Andrew Robson, Simon Barnes Chief Sports Writer, Gary Jacob and Russell Kempson, Andrew Pierce, Neelam Verjee, Lawrence T. Roach, Thelma Hewitt, Sarah Potter, Robert Thicknesse, David Rhys Jones, Richard Hobson, Nick Hawton, Ivo Tennant, Tony Halpin and Alexandra Blair, Philip Howard, Carol Midgley, David Lister Scotland Correspondent, Christine Seib, James Bone, James Ducker, Penny Wark, Nic Hopkins, Bryan Thwaites, Trevor Cunningham, Richard Owen and Daniel McGrory, Catherine Riley Property Editor, Dave Allen, Patrick Kidd, Bob Stanley, Sam Marlowe, Roger Maynard, Geoff Brown, Richard Besston, Andrew Bamji (President-elect), Antonia Senior, Ben Webster Transport Correspondent, Peter Dawson, Pat Gibson, David McVay, John Clarke, Donald Hutera, Mark Serwotka, Beverley Morgan, Tom Bawden, James Doran Wall Street Correspondent, David Hands Rugby Correspondent and Mark Souster, John Prescott, Gary Jacob, Mike Pattenden, Jill Dupleix, Angela Jameson Industrial Correspondent, Dan Sabbagh, Phoebe Greenwood, Christopher McCooey, Stephen Farrell, Peter Davies, David Hands, Charles Bremner, Sarah Jones, Ian MacKinnon and Steve Bird, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Greg Hurst, Derwent May, Daniel Murdoch, Hugo Rifkind, Angela Jameson, Russell Kempson, Daniel McGrory, Oliver Kay, Lisa Freedman, Gerard Baker, J. Murphy, Nick Angel, John Westerby, Patrick Hosking Investment Editor, Mark Henderson Science Correspondent, Pete Paphides, Rob Wright, Geoffrey Dean, Neil Harman Tennis Correspondent, Michael Horsnell and Frances Gibb, Raymond Keene, Vaughan Freeman, Andrew Haldenby, Lewis Smith, Chris Boulton, Matthew Pryor, Kathleen Ferrier, Xan Rice, Caroline Merrell, Neville Scott, Cathy Harris, Rob Chapman, Patrick Hosking, Helen Nugent, Richard Owen, Hazel Blears, Christopher Martin-Jenkins Chief Cricket Correspondent, Mick Hume, Jill Sherman and Rosemary Bennett, Barry Heath, Nick Hasell, Nick Kelly, Tim Vine, PP, Paul Simons, Mike Mulvihill, Michelle Henery, John Goodbody, Mary Ann Sieghart, Tosin Sulaiman, Slew Hock Huang, Rajeev Syal and Ben Webster, Tom Jago, Mel Webb, Ian Johns, Christopher Browne, Dominic Maxwell, Graham Searjeant Financial Editor, Anjana Ahuja, George Caulkin, Matt Baker, Michael Austin, Alan Lee, Ben MacIntyre, Peter Shapiro, Richard Beeston, Catherine Langley, Lucia van der Post, Mark Henderson, Chris Ayres, Lisa Verrico, James Jackson, Carl Mortished International Business Editor, Mark Baldwin, Sarah Butler, Ashling O'Connor, Angus Batey, Dr Thomas Stuttaford, Stephen Dalton, Bill Edgar, Richard Morrison, Tony Halpin, Gordon Brown, Geoffrey Warner, Alexandra Blair Education Correspondent, Olav Bjortomt, Anthony Adams, Peter Kottler, Richard Ford, Patience Wheatcroft, Joe Bolger, Christopher Irvine, Elizabeth Judge Telecoms Correspondent,
... figures marred by UK Work officially began on 4G, the next generation of … Misys defies critics on ...
