1885, Domestic Various: Volume 341:1 Letter. From Henry James. To Earl Granville.
0000 - Gale Group | NCCO AsiaWest
Eleanor Egan, Philip Dundee, Nathan Lawrentschuk,
... 948Abstract Full Text Full Text PDF PubMed Scopus (341) Google Scholar One report documented perineal hemorrhage after ... 948Abstract Full Text Full Text PDF PubMed Scopus (341) Google Scholar As identification of the injured vessel ... 948Abstract Full Text Full Text PDF PubMed Scopus (341) Google Scholar and we would recommend it only ... 948Abstract Full Text Full Text PDF PubMed Scopus (341) Google ScholarConclusionVulvar hematoma is an uncommon presentation that ... 948Abstract Full Text Full Text PDF PubMed Scopus (341) Google Scholar One report documented perineal hemorrhage after ...
Tópico(s): Maternal and fetal healthcare
2009 - Elsevier BV | American Journal of Obstetrics and Gynecology
Project Gutenberg
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Robert Z. Orlowski, Thomas E. Stinchcombe, Beverly S. Mitchell, Thomas C. Shea, Albert S. Baldwin, Stephanie Stahl, Julian Adams, Dixie‐Lee Esseltine, Peter J. Elliott, Christine Pien, Roberto Guerciolini, Jessica Anderson, Natalie D. Depcik‐Smith, Rita Bhagat, Mary Jo Lehman, Steven Novick, Owen A. O’Connor, Steven L. Soignet,
... the proteasome inhibitor bortezomib (previously known as PS-341) in patients with refractory hematologic malignancies.Patients received PS-341 twice weekly for 4 weeks at either 0. ... a 2-week rest. The PD of PS-341 was evaluated by measurement of whole blood 20S ... Twenty-seven patients received 293 doses of PS-341, including 24 complete cycles. DLTs at doses above ... 04-mg/m(2) MTD attributed to PS-341 included thrombocytopenia, hyponatremia, hypokalemia, fatigue, and malaise. In ... a substantial acetaminophen ingestion. PD studies revealed PS-341 induced 20S proteasome inhibition in a time-dependent ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2002 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Teru Hideshima, Dharminder Chauhan, Paul G. Richardson, Constantine S. Mitsiades, Nicholas Mitsiades, Toshiaki Hayashi, Nikhil C. Munshi, Lenny Dang, Alfredo Castro, Vito J. Palombella, Julian Adams, Kenneth C. Anderson,
... and its immunomodulatory derivatives (IMiDs), proteasome inhibitor PS-341, and As2O3 act directly on multiple myeloma (MM) ... to overcome drug resistance. Although Thal/IMiDs, PS-341, and As2O3 inhibit nuclear factor (NF)-κB activation, ... Our studies demonstrate that PS-1145 and PS-341 block TNFα-induced NF-κB activation in a ... adherent to BMSCs. However, in contrast to PS-341, PS-1145 only partially (20–50%) inhibits MM ... all of the anti-MM activity of PS-341. Importantly, however, TNFα induces MM cell toxicity in ...
Tópico(s): Ubiquitin and proteasome pathways
2002 - Elsevier BV | Journal of Biological Chemistry
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Toshiaki Hayashi, Teru Hideshima, Kenneth C. Anderson,
... immunomodulatory derivatives, as well as proteasome inhibitor PS-341, are examples of such agents targeting the tumour ... et al, 1994). Specifically, the proteasome inhibitor PS-341 directly inhibits proliferation and induces apoptosis in both ... doxorubicin and dexamethasone (Hideshima et al, 2001c). PS-341 inhibits p42/44 MAPK growth signalling triggered by ... mediated protection against dexamethasone-induced apoptosis. Importantly, PS-341 inhibits the paracrine growth of human MM cells ... also inhibited. Gene microarry profiling reveals that PS-341 triggers transcriptional changes, including increased apoptotic signalling, decreased ...
Tópico(s): Cell Adhesion Molecules Research
2002 - Wiley | British Journal of Haematology
Project Gutenberg
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Cristina Amat Di San Filippo, Yuhuan Wang, Nicola Longo,
... carnitine) was observed with the substitution of residues 341–454 of OCTN2. An additional chimeric transporter (CHIM-9) in which only residues 341–454 of OCTN2 were substituted by OCTN1 had ... carnitine (20.2 ± 4.5 μm). The Arg-341, Leu-409, and Thr-429 residues are all ... carnitine) was observed with the substitution of residues 341–454 of OCTN2. An additional chimeric transporter (CHIM-9) in which only residues 341–454 of OCTN2 were substituted by OCTN1 had ... carnitine (20.2 ± 4.5 μm). The Arg-341, Leu-409, and Thr-429 residues are all ...
