... Papers: Executive Council Minutes. Executive Council Decisions. Meetings 489-492: 3rd Quarter. 1933. CO 814/29-0002. ...
1933 - Gale Group | ArchivesUnbound Arabi Israeli
Liguo Song, Luyan Mu, Hongliang Wang,
... tissue damage. Although studies have demonstrated that miR-489-3p is closely related to CIRI, the effects of miR-489-3p on neural function in CIRI have not ... plasmids that interfered with the expression of miR-489-3p or Sirtuin1 (SIRT1) were injected into the ... determined. In addition, the expression levels of miR-489-3p and SIRT1 were detected by reverse transcription ... Western blot, and the targeting relationship between miR-489-3p and SIRT1 was verified by bioinformatics analysis ... experimental results found that in tMCAO mice, miR-489-3p in brain tissue was up-regulated and ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2022 - Taylor & Francis | Bioengineered
Leaflet: Army Council Instruction. No. 489. Almeric Paget Military Massage Corps. British Red Cross Society. 1919. B.R.C.S. 25.6/16. Book.
1919 - Gale Group | ArchivesUnbound Women-War
Fagen Li, Ke Cao, Maoyun Wang, Yi Liu, Yin Zhang,
... dihydrolipoamide S-succinyltransferase (circDLST) in GC. CircDLST, microRNA-489-3p (miR-489-3p), and eukaryotic translation initiation factor 4A1 (EIF4A1) ... assay, and transwell assay. The interaction between miR-489-3p and circDLST or EIF4A1 was analyzed by ... vivo. CircDLST and EIF4A1 were upregulated but miR-489-3p was downregulated in GC cells. AS-IV ... by downregulating circDLST. CircDLST served as a miR-489-3p sponge, and miR-489-3p inhibition reversed anti-tumor function of AS-IV. EIF4A1 was a target for miR-489-3p and circDLST sponged miR-489-3p to ...
Tópico(s): MicroRNA in disease regulation
2022 - Taylor & Francis | Bioengineered
May-Dec., 1897, Consular Despatches.: Volume 489 Letter. To Marquis of Salisbury K.G. Tokio.
0000 - Gale Group | NCCO AsiaWest
Dan Zhang, Zhiwei He, Yiyi Shen, Jie Wang, Tao Liu, Jianxin Jiang,
... analysis the glycolysis associated miRNAs and verified miRNA-489-3p was involving in glycolysis. We used RNA ... PCR to analyze the differential expression of miR-489-3p in pancreatic cancer tissues and adjacent tissues ... were used to evaluated the role of miR-489-3p in the proliferation, metastasis and glucose metabolism ... the mechanism underlying in the role of miRNA-489-3p.We determined that glycolysis associated miRNA miR-489-3p was downregulated in pancreatic cancer tissues and ... and loos of function experiments confirmed that miR-489-3p could inhibit the proliferation, metastasis and glucose ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2021 - Frontiers Media | Frontiers in Oncology
Project Gutenberg
May-Dec., 1897, Consular Despatches.: Volume 489
0000 - Gale Group | NCCO AsiaWest
Guiwen Guan, Jun Zou, Ting Zhang, Fengmin Lu, Xiangmei Chen,
... 3,169 nt, 203 nt, 283 nt and 489 nt were the main splicing sites of HBV. ... s study, we also found that 2,447/489 (the splicing editing between 2,447 nt and 489 nt) were the major HBV splicing variants, which ... this study (Fig. 1C). Of these 2,447/489 splicing variants, up to 97.8% were transcribed ... 2,446A2,447T489G formed by the 2,447/489 splicing variants. Therefore, the mechanism relevant to the ... 3,169 nt, 203 nt, 283 nt and 489 nt were the main splicing sites of HBV. ... s study, we also found that 2,447/489 (the splicing editing between 2,447 nt and ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Elsevier BV | Journal of Hepatology
May-Dec., 1897, Consular Despatches.: Volume 489 Letter. From Thomas C. Thomecraft. To J. C. Hall. Kobe, Japan.
0000 - Gale Group | NCCO AsiaWest
Yujian Ye, Ping Wang, Fangmei Zhou,
... aimed to investigate the functional role of miR‑489‑3p in psoriasis. The present study first assessed the expression levels of miR‑489‑3p and Toll‑like receptor (TLR)4 mRNA ... of Toll‑like receptor (TLR)4 by miR‑489‑3p. Moreover, a Cell Counting Kit (CCK)‑8 ... transfected with TLR4‑small interfering RNA and miR‑489‑3p‑inhibitor plasmids, and analysis of cell proliferation ... assay and ELISA. It was found that miR‑489‑3p expression was downregulated in patients with psoriasis. ... that TLR4 was a direct target of miR‑489‑3p. This was confirmed via luciferase reporter assays ...