2005 - Gale Group | TDA
Ziran Wang, Lingjun Kong, Guoju Luo, Han Zhang, Fengchun Sun, Wenjuan Liang, Wei Wu, Zijian Guo, Rui Zhang, Yaling Dou,
... elucidate the clinical impact of the PAI-1 4G/5G polymorphism in Chinese patients with VTE.A ... for detecting F5 G1691A (FVL) and PAI-1 4G/5G polymorphisms was evaluated by using sequencing method ... standard. Besides, the association of the PAI-1 4G/5G polymorphism with susceptibility, treatment efficacy and recurrence ... plasma PAI-1 antigen levels and PAI-1 4G/5G polymorphisms were determined on additional 64 subjects ( ... accurate in determining the FVL and PAI-1 4G/5G polymorphisms without interference from bilirubin and lipids ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2022 - BioMed Central | Thrombosis Journal
Giles Smith, Andrew Robson, Phil Yates, Susan Whitfield, Bel Mooney, David Brown, Alexandra Frean, Frances Gibb Legal Editor, Gary Duncan, Amanda Ursell, Julian Neely, James Harding, David Rose, Baroness Williams of Crosby, Ivo Tennant, Philip Howard, Carol Midgley, Christine Seib, David Chater, Ben Hoyle Arts Reporter, Jeremy Kingston, James Ducker, John Grice, Justin McCracken Deputy Chief Executive, Elizabeth Judge, Rosalind Renshaw, Carl Mortished, Patrick Kidd, Simon Stevens, Kevin Eason, Geoff Brown, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Ben Webster Transport Correspondent, Jane MacArtney, Valerie Elliott, Donald Hutera, Tony Stone, Siobhan Kennedy, Dominic Walsh, Steve Bird, Ruth Gledhill, Dan Sabbagh Media Editor, Tom Bawden, Rory Watson, Simon Marsh, Gary Jacob, Jim Whyman, Daniel Finkelstein, Tim Reid, Ruth Gledhill Religion Correspondent, Richard Ford Home Correspondent, Nicholas Blanford, Alan Hamilton, Stephen Farrell, Elizabeth Colman, Julian Thomas, Richard Lloyd Parry, David Hands, Charles Bremner, Jonathan Richards, Ron Lewis, Adam Sherwin Media Correspondent, Lisa Armstrong Fashion Editor, Marie Tourres, Hugo Rifkind, Derwent May, Eric Campbell, Russell Kempson, Edward Fennell, Gary Duncan Economics Editor, Councillor Merrick Cockell, Carola Long, Sarah Vine, James Harding Business Editor, Rick Broadbent, Tom Baldwin, James Rossiter, Gary Slapper, David Robertson Business Correspondent, Rob Wright, Dean Jones, Michael Wrigley, Alice Olins, Gabriel Rozenberg, Neil Harman Tennis Correspondent, David Powell Athletics Correspondent, Raymond Keene, Christine Buckley, Matt Hughes, Christine Buckley Industrial Editor, Jane MaCartney, Nigel Hawkes, Jeremy Page, Peta Bee, Chris Campling, Bronwen Maddox, Hattie Garlick, Helen Nugent, Richard Owen, Peter Moore-Dutton, Monica Seeley, Francesca Steele, Gabriel Rozenberg Economics Reporter, Nick Hasell, John D. Symonds, Grayson Perry, David Hands Rugby Correspondent, Tom Dart, Kevin Maher, Paul Simons, John Hopwood, Nick Szczepanik, Anne Ashworth, Joanna Pitman, Steve Hawkes, Sandy Pratt, Michele Kirsch, Anthony Browne Chief Political Correspondent, Thomas Catan, George Caulkin, Sophie Yu, Alan Lee, Anthony Loyd, Peter Riddell, Ben MacIntyre, Pete Taylor, Michael Gove, Ben Webster, Ian Whittell, David Sanderson, Martin Waller, Chris Ayres, James Jackson, Patrick Foster, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Angus Batey, Sam Coates Political Correspondent, Stephen Dalton, David Powell, Frances Gibb, Alice Miles, Alan Lee Racing Correspondent, Alexandra Blair Education Correspondent, John Glanfield, Miles Costello, Fiona Hamilton, David Robertson, Bryce Elder, Joe Bolger, Elizabeth Judge Telecoms Correspondent, Virginia Matthews,
... Multiple Display Advertising Items Timesonline The future is 4G and all about speed Inside Track Optionetics Top ...
