Project Gutenberg
Volume 259:366 Letter. From J. Kennedy. To Earl Granville K.G. Yedo.
0000 - Gale Group | NCCO AsiaWest
Tamara Vervloessem, Binu K. Sasi, Elena Xerxa, Spyridoula Karamanou, Justin Kale, Rita M. La Rovere, Supriya Chakraborty, Flore Sneyers, Meike Vogler, Anastassios Economou, Luca Laurenti, David W. Andrews, Dimitar G. Efremov, Geert Bultynck,
... precision medicine for treating CLL patients. Recently, BDA-366 was identified as a small molecule BH4-domain ... kill lung cancer and multiple myeloma cells. BDA-366 was proposed to switch Bcl-2 from an ... therapeutic potential and mechanism of action of BDA-366 in CLL and DLBCL. Although BDA-366 displayed selective toxicity against both cell types, the BDA-366-induced cell death did not correlate with Bcl- ... the absence of Bcl-2. Moreover, although BDA-366 provoked Bax activation, it did neither directly activate ...
Tópico(s): Phagocytosis and Immune Regulation
2020 - Springer Nature | Cell Death and Disease
Project Gutenberg
Volume 259:366
0000 - Gale Group | NCCO AsiaWest
Tamara Vervloessem, Rita La Rovere, Geert Bultynck,
... co-workers identified, by screening chemical compounds, BDA-366 that binds with very high affinity (Kd of ∼ ... XL, Mcl-1 or Bfl-1 [7]. BDA-366 induced a conformational change in Bcl-2, resulting ... to apoptosis (Fig. (Fig.1).1). Hence, BDA-366 resulted in cell death in different lung cancer ... with low or zero Bcl-2 levels. BDA-366, applied intraperitoneally, also prevented the growth of lung ... upregulation of endogenous Bcl-2 levels. Importantly, BDA-366 displayed synergistic action with RAD001, an mTOR inhibitor ...
Tópico(s): Computational Drug Discovery Methods
2015 - Impact Journals LLC | Aging
Volume 259:366
0000 - Gale Group | NCCO AsiaWest
Hasan Volkan Kara, Stafford S. Balderson, Thomas A. D’Amico,
... STS Database.J Thorac Cardiovasc Surg. 2010; 139: 366-378Abstract Full Text Full Text PDF PubMed Scopus ( ... STS Database.J Thorac Cardiovasc Surg. 2010; 139: 366-378Abstract Full Text Full Text PDF PubMed Scopus ( ... STS Database.J Thorac Cardiovasc Surg. 2010; 139: 366-378Abstract Full Text Full Text PDF PubMed Scopus ( ... STS Database.J Thorac Cardiovasc Surg. 2010; 139: 366-378Abstract Full Text Full Text PDF PubMed Scopus ( ... STS Database.J Thorac Cardiovasc Surg. 2010; 139: 366-378Abstract Full Text Full Text PDF PubMed Scopus ( ...
Tópico(s): Tracheal and airway disorders
2014 - Elsevier BV | The Annals of Thoracic Surgery
Alexander Street
Volume 259:366 Letter. From R. Eusden. To J. G. Kennedy Esq.
0000 - Gale Group | NCCO AsiaWest
Robert W. O’Rourke, Carey N. Lumeng,
... Cella M, McCartney SA, et al, on page 366.A major advancement in obesity research over the ... insulin resistance in obese individuals.Gastroenterology. 2013; 145: 366-374Abstract Full Text Full Text PDF PubMed Scopus ( ... insulin resistance in obese individuals.Gastroenterology. 2013; 145: 366-374Abstract Full Text Full Text PDF PubMed Scopus ( ... insulin resistance in obese individuals.Gastroenterology. 2013; 145: 366-374Abstract Full Text Full Text PDF PubMed Scopus ( ... insulin resistance in obese individuals.Gastroenterology. 2013; 145: 366-374Abstract Full Text Full Text PDF PubMed Scopus ( ...
Tópico(s): Adipose Tissue and Metabolism
2013 - Elsevier BV | Gastroenterology
IEEE Xplore
Amaya Virós, Robert Hayward, Matthew J. Martin, Sharona Yashar, Clarissa C. Yu, Berta Sánchez-Laorden, Alfonso Zambon, Dan Niculescu‐Duvaz, Caroline J. Springer, Roger S. Lo, Richard Marais,
... treated with vemurafenib.N Engl J Med. 2012; 366: 707-714Crossref PubMed Scopus (1769) Google Scholar, validating ... treated with vemurafenib.N Engl J Med. 2012; 366: 707-714Crossref PubMed Scopus (1769) Google Scholar. This ... with BRAF inhibitors.N Engl J Med. 2012; 366: 207-215Crossref PubMed Scopus (866) Google Scholar. We ... with BRAF inhibitors.N Engl J Med. 2012; 366: 207-215Crossref PubMed Scopus (866) Google Scholar. FVB/ ... with BRAF inhibitors.N Engl J Med. 2012; 366: 207-215Crossref PubMed Scopus (866) Google Scholar. We ...
