Project Gutenberg
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Robert Terkeltaub, D. Clark, C. Tosone, B. Kandinov, P. Zhang, N. Dahl, D. Grujic, D. Goldfarb,
... of urate secretion, a new oral therapy, ALLN-346 (engineered urate oxidase), is under development as a ... safety, tolerability, and initial bioactivity data of ALLN-346 in adults with hyperuricemia and CKD. Methods This ... 1) to receive either 5 capsules of ALLN-346 or matching placebo, three times daily for 7 ... monitored throughout the study. To assess possible ALLN-346 systemic absorption, a specific ELISA was used on ... Results Of the 11 patients 7 received ALLN-346 and 4 received placebo. Most patients had Stage ...
Tópico(s): Metabolism and Genetic Disorders
2022 - BMJ | Annals of the Rheumatic Diseases
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Claire Fletcher, Lin Deng, Folake Orafidiya, Wei Yuan, Marc Lorentzen, O. W. Cyran, Anabel Varela‐Carver, Theodora A. Constantin, Damien A. Leach, Felix Dobbs, I. Figueiredo, Bora Gürel, Eileen E. Parkes, Denisa Bogdan, Ronnie Rodrigues Pereira, Shuang G. Zhao, Antje Neeb, Fadi Issa, Joanna Hester, Hiromi Kudo, Y. Liu, Yiannis Philippou, Robert G. Bristow, Karen E. Knudsen, Richard J. Bryant, Felix Y. Feng, Simon H. Reed, Ian G. Mills, Johann S. de Bono, Charlotte L. Bevan,
Abstract Background miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts ... We sought to delineate the impact of miR-346 on DNA damage, and its potential as a ... mapping of DNA breaks (INDUCE-seq). Results miR-346 induces rapid and extensive DNA damage in PC ... to checkpoint activation and cell cycle arrest. miR-346 also interacts with genome-protective lncRNA NORAD to ... in biopsy RNA-seq studies. In contrast, miR-346 is associated with improved PC survival. INDUCE-seq ...
Tópico(s): Prostate Cancer Treatment and Research
2022 - BioMed Central | Molecular Cancer
Project Gutenberg
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Wenxing Wang, Jingying Liu, Enjie Pan,
... of trophoblast cells.The expression of circHIPK3, microRNA-346 (miR-346) and potassium channel modulatory factor 1 (KCMF1) mRNA ... cytometry assay, respectively. The predicted relationship between miR-346 and circHIPK3 or KCMF1 by bioinformatics was confirmed ... assay.CircHIPK3 and KCMF1 were downregulated, while miR-346 was upregulated in placenta tissues from PE patients. ... alleviated cell cycle arrest and cell apoptosis. MiR-346 was a target of circHIPK3, and miR-346 restoration reversed the effects of circHIPK3 upregulation. In ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Elsevier BV | Placenta
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Einat B. Vitner, Hagit Achdout, Roy Avraham, Boaz Politi, Lilach Cherry, Hadas Tamir, Yfat Yahalom-Ronen, Nir Paran, Sharon Melamed, Noam Erez, Tomer Israely,
... tartaric acid salt (Genz-123346), termed hereinafter GZ-346. GZ-346 is an analogue of the United States Food ... incubated with 10-μM GZ-161 or GZ-346 1 h before infection with SARS-CoV-2 ( ... ml were detected in GZ-161– and GZ-346–treated cells, respectively, indicating significant inhibition of virus ... addition, the ability of GZ-161 and GZ-346 to inhibit single-cycle infection was studied. Vero ... Scopus (309) Google Scholar). GZ-161 and GZ-346 reduced viral release by 70% and 76%, respectively, ... and cell cytotoxicity of GZ-161 and GZ-346 against SARS-CoV-2 infection, we measured their ...
Tópico(s): Lipid Membrane Structure and Behavior
2021 - Elsevier BV | Journal of Biological Chemistry
IEEE Xplore
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Agnieszka Kempińska‐Podhorodecka, Małgorzata Blatkiewicz, Ewa Wunsch, Łukasz Krupa, Krzysztof Gutkowski, Piotr Milkiewicz, Małgorzata Milkiewicz,
... patients with UC. The oncogenic properties of microRNA-346 (miR-346) have been recently reported. We investigated the expression of miR-346 and its 2 target genes, the receptor of ... of VDR, TNF-α, 18S RNA, p27, miR-346, and reference microRNA, miR-191, were evaluated by ... and TaqMan MicroRNA Assays. Functional studies with miR-346 mimic and inhibitor were conducted in HepG2 and ... cells. The effect of ursodeoxycholic acid on miR-346 expression was examined in Caco-2 cells.An increased expression of miR-346 in the ascending colon of PSC-UC was ...
