AbstractCauses of fetal ascites are reviewed, and 3 new cases are reported. A protocol is suggested for intrauterine investigation of the spectrum of diseases causing fetal ascites. There is some overlap with causes of hydrops fetalis.Key Words: asciteshydropsfetal diseasesabnormalities
Tópico(s): Genetic and Kidney Cyst Diseases
1985 - Taylor & Francis | Pediatric Pathology
Sarah Jayne Boulton, Alasdair Anderson, Helen Swalwell, J. R. Henderson, Philip Manning, Mark A. Birch‐Machin,
During investigation of UVA-induced oxidative stress in HaCaT keratinocytes with dihydrorhodamine 123 (DHR123) and 2′,7′-dichlorodihydrofluorescein diacetate (DCF-DA), exaggerated baseline values were observed within control samples, suggesting a mechanism of probe oxidation and subsequent change in fluorescence intensity (FI) independent of cellular ROS generation. The effects of diluent, UVA pre-treatment and loading protocols upon the FI of the probes have therefore been investigated. The study ...
Tópico(s): bioluminescence and chemiluminescence research
2010 - Taylor & Francis | Free Radical Research
N. Chavda, Ian Mackie, John B. Porter, Paul Harrison, K.G. Patterson, Samuel J. Machin,
Young or reticulated platelets contain some residual mRNA, which is rapidly degraded after platelet release into the circulation. In order to minimize platelet activation and possible loss of large platelets during sample handling a whole blood method has been developed utilising the RNA fluorochrome thiazole orange (TO) in combination with an antibody to anti-glycoprotein Ib (GpIb) directly conjugated to phycoerythrin (PE), to specifically stain reticulated platelets via flow cytometric analysis. ...
Tópico(s): Blood groups and transfusion
1996 - Informa | Platelets
Assessment serves as an important motivation for learning. However, multiple choice and short answer question formats are often considered unsatisfactory for assessment of medical humanities, and the social and behavioural sciences. Little consensus exists as to what might constitute 'best' assessment practice. What we did: We designed an assessment format closely aligned to the curricular approach of problem-based learning which allows for greater assessment of students' understanding, depth of ...
Tópico(s): Empathy and Medical Education
2015 - Taylor & Francis | Medical Teacher
John F. Anderson, Steven M. Kent, Geoffrey A. Machin,
Histologic detection of micrometastatic melanoma in the placenta led to the clinical diagnosis in the mother. Metastases were present in the intervillous space and in villous stroma. The infant has survived and has no evidence of disease at one year of age. The mother died of metastatic disease 6 months postpartum. Literature review shows that only 25% of infants with placental metastatic melanoma succumb to the disease. In a review series of 16 cases, there are some maternal clinical factors which ...
Tópico(s): Cutaneous Melanoma Detection and Management
1989 - Taylor & Francis | Pediatric Pathology
E. F. J. Ring, H C McEvoy, Anna Jung, Janusz Żuber, G. Machin,
Significant changes in recording of human body temperature have been taking place worldwide in recent years. The clinical thermometer introduced in the mid-19th century by Wunderlich has been replaced by digital thermometers or radiometer devices for recording tympanic membrane temperature. More recently the use of infrared thermal imaging for fever screening has become more widespread following the SARS infection, and particularly during the pandemic H1N1 outbreak. Important new standards that ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2010 - Taylor & Francis | Journal of Medical Engineering & Technology
Jenny Wigram, George Lewith, David Machin, J Church,
AbstractThirty-four patients undergoing upper abdominal surgery were entered into a randomised, controlled trial of electroacupuncture of the ear to alleviate postoperative pain. Nineteen patients received electroacupuncture and papaveretum on demand and 15 patients received papaveretum only. Patients estimated pain using a visual analogue scale every 8h for the 2 post-operative days. They also completed a questionnaire on pain recall towards the end of the post-operative week.The electroacupuncture ...
