Project Gutenberg
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
... calcium, and act as positive allosteric modulators. R-568, which was initially tested in clinical trials, has ... starting at 20 wk of age with R-568 or 2% calcium gluconate added to the drinking ... three-fold increase in serum PTH levels. R-568 (alone or with calcium) is marginally more effective ... in preventing the cystic expansion, suggesting that R-568 has beneficial effects on cyst growth independent from ... despite significant hypocalcemia in rats treated with R-568 alone. The three treatments are equally effective in ...
Tópico(s): Genetic Syndromes and Imprinting
2009 - American Society of Nephrology | Journal of the American Society of Nephrology
Abyssinia Expeditionary Force IOR/L/MIL/5/568 Report.
0000 - Gale Group | NCCO EuropeAfrica
Jianmin Sun, Malin Pedersen, Lars Rönnstrand,
... cells is Src. Binding of Src to Tyr-568 in c-Kit leads to its activation and ... PubMed Scopus (89) Google Scholar). Antibodies recognizing pTyr-568, pTyr-703, pTyr-Y721, and pTyr-936 in ... In SCF-induced c-Kit signaling, phosphorylated Tyr-568 is responsible for activation of Src kinases, which ... 42) Google Scholar). Using phosphospecific antibodies against pTyr-568, pTyr-703, pTyr-721, and pTyr-936 in ... compared with D816V mutant. We found that Tyr-568, Tyr-703, Tyr-721, and Tyr-936 were ... generated mutants of the Src binding site Tyr-568 in both wild-type c-Kit and c- ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2009 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
Produção Nacional
Revisado por pares
Christina R. Ferreira, Sérgio A. Saraiva, Rodrigo Ramos Catharino, Jerusa S. Garcia, Fábio C. Gozzo, Gustavo B. Sanvido, Luiz F. A. Santos, E.G. Lo Turco, J. H. F. Pontes, Andréa Cristina Basso, Ricardo Pimenta Bertolla, Roberto Sartori, M. M. Guardieiro, Felipe Perecin, Flávio Vieira Meirelles, Juliano Rodrigues Sangalli, Marcos N. Eberlin,
... between ruminantia and feloideae spermatozoa.Theriogenology. 2009; 71: 568-575Crossref PubMed Scopus (37) Google Scholar723.5[PC ( ... between ruminantia and feloideae spermatozoa.Theriogenology. 2009; 71: 568-575Crossref PubMed Scopus (37) Google Scholar731.5[SM ( ... between ruminantia and feloideae spermatozoa.Theriogenology. 2009; 71: 568-575Crossref PubMed Scopus (37) Google Scholar758.6[PC ( ... between ruminantia and feloideae spermatozoa.Theriogenology. 2009; 71: 568-575Crossref PubMed Scopus (37) Google Scholar760.6[PC ( ...
Tópico(s): Lipid metabolism and biosynthesis
2009 - Elsevier BV | Journal of Lipid Research
Abyssinia Expeditionary Force IOR/L/MIL/5/568 Report.
0000 - Gale Group | NCCO EuropeAfrica
Sharon M. Moe, Mark F. Seifert, N. X. Chen, Rachel M. Sinders, Xingjuan Chen, Danxia Duan, C. M. Henley, David E. Martin, Vincent H. Gattone,
... We studied the effects of the calcimimetic R-568, R-568 with calcium (R-568 + Ca) or calcium (Ca) alone compared with control ... respectively).The results demonstrated similar efficacy of R-568, R-568 + Ca and Ca in lowering PTH levels. R-568 alone lowered plasma calcium compared to control over ... weeks. Animals treated with Ca alone or R-568 + Ca had lower phosphorus levels; the Ca alone ... calcification worsened by most assessments in the R-568 + Ca and Ca alone treated animals compared with R-568 alone whereas R-568 alone treatment showed beneficial ...
Tópico(s): Genetic Syndromes and Imprinting
2009 - Oxford University Press | Nephrology Dialysis Transplantation
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
Huai-fu Li, Guo-feng Ruan, Zhijun Li, Ziwei Liu, Xiaoqing Zheng, Hao Zheng, Guangming Cheng, Benyi Li, Ming Zhan,
... was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress ... this study, we investigated the effect of R-568 on cellular survival of prostate cancer cells. Prostate ... utilized to assess apoptotic events induced by R-568 treatment. JC-1 staining was used to evaluate ... prostate cancer LNCaP and PC-3 cells, R-568 treatment significantly reduced cellular survival in a dose- and time-dependent manner. R-568-induced cell death was an apoptotic event, as ... down calcium sensing receptor (CaSR) significantly reduced R-568-induced cytotoxicity. Enforced expression of Bcl-xL gene ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2009 - BioMed Central | Journal of Experimental & Clinical Cancer Research
Abyssinia Expeditionary Force IOR/L/MIL/5/568 Memorandum.
