Alexander Street
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Han Yu, Weiyuan Wei, Wenlong Cao, Zexu Zhan, Lin‐Hai Yan, Kun Wu, Dongyi Xie, Bin Cai, Yubo Xie, Qiang Xiao,
... analysis has reported that the expression of miR-593-5p is associated with lymph node metastasis in ... GC); however, the function and mechanism of miR-593-5p in GC have not been described yet. miR-593-5p has also not been elucidated widely in other cancers. Methods: miR-593-5p expression was detected by quantitative RT-PCR ( ... evaluated by wound-healing and transwell assays. miR-593-5p-influenced gene expression profiles were detected by ... chip method in MGC-803 cells, and miR-593-5p candidate target genes were predicted using bioinformatics ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Dove Medical Press | OncoTargets and Therapy
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Nicole M. Chapman, Hongbo Chi,
... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ... et al.Cell Metab. 2017; 25 (this issue): 593-609Abstract Full Text Full Text PDF PubMed Scopus ( ...
Tópico(s): Immune Cell Function and Interaction
2017 - Cell Press | Cell Metabolism
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Yoshiko Awazu, Akio Mizutani, Yoshinori Nagase, Shuntarou Tsuchiya, Kazuhide Nakamura, Yuichi Kakoi, Osamu Kitahara, Toshiyuki Takeuchi, Seiji Yamasaki, Naoki Miyamoto, Hidehisa Iwata, Hiroshi Miki, Shinichi Imamura, Akira Hori,
We recently reported that TAK-593, a novel imidazo[1,2-b]pyridazine derivative, is a highly potent and selective inhibitor of the vascular endothelial growth factor ( ... factor (PDGF) receptor tyrosine kinase families. Moreover, TAK-593 exhibits a uniquely long-acting inhibitory profile towards ... PDGFRβ). In this study, we demonstrated that TAK-593 potently inhibits VEGF- and PDGF-stimulated cellular phosphorylation ... and human coronary artery smooth muscle cells. TAK-593 also potently inhibits VEGF-induced tube formation of ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2013 - Wiley | Cancer Science
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Michael H. Davidson, Serena Tonstad, Suzanne Oparil, Michael Schwiers, Wesley Day, Charles H. Bowden,
... 1352Abstract Full Text Full Text PDF PubMed Scopus (593) Google Scholar, 3Garvey W.T. Ryan D.H. ... 1352Abstract Full Text Full Text PDF PubMed Scopus (593) Google Scholar In the present subanalysis, we evaluated ... 1352Abstract Full Text Full Text PDF PubMed Scopus (593) Google Scholar Briefly, CONQUER was a 56-week, ... 1352Abstract Full Text Full Text PDF PubMed Scopus (593) Google Scholar Hypertension was defined as systolic blood ... 1352Abstract Full Text Full Text PDF PubMed Scopus (593) Google Scholar After a 2-week screening period, ...
Tópico(s): Diabetes Treatment and Management
2013 - Elsevier BV | The American Journal of Cardiology
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Hidehisa Iwata, Shinichi Imamura, Akira Hori, Mark S. Hixon, Hiroyuki Kimura, Hiroshi Miki,
... for targeting tumor angiogenesis. We discovered that TAK-593, a novel imidazo[1,2-b]pyridazine derivative, ... kinases from the VEGFR and PDGFR families. TAK-593 was highly selective for these families, with an ... more than 200 protein and lipid kinases. TAK-593 displayed competitive inhibition versus ATP. In addition, TAK-593 inhibited VEGFR2 and PDGFRβ in a time-dependent ... preincubation experiments revealed that the binding of TAK-593 to VEGFR2 and PDGFRβ occurs via a two-step slow binding mechanism. Dissociation of TAK-593 from VEGFR2 was extremely slow (t(1/2) > ...
