Produção Nacional
Revisado por pares
José Coelho Neto, Ana Flávia Belchior de Andrade, Rogério Araújo Lordeiro, Yuri Machado, Mathieu Elie, E. Ferrari, Luciano C. Arantes,
25I-NBOH is a novel psychoactive substance (NPS) recently reported to have been found on blotter paper samples ... chromatography–mass spectrometry (GC–MS), which can misidentify 25I-NBOH (and indeed the other members of the NBOH ... is often non-standard. While direct detection of 25I-NBOH under routine GC–MS conditions is still achieved, ... the detection of an additional peak due to 25I-NBOH degradation. Consequently, the presence of this secondary early chromatographic peak allowed for the distinction between 25I-NBOH and 2C-I using routine GC–MS without ...
Tópico(s): Psychedelics and Drug Studies
2017 - Springer Science+Business Media | Forensic Toxicology
Produção Nacional
Revisado por pares
Ana Flávia Belchior de Andrade, José González-Rodrı́guez,
25I-NBOH is a new potent serotonin 5-HT2A receptor agonist recently identified in blotter paper seizures. This ... misidentification. In this paper, the voltammetric behavior of 25I-NBOH and 2C-I was investigated and their electroanalytical ... and sensitive electrochemical method for the detection of 25I-NBOH using a SPCE is described and all method ... method is selective and achieves full differentiation between 25I-NBOH, 2C-I and 25I-NBOMe.
Tópico(s): Analytical Chemistry and Chromatography
2019 - Royal Society of Chemistry | The Analyst
Produção Nacional
Revisado por pares
Luciano C. Arantes, E. Ferrari, Luciano Figueiredo de Souza, Andriele Costa Cardoso, Thaynara Lino Fernandes Alcântara, Luciano M. Lião, Yuri Machado, Rogério Araújo Lordeiro, José Coelho Neto, Ana Flávia Belchior de Andrade,
... several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C- ... its being a potent 5-HT2A receptor agonist, 25I-NBOH is neither registered in the United Nations Office ... seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - Springer Science+Business Media | Forensic Toxicology
Line Nielsen, Niels Bjerre Holm, Sebastian Leth‐Petersen, Jesper L. Kristensen, Lars Olsen, Kristían Línnet,
... 2‐(4‐iodo‐2,5dimethoxyphenyl)ethylamino]methyl]phenol (25I‐NBOH) and to characterize the metabolites. The following approaches ... substantiated by an evaluation of 25I‐NBOMe and 25I‐NBOH metabolism in single donor HLM. The metabolism pathways of 25I‐NBOMe and 25I‐NBOH were NADPHdependent with intrinsic clearance values of (CLint) ... identified as CYP3A4 and CYP2D6, respectively. The compound 25I‐NBOH was also liable to direct glucuronidation, which may ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2016 - Wiley | Drug Testing and Analysis
Amy J. Eshleman, Katherine M. Wolfrum, John F. Reed, Sunyoung O. Kim, Robert A. Johnson, Aaron Janowsky,
... 4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol (25I-NBOH); and 2-(2,5-dimethoxy-4-nitrophenyl)-N-( ... HT1A receptor. 25D-NBOMe, 25E-NBOMe, 25H-NBOMe, 25I-NBOH and 25N-NBOMe had very high affinity for, ... HT2A receptor functional assay, 25D-NBOMe, 25E-NBOMe, 25I-NBOH and 25N-NBOMe had subnanomolar to low nanomolar ...
Tópico(s): Forensic Toxicology and Drug Analysis
2018 - Elsevier BV | Biochemical Pharmacology
Produção Nacional
Revisado por pares
Damila Rodrigues de Morais, Ingrid Lopes Barbosa, Kelly Francisco da Cunha, Guilherme L. Tripodi, Célio Fernando Figueiredo Angolini, Marcos Fernando Franco, Elvis Medeiros de Aquino, Marcos N. Eberlin, José Luiz Costa,
... the detection of NPS in blotter papers. For 25I‐NBOH (N‐(2‐hydroxybenzyl)‐2‐(4‐iodo‐2,5‐ ... as an efficient, sensitive, and secure alternative for 25I‐NBOH screening.
