Toshiyuki Nakayama, Kazuyuki Yamazumi, Takashi Uemura, Ayumi Yoshizaki, Yuichi Yakata, Mutsumi Matsuu‐Matsuyama, Kazuko Shichijo, Ichiro Sekine,
X rays are well known to cause genetic damage and to induce many types of carcinomas in humans. The Apc(min/+) mouse, an animal model for human familial adenomatous polyposis (FAP), contains a truncating mutation in the APC gene and spontaneously develops intestinal adenomas. To elucidate the role of X rays in the development of intestinal tumors, we examined the promotion of carcinogenesis in X-irradiated Apc(min/+) mice. Forty out of 77 (52%) X-irradiated Apc(min/+) mice developed adenocarcinomas ...
Tópico(s): Effects of Radiation Exposure
2007 - Radiation Research Society | Radiation Research
Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Takamitsu Morioka, Yukiko Nishimura, Hiroji Uemura, Kenta Akimoto, Yuki Furukawa, Masahiro Fukushi, Keiji Wakabayashi, Michihiro Mutoh, Yoshiya Shimada,
A detailed understanding of the relationship between radiation-induced breast cancer and obesity is needed for appropriate risk management and to prevent the development of a secondary cancer in patients who have been treated with radiation. Our goal was to develop an animal model to study the relationship by combining two existing Sprague-Dawley rat models of radiation-induced mammary carcinogenesis and diet-induced obesity. Female rats were fed a high-fat diet for 4 weeks and categorized as obesity ...
Tópico(s): FOXO transcription factor regulation
2016 - Radiation Research Society | Radiation Research
Suyoun Chung, Hidewaki Nakagawa, Kenji Tamura, Mutsuo Furihata, Motohide Uemura, Toyomasa Katagiri, Yasutomo Nasu, Hiromi Kumon, Tsuneharu Miki, Taro Shuin, Tomoaki Fujioka, Yusuke Nakamura,
AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 5404 Despite high response rates and clinical benefits, androgen ablation therapy does not cure advanced or relapsed prostate cancer, because hormone refractory prostate cancer (HRPC) cells inevitably emerge. There are no effective treatments available for HRPCs, and identification of novel molecular targets and therapeutic approach targeting them are urgently required. We generated the genome-wide gene expression profiles of clinical HRPC cells ...
Tópico(s): Ubiquitin and proteasome pathways
2007 - American Association for Cancer Research | Cancer Research