1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Shilpi Goenka, Sanford R. Simon,
CMT-308 is a nonantimicrobial chemically-modified tetracycline (CMT), which we have previously shown exhibits antifungal activity and pleiotropic ... on its chemical structure, we hypothesized that CMT-308 could inhibit melanogenesis and might be a candidate ... to unregulated melanin biosynthesis and/or transport. CMT-308 was first studied for any effects on activity ... least squares fitting. Next, the effects of CMT-308 were tested in mammalian cell cultures using B16F10 ... Our results showed that micromolar concentrations of CMT-308 inhibited mushroom tyrosinase enzyme activity, using the first ...
Tópico(s): Skin Protection and Aging
2020 - Multidisciplinary Digital Publishing Institute | Biomedicines
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
IEEE Xplore
Yasutaka Murahashi, Fumiko Yano, Ryota Chijimatsu, Hideki Nakamoto, Yuji Maenohara, Masahiro Amakawa, Yoshihide Miyake, Hiroyuki Yamanaka, Kousuke Iba, Toshihiko Yamashita, Sakae Tanaka, Taku Saito,
... examined the efficacy of oral administration of KAG-308, an EP 4 -selective agonist, in surgically induced ... and synovitis were significantly inhibited by the KAG-308 treatment. Chondrocyte hypertrophy and expression of tumor necrosis ... in the synovium were suppressed in the KAG-308-treated mice. In cultured chondrocytes, hypertrophic differentiation was inhibited by KAG-308 and intranuclear translocation of histone deacetylase 4 (Hdac4) ... TNF and Mmp13 was also suppressed by KAG-308. KAG-308 was detected in the synovium and ...
Tópico(s): NF-κB Signaling Pathways
2019 - Nature Portfolio | Scientific Reports
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Nileeka Balasuriya, Maya T. Kunkel, Xuguang Liu, Kyle K. Biggar, Shawn S.‐C. Li, Alexandra C. Newton, Patrick O’Donoghue,
... to Akt phosphorylation at two regulatory sites (Thr-308 and Ser-473), acutely activating Akt signaling. Delineating ... an increase attributable primarily to phosphorylation at Thr-308. Live imaging of COS-7 cells confirmed that phosphorylation of Thr-308, but not Ser-473, is required for cellular ... in vitro and in the cell that pThr-308 function cannot be mimicked with acidic residues, nor could unphosphorylated Thr-308 be mimicked by an Ala mutation. An Akt1 variant with pSer-308 achieved only partial enzymatic and cellular signaling activity, ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2018 - Elsevier BV | Journal of Biological Chemistry
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Kyung‐A Shin, Ki Deok Park, Jaeki Ahn, Yongbum Park, Young Joo Kim,
... who participated in a marathon, 100 km-, or 308 km ultramarathon, 15 athletes with similar physical and ... 0.05) and were significantly higher after the 308 km race than the marathon or 100 km ... 05). Total protein was significantly lower after the 308 km race than the marathon or 100 km ... after the marathon but significantly decreased after the 308 km course (P <0.05). Total and direct ... were significantly increased after the 100 km and 308 km races (P <0.05), and were significantly higher after the 308 km than the marathon or 100 km course ( ...
Tópico(s): Cardiovascular and exercise physiology
2016 - Wolters Kluwer | Medicine
1883, Domestic Various: Volume 308:203 Letter. Admiralty.
0000 - Gale Group | NCCO AsiaWest
Kyung‐Wan Nam, Eun-Sol Ha, Jeong-Soo Kim, Do-Hoon Kuk, Dong-Hyeon Ha, Min‐Soo Kim, Cheong‐Weon Cho, Sung‐Joo Hwang,
... analysed across the temperature range of 288.15–308.15 K under atmospheric pressure by using a ... fraction solubility of 3.08 × 10−3 at 308.15 K was observed for tetrahydrofuran, followed by acetone (1.82 × 10−3 at 308.15 K), acetonitrile (1.22 × 10−3 at 308.15 K), methanol (1.11 × 10−3 at 308.15 K), ethanol (6.17 × 10−4 at 308.15 K), 1-butanol (6.17 × 10−4 at 308.15 K), 1-propanol (6.16 × 10−4 at 308.15 K), and 2-propanol (4.13 × 10−4 at 308.15 K). The experimental solubility in all solvents ...