2007 - Gale Group | TDA
Qiang Zhang, Yunrui Jin, Xuemei Li, XingQiao Peng, Na Peng, Jifang Song, Mingfang Xu,
Background: A 4G/5G polymorphism in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene has been ... controls were included. Overall, the variant PAI-1 4G/4G and PAI-1 4G/5G was associated with venous thromboembolism risk, compared ... the analysis. Stratified analysis revealed that PAI-1 4G/4G and PAI-1 4G/5G genotypes were associated with an increased VTE ... all five genetic models. Conclusions: The PAI-1 4G/5G polymorphism may be a potential biomarker of ... to further assess the association between PAI-1 4G/4G polymorphisms and VTE risk.
Tópico(s): Venous Thromboembolism Diagnosis and Management
2020 - Hogrefe Verlag | VASA
Evan Conceicao, Ronald Mckinnon Professor, Andrew Mitchell, Janet Annesley Vice president, Derek E. Barrett, Sir Peter Hall Professor, Tom O'brien, Eric Freeman, Jerome Zukosky,
... in South-East Asia From Russia with bandwidth 4G mobile networks Billions of throats Beer in Asia ...
2010 - Gale Group | The Economist
... Previous studies investigating the association between PAI-1 4G/5G (rs1799889) gene polymorphism and the risk of ... showed no significant associations between the PAI-1 4G/5G polymorphism and the risk of AD and ... For the risk of MetS, the PAI-1 4G/5G (rs1799889) polymorphism may be associated with the risk of MetS (4G vs 5G, OR = 1.31, 95%CI = 1.04–1.64, P = .021), especially in Asians (4G/4G vs 4G/5G+5G/5G, OR = 1.38, 95%CI = ... and patients with mean age > 50 years old (4G/4G vs 4G/5G+5G/5G, OR = 1.36, ...
Tópico(s): Nuclear Receptors and Signaling
2020 - Wolters Kluwer | Medicine
Abdul Kader Jaffer, Martin Berridge, Frank Scheelen, Hans Wynberg, Walt Gardner, John Webster, Randhir Singh Bains,
... Windows Server 2003 Move over 3G: here comes 4G Wireless telecoms Virgin on the ridiculous British airlines ...
2003 - Gale Group | The Economist
Shu Yu, Hui Xu, Xiaojing Chi, Wei Li, Qiong Cheng, Yumin Yang, Chun Zhou, Fei Ding,
... acetamido-2-deoxy-β-d-pyranoside (salidroside analog-4g, SalA-4g), has shown neuroprotective prospects for the treatment of ... dose-response and time window study for SalA-4g, and the mechanism of SalA-4g-mediated neuroprotection remain unclear. Here, we systematically investigated the therapeutic time window and dosage of SalA-4g in permanent focal cerebral ischemia in rats. SalA-4g dose-dependently improved stroke outcome. Either pre-treatment or post-treatment of SalA-4g exhibited notable neuroprotection, and maintained for up to ...
