Davide De Cicco, Gianpaolo Tartaro, Fortunato Ciardiello, Morena Fasano, Raffaele Rauso, Francesca Fiore, Chiara Spuntarelli, Antonio Troiano, Giorgio Lo Giudice, Giuseppe Colella,
Background: health-related quality of life (HRQOL) represents a secondary endpoint of medical interventions in oncological patients. Our aim was to highlight potential sources of bias that could be encountered when evaluating HRQOL in oral cancer patients. Methods: this review followed PRISMA-ScR recommendations. Participants: patients treated for oral cancer. Concept: HRQOL assessed by EORTC QLQ-C30 and QLQ-H&N35/QLQ-H&N43. A critical appraisal of included studies was performed to evaluate ...
Tópico(s): Cancer survivorship and care
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Chiara Mondello, Chariklia Petropoulou, Daniela Monti, Esftathios S. Gonos, Claudio Franceschi, Fiorella Nuzzo,
Several lines of evidence indicate that telomere shortening duringin vitroaging of human somatic cells plays a causal role in cellular senescence. A critical telomere length seems to be associated with the replicative block characterizing senescent cells. In this paper we analyzed the mean length of the terminal restriction fragments (TRF) in fibroblast strains from 4 healthy centenarians, that is, in cells agedin vivo,and from 11 individuals of different ages. No correlation between mean TRF length ...
Tópico(s): Microplastics and Plastic Pollution
1999 - Elsevier BV | Experimental Cell Research
Francesco Menzella, Francesca Bertolini, Mirella Biava, Carla Galeone, Chiara Scelfo, Marco Caminati,
Patients with severe asthma have a greater risk of asthma-related symptoms, morbidities, and exacerbations. Moreover, healthcare costs of patients with severe refractory asthma are at least 80% higher than those with stable asthma, mainly because of a higher use of healthcare resources and chronic side effects of oral corticosteroids (OCS). The advent of new promising biologicals provides a unique therapeutic option that could achieve asthma control without OCS. However, the increasing number of ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2018 - BioExcel Publishing Ltd | Drugs in Context
Francesco Menzella, Mirella Biava, Chiara Barbieri, Francesco Livrieri, Nicola Facciolongo,
At the end of December 2019, a novel coronavirus, the severe acute respiratory syndrome coronavirus 2, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China and then the entire world, forcing the World Health Organization to make the assessment that the coronavirus disease (COVID-19) can be characterized as a pandemic, the first ever caused by a coronavirus.To date, clinical evidence and guidelines based on reliable data and randomized clinical trials ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2020 - BioExcel Publishing Ltd | Drugs in Context
Martina Biggioggero, Andrea Becciolini, Chiara Crotti, Elena Agape, Ennio Giulio Favalli,
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint involvement, extra-articular manifestations, comorbidities, and increased mortality. In the last few decades, the management of RA has been dramatically improved by the introduction of a treat-to-target approach aiming to prevent joint damage progression. Moreover, the increasing knowledge about disease pathogenesis allowed the development of a new drug class of biologic agents targeted on immune cells and ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2019 - BioExcel Publishing Ltd | Drugs in Context
Rosalba Torrisi, Flavia Jacobs, Chiara Miggiano, Rita De Sanctis, Armando Santoro,
De novo metastatic breast cancer (dnMBC) accounts for ~6–10% of all breast cancers and for ~30% of MBC with increasing incidence over time. Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) tumours are the most frequent subtype with a similar incidence to that observed amongst recurrent MBC (rMBC). Higher frequency of PI3KCA and ARID2 mutations and a lower frequency of ESR1 mutations and of genes involved in DNA damage, as compared with rMBC, have been reported in ...