Tópico(s): Complementary and Alternative Medicine Studies
1986 - Taylor & Francis | Physiotherapy Practice
J. W. Hand, David Machin, C. C. Vernon, Jill B. Whaley,
AbstractAn analysis of 351 HT treatment sessions administered to 101 patients receiving radiotherapy and hyperthermia (RT + HT) who were entered into Phase III concurrent randomized trials for recurrent (BrR) and intact (BrI) breast tumours is presented. A complete response (CR) was recorded in 50 of 84 (595%) fields in the case of recurrent breast patients and in 10 of 17 (59%) fields in the case of the intact breast patients. In comparison, 15 of 60 (25%) patients entered into BrR who received RT alone ...
Tópico(s): Infrared Thermography in Medicine
1997 - Taylor & Francis | International Journal of Hyperthermia
Geoffrey A. Machin, Louis H. Honoré, E A Fanning, Marion G. Molesky,
Perinatally acquired neonatal tuberculosis occurs rarely, is difficult to diagnose, may be the indicator of untreated tuberculosis in the mother, and could result in nosocomial transmission to neonatal patients, visitors to neonatal intensive care units, and health care workers. The disease may be more common in certain ethnic and social groups. Neonatal mortality approaches 30%. We report two cases with different outcomes. A neonate was treated for clinical miliary tuberculosis and survived; Mycobacterium ...
Tópico(s): Infectious Diseases and Tuberculosis
1992 - Taylor & Francis | Pediatric Pathology
Francis J. Giles, Cathy C. Anderson, Ian R. Grant, A. V. Hoffbrand, Atul Mehta, S. J. Machin, Anthony H. Goldstone,
Recombinant alpha 2a, 2b and 2c interferons have been shown to be effective short-term agents in essential thrombocythaemia and thrombocythaemia associated with the other myeloproliferative disorders, including chronic granulocytic leukaemia, polycythaemia rubra vera and myelofibrosis. Few data exist on the use of the recombinant interferons as maintenance agents in patients with thrombocythaemia. We report on a cohort of 22 previously untreated patients, with essential thrombocythaemia, treated ...
Tópico(s): Chronic Myeloid Leukemia Treatments
1990 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Geoffrey A. Machin, Steven M. Kent,
A female infant with an extensive congenital hemangioma of the left knee region was treated medically for consumption coagulopathy; the hemangioma began to shrink, the coagulopathy improved, and the infant was clinically well when she died suddenly at the age of 4 weeks. The cause of death was a saddle pulmonary ihromboembolus which had originated in the hemangioma. This is the first documented case of fatal thromboembolism complicating a conservatively managed extensive neonatal hemangioma. Causes ...
Tópico(s): Parvovirus B19 Infection Studies
1989 - Taylor & Francis | Pediatric Pathology
Shoumo Bhattacharya, S. J. Machin, Avijit Lahiri,
The murine monoclonal antibody 7E3 blocks the platelet glycoprotein IIb/IIIa receptor, and is a potent inhibitor of platelet function in both animals and man. Animal models of the acute coronary syndromes suggest that 7E3 abolishes the in vivo formation of platelet thrombi, accelerates thrombolysis with tissue plasminogen activator, and prevents subsequent reocclusion. Human studies with 7E3 suggest that complete inhibition of platelet function may be safely undertaken for periods of up to 36 h, ...
Tópico(s): Acute Myocardial Infarction Research
1992 - Informa | Platelets
In 272 consecutive neonatal autopsies in one institution, 70 patients had had intercostal drainage tubes inserted to treat air leak secondary to pulmonary disease. In 9 of these cases, one or more chest tubes penetrated lung parenchyma. The majority of these occurred in infants less than 36 weeks' gestation with hyaline membrane disease and its sequelae. Laceration of lung parenchyma most commonly occurred when tubes were inserted on the left side at 5 days or later and when multiple tubes were ...
Tópico(s): Trauma Management and Diagnosis
1984 - Taylor & Francis | Pediatric Pathology
Anna Chiumento, Atıf Rahman, Laura Machin, Lucy Frith,
Given increasing globalisation, the continuing prevalence of emergencies, and the importance of rigorous research to ensure the mental health needs of populations exposed to emergencies are effectively met, cross-language research will continue to arise. Drawing upon the lead author’s experience of conducting a cross-language qualitative study in three post-conflict settings in South Asia, this article discusses methodological considerations raised when interviewing with interpreters. These include ...