Tópico(s): Forensic Toxicology and Drug Analysis
2017 - Wiley | Journal of Mass Spectrometry
Produção Nacional
Revisado por pares
Ana Flávia Belchior de Andrade, Mathieu Elie, Christian Weck, Jorge J. Zacca, Mônica P. Souza, Luíza Nicolau Brandão Caldas, José González-Rodrı́guez,
... for drug analysis. Nevertheless, thermolabile NPS, such as 25I-NBOH can generate artefacts in the traditional GC-MS ... paper, we describe the fragmentation mechanism of the 25I-NBOH into a major peak corresponding to 2C-I ... flow ratio, although with no success to prevent 25I-NBOH thermo degradation in the GC injector. Furthermore, differential scanning calorimetry and thermogravimetric analysis demonstrated that 25I-NBOH's thermal stability is due to a smaller ... perform derivatization experiments and demonstrate how to overcome 25I-NBOH degradation in the GC/MS analysis.
Tópico(s): Advanced Chemical Sensor Technologies
2020 - Elsevier BV | Forensic Science International
April Contreras, Matthew Khumnark, Rochelle M. Hines, Dustin J. Hines,
... the potent and highly selective 5-HT2AR agonist 25I-NBOH in mice, we observe a disorganization of behavior ... an integral component of ritualistic hallucinogen practices, attenuates 25I-NBOH induced HTR and Phase 2 waveforms, yet increases ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2021 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Wellington Alves de Barros, Marina de Magalhães Silva, Maria Dayanne de A. Dantas, Josué Carinhanha Caldas Santos, Isis Martins Figueiredo, Otávio Augusto Chaves, Carlos Maurício R. Sant’Anna, Ângelo de Fátima,
25I-NBOH and 25I-NBOMe simultaneously bind to sites I and II of HSA, which may affect their ...
Tópico(s): Drug Transport and Resistance Mechanisms
2021 - Royal Society of Chemistry | New Journal of Chemistry
Kyung Sik Yoon, Hye Jin, Sun Ok Choi, Jin‐Moo Lee,
... 4-Iodo-2,5-dimethoxyphenyl)ethylamino)methyl)phenol (25I-NBOH) and 2-(((2-(4-chloro-2,5-dimethoxyphenyl) ... the present study, we evaluated the cardiotoxicity of 25I-NBOH and 25C-NBOH using 3-(4,5-dimethylthiazol- ... cardiovascular system. In the MTT assay, treatment with 25I-NBOH or 25C-NBOH dramatically decreased viability of H9c2 ... and RR intervals in the rat ECG measurement. 25I-NBOH down-regulated the PAK1 protein expression in rat ... in H9c2 cells. In an in-depth study, 25I-NBOH inhibited potassium channels in the hERG assay, but ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2021 - Elsevier BV | Toxicology Letters
Produção Nacional
Revisado por pares
Augusto dos Santos Novais, Daiane Gabriela Ribeiro, Larissa M.A. Melo, E. Ferrari, Luciano C. Arantes, Bruno Gabriel Lucca, Edmar Isaías de Melo, Ricardo F. Brocenschi, Wallans Torres Pio dos Santos, Rodrigo Amorim Bezerra da Silva,
... of some seized illicit drugs (MDMA, LSD and 25I-NBOH) using typical working electrodes (gold, glassy carbon and ...
Tópico(s): Electrochemical sensors and biosensors
2023 - Elsevier BV | Sensors and Actuators B Chemical
Produção Nacional
Revisado por pares
Vinícius L. Meira, Adriana Souza de Oliveira, Luciana S.A. Cohen, Cecília de Andrade Bhering, Karen M. de Oliveira, Denilson Soares de Siqueira, Marco Antônio Martins de Oliveira, Francisco Radler de Aquino Neto, Gabriela Vanini,
... were synthetic phenethylamines, i.e., molecules from the 25I-NBOH (2-(((4-iodo-2,5-dimethoxyphenethyl)amino)methyl) ...