Tópico(s): MicroRNA in disease regulation
2020 - Lippincott Williams & Wilkins | Clinical and Translational Gastroenterology
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Yu‐Gang Wang, Juan Liu, Min Shi, Fa‐Xiang Chen,
... they can play important roles in tumorigenesis. MicroRNA 346 (miR‐346) has been demonstrated in various human cancer types, including HCC. MiR‐346 was found to be increased in HCC cells ... DGCR5 can act as a sponge of miR‐346 to modulate the progression of HCC. The binding correlation between DGCR5 and miR‐346 was validated in our research. Subsequently, Krüppel‐like ... was predicted as a downstream target of miR‐346 and miR‐346 can induce the development of HCC by inhibiting ... the inhibited levels of KLF14 repressed by miR‐346 mimics in MHCC‐97H and Hep3B cells. Taken ...
Tópico(s): MicroRNA in disease regulation
2018 - Wiley | Journal of Cellular Physiology
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Qiang Yu, Yang Xia, Weidong Duan, Chonghui Li, Ying Luo, Shichun Lu,
... are important in tumorigenesis. Abnormal expression of microRNA-346 (miR-346) has been demonstrated in various types of human ... remains to be elucidated. Expression levels of miR-346 in liver cancer cell lines were determined by quantitative polymerase chain reaction. The effect of miR-346 on proliferation was evaluated by an MTT assay; ... western blotting. The present study observed that miR-346 was upregulated in liver cancer cell lines. miR-346 overexpression promoted cell proliferation, migration and invasion in ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Spandidos Publishing | Oncology Letters
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Nicole Glodde, Michael Hölzel,
... 1099Abstract Full Text Full Text PDF PubMed Scopus (346) Google Scholar demonstrate that oncogenic RAS signaling promotes ... 1099Abstract Full Text Full Text PDF PubMed Scopus (346) Google Scholar demonstrate that oncogenic RAS signaling promotes ... 1099Abstract Full Text Full Text PDF PubMed Scopus (346) Google Scholar unveil a so far unknown link ... 1099Abstract Full Text Full Text PDF PubMed Scopus (346) Google Scholar asked whether oncogenic RAS signaling directly ... 1099Abstract Full Text Full Text PDF PubMed Scopus (346) Google Scholar corroborated their findings by showing downregulation ...
Tópico(s): Immune cells in cancer
2017 - Cell Press | Immunity
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Fan Yang, Long-ji Luo, Lei Zhang, Dandan Wang, Su‐Jin Yang, Li Ding, Jian Li, Dan Chen, Rong Ma, Jian Wu, Jinhai Tang,
... cancers, including breast cancer. In our study, miR-346 mimic, inhibitor, negative control or si-SRCIN1 were ... PCR (qRT-PCR) was used to measure miR-346 and SRCIN1 mRNA expressions and western blot was ... assay data showed the target correlation of miR-346 and SRCIN1. Firstly, we found that the expression of miR-346 was higher in breast cancer tissues than in ... and there was significant inversed correlation between miR-346 and SRCIN1. Overexpression of miR-346 promoted cell proliferation, colony formation, migration and invasion, ...
Tópico(s): Cancer-related molecular mechanisms research
2016 - Elsevier BV | Gene
1886, Foreign: Volume 346:49
0000 - Gale Group | NCCO AsiaWest
Jing Xiao, Dong Liu, Wenju Jiao, Jia Guo, Xiaoyang Wang, Xiaoxue Zhang, Shan Lu, Zhanzheng Zhao,
Recent studies have shown that microRNA (miR)-346 regulates the expression of glycogen synthase kinase (GSK)-3β and activates the Wnt/β-catenin pathway, which regulates the differentiation of human bone ... mesenchymal stem cells. Here, we explored whether miR-346 was involved in high glucose-induced epithelial-mesenchymal ... mouse podocytes and examined the relationship between miR-346 and GSK-3β expression. The expression of miR-346 in podocytes was measured in the presence of ... concentrations of glucose. Podocytes were transfected with miR-346 mimic or miR-346 inhibitor to test whether ...
Tópico(s): Kruppel-like factors research
2015 - Elsevier BV | Gene