Project Gutenberg
Abyssinia Expeditionary Force IOR/L/MIL/5/545
0000 - Gale Group | NCCO EuropeAfrica
Lei Zhang, Ranran Yu, Chunhua Li, Yu Dang, Xiaoyu Yi, Lei Wang,
... CRC. The detection for circ_0026416 expression, miR-545-3p expression, and myosin VI (MYO6) mRNA expression ... 0026416 in vivo. The potential relationship between miR-545-3p and circ_0026416 or MYO6 was verified ... knockdown also blocked tumor growth in vivo. MiR-545-3p was a target of circ_0026416, and ... 0026416 knockdown blocked CRC development by enriching miR-545-3p. In addition, miR-545-3p targeted MYO6 and inhibited MYO6 expression. MiR-545-3p enrichment suppressed CRC cell malignant behaviors by ... 0026416 knockdown depleted MYO6 expression by enriching miR-545-3p. Circ_0026416 downregulation blocked the development of ...
Tópico(s): MicroRNA in disease regulation
2021 - BioMed Central | World Journal of Surgical Oncology
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Na Wang, Yunfeng Guo, Liqin Song, Tong Tong, Xiaomei Fan,
... called circ_0067835) in ECa.Circ-IFT80, microRNA-545-3p (miR-545-3p), and family with sequence similarity 98 member ... employed to verify the binding relationship between miR-545-3p and circ-IFT80 or FAM98A. Xenograft assays ... IFT80 and FAM98A were up-regulated, and miR-545-3p was down-regulated in ECa tissues and ... circ-IFT80 harbored a binding site for miR-545-3p, and the effects of circ-IFT80 were mediated by miR-545-3p. FAM98A was a direct target of miR-545-3p, and miR-545-3p hindered ECa cell progression via targeting FAM98A. ...
Tópico(s): Cancer-related molecular mechanisms research
2021 - Korean Society of Gynecologic Oncology | Journal of Gynecologic Oncology
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Sixin Zheng, Lingling Hu, Qingwen Song, Yuqiang Shan, Guang Yin, Hanzhang Zhu, Wencheng Kong, Chunhua Zhou,
... this study, we examined whether and how miR-545 modulates ferroptosis in colorectal cancer (CRC). HT-29 ... selective lethal 3 (RSL3) with or without miR-545 overexpression or knockdown vectors. Our results demonstrate that miR-545 overexpression inhibited, while miR-545 knockdown further increased, erastin and RSL3-induced upregulation ... oxygen species (ROS), and Fe2+ levels. Similarly, miR-545 overexpression partially reversed, while miR-545 knockdown enhanced, the erastin and RSL3-induced reduction ... was identified as a target gene of miR-545. To determine whether miR-545 suppresses ferroptosis via ...
Tópico(s): RNA modifications and cancer
2021 - Impact Journals LLC | Aging
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang, Jinquan Cui,
... This study focuses on the function of miR-545 on OC development and the molecules involved. Methods miR-545 expression in OC tissues and cell lines was ... of patients was analyzed. Altered expression of miR-545 was induced to determine its role in proliferation, ... endothelial cells (HUVECs). The targeting mRNAs of miR-545 were predicted and validated through luciferase assays. Gain- ... in nude mice. Results Poor expression of miR-545 was found in OC tissues and cells compared ... indicated unfavorable prognosis in patients. Overexpression of miR-545 suppressed growth, migration, invasion and angiogenesis of OC ...
Tópico(s): MicroRNA in disease regulation
2021 - BioMed Central | BMC Cancer
IEEE Xplore
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Jingping Sun, Haiyan Min, Lijiang Yu, Guiping Yu, Yujia Shi, Jinghua Sun,
... RNA AFAP1-AS1 (LncRNA AFAP1-AS1 ) and microRNA-545-3p ( miR-545-3p ) were reported to play important roles in ... the functional mechanisms of AFAP1-AS1 and miR-545-3p in lung cancer. Quantitative real time polymerase ... to determine the levels of AFAP1-AS1 , miR-545-3p and hepatoma-derived growth factor (HDGF). Cell ... invasion assays, respectively. Furthermore, the interaction between miR-545-3p and AFAP1-AS1 or HDGF was predicted ... AFAP1-AS1 and HDGF were increased, while miR-545-3p was decreased in lung cancer tissues and ...