Tópico(s): Cellular Mechanics and Interactions
2012 - Elsevier BV | Journal of Investigative Dermatology
Tim Hunt, Kim Nasmyth, Béla Novák,
... not imply uniformity. Phil. Trans. R. Soc. B 366, 3498–3507.doi:10.1098/rstb.2011.0079 ( ... kinases and phosphatases. Phil. Trans. R. Soc. B 366, 3508–3520.doi:10.1098/rstb.2011.0124 ( ... entry into gametogenesis. Phil. Trans. R. Soc. B 366, 3521–3531.doi:10.1098/rstb.2011.0081 ( ... cell cycle control. Phil. Trans. R. Soc. B 366, 3532–3544.doi:10.1098/rstb.2011.0078 ( ... eukaryotic DNA replication. Phil. Trans. R. Soc. B 366, 3545–3553.doi:10.1098/rstb.2011.0073 ( ... phase checkpoint pathway. Phil. Trans. R. Soc. B 366, 3554–3561.doi:10.1098/rstb.2011.0071 ( ...
Tópico(s): Cancer-related Molecular Pathways
2011 - Royal Society | Philosophical Transactions of the Royal Society B Biological Sciences
Linda Partridge, Janet M. Thornton, Gillian P. Bates,
... a complex process. Phil. Trans. R. Soc. B 366, 17–27.doi:10.1098/rstb.2010.0198 ( ... ageing in mammals. Phil. Trans. R. Soc. B 366, 28–34.doi:10.1098/rstb.2010.0281 ( ... of human longevity. Phil. Trans. R. Soc. B 366, 35–42.doi:10.1098/rstb.2010.0284 ( ... of human ageing. Phil. Trans. R. Soc. B 366, 43–50.doi:10.1098/rstb.2010.0259 ( ... ageing-related disease. Phil. Trans. R. Soc. B 366.doi:10.1098/rstb.2010.0292 (doi:10. ... biology for ageing. Phil. Trans. R. Soc. B 366, 51–63.doi:10.1098/rstb.2010.0286 ( ... ageing and longevity. Phil. Trans. R. Soc. B 366, 64–70.doi:10.1098/rstb.2010.0275 ( ...
Tópico(s): Aging and Gerontology Research
2010 - Royal Society | Philosophical Transactions of the Royal Society B Biological Sciences
Miscellaneous Free eBooks
Christian Lemaire, Joël Aerts, Samuël Voccia, Lionel Libert, F. Mercier, David Goblet, Alain Plenevaux, André Luxen,
... Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorJoël J. ... Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorSamuel Voccia ... Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorFrédéric Mercier ... Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorDavid Goblet, ... Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorAlain R. ...
Tópico(s): Chemical Reactions and Isotopes
2010 - Wiley | Angewandte Chemie
Miscellaneous Free eBooks
Volume 259:366 Letter. From J. Kennedy To Earl Granville K.G. Yedo.
0000 - Gale Group | NCCO AsiaWest
Gordon Clapworthy, Marco Viceconti, Peter V. Coveney, Peter Köhl,
... modelling of biosystems. Phil. Trans. R. Soc. A. 366, 3045–3065.doi:10.1098/rsta.2008.0076. . ... virtual physiological human. Phil. Trans. R. Soc. A. 366, 2979–2999.doi:10.1098/rsta.2008.0089. . ... tools and techniques. Phil. Trans. R. Soc. A. 366, 3017–3043.doi:10.1098/rsta.2008.0094. . ... virtual physiological human. Phil. Trans. R. Soc. A. 366, 3091–3110.doi:10.1098/rsta.2008.0099. . ... 2008Genes and causation. Phil. Trans. R. Soc. A. 366, 3001–3015.doi:10.1098/rsta.2008.0086. . ... large-scale data. Phil. Trans. R. Soc. A. 366, 3067–3089.doi:10.1098/rsta.2008.0085. . ...
Tópico(s): Interdisciplinary Research and Collaboration
2008 - Royal Society | Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
Marie-France Langelier, Kristin M. Servent, Elizabeth E. Rogers, John M. Pascal,
... the PARP-1 gene coding for residues 216–366, residues 1–366, and residues 379–1014 were placed in the ... XhoI such that the protein fragments PARP-1216–366, PARP-11–366, and PARP-1379–1014 were each produced with ... Protein Expression and Purification–PARP-1wt, PARP-1216–366, and PARP-11–366 were expressed in Escherichia coli strain BL21(DE3) ... length PARP-1 constructs and the PARP-11–366 and PARP-11–234 fragments, the heparin column ... mm to 1 m NaCl. For PARP-1216–366, the heparin column was equilibrated with only 50 ...
Tópico(s): Integrated Circuits and Semiconductor Failure Analysis
2007 - Elsevier BV | Journal of Biological Chemistry