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Frontmatter: Health Tract. No. 279. Essay: Madness, Cleanliness and Character, Passing Away, Health Hodge Podge, The Tomatoe, Subscribers, Vital Capacity, The Last Hope, Army Disease ...

1867 - Gale Group | NCCO-STM 1of2

Artigo Acesso aberto Revisado por pares

Xixi Li, S. Jack Hu, Hongbo Zhang, Haitao Yin, Huan Wang, Dan Zhou, Yan Sun, Lei Ma, Bo Shen, Changliang Zhu,

... In this study, the functions of microRNA (miR)-279-3p and its target CYP325BB1 in the regulation ... used to detect the expression levels of miR-279-3p and CYP325BB1. Then, the dual-luciferase reporter ... and in vitro.The expression patterns of miR-279-3p and CYP325BB1 were compared between deltamethrin-sensitive ( ... strain) mosquitoes. Luciferase activity was downregulated by miR-279-3p, the effect of which was ablated by ... In DR-strain mosquitoes, the expression of miR-279-3p was increased by microinjection and oral feeding ...

Tópico(s): Malaria Research and Control

2021 - BioMed Central | Parasites & Vectors

Documentos governamentais Acesso aberto

I.J.S. Finden,

... had mentioned in a previous letter (see p 279) would be a philanthropic venture even though he ...

1838 - Gale Group | SAS Part 1

Artigo Acesso aberto Revisado por pares

Gaihong Zhao, Tingting Li, Xuemin Liu, Taoqing Zhang, Zhaoxia Zhang, Kang Li, Jie Song, Shijun Zhou, Xin Chen, Xiao Wang, Jiangnan Li, Li Huang, Changyao Li, Zhigao Bu, Jun Zheng, Changjiang Weng,

... 107). Interestingly, unlike the effect of GSDMD-N1–279 fragment produced by caspase-1-mediated cleavage, the ... 107). Interestingly, unlike the effect of GSDMD-N1–279 fragment produced by caspase-1-mediated cleavage, the ... GSDMD-N1–107). Mechanistically, unlike the GSDMD-N1–279 produced by caspase-1, the GSDMD-N1–107 ... constructed two other plasmids expressing swine GSDMD-N1–279 and GSDMD-C280–488 that mimic the cleavage ... addition, we constructed a plasmid expressing GSDMD-C108–279, a cleavage product of GSDMD by ASFV S273R ...

Tópico(s): Vector-Borne Animal Diseases

2021 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Vladimiro L. Vida, Alvise Guariento,

... of patients with scimitar syndrome undergoing surgery (n = 279)Mean ± SEM or nDemographics Male patients109/279 (39%) Age at surgery, mo10.2 ± 0.9 ... of age at diagnosis 1 y; 10 y59/279 (21%)Characteristics Symptoms at diagnosis210/279 (76%)Cardiac symptoms at diagnosis147/279 (53%)Respiratory symptoms at diagnosis142/279 (51%) Need for medications at diagnosis48/279 (17%) Pulmonary hypertension at diagnosis105/279 (38%) mPAP at diagnosis, mm Hg29.2 ± 0.1 Associated CHDs194/279 (69%)Atrial septal defect168/279 (60%)Complex CHDs63/ ...

Tópico(s): Congenital Heart Disease Studies

2020 - Elsevier BV | JTCVS Techniques

Carta Acesso aberto Brasil Produção Nacional Revisado por pares

Ruffo Freitas‐Júnior, Leonardo Ribeiro Soares, Carlos H. Barrios,

... individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). ... individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). ... individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). ... individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). ... individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2). ...

Tópico(s): Cancer Risks and Factors

2015 - Elsevier BV | The Lancet

Livro

Alexander Street

Artigo Acesso aberto Revisado por pares

Kailiang Sun, David Jee, Luis F. de Navas, Hong Duan, Eric C. Lai,

... physiology. A particularly compelling locus is Drosophila mir-279, which was reported as essential to restrict the ... The mir-996 locus is located near mir-279 and bears a similar seed, but they otherwise ... single and double deletion mutants of the mir-279 and mir-996 hairpins, and cursory analysis suggested ... However, discrepancies in the strength of individual mir-279 deletion alleles led us to uncover that all extant mir-279 mutants are deficient for mature miR-996, even ... deletion background, allowing a pure assessment of miR-279 and miR-996 requirements. Surprisingly, detailed analyses of ...