Tópico(s): Flavonoids in Medical Research
2018 - Elsevier BV | Neuroscience
Jonathan Northcroft, P B, Simon Hacker's, John Dugdale, Barbara Hall, Mick Channon, Nigel Botherway, Jeff Dawson, Carl Fogarty, Tony Hammond, Tony Barrell, Fred Redwood, Brian Glauville, Jim Munro, Jon Swain, Tessa Mayes, Helen Davies, Peter Whittle, Sally Brock, Rob Hughes, Jason Dawe, John Peter, Amanda Ursell, Graeme Dott, Alexia Brue, Jonathan Miller, Robin Eggar, Felicity Lawrence, Andrew Longmore, Steven Baker, Lesley White, Adam Hathaway, Jane Mulkerrins, Susan d'Arcy, Martin Riley, Frank Whitford, Ivo Tennant, Nicolette Jones, Ferdinand Mount, Matt Wolf, Kathryn Cooper, Daniel Emerry, Rupert Eden, William Lewis, P D, David Smith, Tim Richards, Michelle Dillon, Tim Edwards, David Cracknell Political Editor, Steven Poole, Neil Wormald, E P, Andrew Williams, Andrew Sullivan, Richard Simpson, Kate Reardon, Clive Davis, Stephen Grey, K R, Benedict Allen, Adam Lively, Andrew Porter, A C, Dominic Bradbury, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Ariel Leve, Anthony Sattin, Jill Barker founder of Green Baby, Steve Hiett, Robert Winnett, T E, Irwin Stelzer, Adrian Furnham, Peter Wilson, Rosie Millard, David Dougill, Poppy Simpson, Martin Sixsmith, Emma John, Matthew Sweet, Tony Marcus, Paul Flynn, David Hewson, Ishbel Matheson, Alistair Weaver, Caryl Phillips, David Bond, Ian Hoyle, Hugh Canning, Alasdair Reid, Burlington Bertle, Hugh Mcllvanney, Vivian Dunn, Jeremy Clarkson, David Cairns, Edward Porter, Peter Conradi, Stewart Lee, Victoria Segal, Dean Nelson, David Connett, Michael Portillo, Ryan Gilbey, Patricia Nicol, Anthony Peregrine, Pote Oliver, Sarah Dempster, Hywel Duck, Dave Pollard, Professor Gidson Garter, Peter Tallack, Geoff Bradford, Bede Howell, Greg Struthers, Martine McCutcheon, Lydia Slater, Sussan Clark, Adam Nathan, Peter White, Andrew Peter, Peter Turion, Judith O'Relly, Andrew Porter Deputy Political Editor, Jonathan Hall, Mike Laws, Raymond Blanc, Christopher Silvester, Stuart Wavell, Roger Eglin, Debbie Cowan, Paul Donovan, Peter Hounam, Tony Thorn, Vincent Crump, Paul Kimmage, Giles Hattersley, Chris Woodhead, Peter Earle, Lucinda Kemeny, Jasper Gerard, Paul Driver, Michael Woodhead, Sarah Counsell, Nicholas Hellen, John Follain, Richard Brooks, Harvey Cole, Ian Hawkey, Marina Benjamin, Alex Clark, Shelley Von Strunckel, David Leppard, Paul Durman, Dr Samed Samadian, Mark Edwards, David Evans, Rachel Bridge, Peter Batt, John Lobb, Bonnie Rakhit, Sue Pearson, Philip Dowse, Stewart Michell, Bill Allan's, Christina Lamb, Alan Combes, Alison Elvey de Rios, Raymond Keene, Will Rhode, Hashem Mohsen Lazem, Douglas Alexander, Hew Strachan, David Cracknell, Gordon Cruickshank, Katrina Manson, Zoe Brennan, Cosmo Landesman, Andrew Roberts, Diana Wright, Alice Douglas, Stephen Jones, Dominic O'Connell, Louise Armitstead, Nick Cain, M Diddams, Hildur Helga Sigurdardottir, Michael Wright, Sandy Belfour, Jose Mourinho, Alan Pavelin, Natalie Graham, Jane Hughes, Caroline Donald, David Scott, Wilbur Smith, Colin Montgomere, David Walsh, Trevor Lewis, Jack Grimston, Bryan Appleyard, Stephen Armstrong, John Elliott, Bethan Cole, Dorothy Gray, Victoria O'brien, Roland White, Shane Watson, Sergel Leonov, Maurice Chittenden, Judy Sahm, Saul David, Richard Brooks Arts Editor, Yuba Bessaoud, Judith O'Reilly, Mark Franchetti, Richard Rae, Ray Hutton, Martin Ivens, John Ungoed-Thomas, Rob Ballantyne, Collin McDOWELL, Peter Edward, Brendan Simms, John Crossland, Michael Sheridan, Clare Francis, Margaret Walters, John Harlow, Alison Wear, Barry Collins, Ann McElhinney, John Waples, Hunter Davies, Jeremy Hart, A A Gill, Kevin Brown, David Diprose, Matthew Campbell, Brian Glanville, Dave Eggers, Stan Greenbarg, Des MacHale, Tom Robbins, Stephen Pettitt, Jonathan Carr-Brown, Jonathan Leake Science Editor, John Motson's, Rw Johnson, Justin Sparks, Sally Kinnes, Brian Laudrup, C Harpen, Michael Bright, Naomi Caine, Daniel Emery, John Aizlewood, Minette Marrin, Alan Gibbons, James Knight, Andrew Frankel, Graham Norwood, Lois Rogers Medical Editor, Joe Lovejoy, Jonathan Futrell, David Budworth, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Dan Cairns, Julian Ryall, Stewart Mitchell, Susan Belford, David Smith Economics Editor, Penny Perrick, Susannah Price, Dr Richard Long, Sarah Baxter, Brian Schofield, Carey Scott, Wanda Pratt, Matthew Goodman, Julia Langdon, Suzanne Kelly, John Scarlett, Phillip Smith, Ed Hughes, Simon Howard, David Canningham, Barry Newcombe, Jon Bennett, Dominic Rushe, A Hubble, Simon Cole, Sian Griffiths, Karen Robinson, Helen Stewart,
... Cinnamon Baked Pears with Manuka Honey (100 calories; 4g fibre) Six alternative supper suggestions Marks & Spencer What' ...
