IEEE Xplore
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451 Letter. From Gerard Lowther. To Earl of Kimberley K. G. Tokio.
0000 - Gale Group | NCCO AsiaWest
Yu Du, Zhuang Miao, Lijuan Qiu, Yan Lv, Kedi Wang, Lusheng Guo,
... high. The function and important role of miR-451 and miR-506 in a series of cancers ... the clinical diagnosis and prognostic significance of miR-451 and miR-506 expression in breast cancer. Methods. ... reaction (qRT-PCR) was applied to detect miR-451 and miR-506 expression in serum and tissues. The relationship of miR-451 and miR-506 with clinical parameters was determined ... conducted to evaluate the diagnostic accuracy of miR-451 and miR-506 in breast cancer. In addition, we determined the prognostic performance of miR-451 and miR-506 using Kaplan–Meier survival assay. ...
Tópico(s): HER2/EGFR in Cancer Research
2022 - Hindawi Publishing Corporation | Journal of Healthcare Engineering
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Jisong Liu, Fuxi Xing, Quanyou Fu, Bo He, Zhigang Jia, Juan Du, Yong Li, Xiangzhou Zhang, Xu‐Lin Chen,
... previous study, we have proved that exosomal miR-451 from human umbilical cord mesenchymal stem cells (hUC- ... injury (ALI). However, the mechanism of exosomal miR-451 in ALI remains unclear. Therefore, this study aimed ... molecular mechanism of hUC-MSCs-derived exosomal miR-451 on ALI by regulating macrophage polarization. Exosomes were ... nanoparticle tracking analysis (NTA). The expression of miR-451, macrophage migration inhibitory factor (MIF) and PI3K/AKT ... was used to detect the regulation of miR-451 to MIF. The contents of cytokines were detected ...
Tópico(s): Circular RNAs in diseases
2022 - Wiley | Environmental Toxicology
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Zhijie Lin, Xiaoyan Xie, Min Gu, Qian Chen, Guotao Lu, Xiaoqin Jia, Weiming Xiao, Jun Zhang, Duonan Yu, Weijuan Gong,
The microRNAs miR-144/451 are highly conserved miRNA that is strongly induced during erythropoiesis. Despite the biological functions of miR-144/451 have been extensively studied in erythropoiesis and tumorigenesis, ... In this study, we showed that miR-144/451 -/- DCs exhibit increased activation. Mechanistically, the miR-144 ... IRF5 in DCs. Ectopic expression of miR-144/451 by lentiviruses downregulates the levels of IRF5 and ... shRNA significantly inhibits activities of the miR-144/451 -/- DCs. Expression of miR144/451 was decreased in ...
Tópico(s): Immune Cell Function and Interaction
2022 - Frontiers Media | Frontiers in Immunology
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Yingchun Zhang, Xiaojuan Chu, Qingjie Wei,
MiR-451 plays a tumor suppressive role in a variety of cancers. However, the function of miR-451 in acute myeloid leukemia (AML) has not been ... Herein, we focused on the effect of miR-451 in pediatric AML and its regulatory mechanism. MiR-451 and high mobility group box 1 (HMGB1) levels ... and THP-1 cells were treated with miR-451 mimics, pcDNA-HMGB1, and corresponding controls. The changes in apoptosis and autophagy were evaluated in miR-451 overexpressed AML cells with MTT and flow cytometry. The interaction between miR-451 and HMGB1 was determined by dual-luciferase reporter ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Begell House | Journal of Environmental Pathology Toxicology and Oncology
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Mengmeng Wang, Ying Bai, Haitao Chi, Ping Lin, Yu‐Wei Wu, Jiahui Cui, Yi Wang, Jing Sun, Ming‐Fei Lang,
... the peripheral blood of ischemic stroke patients, miR-451 was identified as a differentially expressed miRNA along ... ischemic stroke. To investigate the role of miR-451, middle cerebral artery occlusion (MCAO) was performed as ... stroke model in mice. Intracerebroventricular administration of miR-451 mimic in the MCAO mice significantly decreased infarct size, while miR-451 inhibitor significantly increased infarct size. To understand the molecular mechanism of the protective effect of miR-451, Phd3 (also Egln3) was validated as a new ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Elsevier BV | Experimental Neurology
Project Gutenberg
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451 Letter. From Gerard Lowther. To Earl of Kimberley K.G. Tokio.
