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Revisão Acesso aberto Revisado por pares

Geraldine Zimmer‐Bensch, Hans Zempel,

Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults. All tauopathies share ectopic expression, mislocalization, or aggregation of the microtubule associated protein TAU, encoded by the MAPT gene. As TAU is a neuronal protein widely expressed in the CNS, the overwhelming majority of tauopathies are neurological disorders. They are characterized ...

Tópico(s): Dementia and Cognitive Impairment Research

2021 - Multidisciplinary Digital Publishing Institute | Cells

Capítulo de livro

Timothy R. Lezon, Indira H. Shrivastava, Zheng Yang, İvet Bahar,

... Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, ... Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, ... Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, ... Biology, School of Medicine, University of Pittsburgh, Suite 3064, Biomedical Science Tower 3, 3051 Fifth Ave., Pittsburgh, ... with Coarse-Grained Alchemical MethodsHuanghao Mai, Matthew H. Zimmer and Thomas F. Miller6 January 2023 | The Journal ...

Tópico(s): Gene Regulatory Network Analysis

2009 - World Scientific | World Scientific lecture notes in complex systems

Artigo Revisado por pares

Demyan E. Prokopchuk, Jessica F. Sonnenberg, Nils Meyer, Marco Zimmer-De Iuliis, Alan J. Lough, Robert H. Morris,

The reaction of the iron complex trans-[Fe(CO)(MeCN)(PPh2C6H4CH═NCH2−)2-κ4P,N,N,P](BF4)2 (1) with KOiPr in benzene produced the unusual complex [Fe(CO)(PPh2C6H4CH═NCH2CH2NHCHC6H4PPh2)-κ5P,N,C,N,P][BF4] (2), which has been characterized by spectroscopy and by single-crystal X-ray diffraction. The C–N bond length in this complex indicates that it is best viewed as an iron(II) ligand-folded ferraaziridine-κ2C,N complex instead of an iron(0) η2-iminium complex. Density functional theory (DFT) calculations ...

Tópico(s): Synthesis and Catalytic Reactions

2012 - American Chemical Society | Organometallics

Artigo Revisado por pares

R. Böhme, K. Zimmer,

The determination of materials erosion thresholds is of key importance for laser micromachining processes themselves and their applications. At laser-induced backside wet etching (LIBWE) of fused silica with organic liquid toluene employing an excimer laser (λ = 248 nm, τp = 25 ns), the threshold fluence is reduced from 1.10 J cm−2 to 0.22 J cm−2 with an increasing number of pulses from a single pulse to an almost infinite quantity, respectively. A similar effect is observed with an increasing laser spot ...

Tópico(s): Laser-induced spectroscopy and plasma

2007 - Institute of Physics | Journal of Physics D Applied Physics

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Gonzalo Sepúlveda-Hermosilla, Matías Freire, Alejandro Blanco, Javier F. Cáceres, Rodrigo Lizana, Liliana Ramos, Rodrigo Assar, Diego Ampuero, Osvaldo Rudy Aren, Sara Chernilo, M. Loreto Spencer, Giuliano Bernal, Jacqueline Flores, Germán Rasse, Carolina Sánchez‐Rodríguez, Katherine Marcelain, Solange Rivas, Gabriela P. Branco, María Galli de Amorim, Diana Noronha Nunes, Emmanuel Dias‐Neto, H. Freitas, Cristina Fernández, Paola Pérez, Ricardo Armisén, Luiz H. Araujo, Luís A. Pires, Nils Gunnar Skare, Gustavo Girotto, Manuela Zereu, H. Freitas, Hakaru Tadokoro, Ana Caroline Zimmer Gelatti, Jose Fernando Moura, Clarissa Mathias, Pedro R. de Marchi, Fernando Silva, Mayler Olombrada Nunes de Santos, Marianna Deway Andrade Dracoulakis, Renata Pinho Costa, Luciana Castro, Paulo Guilherme de Oliveira Salles, Clodoaldo Zago Campos, M Livia, Sara Chernilo, Osvaldo Arén Frontera, Eduardo Yañez Ruiz, Mónica Ahumada Olea, Giuliano Bernal, M. Loreto Spencer, Alejandro Ortega Vasquez, Germán Rasse, Juan Bertoglio, Jose David Zorrilla Silvera, Hernan Moron Escobar, Luis Riva Gonzalez, Luis López, José Luis Fernando Hurtado De Mendoza Acurio, G Mendoza, Alfredo Aguilar, Gerardo Campos Siccha, Ricardo Sanchez Sevillano, Cristina Fernández, Sylvia Chandía, Pablo Araos, Ana Mejías, Francisca Angulo, Carolina Sánchez‐Rodríguez, Jessica Troncoso, D. Jara, Marcela Astete, María Jesús Galleguillos, Emmanuel Dias‐Neto, H. Freitas, María Galli de Amorim, Diana Noronha Nunes, Gabriela P. Branco, Marina Eloi, Melissa Pool Pizzi, Jordana Silva, Thais Fernanda Bartelli, Katherine Marcelain, Jessica Toro, Luciana Oliveira-Cruz, Daniela Diez, Solange Rivas,

... standard-of-care testing results on adenocarcinomas (n = 3064) Positive1334.3 Negative293195.7 Chile (n = 1636)Positive654Negative157196 ...

Tópico(s): Genetic factors in colorectal cancer

2021 - Elsevier BV | Journal of Molecular Diagnostics

Artigo Acesso aberto Revisado por pares

Jasvinder A. Singh, Bella Mehta, Serene Z. Mirza, Mark P. Figgie, Peter K. Sculco, Michael L. Parks, Susan M. Goodman,

... None declared, Michael Parks Grant/research support from: Zimmer Biomet, Employee of: Zimmer Biomet, Susan Goodman Grant/research support from: Novartis: ...

Tópico(s): Bone and Joint Diseases

2019 - BMJ | Annals of the Rheumatic Diseases