Tópico(s): Amino Acid Enzymes and Metabolism
2003 - Elsevier BV | Journal of Biological Chemistry
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
... serine 338 by PAK1 and tyrosines 340 and 341 by Src relieves autoinhibition and that this occurs ... phosphorylation of serine 338 and tyrosines 340 and 341. Exposure of cells to mitogens or growth factors ... serine 338 by PAK1 and tyrosines 340 and 341 by Src relieves autoinhibition and that this occurs ... phosphorylation of serine 338 and tyrosines 340 and 341. extracellular signal-regulated kinase Ras binding domain cysteine- ... serines 338 and 339 and tyrosines 340 and 341. Phosphorylation of these sites is essential for Raf- ...
Tópico(s): Melanoma and MAPK Pathways
2003 - Elsevier BV | Journal of Biological Chemistry
Alexander Street
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Pascale G. Charest, Michel Bouvier,
... vasopressin receptor, by site-directed mutagenesis of cysteines 341 and 342, significantly delayed and decreased both agonist- ... vasopressin receptor, by site-directed mutagenesis of cysteines 341 and 342, significantly delayed and decreased both agonist- ... has been shown to occur on cysteine residues 341 and 342 in the carboxyl tail of the ... report that the lack of palmitoylation at cysteines 341 and 342 significantly decreases the rate and extent ... The V2R mutant lacking the palmitoylation sites cysteine 341 and cysteine 342 (C341A/C342A-V2R) was constructed ...
Tópico(s): Neuropeptides and Animal Physiology
2003 - Elsevier BV | Journal of Biological Chemistry
Henry James, Farrer Herschell,
1885, Domestic Various: Volume 341:1 Letter. From Henry James, Farrer Herschell. Japan.
0000 - Gale Group | NCCO AsiaWest
Teru Hideshima, Dharminder Chauhan, Toshiaki Hayashi, Masaharu Akiyama, Nicholas Mitsiades, Constantine S. Mitsiades, Klaus Podar, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson,
Proteasome inhibitor PS-341 is one of the most promising novel agents against multiple myeloma (MM). We have previously shown that PS-341 inhibits IL-6 triggered phosphorylation of extracellular signal- ... further examined whether clinically achievable concentrations of PS-341 could inhibit IL-6 triggered signaling cascades in MM. We found that PS-341 inhibited not only ERK, but also signal transducers ... hypothesized that gp130 could be involved in PS-341-induced blockade of signaling cascades mediating MM cell ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2003 - Springer Nature | Oncogene
1885, Domestic Various: Volume 341:1
0000 - Gale Group | NCCO AsiaWest
Dongren Wang, Klaus Wurst, Wolfgang Knolle, Ulrich Decker, Lutz Prager, Sergej Naumov, Michael R. Buchmeiser,
... IOM), Permoserstrasse 15, 04318 Leipzig, Germany, Fax: (+49) 341-235-2584 http://www.iom-leipzig.de/index_ ... IOM), Permoserstrasse 15, 04318 Leipzig, Germany, Fax: (+49) 341-235-2584 http://www.iom-leipzig.de/index_ ... IOM), Permoserstrasse 15, 04318 Leipzig, Germany, Fax: (+49) 341-235-2584 http://www.iom-leipzig.de/index_ ... IOM), Permoserstrasse 15, 04318 Leipzig, Germany, Fax: (+49) 341-235-2584 http://www.iom-leipzig.de/index_ ... IOM), Permoserstrasse 15, 04318 Leipzig, Germany, Fax: (+49) 341-235-2584 http://www.iom-leipzig.de/index_ ...
Tópico(s): Chemical Synthesis and Analysis
2008 - Wiley | Angewandte Chemie International Edition
1885, Domestic Various: Volume 341:1 Letter. To Under Secretary. Whitehall.
0000 - Gale Group | NCCO AsiaWest
Chunyang Li, Shuzhen Chen, Ping Yue, Xingming Deng, Sagar Lonial, Fadlo R. Khuri, Shi‐Yong Sun,
... emerged as an important cancer therapeutic target. PS-341 (also called Bortezomib or Velcade) is the first ... of cancers. One proposed mechanism by which PS-341 exerts its anticancer effect is inactivation of nuclear ... degradation. In this study, we show that PS-341 at concentrations that effectively inhibited the growth of ... induced IkappaB(alpha) degradation. As a result, PS-341 facilitated p65 nuclear translocation and increased NF-kappaB activity. Moreover, IkappaB(alpha) degradation by PS-341 occurred early before induction of apoptosis and could ...
Tópico(s): NF-κB Signaling Pathways
2010 - Elsevier BV | Journal of Biological Chemistry