Pablo Américo Barbieri, C Bertazzoli, A. Di Marco, L. Fuoco, E Turolla,
The antitumour activity of some pyrimidine thio-derivatives has been studied simultaneously with their chronic toxic action. 2-thiocytosine (showing a rapid and nearly total urinary elimination), subcutaneously injected to rats in dose of 100 mg/kg for 39 times consecutively, induces only a slight reduction of erythrocytes and leukocytes in the circulating blood, with relative lymphocytopenia and moderate increase in leukocyte fragility, whereas the values of basal metabolism and weight curve are ...
Tópico(s): Acute Lymphoblastic Leukemia research
1957 - SAGE Publishing | Tumori Journal
Shirley Aparecida Ferreira, Carmem Lúcia de Mello Sartori Cardoso da Rocha,
... metilação do DNA que converte uma citosina em 5-metilcitosina, no promotor do gene, suprimindo a sua transcrição. ...
Tópico(s): Polyamine Metabolism and Applications
2021 - Brazilian Journal of Development | Brazilian Journal of Development