Tópico(s): Forensic Fingerprint Detection Methods
2020 - Elsevier BV | Forensic Science International
Produção Nacional
Revisado por pares
Yuri Machado, José Coelho Neto, Rogério Araújo Lordeiro, Rosemeire B. Alves, Evandro Piccin,
... drug market remains dynamic. After the introduction of 25I-NBOH, an N -benzylphenethylamine and new psychoactive substance, as ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2019 - Springer Science+Business Media | Forensic Toxicology
Maren Hermanns‐Clausen, Verena Angerer, Josephine Kithinji, Christina Grumann, Volker Auwärter,
... ng/mL), 2C-I (12 ng/mL) and 25I-NBOH (<1 ng/mL) (LC-ESI-MS/MS). The ...
Tópico(s): Amino Acid Enzymes and Metabolism
2017 - Taylor & Francis | Clinical Toxicology
Produção Nacional
Revisado por pares
Richard Bade, Denice van Herwerden, Nikolaos I. Rousis, Sangeet Adhikari, Darren Allen, Christine Baduel, Lubertus Bijlsma, Tim Boogaerts, Daniel A. Burgard, Andrew Chappell, Erin M. Driver, Fernando F. Sodré, Despo Fatta‐Kassinos, Emma Gracia‐Lor, Elisa Gracia-Marín, Rolf U. Halden, Ester Heath, Emma L. Jaunay, Alex J. Krotulski, Foon Yin Lai, Arndís Sue Ching Löve, Jake O’Brien, Jeong‐Eun Oh, Daniel Pasin, Marco Pineda Castro, Magda Psichoudaki, Noelia Salgueiro‐González, Cezar Silvino Gomes, Bikram Subedi, Kevin V. Thomas, Νikolaos S. Τhomaidis, Degao Wang, Viviane Yargeau, Saer Samanipour, Jochen F. Mueller,
... 2%), 3-chloromethcathinone (4%), mitragynine (6%), phenibut (2%), 25I-NBOH (2%) and trimethoxyamphetamine (2%). The latter three have ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2024 - Elsevier BV | Journal of Hazardous Materials
Produção Nacional
Revisado por pares
Camila Medeiros de Almeida, Fernanda E. Pinto, Nayara Araújo dos Santos, Lindamara M. Souza, Bianca B. Merlo, Christopher J. Thompson, Wanderson Romão,
... to analyze seven blotter papers of NBOMes containing 25I-NBOH (2-({[2-(4-iodo-2,5-dimethoxyphenyl)ethyl] ...
Tópico(s): Psychedelics and Drug Studies
2019 - Elsevier BV | Microchemical Journal
Xue Qin Ng, Asimah Hamzah, Mei Ling Evelyn Goh, Hooi Yan Moy, Yi Ju Yao, Chi Pang Lui,
... 25I-NBOMe, 25H-NBOMe, 25C-NBOH, 25B-NBOH, 25I-NBOH and 25H-NBOH) along with LSD, 2-oxo- ...
Tópico(s): Mass Spectrometry Techniques and Applications
2019 - Taylor & Francis | Australian Journal of Forensic Sciences
D. Gallart-Mateu, Jaume Béjar-Grimalt, Francesc A. Esteve‐Turrillas, Sergio Armenta, Salvador Garrigues, Miguel de la Guárdia,
... evaluated with 11 blotter samples that contained DOC, 25I-NBOH, 25E-NBOH, DOM, and LSD, providing the same ...
Tópico(s): Analytical Chemistry and Chromatography
2022 - Elsevier BV | Microchemical Journal
Hyewon Seo, Hye Hyun Yoo, Jin Tae Hong, Yhun Yhong Sheen,
... NBOMe, 25BNBOMe, 25E-NBOMe, 25N-NBOMe, 25C-NBOH, 25I-NBOH, 25B-NBF, 25C-NBF, and 25I-NBF) in ...