Tópico(s): Immune Response and Inflammation
2021 - Spandidos Publishing | Experimental and Therapeutic Medicine
May-Dec., 1897, Consular Despatches.: Volume 489
0000 - Gale Group | NCCO AsiaWest
Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Sima Orouei, Amirhossein Zabolian, Hossein Saleki, Negar Azami, Kiavash Hushmandi, Behzad Baradaran, Mehrdad Hashmi, Amir R. Aref, Yavuz Nuri Ertaş, Ali Zarrabi, Milad Ashrafizadeh, Saeed Samarghandian,
... as neurological disorders, cardiovascular diseases, and cancer. miRNA-489 is a new emerging miRNA and studies are ... in pathological conditions. Herein, potential function of miRNA-489 as tumor-suppressor in various cancers is described. miRNA-489 is able to sensitize cancer cells into chemotherapy ... SUZ12 as oncogenic pathways, are affected by miRNA-489 in suppressing metastasis of cancer cells. Wnt/β- ... and malignancy of tumors is inhibited via miRNA-489 function. For enhancing drug sensitivity of tumors, restoring ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Elsevier BV | International Journal of Biological Macromolecules
May-Dec., 1897, Consular Despatches.: Volume 489 Letter. From J. C. Hall. To Sir, E. M. Satow K.C.M.G. Hiogo.
0000 - Gale Group | NCCO AsiaWest
Renli Qi, Xu Han, Jing Wang, Xiaoyu Qiu, Qi Wang, Feiyun Yang,
... functional role and underlying regulatory mechanism of microRNA-489-3p (miR-489) in adipocytes. The expression patterns of miR-489 in mice were measured by qRT-PCR. Overexpression and knockdown of miR-489 by mimic and inhibitor transfections in 3T3-L1 preadipocytes revealed the regulatory effect of miR-489 on cellular proliferation and differentiation and energy turnover. ... used to identify the direct target of miR-489. The results showed that miR-489 was highly expressed in the visceral fat tissue ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2021 - Elsevier BV | Life Sciences
IEEE Xplore
May-Dec., 1897, Consular Despatches.: Volume 489
0000 - Gale Group | NCCO AsiaWest
Peide Bai, Wei Li, Zhenghua Wan, Yujuan Xiao, Wen Xiao, Xuegang Wang, Zhun Wu, Kaiyan Zhang, Yongfeng Wang, Bin Chen, Jinchun Xing, Tao Wang,
miR-489-3p Inhibits Prostate Cancer Progression by Targeting DLX1 Peide Bai,1 Wei Li,1 Zhenghua Wan,2 ... we aimed to investigate the role of miR-489-3p in the regulation of DLX1 expression and ... reporter assay was performed to determine whether miR-489-3p directly targets DLX1. We transfected 22Rv1 and DU145 cells with miR-489-3p mimics to overexpress miR-489-3p and then evaluated its effect on cellular ... in both PCa tissues and cell lines. MiR-489-3p directly targeted DLX1 and downregulated its expression. ...
Tópico(s): RNA modifications and cancer
2020 - Dove Medical Press | Cancer Management and Research
May-Dec., 1897, Consular Despatches.: Volume 489
0000 - Gale Group | NCCO AsiaWest
Young Hwa Soung, Heesung Chung, Cecilia Yan, Andrew Fesler, Hyungjin Kim, Eok‐Soo Oh, Jingfang Ju, Jun Chung,
... these tumor suppressing miRs, we found that miR-489 is most anti-proliferative in TNBC cells. miR-489 also blocked DNA damaging responses (DDRs) in TNBC cells. To define the mechanism by which miR-489 inhibits TNBC cell functions, we screened the potential target genes of miR-489 and identified MDC-1 and SUZ-12 as novel target genes of miR-489 in TNBC cells. To further exploit the therapeutic potentials of miR-489 in TNBC models, we chemically modified the guide strand of miR-489 (CMM489) by replacing Uracil with 5-fluorouracil (5- ...
Tópico(s): MicroRNA in disease regulation
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Geological Society
May-Dec., 1897, Consular Despatches.: Volume 489
0000 - Gale Group | NCCO AsiaWest
Haiyan Zhang, Lingyun Li, Cuicui Yuan, Congcong Wang, Tiantian Gao, Zhiwei Zheng,
... the biological functions and potential mechanism of miR-489 in GC progression. Methods Quantitative real-time PCR ( ... the mRNA expression and protein levels of miR-489 and HDAC7. The relationship between miR-489 and HDAC7 was analyzed by Spearman rank correlation. ... were conducted for determining the effect of miR-489 and HDAC7 on GC cell viability, migration, and ... used to confirm the target gene of miR-489 in GC cells. Results The findings showed that miR-489 was dramatically decreased in GC tissues and GC ...
Tópico(s): Circular RNAs in diseases
2020 - BioMed Central | World Journal of Surgical Oncology