Tópico(s): Breast Cancer Treatment Studies
2023 - BioExcel Publishing Ltd | Drugs in Context
Biagio Ricciuti, Alessia Mira, Elisa Andrini, Pietro Scaparone, Sandra Vietti Michelina, Federica Pecci, Luca Cantini, Andrea De Giglio, Giuseppe Lamberti, Chiara Ambrogio, Giulio Metro,
Constitutive KRAS signalling drives tumorigenesis across several cancer types. In non-small-cell lung cancer (NSCLC) activating KRAS mutations occur in ~30% of cases, and the glycine to cysteine substitution at codon 12 (G12C) is the most common KRAS alteration. Although KRAS mutations have been considered undruggable for over 40 years, the recent discovery of allelic-specific KRAS inhibitors has paved the way to personalized cancer medicine for patients with tumours harbouring these mutations. Here, ...
Tópico(s): HER2/EGFR in Cancer Research
2022 - BioExcel Publishing Ltd | Drugs in Context
Produção Nacional
Revisado por pares
Riyaz Patel, Vinicius Tragante, Amand F. Schmidt, Raymond O. McCubrey, Michael V. Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S. Virani, Karol Kamiński, Jochen D. Muehlschlegel, Hooman Allayee, Peter Almgren, Maris Alver, E.V. Baranova, Hassan Behloui, Bram Boeckx, Peter S. Braund, Lutz Philipp Breitling, Graciela Delgado, Núbia E. Duarte, Marie‐Pierre Dubé, Line Dufresne, Niclas Eriksson, Luisa Foco, Markus Scholz, Crystel M. Gijsberts, Charlotte Glinge, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A. Hubác̆ek, Marcus E. Kleber, Daniel Kofink, Salma Kotti, Pekka Kuukasjärvi, Vei-Vei Lee, Andreas Leiherer, Petra Lenzini, Daniel L. Levin, Leo‐Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P. Nelson, Kjell Nikus, Anna P. Pilbrow, Rafał Płoski, Yan V. Sun, Michael W.T. Tanck, W.H. Wilson Tang, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Ragnar O. Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Lawien Al Ali, Eric Boerwinkle, Carlo Briguori, John F. Carlquist, Kathryn Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Thomas Engstrøm, Natalie Fitzpatrick, Kim Fox, Bruna Gigante, Stefan James, Marja‐Liisa Lokki, Paulo A. Lotufo, Nicola Marziliano, Ify Mordi, Joseph B Muhlestein, Christopher Newton‐Cheh, Jan Piťha, Christoph H. Saely, Ayman Samman‐Tahhan, Pratik B. Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A.M. Wilde, Ian Ford, David J. Stott, Ale Algra, Maria Grazia Andreassi, Diego Ardissino, Benoît J. Arsenault, Christie M. Ballantyne, Thomas O. Bergmeijer, Connie R. Bezzina, Simon C. Body, Eric Boersma, Peter Bogaty, Michiel L. Bots, Hermann Brenner, Jasper J. Brugts, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M. Cooper‐DeHoff, Sharon Cresci, Nicolas Danchin, Ulf dé Fairé, Robert N. Doughty, Heinz Drexel, James C. Engert, Keith A.A. Fox, Domenico Girelli, Diederick E. Grobbee, Emil Hagström, Stanley L. Hazen, Claes Held, Harry Hemingway, Imo E. Hoefer, G. Kees Hovingh, Reza Jabbari, Julie A. Johnson, J. Wouter Jukema, Marcin Kaczor, Mika Kähönen, Jiří Kettner, Marek Kiliszek, Olaf H. Klungel, Bo Lagerqvist, Diether Lambrechts, Jari Laurikka, Terho Lehtimäki, Daniel Lindholm, Bakhtawar K. Mahmoodi, Anke H. Maitland‐van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Anna Niemcunowicz‐Janica, Oliviero Olivieri, Grzegorz Opolski, Nicholette D. Palmer, Gerard Pasterkamp, Carl J. Pepine, Alexandre C. Pereira, Louise Pilote, Arshed A. Quyyumi, Mark Richards, Marek Sanak, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J. G. Smith, John A. Spertus, Steen Stender, Alexandre F.R. Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jean‐Claude Tardif, Jurriën M. ten Berg, Jacob Tfelt‐Hansen, George Thanassoulis, Joachim Thiery, Christian Torp‐Pedersen, Yolanda van der Graaf, Frank L.J. Visseren, Johannes Waltenberger, Peter Weeke, Pim van der Harst, Chim C. Lang, Naveed Sattar, Vicky A. Cameron, Jeffrey L. Anderson, James M. Brophy, Guillaume Paré, Benjamin D. Horne, Winfried März, Lars Wallentin, Nilesh J. Samani, Aroon D. Hingorani, Folkert W. Asselbergs,
Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants ...