Tópico(s): Cancer Mechanisms and Therapy
2010 - American Chemical Society | Biochemistry
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Alexandra Naba, Céline Reverdy, Daniel Louvard, Monique Arpin,
... the two-hybrid screen comprises amino acids 255–593. (B) GST or GST-Fes255–593 immobilized on glutathione beads was incubated with lysates ... with the GST alone or with GST-Fes255–593 (right panel). The interaction of WT ezrin with GST-Fes255–593 is abolished when the cells were treated with ... of GST proteins. (C) GST or GST-Fes255–593 immobilized on glutathione beads was incubated with lysates ... WT and Y145F ezrin interact with GST-Fes255–593, whereas Y477F ezrin does not. Lower panels: Coomassie ... or with PP2 or SU6656. (E) GST-Fes255–593 binds to a peptide comprising phosphorylated tyrosine 477 ...
Tópico(s): Multiple Myeloma Research and Treatments
2007 - Springer Nature | The EMBO Journal
July-Nov.,1905, Diplomatic Despatches.: Volume 593 Letter.
0000 - Gale Group | NCCO AsiaWest
... complex (7Zou L. Stillman B. Science. 1998; 280: 593-596Crossref PubMed Scopus (275) Google Scholar). Phosphorylation of ... in vitro, S. pombe Mcm10p (amino acids 1-593; SpMcm10p) binds preferentially to single-stranded DNA (ssDNA) ... demonstrate that full-length SpMcm10p (amino acids 1-593) and its C-terminal fragment (amino acids 416-593) contain primase activity that catalyzes the synthesis of ... subsequent analysis. Mcm10p-(1-303) and Mcm10p-(416-593) were purified similarly, except that Mcm10p-(416-593) was isolated using a 1-ml Mono Q ...
Tópico(s): RNA modifications and cancer
2006 - Elsevier BV | Journal of Biological Chemistry
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Satoko Yoshida, Martin Parniske,
... one Ser (Ser-580) and one Thr (Thr-593) from the juxtamembrane region, and two Ser (Ser- ... each of Ser-754, Thr-760, and Thr-593 were detected. MS-Spectra identified phosphorylated Ser-754 ... the preincubated sample (Fig. 7B). Phosphorylation of Thr-593 could not be detected in either sample. Because ... plant species. We found three crucial residues, Thr-593, Ser-754, and Thr-760, that are required ... a stronger defect than Thr-462. Residue Thr-593 is located just before the ATP binding site ... 38 in Pto is equivalent to SYMRK Thr-593 (Fig. 8). Mutation of this residue leads to ...
Tópico(s): Mycorrhizal Fungi and Plant Interactions
2004 - Elsevier BV | Journal of Biological Chemistry
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
Young Jun Im, Young Na, Gil Bu Kang, Seong‐Hwan Rho, Mun‐Kyoung Kim, Jun Hyuck Lee, Chin Ha Chung, Soo Hyun Eom,
... a salt bridge between Asp-547 and Lys-593 in Mj-Lon. Moreover, unlike Ec-Lon, Mj- ... in Mj-Lon suggest that the charged Lys-593 assists in lowering the pKa of the Ser- ... a salt bridge between Asp-547 and Lys-593 in Mj-Lon. Moreover, unlike Ec-Lon, Mj- ... in Mj-Lon suggest that the charged Lys-593 assists in lowering the pKa of the Ser- ... and the catalytic residues, Ser-550 and Lys-593, are located at almost identical positions within each ... a pseudocatalytic triad comprised of Ser-550, Lys-593, and Asp-547 (Fig. 3B). Asp-547 and ...
Tópico(s): RNA and protein synthesis mechanisms
2004 - Elsevier BV | Journal of Biological Chemistry
July-Nov.,1905, Diplomatic Despatches.: Volume 593
0000 - Gale Group | NCCO AsiaWest
... have been backcrossed into the recurrent parent 5-593 with black seedcoats and violet flowers. The cross, p BC 3 5-593 × t stp mic BC 3 5-593 (black seeds with a long white micropyle stripe ... two recessive P alleles ( p BC 3 5-593 and p gri BC 3 5-593) and three recessive alleles at the stippled seedcoat gene Stp ( stp BC 3 5-593, stp hbw BC 3 5-593, and stp mic BC 3 5-593) expressed no genetic complementation in seedcoats and flowers ... made between t self-colored BC 3 5-593 and three other parents— p stp BC 3 ...
Tópico(s): Plant Gene Expression Analysis
2003 - American Society for Horticultural Science | Journal of the American Society for Horticultural Science