Tópico(s): RNA modifications and cancer
2020 - Lippincott Williams & Wilkins | Anti-Cancer Drugs
Abyssinia Expeditionary Force IOR/L/MIL/5/545
0000 - Gale Group | NCCO EuropeAfrica
Timothy J Wilt, Kristen Ullman, Eric J. Linskens, Roderick MacDonald, Michelle Brasure, Elizabeth Ester, Victoria A. Nelson, Jayati Saha, Shahnaz Sultan, Philipp Dahm,
... 07 (0.8–1.5) 10.8 (59/545) 10.1 (55/545) 0.7 (−2.9–4.4) ⊕⊕⊕◯ Moderate* AM ... 96 (0.63–6.12) 1.5 (8/545) 0.7 (4/545) 0.7 (−0.5–1.9) ⊕⊕◯◯ Low† AM ... 1 (1.15–3.7) 6.0 (33/545) 2.9 (16/545) 3.1 (0.67–5.6) ⊕⊕⊕◯ Moderate* AM ... 30) 9.9 (55/553) 10.8 (59/545) −0.9 (−4.5–2.7) ⊕⊕⊕◯ Moderate* RP ... 87) 0.9 (5/553) 1.5 (8/545) −0.6 (−1.8–0.7) ⊕⊕◯◯ Low† RP ... 72) 2.4 (13/553) 6.4 (33/545) −4.0 (−6.1–−1.3) ⊕⊕⊕◯ Moderate* RP ... 04) 9.9 (55/553) 10.1 (55/545) −0.1 (−3.7–3.7) ⊕⊕⊕◯ Moderate* RP ...
Tópico(s): Cancer, Lipids, and Metabolism
2020 - Lippincott Williams & Wilkins | The Journal of Urology
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Xudong Ma, Jing Luo, Yi Zhang, Da‐Li Sun, Yueying Lin,
... by RT-qPCR. Overexpression of MCM3AP-AS1, miR-545, and CDK4 in CRC cells was achieved to ... to analyze the roles of MCM3AP-AS1, miR-545, and CDK4 in regulating the cell cycle progression ... MCM3AP-AS1 is predicted to interact with miR-545. In CRC cells, overexpression of MCM3AP-AS1 and miR-545 was achieved, while their overexpression did not affect ... CDK4, which is a downstream target of miR-545. Cell cycle analysis showed that overexpression of MCM3AP- ... and CDK4 suppressed G1 arrest induced by miR-545. In addition, overexpression of MCM3AP-AS1 reduced the ...
Tópico(s): Viral-associated cancers and disorders
2020 - Dove Medical Press | Cancer Management and Research
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
... fragments (Fabs) of the clinically used antibody mAb120.545. The structure revealed that STEAP1 adopts a reductase- ... fragments (Fabs) of the clinically used antibody mAb120.545. The structure revealed that STEAP1 adopts a reductase- ... production and characterization of two monoclonal antibodies (mAb120.545 and mAb92.30) that bind STEAP1 with nanomolar ... recently, clinical studies employing humanized variants of mAb120.545 that target STEAP1 were conducted, including 1) a ... three Fab fragments of the therapeutically relevant mAb120.545. The Fabs dock on the extracellular helices of ...
Tópico(s): Electron and X-Ray Spectroscopy Techniques
2020 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/545 Government document. Bombay Castle.
0000 - Gale Group | NCCO EuropeAfrica
Yao-Tsung Tsai, Chen-Hsien Liang, Jin-Hsuan Yu, Kuan-Chih Huang, Chia-Hao Tung, Jia-En Wu, Yi-Ying Wu, Chih-Hsien Chang, Tse‐Ming Hong, Yuh-Ling Chen,
... Gal-1-targeting DNA aptamer (AP-74 M-545) and demonstrated its antitumor effect by restoring immune function. AP-74 M-545 binds to Gal-1 with high affinity. AP-74 M-545 targets tumors in murine tumor models but suppresses ... and CD8+ T cells in AP-74 M-545-treated tumor tissues. AP-74 M-545 suppresses T cell apoptosis by blocking the binding ... immunity. These results indicate that AP-74 M-545 may be a potential strategy for cancer immunotherapy. ... Gal-1-targeting DNA aptamer (AP-74 M-545) and demonstrated its antitumor effect by restoring immune ...
Tópico(s): Invertebrate Immune Response Mechanisms
2019 - Cell Press | Molecular Therapy — Nucleic Acids
Abyssinia Expeditionary Force IOR/L/MIL/5/545
0000 - Gale Group | NCCO EuropeAfrica
Sun Ying, Feng Long, Jiansheng Li, Huaming Xu, Mei Xue, Lingyan Feng, Huijuan Sun, Jianfeng Gao, Xiaoli Zhang,
... replication. This study investigated the role of miR-545 in the EV71 replication and explored the underlying molecular mechanisms. We showed that miR-545 was upregulated in the EV71-infected human embryonic ... cells and rhabdomyosarcoma (RD) cells. Overexpression of miR-545 promoted the viral replication of EV71 and attenuated ... HEK293 and RD cells; while knockdown of miR-545 significantly suppressed the EV71 replication in these two ... analysis and luciferase reporter assay showed that miR-545 directly targeted the 3'untranslated region of phosphatase ...
Tópico(s): RNA Research and Splicing
2019 - Wiley | Journal of Cellular Physiology