu, M. Merle Elloso, Anne M. Fourie, Steven Fakharzadeh, Jonathan P. Sherlock, Ya‐Wen Yang, J. Daniel, Iain B. McInnes,
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated ... arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23–driven diseases, improve upon current approaches to treating ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2024 - Frontiers Media | Frontiers in Immunology
Feb. 23, 1877-Feb. 23, 1880
0000 - Gale Group | NCCO AsiaWest
Tobias Wertheimer, Pascale Zwicky, Lukas Rindlisbacher, Colin Sparano, Marijne Vermeer, Bruno Marcel Silva de Melo, Claudia Haftmann, Tamina Rückert, Aakriti Sethi, Stefanie Schärli, Anna Huber, Florian Ingelfinger, C. Xu, Daehong Kim, Philipp Häne, André Fonseca da Silva, Andreas Muschaweckh, Nicolás Gonzalo Núñez, Sinduya Krishnarajah, Natalie Köhler, Robert Zeiser, Mohamed Oukka, Thomas Korn, Sònia Tugues, Burkhard Becher,
Abstract Interleukin-23 (IL-23) is a proinflammatory cytokine mainly produced by myeloid cells that promotes tumor growth in various preclinical cancer models and correlates with adverse outcomes. However, as to how IL-23 fuels tumor growth is unclear. Here, we found ... macrophages to be the main source of IL-23 in mouse and human tumor microenvironments. Among IL-23-sensing cells, we identified a subset of tumor- ... responsible for the tumor-promoting effect of IL-23. Mechanistically, we found that IL-23 sensing represents ...
Tópico(s): Immunotherapy and Immune Responses
2024 - Nature Portfolio | Nature Immunology
Feb. 23, 1877-Feb. 23, 1880
0000 - Gale Group | NCCO AsiaWest
Londen C. Johnson, An A. Vo, John Clancy, Krista M Myles, Murugesan Pooranachithra, Joseph Aguilera, Max T. Levenson, Chloe Wohlenberg, Andreas Rechtsteiner, James Matthew Ragle, Andrew Chisholm, Jordan D. Ward,
... is subsequently shed. The nuclear hormone receptor NHR-23 (also known as NR1F1) is an important regulator of C. elegans molting. NHR-23 expression oscillates in the epidermal epithelium, and soma-specific NHR-23 depletion causes severe developmental delay and death. Tissue-specific RNAi suggests that nhr-23 acts primarily in seam and hypodermal cells. NHR-23 coordinates the expression of factors involved in molting, ... transport/metabolism and remodeling of the aECM. NHR-23 depletion causes dampened expression of a nas-37 ...
Tópico(s): Spaceflight effects on biology
2023 - The Company of Biologists | Development
Feb. 23, 1877-Feb. 23, 1880 Letter. From David B. Sickels. To Honorable Charles Payson. Bangkok, Siam.
0000 - Gale Group | NCCO AsiaWest
Peng Zhao, Hui Song, Fu‐Tian Gao, Chen Liang, Jianfei Qiu, Jun Jin, Chaolan Pan, Yunyan Tang, Meijun Chen, Yang Pan, Yanmei Li, Lie‐Jun Huang, Jue Yang, Xiao‐Jiang Hao,
... chemically synthesized a derivative of curcumol, named HCL-23, by structural modification and explored its effect on ... MTT and colony formation assays demonstrated that HCL-23 significantly inhibited TNBC cells proliferation. HCL-23 induced G2/M phase cell cycle arrest and ... adhesion, cell migration, apoptosis, and ferroptosis. Furthermore, HCL-23 induced apoptosis via the loss of mitochondrial membrane ... caspase family in TNBC cells. In addition, HCL-23 was verified to trigger ferroptosis through increasing cellular ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2023 - Multidisciplinary Digital Publishing Institute | Molecules
IEEE Xplore
pp 275 a-d [1841 June 23]. Edward Buxton to Buxton, informing him of the death of Sir John Jeremie in Sierra Leone of Port Locco fever on April 23, with a newspaper report of his death. Also ...
1841 - Gale Group | SAS Part 1
Florence Lima, Marie‐Claude Monier‐Faugere, Hanna Mawad, Valentin David, Hartmut H. Malluche,
... loss of kidney function. Fibroblast growth factor (FGF)-23 and sclerostin, both produced by osteocytes, are increased ... impact of decline in kidney function on FGF-23 and sclerostin protein expression in bone and to ... performed on undecalcified bone sections to quantify FGF-23 and sclerostin expression. Bone sections were also evaluated ... histomorphometry for bone turnover, mineralization, and volume.FGF-23 expression in bone correlated positively with CKD stages ( ... starting at CKD-2. No difference in FGF-23 expression was seen between trabecular and cortical bone. ...
Tópico(s): Connective tissue disorders research
2023 - Dustri-Verlag | Clinical Nephrology
Feb. 23, 1877-Feb. 23, 1880 Letter. To Honorable John L. Cadwalader.
