Philip M. Bath, Lisa J Woodhouse, Jason P. Appleton, Maia Beridze, Hanne Christensen, Robert A. Dineen, Katie Flaherty, Lelia Duley, Timothy J. England, Diane Havard, Stan Heptinstall, Marilyn James, Chibeka Kasonde, Kailash Krishnan, Hugh S. Markus, Alan Montgomery, Stuart J. Pocock, Marc Randall, Annemarei Ranta, Thompson Robinson, Polly Scutt, G.S. Venables, Nikola Sprigg,
Background Two antiplatelet agents are better than one for preventing recurrent stroke after acute ischaemic stroke or transient ischaemic attack (TIA). Therefore, intensive treatment with three agents might be better still, providing it does not cause undue bleeding. Objective To compare the safety and efficacy of intensive therapy with guideline antiplatelet therapy for acute ischaemic stroke and TIA. Design International prospective randomised open-label blinded end-point parallel-group superiority ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2018 - NIHR Journals Library | Health Technology Assessment
Nikola Sprigg, Katie Flaherty, Jason P. Appleton, Rustam Al‐Shahi Salman, Dániel Bereczki, Maia Beridze, Alfonso Ciccone, Rónán Collins, Robert A. Dineen, Lelia Duley, J.J. Egea-Guerrero, Timothy J. England, Michał Karliński, Kailash Krishnan, Ann Charlotte Laska, Zhe Kang Law, Christian Ovesen, Şerefnur Öztürk, Stuart J. Pocock, Ian Roberts, Thompson Robinson, Christine Roffe, Nils Peters, Polly Scutt, Jegan Thanabalan, David J. Werring, David K. Whynes, Lisa J Woodhouse, Philip M. Bath,
Background Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. Objective The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous intracerebral haemorrhage (ICH). Design The TICH-2 (Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage) study was a pragmatic, Phase III, prospective, double-blind, randomised placebo-controlled trial. Setting Acute stroke services at 124 hospitals ...
Tópico(s): Neurosurgical Procedures and Complications
2019 - NIHR Journals Library | Health Technology Assessment
Cathy Creswell, Eleanor Leigh, Michael Larkin, G. Lynn Stephens, Mara Violato, Emma Brooks, Samantha Pearcey, Lucy Taylor, Paul Stallard, Polly Waite, Shirley Reynolds, Gordon Taylor, Emma Warnock‐Parkes, David M. Clark,
Background Social anxiety disorder (SAD) is common, typically starts in adolescence and has a low natural recovery rate. Existing psychological treatments for adolescent SAD are only moderately effective. It is possible that recovery rates for adolescents could be substantially improved by adapting a psychological therapy that is highly effective among adults with SAD. Objectives To train child and adolescent mental health services (CAMHS) therapists to deliver cognitive therapy for SAD in adolescents ( ...
Tópico(s): Adolescent and Pediatric Healthcare
2021 - NIHR Journals Library | Health Technology Assessment
Alasdair M. J. MacLullich, Susan D. Shenkin, Steve Goodacre, Mary Godfrey, Janet Hanley, Antaine Stíobhairt, Elizabeth Lavender, Julia Boyd, Jacqueline Stephen, Christopher J. Weir, Allan MacRaild, Jill Steven, Polly Black, Katharina Diernberger, Peter Hall, Zoë Tieges, Chris Fox, Atul Anand, John Young, Najma Siddiqi, Alasdair Gray,
Delirium is a common and serious neuropsychiatric syndrome, usually triggered by illness or drugs. It remains underdetected. One reason for this is a lack of brief, pragmatic assessment tools. The 4 'A's test (Arousal, Attention, Abbreviated Mental Test - 4, Acute change) (4AT) is a screening tool designed for routine use. This project evaluated its usability, diagnostic accuracy and cost.Phase 1 - the usability of the 4AT in routine practice was measured with two surveys and two qualitative studies of ...
Tópico(s): Respiratory Support and Mechanisms
2019 - NIHR Journals Library | Health Technology Assessment
Emily Peckham, Catherine Arundel, Della Bailey, Suzanne Crosland, Caroline Fairhurst, Paul Heron, Catherine Hewitt, Jinshuo Li, Steve Parrott, Tim Bradshaw, Michelle Horspool, Elizabeth Hughes, Tom Hughes, Suzy Ker, Moira Leahy, Tayla McCloud, David Osborn, J. Reilly, Thomas Steare, Emma Ballantyne, Polly Bidwell, Susan Bonner, Diane Brennan, Tracy Callen, Alex Carey, Charlotte Colbeck, Debbie Coton, Emma Donaldson, Kimberley Evans, Hannah Herlihy, Wajid Khan, Lizwi Nyathi, Elizabeth Nyamadzawo, Helen Oldknow, Peter Phiri, Shanaya Rathod, Jamie Rea, Crystal-Bella Romain-Hooper, Kaye Smith, Alison Stribling, Carinna Vickers, Simon Gilbody,
Background There is a high prevalence of smoking among people with severe mental ill health (SMI). Helping people with SMI to quit smoking could improve their health and longevity, and reduce health inequalities. However, those with SMI are less likely to access and engage with routine smoking cessation services than the general population. Objectives To compare the clinical effectiveness and cost-effectiveness of a bespoke smoking cessation (BSC) intervention with usual stop smoking services for ...
Tópico(s): Health, psychology, and well-being
2019 - NIHR Journals Library | Health Technology Assessment