Tópico(s): Lipoproteins and Cardiovascular Health
2019 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Cristina Capittini, Annalisa De Silvestri, Chiara Rebuffi, Carmine Tinelli, Dimitri Poddighe,
Background and Objectives: Celiac disease (CD) is a multifactorial immune-mediated disorder, triggered by the ingestion of gluten in genetically-predisposed subjects carrying MHC-DQ2 and -DQ8 heterodimers, which are encoded by four HLA-DQ allelic variants, overall. This meta-analysis aims at providing further epidemiological support to the predominant relevance of one specific allele, namely HLA-DQB1*02, in the predisposition and genetic risk of CD. Materials and Methods: We performed a search of ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2019 - Multidisciplinary Digital Publishing Institute | Medicina
Martina Biggioggero, Andrea Becciolini, Chiara Crotti, Elena Agape, Ennio Giulio Favalli,
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint involvement, extra-articular manifestations, comorbidities, and increased mortality. In the last few decades, the management of RA has been dramatically improved by the introduction of a treat-to-target approach aiming to prevent joint damage progression. Moreover, the increasing knowledge about disease pathogenesis allowed the development of a new drug class of biologic agents targeted on immune cells and ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2019 - BioExcel Publishing Ltd | Drugs in Context
Andrea De Giglio, Alessandro Di Federico, Chiara Deiana, Biagio Ricciuti, Marta Brambilla, Giulio Metro,
The therapeutic approach to patients affected by advanced non-small-cell lung cancer (NSCLC) is facing rapid and continuous evolution. In recent years, the emergence of new treatment strategies, such as immunotherapy and tyrosine kinase inhibitors, has revolutionized the treatment algorithm and the prognosis of patients with NSCLC. In the non-oncogene-addicted disease, immune-checkpoint inhibitors, either as single agents or combined with chemotherapy, outperformed standard chemotherapy in both untreated ...
Tópico(s): Colorectal Cancer Treatments and Studies
2022 - BioExcel Publishing Ltd | Drugs in Context
Giovanna Malara, Chiara Verduci, Maria Altomonte, Maria Cuzzola, Caterina Trifirò, Cristina Politi, Giovanni Tripepi,
The anti-inflammatory drug, thalidomide, is often administered off-label especially in dermatology patients with diseases refractory to different medications. The drug's mechanism of action is not well understood but clinical evidence suggests an immunomodulatory function. Although this drug is a useful tool for several dermatoses, there are associations between its use and neurotoxic and teratogenic side effects. Consequently, it is reserved only for severe and refractory cases.Herein, we present ...
Tópico(s): Peripheral Neuropathies and Disorders
2022 - BioExcel Publishing Ltd | Drugs in Context
Matteo Bassetti, Paolo Pelosi, Chiara Robba, Antonio Vena, Daniele Roberto Giacobbe,
Randomized controlled trials (RCTs) are the best way to find effective and acceptable safe treatments for COVID-19 and any possible future outbreak. However, caution is needed when comparing the number of participants in RCTs with that of patients with COVID-19 treated with compassionate and/or off-label drugs to support the hypothesis that the latter are preferred by clinicians as an alternative to the former.