Tópico(s): Qualitative Research Methods and Ethics
2017 - SAGE Publishing | Qualitative Research
Gordon S. Crabtree, Geoffrey A. Machin, J. M. E. Martin, S F Nicholson, Carl Nimrod,
AbstractTwo fetuses are described in whom deformation was caused by uterine malformation (bicornuate uterus). It is necessary to distinguish between fetal malformation and deformation, since the latter type of anomaly indicates that the uterine environment is distorted. Correction of this uterine malformation can significantly improve the prospects for future pregnancies.Key Words: fetal deformationuterine malformationbicornuate uterus
Tópico(s): Urological Disorders and Treatments
1984 - Taylor & Francis | Pediatric Pathology
Dominick J. H. McCabe, Paul Harrison, Samuel J. Machin, Hilary Watt, Martin M. Brown,
... comprehensive systematic review of the literature, Platelets, 10.3109/09537104.2015.1049139, 26:5, (402-412), Online publication date: 4-Jul-2015. McCabe D, Harrison P, Mackie I, Sidhu P, Lawrie A, Purdy G, Machin S and Brown M (2009) Assessment of the ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2004 - Lippincott Williams & Wilkins | Stroke
Five hundred consecutive cases with histologic chorioamnionitis and umbilical cord inflammation were analyzed to develop a staging system for funisitis and to correlate stage of funisitis with stage of chorioamnionitis in order to estimate the timing of various stages of funisitis. Funisitis progresses through venous involvement (with or without Wharton's jelly inflammation) to arterial involvement without Wharton's jelly and then full involvement of all three vessels and surrounding Wharton's jelly. ...
Tópico(s): Neonatal Respiratory Health Research
2011 - Taylor & Francis | Fetal and Pediatric Pathology
... J.R., Gale, R.E., Harrison, C.N., Machin, S.J. & Linch. D.C. (2000) Lack of ... CASPubMedWeb of Science®Google Scholar Harrison, C.N. & Machin, S.J. (1997) Essential thrombocythaemia and antiphospholipid antibodies. ... Chitolie, A., Carr, P., Dave, M., Mackie, I. & Machin, S.J. (1998b) Evaluation of risk factors for ... Google Scholar Harrison, C.N., Gale, R.E., Machin, S.J. & Linch, D.C. (1999a) A large ... Gale, R.E., Mire-Sluis, A., Pezella, F., Machin, S.J. & Linch, D.C. (1999b) Platelet c- ... Sud, R., Gale, R.E., Harrison, C.N., Machin, S.J. & Linch, D.C. (2000) 'Mutations in ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2002 - Wiley | British Journal of Haematology
... 60, 54 – 58. Google Scholar Carreras, L.O., Machin, S.J., Deman, R., Defreyn, G., Vermylen, J., ... Scholar Rustin, M.H.A., Bull, H.A., Machin, S.J., Isenberg, D.A., Smith, M.L. & ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
1990 - Wiley | British Journal of Haematology
... 10.1111/j.1748-1090.1976.tb00130.xJohn Machin Water balance inTenebrio molitor, L. Larvae; the effect ... Sep 2008): 49–54.https://doi.org/10.3109/13813457409070451B.K. Srivastava, V.G. Gokhale, M.M. ... Sep 2008): 95–99.https://doi.org/10.3109/13813456409105255R.H. Dadd The nutritional requirements of locusts— ... Sep 2008): 270–275.https://doi.org/10.3109/13813455809084202Lucien Huot, Jean Leglercq Nutrition Protidique Chez Tenebrio ... Sep 2008): 276–281.https://doi.org/10.3109/13813455809084203 Société Belge DE Biochimie: 20 e réunion: ...