2004 - Gale Group | Sunday Times HA GDA
Najiba Fekih‐Mrissa, Malek Mansour, Aicha Sayeh, Ines Bedoui, Meriem Mrad, A. Riahi, Ridha Mrissa, Brahim Nsiri,
... increased risk of AD in carriers of the 4G/4G and 4G/5G genotypes versus the wild-type 5G/5G genotype (4G/4G: 28.33% in patients vs 10.0% in controls; P < 10 −3 ; OR = 8.78; 4G/5G: 55.0% in patients vs 38.33% ... controls; OR = 4.45; P < 10 −3 ). The 4G allele was also more frequently found in patients ... For all participants and by gender, homozygotic carriers (4G/4G) were at an increased risk of AD over ...
Tópico(s): GDF15 and Related Biomarkers
2017 - SAGE Publishing | American Journal of Alzheimer s Disease & Other Dementias®
Mohammad Suhail Akhter, Arijit Biswas, Saleh Mohammed Abdullah, Madhuri Behari, Renu Saxena,
... and progression of vascular diseases including stroke. A 4G/5G, PAI-1 gene polymorphism has been found ... study was to determine the potential association of 4G/5G polymorphism and plasma PAI-1 levels in ... age- and sex-matched controls were studied. The 4G/5G polymorphism was genotyped in the study population ... compared to the controls ( P = .03). The variant 4G allele for the PAI-I 4G/5G polymorphism showed both genotypic ( P = .0013, χ ... OR = 1.99) with IS. The homozygous variant 4G/4G also was found to be associated with ...
Tópico(s): S100 Proteins and Annexins
2017 - SAGE Publishing | Clinical and Applied Thrombosis/Hemostasis
Aniket Prabhudesai, Shrimati Shetty, Kanjaksha Ghosh, Bipin Kulkarni,
The role of PAI-1 4G/5G polymorphism in venous thrombosis has been contradictory. PAI-1 4G/4G genotype is associated with elevated levels of PAI-1 ... of genotypes and frequency of alleles of the 4G/5G polymorphism of PAI-1 gene in Indian ... alongside 251 healthy controls for the PAI-1 4G/5G polymorphism by allele-specific PCR.Frequency of 4G/4G genotype was higher in all groups in comparison with controls. 4G/4G was associated with PVT risk (OR=2.51, ...
Tópico(s): Blood properties and coagulation
2017 - Wiley | European Journal Of Haematology
Robert M. Silver, George R. Saade, Vanessa Thorsten, Corette B. Parker, Uma M. Reddy, Carolyn Drews‐Botsch, Deborah Conway, Donald R. Coustan, Donald J. Dudley, Radek Bukowski, Carol J. Hogue, Halit Pınar, Michael W. Varner, Robert L. Goldenberg, Marian Willinger,
... and A1298C, and plasminogen activating inhibitor (PAI)-1 4G/5G mutations was done on maternal and fetal ( ... other maternal thrombophilia, even after stratified analyses. Fetal 4G/4G PAI-1 (OR, 0.63; 95% confidence interval, ... associated with stillbirth, and the fetal PAI-1 4G/4G polymorphism was associated with live birth. Our data ... and A1298C, and plasminogen activating inhibitor (PAI)-1 4G/5G mutations was done on maternal and fetal ( ... other maternal thrombophilia, even after stratified analyses. Fetal 4G/4G PAI-1 (OR, 0.63; 95% confidence ...