0000 - Gale Group | NCCO AsiaWest
Nan Yang, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang,
... lacking. Our previous studies have shown that miRNA-451 is closely related to the development and progression of glioma. miRNA-451 is a tumor suppressor whose expression is negatively ... IKKβ is a potential direct target of miRNA-451 in glioma. In this study, we transfected lentivirus expressing miRNA-451 to test the effect of miRNA-451 overexpression on malignant glioma cell lines and confirmed that IKKβ is a target gene of miRNA-451 by luciferase assay. By targeting IKKβ, MTT, cell ... migration were significantly suppressed in the LV-miRNA-451 group. Western blotting results showed that the expression ...
Tópico(s): interferon and immune responses
2021 - Taylor & Francis | Cell Cycle
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Xiaohong Wang, Yin Hong, Lei Wu, Xiao‐Chun Duan, Yue Hu, Yongan Sun, Yan-qiu Wei, Zhen Dong, Cheng-Hao Wu, Duonan Yu, Jun Xu,
... underlying mechanism of the cluster of microRNA-144/451 (miR-144/451) in the models with intracerebral hemorrhage (ICH). A ... a model of mice with simple miR-144/451 gene knockout (KO) were used in this study. ... The results revealed that the expression of miR-451 significantly decreased in the mice with ICH, whereas ... changes. KO of the cluster of miR-144/451 exacerbated the neurological deficits and brain edema in ... the KO of the cluster of miR-144/451 significantly promoted the secretion of TNF-α and ... mice with ICH. In addition, the miR-144/451's depletion inhibited the regulatory axis' activities of ...
Tópico(s): Cancer-related gene regulation
2021 - Frontiers Media | Frontiers in Neurology
Alexander Street
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Chunrong Wu, Xiaohu Liu, Bo Li, Guiying Sun, Chunfang Peng, Debing Xiang,
... CRC). Therefore, the biological behavior of microRNA (miR)‑451 in CRC deserves further investigation. Reverse transcription‑quantitative ... applied to measure the relative expression of miR‑451 in blood serum specimens from patients with CRC ... In vitro , HCT116 cells were transfected with miR‑451 mimics, a miR‑451 inhibitor, or SAMD4B plasmids. Proliferation, migration and apoptosis ... assay was used to identify targets of miR‑451 and western blotting performed to explore the internal mechanisms of miR‑451 regulation. In vivo , the effect of miR‑451 ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Spandidos Publishing | Molecular Medicine Reports
Alexander Street
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Kayla M. Scott, David J. Cohen, M. Hays, Dane W. Nielson, Mark W. Grinstaff, Taylor B. Lawson, Brian D. Snyder, Barbara D. Boyan, Zvi Schwartz,
... stimulates proliferation of growth plate chondrocytes whereas miR-451 stimulates terminal differentiation and matrix turnover. Here, we ... vitro model of osteoarthritis.MethodsmiR-122 and miR-451 presence in rat articular cartilage was assessed using ... with lipofectamine (Lipo) and miR-122 or miR-451 for 24-h, then treated with 10 ng/ ... Cells were treated with miR-122 or miR-451 inhibitors to verify miR-specific effects.ResultsBoth miR-122 and miR-451 were increased in the OA articular cartilage compared ...
Tópico(s): Cancer-related molecular mechanisms research
2020 - Elsevier BV | Osteoarthritis and Cartilage
Alexander Street
Mar.-Apr., 1895, Diplomatic Despatches.: Volume 451
0000 - Gale Group | NCCO AsiaWest
Leiwang Long, Yunbin Xiao, Xiao-Cheng Yin, Gao Shun-li, Lingzhi Zhou, Hui Liu,
... investigated expression of serum miR-27b and miR-451 in patients with congenital heart disease associated pulmonary ... the qualification of serum miR-27b and miR-451, and an automatic biochemical analyzer was used for ... miR-27b, BNP and ADMA but lower miR-451 than the controls. Serum miR-27b was positively ... pressure (mPAP), BNP and ADMA, whereas serum miR-451 was negatively correlated with them. The combined detection of miR-27b and miR-451 was more valuable than a single detection in ... regression analysis showed that ADMA, miR-27b, miR-451 and ventricular septal defect (VSD) were independent risk ...
Tópico(s): Extracellular vesicles in disease
2020 - Spandidos Publishing | Experimental and Therapeutic Medicine