Tópico(s): Genetics, Aging, and Longevity in Model Organisms

2015 - Public Library of Science | PLoS Genetics

Carta Acesso aberto Revisado por pares

Hu Zhu, Bryan L. Roth,

... 808Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar determine that the chemogenetic silencer hM4Di- ... 808Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar determine that the chemogenetic silencer hM4Di- ... 808Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar, who via clever modifications of the ... 808Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar confirm that hM4Di activation leads to ... 808Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar chose a well-characterized and popular ...

Tópico(s): Neuroscience and Neuropharmacology Research

2014 - Cell Press | Neuron

Artigo Acesso aberto Revisado por pares

Said Rahim, Tsion Z. Minas, Sung-Hyeok Hong, Sarah Justvig, Haydar Çelik, Yasemin Saygıdeğer, Jenny Han, Abraham T. Kallarakal, Yali Kong, Michelle A. Rudek, Milton L. Brown, Bhaskar Kallakury, Jeffrey A. Toretsky, Aykut Üren,

... recently demonstrated that the small molecule YK-4-279 inhibits biological activity of ETV1 in fusion-positive ... C6 tumors. Animals were treated with YK-4-279, and its effects on primary tumor growth and lung metastasis were evaluated. YK-4-279 treatment resulted in decreased growth of the primary ... tumors were grown to comparable sizes, YK-4-279 inhibited tumor metastasis to the lungs. Expression of ... FKBP10 and GLYATL2 were reduced in YK-4-279 treated animals. ETS fusion-negative PC-3M-luc- ... were unresponsive to the compound. Furthermore, YK-4-279 is a chiral molecule that exists as a ...

Tópico(s): Cancer-related gene regulation

2014 - Public Library of Science | PLoS ONE

Artigo Revisado por pares

Jean‐Pierre Lin, Daniel E. Lumsden, Hortensia Gimeno, Marta Kamińska,

... assessable children, 15/294 had pure spasticity, leaving 279/294 with dystonia classified as primary (30/279: 10.7%); primary-plus (19/279: 6.8%) and secondary (230/279: 82.4%) dystonia, including heredodegenerative dystonia (29/279: 10.3%); 150/279 (53.7%) with cerebral palsy and 51/279 (18.2%) acquired brain injury. Definitive diagnoses were ... heredodegenerative and secondary-static dystonias respectively. Only 91/279 (32.6%) experienced a period of normal motor development. Carers perceived dystonia deterioration in 168/279 (60.2%), stabilisation in 88/279 (31.5%) ...

Tópico(s): Neurological disorders and treatments

2014 - BMJ | Journal of Neurology Neurosurgery & Psychiatry

Artigo Revisado por pares

Siwoo Cho, Sangmin Lee, Seonghee Jeong, Yeongae Kim, Song Cheol Kim, Woonbong Hwang, Jaesung Park,

... Pohang, Gyoengbuk, Republic of Korea. Fax: +82-54-279-5899; Tel: +82-54-279-5418 Search for other works by this author ... Pohang, Gyoengbuk, Republic of Korea. Fax: +82-54-279-5899; Tel: +82-54-279-5418 Search for other works by this author ... Pohang, Gyoengbuk, Republic of Korea. Fax: +82-54-279-5899; Tel: +82-54-279-5418 Search for other works by this author ... Pohang, Gyoengbuk, Republic of Korea. Fax: +82-54-279-5899; Tel: +82-54-279-5418 Search for other works by this author ... Pohang, Gyoengbuk, Republic of Korea. Fax: +82-54-279-5899; Tel: +82-54-279-5418School of Interdisciplinary ...

Tópico(s): Adenosine and Purinergic Signaling

2013 - Oxford University Press | Integrative Biology

Artigo Acesso aberto Revisado por pares

Said Rahim, Elspeth M. Beauchamp, Yali Kong, Milton L. Brown, Jeffrey A. Toretsky, Aykut Üren,

... We recently reported the development of YK-4-279, a small molecule inhibitor of EWS-FLI1 oncoprotein ... FLI1, we tested the ability of YK-4-279 to inhibit biological functions of ERG and ETV1 proteins in prostate cancer. YK-4-279 inhibited ERG and ETV1 mediated transcriptional activity in a luciferase assay. YK-4-279 also decreased ERG and ETV1 downstream target mRNA ... and ERG fusion positive VCaP cells. YK-4-279 reduced the motility of LNCaP cells in a ... negative PC3 cells were unresponsive to YK-4-279. SiRNA mediated ERG knockdown in VCaP cells resulted ...

Tópico(s): Ubiquitin and proteasome pathways

2011 - Public Library of Science | PLoS ONE