Tópico(s): Chemical and Physical Properties in Aqueous Solutions
2016 - Elsevier BV | The Journal of Chemical Thermodynamics
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Afrose Liaquat, Gul Zareen Asifa, Asyia Zeenat, Qamar Javed,
... to evaluate the association of the TNF-α −308 G/A and IL-6 −174 G/C ... restriction fragment length polymorphism.RESULTS: The TNF-α −308 variant genotypes GA and AA were more prevalent ... group. The IDCM cases bearing the TNF-α−308 and IL-6 variant genotypes revealed elevated levels ... corresponding controls (P<.05).CONCLUSION: The TNF-α −308 G/A and IL-6 −174 G/C ... In the present study, we investigated TNF-α −308 G/A and IL-6 −174 G/C ... IDCM cases. We hypothesize that the TNF-α −308 G/A and IL-6 −174 G/C ... manufacturer's recommendations.Genotyping of the TNF-α−308 G/A polymorphismPolymorphism in the promoter region at ...
Tópico(s): Cardiomyopathy and Myosin Studies
2014 - King Faisal Specialist Hospital and Research Centre | Annals of Saudi Medicine
1883, Domestic Various: Volume 308:203 Letter.
0000 - Gale Group | NCCO AsiaWest
OECD iLibrary
Yan Sun, Yan Wu, Bihuan Xiao, Lu Li, Li Li, Hong‐Duo Chen, Xing‐Hua Gao,
... solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy ... Objective: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo. Methods: Randomized controlled ... were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB- ... or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB ...
Tópico(s): Acne and Rosacea Treatments and Effects
2014 - Informa | Journal of Dermatological Treatment
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
OECD iLibrary
Qiong Shi, Kai Li, Jun Fu, Yanchun Wang, Cuiling Ma, Qiang Li, Chunying Li, Tianwen Gao,
... benefits of excimer phototherapy (e.g., using the 308‐nm excimer laser or the 308‐nm excimer lamp) for the treatment of vitiligo. Aim To compare the effectiveness of the 308‐nm excimer laser with the 308‐nm excimer lamp in the treatment of vitiligo ... this study. One lesion was treated with the 308‐nm excimer laser, and its counterpart was treated with the 308‐nm excimer lamp. Lesions were treated three times ... similar results in terms of repigmentation. Conclusions The 308‐nm excimer lamp and the 308‐nm excimer ...
Tópico(s): Skin Protection and Aging
2013 - Wiley | Photodermatology Photoimmunology & Photomedicine
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Daniel H. Celik, Francis Mencl, Anthony M. DeAngelis, Joshua Wilde, Sheila Steer, Scott T. Wilber, Jennifer A. Frey, Mary Colleen Bhalla,
... confidence intervals (CIs) ± 10%.We analyzed data from 308 patients. Most patients (241/308, 78%, CI 73%-83%) arrived by EMS, were male (203/308, 66%, CI 60%-71%), and were white (286/308, 93%, CI 89%-96%). Patients arriving by EMS ... most common chief complaint was chest pain (278/308, 90%, CI 86%-93%). Inferior STEMIs were most common (167/308, 54%, CI 49%-60%), followed by anterior (127/308, 41%, CI 48%-60%), lateral (8/308, 3%, CI 1%-5%), and posterior (6/308, 2%, CI 1%-4%). A day-of-the- ... most common for STEMI presentation. Forty percent (122/308, 40%, CI 34%-45%) of patients presented during ...
Tópico(s): Trauma and Emergency Care Studies
2013 - Taylor & Francis | Prehospital Emergency Care
1883, Domestic Various: Volume 308:203
0000 - Gale Group | NCCO AsiaWest
Yafei Guo, Yuanhui Liu, Wang Qin, Chenxiao Lin, Shiqiang Wang, Tianlong Deng,
... ternary system (Na2SO4 + Li2SO4 + H2O) at (288 and 308) K were determined using the isothermal dissolution method. ... results of the ternary system at (288 and 308) K, the phase diagrams and the diagrams of ... composition were plotted. In the ternary system at 308 K, four crystallization regions corresponding to thenardite (Na2SO4, ... either temperature. When the experimental phase diagram at 308 K was compared with that at 288 K, ... with the increase of temperature from (288 to 308) K and (2) the area of the crystallization ...
Tópico(s): Crystallization and Solubility Studies
2013 - American Chemical Society | Journal of Chemical & Engineering Data