... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Fengjie Li, Zhen Liang, Yongqin Jia, Panyang Zhang, Kaijian Ling, Yanzhou Wang, Zhiqing Liang,
... to reveal the mechanism by which decreased miR-324-3p expression suppresses OC proliferation. Quantitative real-time ... hybridization, and immunohistochemistry were performed to estimate miR-324-3p and WNK2 expression levels in OC cells ... were performed to analyze the influence of miR-324-3p and WNK2 on the proliferation and invasion ... were used to test the relationship between miR-324-3p and WNK2 expression. Then, we showed that miR-324-3p expression is decreased in OC cells and ... PCR and luciferase reporter assays demonstrated that miR-324-3p inhibited WNK2 expression by directly binding to ...
Tópico(s): Cancer Mechanisms and Therapy
2022 - Taylor & Francis | Bioengineered
Project Gutenberg
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106 Letter. To Earl Granville K. G. Whitehall.
0000 - Gale Group | NCCO AsiaWest
Geng Li, Zhongqiu Wang, Yongju Tian,
... ZNF252P-AS1) in ovarian cancer. ZNF252P-AS1, miR-324-3p, and lymphocyte antigen 6 family member K ( ... cells. The effect of ZNF252P-AS1 knockdown, miR-324-3p suppression, and LY6K over-expression on apoptosis, ... blot. The interactions between ZNF252P-AS1 and miR-324-3p and between miR-324-3p and LY6K were validated by luciferase assays. ... and LY6K levels were up-regulated, while miR-324-3p was declined in ovarian cancer tissues and ... its apoptosis. Besides, ZNF252P-AS1 interacted with miR-324-3p and reversely regulated its level, and miR- ...
Tópico(s): Circular RNAs in diseases
2022 - BioMed Central | Journal of Ovarian Research
Project Gutenberg
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Shihua Deng, Dongming Wu, Li Li, Teng Liu, Ting Zhang, Jing Li, Ye Yu, Miao He, Yangyang Zhao, Rong Han, Ying Xu,
... study aimed to investigate the effect of miR-324-3p on lung adenocarcinoma cell line A549 resistant ... cis-diamminedichloroplatinum II (DDP, aka cisplatin). The miR-324-3p expression levels in cisplatin-sensitive A549(A549) ... using flow cytometry. The target gene of miR-324-3p was identified and validated with the luciferase ... and western blot assays. The role of miR-324-3p in modulating cisplatin resistance was evaluated in vitro. The expression of miR-324-3p was found to be significantly downregulated in ...
Tópico(s): MicroRNA in disease regulation
2021 - Elsevier BV | Biochemical and Biophysical Research Communications
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106 Letter. Admiralty.
0000 - Gale Group | NCCO AsiaWest
Dishari Ghatak, Arindam Datta, Tanaya Roychowdhury, Samit Chattopadhyay, Susanta Roychoudhury,
... mutant p53. In this study, we identify miR-324-5p as a critical epigenetic regulator of cancer ... p53-driven stemness phenotypes. We report that miR-324–5p is upregulated in human cancer cell lines ... we show that GOF mutant p53 upregulates miR-324–5p expression via c-Myc, an oncogenic transcription ... cancer cells. Our experimental results suggest that miR-324–5p–induced CSC phenotypes stem from the downregulation of CUEDC2, a downstream target gene of miR-324–5p. Accordingly, CUEDC2 complementation diminishes elevated CSC marker ...
Tópico(s): Cancer-related Molecular Pathways
2021 - American Association for Cancer Research | Molecular Cancer Research
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Mengmeng Liang, Xiaofan Yin, Shuai Zhang, Hongbo Ai, Fei Luo, Jianzhong Xu, Ce Dou, Shiwu Dong, Qinyu Ma,
... osteoclast-derived sEVs. One of these miRNAs, miR-324, significantly induced osteogenic differentiation and mineralization of primary ... in a mouse calvarial defect model. Notably, miR-324-enriched sEV-modified scaffold showed the highest capacity on bone regeneration, whereas inhibition of miR-324 in sEVs abrogated these effects. Taken together, our findings suggest that miR-324-contained sEVs released from mature osteoclast play an ... osteoclast-derived sEVs. One of these miRNAs, miR-324, significantly induced osteogenic differentiation and mineralization of primary ...