0000 - Gale Group | NCCO AsiaWest
Raja Atreya, María T. Abreu, James G. Krueger, Kilian Eyerich, Kacey L. Sachen, C Greving, D Hammaker, P Bao, Elizabeth Lacy, I Sarabia, Janise D. Deming, M. Merle Elloso, Christopher T. Ritchlin, Iain B. McInnes, Matthieu Allez, A Fourie,
... CD64, is of particular interest, as CD64+ IL-23-producing myeloid cells are increased in the inflamed ... Fc regions of GUS and RIS. Methods IL-23 binding affinity of GUS and RIS was compared ... and RIS was measured by impact on IL-23-induced signal transducer and activator of transcription 3 ( ... by toll-like receptor stimulation to induce IL-23 production, binding of GUS and RIS to CD64 and capture of endogenously secreted IL-23 was assessed using flow cytometry. The potential impact ... RIS displayed comparable picomolar binding affinity for IL-23 and equivalent high potency for inhibition of IL- ...
Tópico(s): Eosinophilic Esophagitis
2023 - Oxford University Press | Journal of Crohn s and Colitis
Feb. 23, 1877-Feb. 23, 1880 Letter. From F. W. Partridge.
0000 - Gale Group | NCCO AsiaWest
Aiguo Wang, Chunyu Li, Long Li, Renhai Pu, Zeguang Yang, Zhu Nan, Kai Guo,
... biomarker method using C 20 -C 21 -C 23 tricyclic terpanes (TTs) as a tracer, which is ... analysis of 271 C 20 -C 21 -C 23 TT data from 32 basins in 18 countries, ... a relationship between C 20 -C 21 -C 23 TT abundance patterns and depositional environments. This relationship ... result in different C 20 -C 21 -C 23 TT abundance patterns associated with different depositional environments, ... g., C 20 >C 21 >C 23 TT in river-lake transitional, C 20 <C 21 <C 23 TT in marine or saline lacustrine environments, C ...
Tópico(s): Geological formations and processes
2023 - Frontiers Media | Frontiers in Earth Science
Alexander Street
Feb. 23, 1877-Feb. 23, 1880
0000 - Gale Group | NCCO AsiaWest
Xingchen Zhao, Xueying Xiang, Shucheng Wang, Pengnan Jiang, Ding Gao, Li-Ying Yi, Minde An, Fuli Bai, Weiguang Xu, Jianjun Zhang, Jianxin Hu,
... HCFC-22 plants are obliged to limit HFC-23 emissions. Therefore, the study of cost-effective mitigation pathways for HFC-23 is important for the sustainable implementation of KA ... countries. This study constructed an inventory of HFC-23 by-production, emissions, and abatement for HCFC-22 ... predicted the costs and climate benefits of HFC-23 abatement in China's compliance with the KA between 2021 and 2060. Results showed that HFC-23 emissions from HCFC-22 plants in China contributed ... growth in global atmospheric mole fraction of HFC-23 observed by Advanced Global Atmospheric Gases Experiment (AGAGE) ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2023 - KeAi | Advances in Climate Change Research
Feb. 23, 1877-Feb. 23, 1880 Letter. From F. W. Partridge.
0000 - Gale Group | NCCO AsiaWest
Boyd Steere, Catherine B. Beidler, Andrea Martín‐Nalda, S W Bright, Kristy Kikly, Robert J. Benschop,
Interleukin (IL)-23 exists as a heterodimer consisting of p19 and p40 and is a key cytokine for promoting inflammatory responses in a variety of target organs. IL-23 plays a key role in the differentiation and ... T helper 17 cells, and deregulation of IL-23 can result in autoimmune pathologies of the skin, ... antibody directed against the p19 subunit of IL-23. Miri binds human and cynomolgus monkey IL-23 with high affinity and binds rabbit IL-23 weakly but does not bind to rodent IL-23 or the other IL-23 family members IL- ...
Tópico(s): IL-33, ST2, and ILC Pathways
2023 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Feb. 23, 1877-Feb. 23, 1880
0000 - Gale Group | NCCO AsiaWest
Xiaojing Huang, Haojie Shentu, Yujing He, Haijia Lai, Xu Chen, Mei‐Ling Chen, Haowei Zhu,
... In recent years, the use of interleukin (IL) 23 inhibitors in the treatment of psoriatic arthritis (PsA) ... specifically binding to the p19 subunit of IL-23, IL-23 inhibitors block downstream signaling pathways and inhibit inflammatory ... assess the clinical efficacy and safety of IL-23 inhibitors in the treatment of PsA. PubMed, Web ... controlled trials (RCTs) investigating the use of IL-23 in PsA therapy. The main outcome of interest ... our meta-analysis. We found that the IL-23 inhibitor group showed a significantly higher ACR20 response ...
Tópico(s): Dermatology and Skin Diseases
2023 - Springer Science+Business Media | Immunologic Research