Tópico(s): Maternal and fetal healthcare
2016 - Elsevier BV | American Journal of Obstetrics and Gynecology
Fengbo Xu, Huilan Liu, Yi Sun,
... relationship between plasminogen activator inhibitor-1 (PAI-1) 4G/5G insertion/deletion polymorphism and prevalence of diabetic ... 26.04 ng/L); (2) Patients with genotype 4G/4G tended to exhibit higher PAI-1 level; (3) The distribution frequency of genotype 4G/4G in group C was significantly higher than in ... patients, the occurrence of diabetes nephropathy in genotype 4G/4G, 4G/5G and 5G/5G is 35.0%, 30. ... 1 is closely related to PAI-1 gene 4G/5G polymorphism and (3) PAI-1 4G/5G polymorphism is associated with the development and ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2015 - Taylor & Francis | Renal Failure
Leonardo Lorente, María M. Martín, Juan M. Borreguero-León, Ysamar Barrios, Jordi Solé‐Violán, José Ferreres, Lorenzo Labarta, Cèsar Díaz‐Torné, Alejandro Jiménez,
... Two studies have reported that patients with the 4G/4G genotype of the plasminogen activator inhibitor-1 (PAI- ... higher risk of death than those with the 4G/5G or 5G/5G genotypes; one study involved ... there is an association between carriage of the 4G/4G genotype, plasma PAI-1 concentrations and mortality in ... severe septic patients. We determined the PAI-1 4G/5G polymorphism and plasma PAI-1 concentrations in ... total of 260 patients, 82 (31.5%) with 4G/4G, 126 (48.5%) with 4G/5G and 52 ( ...
Tópico(s): Neonatal and Maternal Infections
2015 - Public Library of Science | PLoS ONE
Linda Pasta, Francesca Pasta, Mario D’Amico,
... of these thrombophilic genetic factors (THRGFs): PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and prothrombin 20210A. ... the total group, we found 175 PAI-1 4G-4G, 130 MTHFR 677TT, 42V Leiden 506Q, and 27 ... TRHGF; the more frequent association was PAI-1 4G-4G/MTHFR 677TT, in 36 patients. PAI-1 4G-4G and MTHFR 677TT were significantly more frequent in ...
Tópico(s): Eosinophilic Esophagitis
2015 - Elsevier BV | Journal of Clinical and Experimental Hepatology
Mario D’Amico, Francesca Pasta, Linda Pasta,
The thrombophilic genetic factors (THRGFs), PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q and Prothrombin 20210A, were studied as risk factors in 865 Caucasian patients with liver cirrhosis, consecutively enrolled ... in 339/865 patients (39.2%). PAI-1 4G-4G and MTHFR 677TT were the most frequent THRGFs, ... 05). Two logistic regression analysis, using PAI-1 4G-4G and MTHFR 677TT, as dependent variable, confirmed the ... study shows the pivotal role of PAI-1 4G-4G and MTHFR 677TT in patients with alcohol, cryptogenic ...