Tópico(s): Long-Term Effects of COVID-19
2020 - BioExcel Publishing Ltd | Drugs in Context
Chiara Bertone, Antonella Mollicone, Stefano Russo, Paola Sasso, Romina Fasciani, Cinzia Riccardi, Mirella Lizzano, the ALI working group,
Experiences from clinical practice suggest that hypochlorous acid (HOCl) used as adjuvant treatment can shorten the time to clinical resolution of blepharitis, particularly in relation to the ophthalmic complications that often occur with a blepharitis diagnosis. In addition, in clinical practice, HOCl adjuvant treatment also resulted in a viable option for the management of ophthalmic disorders other than blepharitis. This case series presents and discusses real-life experiences with using an HOCl ...
Tópico(s): Sinusitis and nasal conditions
2022 - BioExcel Publishing Ltd | Drugs in Context
Chiara Dallagiovanna, Laura Mensi, Luca Di Gesaro, Irene La Vecchia, Marco Reschini,
Due to high purity, recombinant human chorionic gonadotropin (hCG) is suitable for subcutaneous injection, and hence for self-administration, in assisted reproduction. To increase usability and reduce the risk of dosing errors, a prefilled pen was produced. We investigated the ease of administration and satisfaction with the product amongst patients and healthcare professionals.A survey was conducted amongst women with infertility who underwent in vitro fertilization treatments with recombinant hCG ...
Tópico(s): Ectopic Pregnancy Diagnosis and Management
2022 - BioExcel Publishing Ltd | Drugs in Context
Maria Rosaria Natale, Chiara Degirolamo, Fabio Perversi, Giustino Varrassi,
pazienti con dolore senza una diagnosi e un ritardato rinvio a specialisti afferenti ai centri di terapia del dolore, l'attuale gestione del dolore cronico richiede una significativa rivalutazione.
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2021 - BioExcel Publishing Ltd | Drugs in Context
Raffaella Palumbo, Erica Quaquarini, Giuseppe Saltalamacchia, Alberto Malovini, Pietro Lapidari, Barbara Tagliaferri, Luca Mollica, Cristina Teragni, Chiara Barletta, Laura D. Locati, Federico Sottotetti,
Breast cancer is the most frequent tumour worldwide, and the HR
Tópico(s): Chronic Lymphocytic Leukemia Research
2023 - BioExcel Publishing Ltd | Drugs in Context
Andrea Camerini, Chiara Caparello, M.C. Pennucci, Matteo Rotellini, I. Stasi, Alessandro Torrini, Enrico Vasile,
Tópico(s): Metastasis and carcinoma case studies
2021 - BioExcel Publishing Ltd | Drugs in Context
Nicoletta Bernardini, Annunziata Dattola, Giacomo Caldarola, Diego Orsini, Chiara Assorgi, Alessandra D'Amore, Giulia Maretti, Antonio Giovanni Richetta, Ersilia Tolino, Nevena Skroza, Concetta Potenza,
Psoriasis is a chronic inflammatory disease that can affect any part of the body but, when it appears in certain areas, like the face, it can have a very significant psychological impact. Biologics, in particular IL-17 and IL-23 drug inhibitors, have shown relevant clinical efficacy in the management of psoriatic lesions in difficult-to-treat areas. In post hoc analysis of phase III trials in plaque psoriasis, bimekizumab has shown safety and complete clearance of high-impact areas. However, these ...
Tópico(s): Mast cells and histamine
2024 - BioExcel Publishing Ltd | Drugs in Context
Chiara Ceccobello, M. H. M. Heemskerk, Y. Cavecchi, W. H. T. Vlemmings, Daniel Tafoya,
Outflows, spanning a wide range of dynamical properties and spatial extensions, have now been associated with a variety of accreting astrophysical objects, from supermassive black holes at the core of active galaxies to young stellar objects. The role of such outflows is key to the evolution of the system that generates them, for they extract a fraction of the orbiting material and angular momentum from the region close to the central object and release them in the surroundings. The details of the ...
Tópico(s): Astrophysics and Cosmic Phenomena
2020 - Oxford University Press | Monthly Notices of the Royal Astronomical Society