Tópico(s): Bone Metabolism and Diseases
2021 - Cell Press | Molecular Therapy — Nucleic Acids
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Min Jiang, Yinxing Zhu, Hong Yu,
... cell carcinoma (ESCC). It was reported that microRNA 324-5p (miR-324-5p) exerted critical functions in some cancers; however, the detailed molecular mechanism of miR-324-5p mediated by 20(S)-Rg3 to suppress ... the function of 20(S)-Rg3 or miR-324-5p on ESCC cell viability by MTT assay, ... and western blot analysis. The binding of miR-324-5p to its target gene, proteasome activator subunit ... 20(S)-Rg3. Moreover, we found that miR-324-5p level was increased under 20(S)-Rg3 treatment. Additionally, overexpressed miR-324-5p inhibited ESCC cell viability, and downregulated miR- ...
Tópico(s): Ginseng Biological Effects and Applications
2021 - SAGE Publishing | Human & Experimental Toxicology
Alexander Street
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106 Letter. From Charles Townley.
0000 - Gale Group | NCCO AsiaWest
Jian Zhao, Wenjia Nie, Liang Dong, Wencong Liu, Wei Wei,
... Circular RNA zinc finger protein 83 (circZNF83), microRNA-324-5p (miR-324-5p), and cyclin-dependent kinase 16 (CDK16) levels ... apoptosis. CircZNF83 served as a sponge of miR-324-5p and circZNF83/miR-324-5p axis was involved in the functional regulation ... Moreover, CDK16 was a downstream target of miR-324-5p and circZNF83 could regulate the CDK16 expression by sponging miR-324-5p. The anti-tumor function of GL63 was also related to the miR-324-5p/CDK16 axis. In addition, GL63 inactivated the ... pathway via downregulating circZNF83 to mediate the miR-324-5p/CDK16 axis. GL63 also repressed tumor growth ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Wiley | Journal of Gastroenterology and Hepatology
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Ye Chen, Chao Zhang, Changxue Xiao, Xiaodong Li, Zhili Hu, Shoudi He, Xiaojun Xiao, Feng Xu,
... of lncH19 were hsa-miR-346, hsa-miR-324-3p, hsa-miR-18a-3p, hsa-miR-18b- ... 346, hsa-miR-18a-3p, and hsa-miR-324-3p showed consistent patterns in A549 NC and ... levels were determined via RT-PCR. hsa-miR-324-3p was inhibited the most compared with hsa- ... validate the functions of the target hsa-miR-324-3p. Results Treatment with 1 and 10 μM ... that miR-346, miR-18a-3p, and miR-324-3p negatively correlate with lncH19. Additionally, Dex increased ... that of the miRNAs. Among the miRNAs, miR-324-3p was the most markedly downregulated miRNA following ...
Tópico(s): MicroRNA in disease regulation
2021 - BioMed Central | Journal of Inflammation
IEEE Xplore
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106 From T. Ohyamap. London.
0000 - Gale Group | NCCO AsiaWest
Chuanbao Wang, Xiuli Guo, Ying Wang, Hai Wang,
... primary regulators. Previous studies have reported that miR-324-5p is involved in the modulation of neural injury, while the underlying mechanisms of miR-324-5p in SCI remain unclear. In a SCI rat model, miR-324-5p was significantly upregulated in the spinal cord tissues after SCI. Downregulation of miR-324-5p via injection of adeno-associated viruses (AAV) expressing miR-324-5p inhibitor relieved animal motor deficits and pathological changes in the tissues. Furthermore, downregulation of miR-324-5p significantly altered the expression of genes regulating ...
Tópico(s): Circular RNAs in diseases
2021 - Elsevier BV | Neuroscience Research
... Do Not Provide An Accurate Description Of Volumes 324 And 325: Volume 324:106
0000 - Gale Group | NCCO AsiaWest
Prashanth Rawla, Jeffrey Pradeep Raj, Alan Jose Kannemkuzhiyil, John Sukumar Aluru, Krishna Chaitanya Thandra, Mahesh Gajendran,
... various manifestations reported in our study were n = 324. These include neurological manifestations (n = 178/324 (54.94%)), cardiovascular and hematological manifestations (n = 113/324 (34.88%)), gastro-intestinal/pancreaticobiliary manifestations (n = 24/324 (7.41%)) and other rarer manifestations involving systems such as renal (n = 4/324; 1.24%), endocrine (n = 1/324; 0.31%), dermatology (n = 1/324; 0.31%), respiratory (n = 1/324; 0.31%), muscular (n = 1/324; 0.31%) and immune system (n = 1/324; 0.31%). Thus, HEV can have extra-hepatic ...
Tópico(s): Viral gastroenteritis research and epidemiology
2020 - Multidisciplinary Digital Publishing Institute | Medical Sciences