Tópico(s): Liver Disease and Transplantation
2015 - Elsevier BV | Gene
Luo Yuezhong, Chao Wang, Haitao Tu,
... study was to investigate whether the four guanosines (4G)/five guanosines (5G) polymorphism in the gene coding ... and DNA sequencing. Associations between the PAI-1 4G/5G polymorphism and clinical features and pathological types ... healthy controls, with significantly higher numbers of the 4G/4G genotype and lower numbers of the 5G5G genotype ... both P<0.05). The frequency of the 4G allele was also significantly higher in PNS patients ... were associated with significantly increased frequencies of the 4G/4G and 4G/5G genotypes, as well as ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2014 - Spandidos Publishing | Molecular Medicine Reports
Xiaonan Liang, Li Xie, Jianwen Cheng, Zhen Tan, Jun Yao, Qian Liu, Wei Su, Xue Qin, Jinmin Zhao,
... of the plasminogen activator inhibitor-1 (PAI-1) 4G/5G gene has been correlated with susceptibility to ... estimation of the relationship between the PAI-1 4G/5G Gene polymorphism and ONFH by performing a ... model. Results A significant association between PAI-1 4G/5G polymorphism and ONFH susceptibility was observed for ... CI 1.279–2.437, P = 0.001), 4G/4G vs. 4G/5G + 5G/5G (OR = 2.050, 95% CI 1.581–2.657, P = 0.000), 4G/4G vs. 5G/5G (OR = 2.553, 95% CI 1.345–4.846, P = 0.004), and 4G vs. 5G (OR = 1.758, 95% CI 1. ...
Tópico(s): Parvovirus B19 Infection Studies
2013 - Elsevier BV | Thrombosis Research
Shangqian Wang, Qiang Cao, Xiaoxiang Wang, Bingjie Li, Min Tang, Wanqing Yuan, Jianzheng Fang, Jian Qian, Chao Qin, Wei Zhang,
... association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive ... of cancer was associated with the PAI-1 4G/4G polymorphism for the allele contrast (4G vs. 5G: OR = 1.10, CI = 1.03– ... 18, I2 = 49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR = 1.21, CI = 1. ... 39, I2 = 51.9%), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G: OR = 1.11, CI = 1. ...
Tópico(s): Cell Adhesion Molecules Research
2013 - Public Library of Science | PLoS ONE
Ivan Šubrt, Zděnka Ulčová-Gallová, Monika Černá, Markéta Hejnalová, Jitka Slovanova, K Bibková, Z Mičanová,
... the frequencies of plasminogen activator inhibitor‐1 (‐675) 4G/5G polymorphism and its relationship with eight antiphospholipid ... loss (RPL). Method of study PAI‐1 (‐675) 4G/5G polymorphism was determined using standard PCR ‐ RFLP ... were calculated. The prevalence of the risk conferring 4G allele and 4G/4G homozygous genotype in patients and controls was compared, ... correlation between aPL s positivity and PAI ‐1 4G/4G genotype was tested by chi‐square test. Results ... significant correlation between RPL and PAI ‐1 (‐675) 4G/4G genotype was found. No correlation between PAI ‐ ...
Tópico(s): Protease and Inhibitor Mechanisms
2013 - Wiley | American Journal of Reproductive Immunology
Wei Sun, Zirong Li, Zhengcai Shi, Bailiang Wang, Fuqiang Gao, Yurun Yang, Wanshou Guo,
... of enzyme-linked immunosorbent assay and PAI-1 4G/5G polymorphism was detected by polymerase chain reaction ... control group 7.96 ± 4.27 U/ml; 4G/4G genotype for the PAI-1 polymorphism detected in ... The plasma PAI activity was related to homozygote 4G/4G genotype. This reveals that homozygote 4G/4G genotype may be a susceptible gene mark to ... blood symbol for screening high-risk susceptible population; 4G/4G PAI-1 genotype may be an etiological factor ...
Tópico(s): Parvovirus B19 Infection Studies
2013 - Springer Science+Business Media | European Journal of Orthopaedic Surgery & Traumatology
Jeong Hyeon Lee, Younghye Kim, Jung-Woo Choi, Young Sik Kim,
... 1 can be controlled by PAI-1 promoter 4G/5G polymorphism. However, the significance of PAI-1 promoter 4G/5G polymorphism in breast cancer patients is contentious. ... Science. The effect sizes of PAI-1 promoter 4G/5G polymorphism on breast cancer risk, lymph node ... combined using a random-effects model.Individuals with 4G/4G genotype had a higher risk of breast cancer than those with the combined 4G/5G and 5G/5G genotypes (OR = 1.388; ... 1.495; p = 0.027) or with the 4G/4G genotype (OR = 1.623; p = 0.018). However, ...
Tópico(s): Cell Adhesion Molecules Research
2013 - Elsevier BV | Archives of Medical Research