Tópico(s): Forensic Toxicology and Drug Analysis
2019 - Korean Society for Mass Spectrometry | Mass spectrometry letters
I. Ezquiaga, M. Grifell, Liliana Galindo, Leticia Martínez, Á. Palma, P. Quintana, Mireia Ventura, Enriqueta Pujol‐Ribera, Lynette M. Pujol, I. Fornís, Marta Torrens, Magı́ Farré,
... 4 as 25C-NBOMe (7.1%), 4 as 25I-NBOH (7.1%) and 12 as other substances (21. ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2016 - Cambridge University Press | European Psychiatry
Logan D. Hickey, Kymeri Davis, Vicky Pai, Mikela Greer, John V. Goodpaster,
... as amphetamine, ephedrine, methamphetamine, 2C-I, 25I-NBOMe, 25I-NBOH, and gamma-hydroxybutyric acid (GHB) were analyzed in ...
Tópico(s): Analytical chemistry methods development
2021 - RELX Group (Netherlands) | SSRN Electronic Journal
Daaniyal D. Munir, Ritu A. Shetty, Michael B. Gatch, Nathalie Sumien, Rebecca Hill, Jeanne A. Priddy, Michael J. Forster,
... compounds, 25B-NBOH, 25C-NBOH, 25E-NBOH, and 25I-NBOH were evaluated for their ability to modify spontaneous ... fully substituted (≥80%) in DOM-trained rats, whereas 25I-NBOH failed to fully substitute for DOM even at ... to DOM and the 25X-NBOMe compounds, whereas 25I-NBOH may be less liable to illicit use.
Tópico(s): Nicotinic Acetylcholine Receptors Study
2024 - Lippincott Williams & Wilkins | Behavioural Pharmacology
John Logie, E. Hoehn, B. B. Chubey,
... 4-iodo-2,5-dimethoxyphenethyl)amino)methyl)phenol (25I-NBOH); and 2-(2,5-dimethoxy-4-nitrophenyl)-N-( ... HT1A receptor. 25D-NBOMe, 25E-NBOMe, 25H-NBOMe, 25I-NBOH and 25N-NBOMe had very high affinity for, ... HT2A receptor functional assay, 25D-NBOMe, 25E-NBOMe, 25I-NBOH and 25N-NBOMe had subnanomolar to low nanomolar ...
Tópico(s): Forensic Toxicology and Drug Analysis
1981 - Elsevier BV | Canadian Institute of Food Science and Technology Journal
Nicolas Fabresse, Olivia Bosc, Anne-Laure Pélissier, Jenny Becam, Caroline Solas,
... after the consumption of a powder identified as 25I-NBOH. The way of exposure was not documented. On ... concentration was 0.4 ng/mL in urine. 25I-NBOH was specifically searched in both samples and was ...
Tópico(s): Genetic Neurodegenerative Diseases
2022 - Elsevier BV | Annales de Toxicologie Analytique
Kennedy R. Wiens, Nicole Brooks, Ishvin Riar, Bridget K. Greuel, Ivan A. Lindhout, Andis Klegeris,
... that of two selective 5-HT2R agonists, namely, 25I-NBOH and Ro60-0175. The role of this subfamily ...
Tópico(s): Chemical synthesis and alkaloids
2024 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Estefany Santos Cordovil, Pablo Abdon Francez,
... não realizar a identificação correta, em virtude de 25I-NBOH ser uma molécula termolábil e necessita de uma ...
Tópico(s): Youth, Drugs, and Violence
2024 - Associação Brasileira de Criminalística | Revista Brasileira de Criminalística
Daniel Gallart Mateu, Jaume Béjar-Grimalt, Francesc A. Esteve‐Turrillas, Sergio Armenta, Salvador Garrigues, Miguel de la Guárdia,
... evaluated with 11 blotter samples that contained DOC, 25I-NBOH, 25E-NBOH, DOM, and LSD, providing the same ...
Tópico(s): Forensic and Genetic Research
2022 - RELX Group (Netherlands) | SSRN Electronic Journal
... involved in the metabolism of 25I-NBOMe and 25I-NBOH. Drug Test. Anal. 9(5), 671–679 (2017). ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2018 - Future Science Ltd | Bioanalysis