Tópico(s): Insect Utilization and Effects
1950 - University of Chicago Press | Physiological Zoology
... Online publication date: 1-Dec-2017. Townsend R, Machin I, Ren J, Trujillo A, Kawaguchi M, Vijapurkar ... using Laser Speckle Flowgraphy, Current Eye Research, 10.3109/02713683.2014.905608, 39:12, (1207-1215), Online ... ethnic groups in Xinjiang, China, Blood Pressure, 10.3109/08037051.2013.838827, 23:3, (154-159), Online ...
Tópico(s): Hormonal Regulation and Hypertension
1999 - Lippincott Williams & Wilkins | Hypertension
Yigal Dror, Victor S. Blanchette,
... Scholar 29 Harrison, C.N., Gale, R.E., Machin, S.J. & Linch, D.C. (1999) A large ... thrombocythemia. Pediatric Hematology/Oncology, 15, 359–363. 10.3109/08880019809014021 Web of Science®Google Scholar Citing Literature ...
Tópico(s): Eosinophilic Disorders and Syndromes
1999 - Wiley | British Journal of Haematology
The impact of a rise in the temperature of the human brain in patients who have suffered cerebral damage is not completely understood. Current studies are ambiguous; some show that a high brain temperature, and others a low brain temperature, is an indicator of poor prognosis. The reported effect is often very subtle, at the <0.5°C level, and this may be due to the performance, or even the location of the temperature sensor. This study investigates the first of these issues, i.e. the performance ...
Tópico(s): Thermoregulation and physiological responses
2010 - Taylor & Francis | Journal of Medical Engineering & Technology
George E. Billman, Peter J. Schwartz, H. L. Stone,
... 143-148), Online publication date: 1-Jun-2015. Machin D, Park W, Alkatan M, Mouton M and ... COPD: Journal of Chronic Obstructive Pulmonary Disease, 10.3109/15412555.2011.647130, 9:2, (160-165), Online ...
Tópico(s): Heart Rate Variability and Autonomic Control
1982 - Lippincott Williams & Wilkins | Circulation
... Scholar 9 Ng KK, Cherney MM, Vazquez AL, Machin A, Alonso JM, Parra F, James MN. Crystal ... Biochem Mol Biol 1993; 28: 375–430 10.3109/10409239309078440 CASPubMedWeb of Science®Google Scholar 15 Bressanelli ...
Tópico(s): Biochemical and Molecular Research
2004 - Wiley | Proteins Structure Function and Bioinformatics
Patrizia Rovere, Maria Grazia Sabbadini, Fausto Fazzini, Attilio Bondanza, Valérie S. Zimmermann, C Rugarli, Angelo A. Manfredi,
... Scholar 90 Pittoni V, Ravirajan CT, Donohoe S, MacHin SJ, Lydyard PM, Isenberg DA. Human monoclonal anti- ...
Tópico(s): T-cell and B-cell Immunology
2000 - Wiley | Arthritis & Rheumatism
... CASPubMedWeb of Science®Google Scholar 36 Sperber GH, Machin GA. The enigma of cephalogenesis. Cleft Palate Craniofac ...
Tópico(s): Oral and Maxillofacial Pathology
1997 - Wiley | Periodontology 2000
Eric B. Keverne, Fran L. Martel, Claire M. Nevison,
... 0100329, 9:6, (e100329) Pearce E, Wlodarski R, Machin A, Dunbar R and Morgan E (2019) Exploring ...
Tópico(s): Primate Behavior and Ecology
1996 - Royal Society | Proceedings of the Royal Society B Biological Sciences
Paul W. Armstrong, Curt D. Furberg,
... Google Scholar2 Colton T, Freedman LS, Johnson AL, Machin D. Practical issues in data monitoring of clinical ... Monitoring Committees (DMC) Encyclopedia of Biopharmaceutical Statistics, 10.3109/9781439822463.063, (397-404), Online publication date: 1- ...
Tópico(s): Meta-analysis and systematic reviews
1995 - Lippincott Williams & Wilkins | Circulation
... 1992.tb00686.xJ. Stephen Bamforth, Clifford Fabian, Geoffrey Machin, Louis Honore Poland anomaly with a limb body ...
Tópico(s): Physiological and biochemical adaptations
1943 - University of Chicago Press | Physiological Zoology