0000 - Gale Group | NCCO EuropeAfrica
Jianxin Hu, Guadalupe Reyes‐Cruz, Wangzhong Chen, Kenneth A. Jacobson, Allen M. Spiegel,
... response to a positive allosteric modulator, NPS R-568. Both in the context of the full-length ... on activation by Ca2+, and on NPS R-568 augmentation of sensitivity to Ca2+. Of the eight ... of Glu837 drastically reduced sensitivity to NPS R-568. Our data point to a key role of ... transmembrane helix seven in response to NPS R-568. We speculate on the basis of these results ... response to a positive allosteric modulator, NPS R-568. Both in the context of the full-length ... on activation by Ca2+, and on NPS R-568 augmentation of sensitivity to Ca2+. Of the eight ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2002 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
... in HEK 293 cells. The phenylalkylamine compound, NPS 568, identified as a positive allosteric modulator of the ... and organic polycations in the presence of NPS 568 but not the synergistic activation of Ca2+ with ... Gd3+ as well as the allosteric modulators NPS 568 and organic polycations that may play important roles ... in HEK 293 cells. The phenylalkylamine compound, NPS 568, identified as a positive allosteric modulator of the ... and organic polycations in the presence of NPS 568 but not the synergistic activation of Ca2+ with ...
Tópico(s): Ion channel regulation and function
2002 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/568 Letter. From W. Wilby Br. Genl.
0000 - Gale Group | NCCO EuropeAfrica
Susanne U. Miedlich, Lúcio Gama, Gerda E. Breitwieser,
... intracellular calcium stores. Phenylalkylamines such as NPS R-568 are allosteric modulators (calcimimetics) that activate CaR by ... with fura-2, whether the calcimimetic NPS R-568 could activate Ca2+ioscillations in HEK-293 cells expressing human CaR. NPS R-568 was more potent than Ca2+e at eliciting ... mm). The oscillation frequencies elicited by NPS R-568 varied over a 2-fold range from peak ... concentrations of both Ca2+e and NPS R-568. Finally, NPS R-568 induced sustained (>15 min after drug removal) Ca2+ ...
Tópico(s): Neuroscience and Neuropharmacology Research
2002 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
Produção Nacional
Revisado por pares
Ana C. Magalhães, Juliana Silva, Kil Sun Lee, Vilma R. Martins, Vânia F. Prado, Stephen Ferguson, Marcus V. Gomez, Helena Brentani, Marco A. M. Prado,
... incubating cells with 40 μg/ml Alexa Fluor 568-labeled transferrin (Tfn-568, Molecular Probes) at 37 °C in 5% CO2 ... were labeled by the endosomal compartment marker Tfn-568 (Fig. 1,D–F). A large proportion of ... of co-localization between GFP-PrPc and Tfn-568 in puncta close to the plasma membrane in ... of GFP-PrPc with the endocytic marker Tfn-568 (Fig. 5,A and B). These results suggest ... in vesicles filled with FM4-64 or Tfn-568 in the presence of Rab5-Q79L (Figs. 4, ... andD).Figure 5GFP-PrPc co-localizes with Tfn-568 in Rab5 Q79L-expressing cells. SN56 cells were ...
Tópico(s): Biotin and Related Studies
2002 - Elsevier BV | Journal of Biological Chemistry
Abyssinia Expeditionary Force IOR/L/MIL/5/568
0000 - Gale Group | NCCO EuropeAfrica
Mohammad Amraei, Zongjian Jia, Pascal Reboul, Ivan R. Nabi,
... addition of 25 μg/ml of either Alexa 568- or FITC-conjugated PGI to NIH-3T3 cells ... addition of 25 μg/ml of either Alexa 568- or FITC-conjugated PGI to NIH-3T3 cells ... molecular weight markers from BioRad. The Alexa Fluor 568 protein labeling kit and the FluoReporter® FITC protein ... kit were purchased from Molecular Probes, and Alexa 568 and FITC-PGI conjugates were prepared according to ... with either the succinimidyl ester of Alexa Fluor 568 carboxylic acid or fluorescein isothiocyanate in bicarbonate buffer ( ...
Tópico(s): Cellular transport and secretion
2003 - Elsevier BV | Journal of Biological Chemistry